pyrimidinones has been researched along with Histiocytosis* in 2 studies
2 other study(ies) available for pyrimidinones and Histiocytosis
| Article | Year |
|---|---|
Response to trametinib of histiocytosis with an activating
Topics: Histiocytosis; Humans; Mutation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Pyridones; Pyrimidinones | 2020 |
Real-time genomic profiling of histiocytoses identifies early-kinase domain BRAF alterations while improving treatment outcomes.
Many patients with histiocytic disorders such as Langerhans cell histiocytosis (LCH) or Erdheim-Chester disease (ECD) have treatment-refractory disease or suffer recurrences. Recent findings of gene mutations in histiocytoses have generated options for targeted therapies. We sought to determine the utility of prospective sequencing of select genes to further characterize mutations and identify targeted therapies for patients with histiocytoses. Biopsies of 72 patients with a variety of histiocytoses underwent comprehensive genomic profiling with targeted DNA and RNA sequencing. Fifteen patients (21%) carried the known Topics: 3T3 Cells; Adult; Anaplastic Lymphoma Kinase; Animals; Drug Resistance, Neoplasm; Female; Histiocytosis; Humans; Imidazoles; Infant; Male; MAP Kinase Kinase 1; Mice; Mutation; Oximes; Prospective Studies; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Sequence Analysis, DNA; Sequence Analysis, RNA; Treatment Outcome; Young Adult | 2017 |