pyrimidinones and Rett-Syndrome

pyrimidinones has been researched along with Rett-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and Rett-Syndrome

Article	Year
mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome. Human molecular genetics, 2016, 05-15, Volume: 25, Issue:10 Rett syndrome (RS) is a neurodevelopmental disorder that shares many symptomatic and pathological commonalities with idiopathic autism. Alterations in protein synthesis-dependent synaptic plasticity (PSDSP) are a hallmark of a number of syndromic forms of autism; in the present work, we explore the consequences of disruption and rescue of PSDSP in a mouse model of RS. We report that expression of a key regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu Topics: Adult; Allosteric Regulation; Animals; Autistic Disorder; Autopsy; Disease Models, Animal; Female; Gene Expression Regulation; Hippocampus; Humans; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Knockout; Motor Cortex; Neuronal Plasticity; Pyrazoles; Pyrimidinones; Receptor, Metabotropic Glutamate 5; Rett Syndrome; Seizures; Signal Transduction; Young Adult	2016

Article

Year

mGlu5 positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome.

Human molecular genetics, 2016, 05-15, Volume: 25, Issue:10

Rett syndrome (RS) is a neurodevelopmental disorder that shares many symptomatic and pathological commonalities with idiopathic autism. Alterations in protein synthesis-dependent synaptic plasticity (PSDSP) are a hallmark of a number of syndromic forms of autism; in the present work, we explore the consequences of disruption and rescue of PSDSP in a mouse model of RS. We report that expression of a key regulator of synaptic protein synthesis, the metabotropic glutamate receptor 5 (mGlu

Topics: Adult; Allosteric Regulation; Animals; Autistic Disorder; Autopsy; Disease Models, Animal; Female; Gene Expression Regulation; Hippocampus; Humans; Male; Methyl-CpG-Binding Protein 2; Mice; Mice, Knockout; Motor Cortex; Neuronal Plasticity; Pyrazoles; Pyrimidinones; Receptor, Metabotropic Glutamate 5; Rett Syndrome; Seizures; Signal Transduction; Young Adult

2016