pyrimidinones and Panuveitis

pyrimidinones has been researched along with Panuveitis* in 2 studies

Reviews

1 review(s) available for pyrimidinones and Panuveitis

Article	Year
Uveitis and serous retinal detachment secondary to systemic dabrafenib and trametinib. Archivos de la Sociedad Espanola de Oftalmologia, 2018, Volume: 93, Issue:9 The case is presented of a 39-year-old woman with metastatic melanoma treated with dabrafenib and trametinib. She presented with a severe acute panuveitis with granulomatous anterior uveitis, vitritis, and multiple serous retinal detachments. Dabrafenib and trametinib were suspended, and treatment with a systemic and topical corticosteroid was started. A good response was obtained, with a recovery of visual acuity of 1.0 in both eyes within two weeks.. Dabrafenib and trametinib can lead to severe uveitis. Treatment with corticosteroids and discontinuation of therapy with dabrafenib and trametinib led to an anatomical and functional improvement, and resolved the episode rapidly. Ophthalmologists must be aware of this toxicity, given the increasing use of those drugs. Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Azetidines; Drug Synergism; Fatal Outcome; Female; Humans; Imidazoles; MAP Kinase Kinase Kinases; Melanoma; Neoplasm Proteins; Oximes; Panuveitis; Piperidines; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Retinal Detachment; Vemurafenib	2018

Article

Year

Uveitis and serous retinal detachment secondary to systemic dabrafenib and trametinib.

Archivos de la Sociedad Espanola de Oftalmologia, 2018, Volume: 93, Issue:9

The case is presented of a 39-year-old woman with metastatic melanoma treated with dabrafenib and trametinib. She presented with a severe acute panuveitis with granulomatous anterior uveitis, vitritis, and multiple serous retinal detachments. Dabrafenib and trametinib were suspended, and treatment with a systemic and topical corticosteroid was started. A good response was obtained, with a recovery of visual acuity of 1.0 in both eyes within two weeks.. Dabrafenib and trametinib can lead to severe uveitis. Treatment with corticosteroids and discontinuation of therapy with dabrafenib and trametinib led to an anatomical and functional improvement, and resolved the episode rapidly. Ophthalmologists must be aware of this toxicity, given the increasing use of those drugs.

Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Azetidines; Drug Synergism; Fatal Outcome; Female; Humans; Imidazoles; MAP Kinase Kinase Kinases; Melanoma; Neoplasm Proteins; Oximes; Panuveitis; Piperidines; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Retinal Detachment; Vemurafenib

2018

Other Studies

1 other study(ies) available for pyrimidinones and Panuveitis

Article	Year
Uveitis associated with concurrent administration of rifabutin and lopinavir/ritonavir (Kaletra). Eye (London, England), 2007, Volume: 21, Issue:12 Topics: Adult; Anti-HIV Agents; Antitubercular Agents; Drug Interactions; HIV Infections; Humans; Lopinavir; Male; Panuveitis; Pyrimidinones; Rifabutin; Ritonavir; Tuberculosis, Pulmonary	2007