pyrimidinones and Multifocal-Choroiditis

To describe a case of bilateral choroidal neovascularization (CNV) in multifocal choroiditis (MFC) associated with dabrafenib and trametinib chemotherapy for metastatic melanoma.. We present a case of a 57-year-old man with MFC who underwent combination therapy with dabrafenib plus trametinib for metastatic melanoma. The patient presented to our ophthalmology department complaining of bilateral vision loss of 2 days' duration. He underwent multimodal imaging showing a MFC reactivation complicated by bilateral CNV. The patient underwent 3 ranibizumab injections in the right eye and 7 ranibizumab injections in the left eye. Anatomical and functional improvement has been observed.. This report emphasizes the importance of strict ophthalmologic follow-up in patients with metastatic melanoma treated with dabrafenib plus trametinib since rare severe ocular toxicities can occur, especially in patients with a history of uveitis.

Topics: Antineoplastic Combined Chemotherapy Protocols; Choroidal Neovascularization; Choroiditis; Fluorescein Angiography; Humans; Imidazoles; Male; Melanoma; Middle Aged; Multifocal Choroiditis; Multimodal Imaging; Oximes; Pyridones; Pyrimidinones; Skin Neoplasms; Tomography, Optical Coherence