pyrimidinones and Glucose-Intolerance

pyrimidinones has been researched along with Glucose-Intolerance* in 2 studies

Other Studies

2 other study(ies) available for pyrimidinones and Glucose-Intolerance

Article	Year
Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice. Molecular metabolism, 2019, Volume: 23 The contribution of brown adipose tissue (BAT) to adult human metabolic control is a topic of ongoing investigation. In context, understanding the cellular events leading to BAT uncoupling, heat production, and energy expenditure is anticipated to produce significant insight into this endeavor. The phosphoinositide interacting regulator of transient receptor potentials (Pirt) was recently put forward as a key protein regulating cold sensing downstream of the transient receptor potential melastatin 8 (TRPM8). Notably, TRPM8 has been identified as a non-canonical regulator of BAT thermogenesis. The aim of this investigation was to delineate the role of Pirt in energy homeostasis and glucose metabolism - and the possible involvement of Pirt in TRPM8-elicited energy expenditure.. To this end, we metabolically phenotyped male and female Pirt deficient (Pirt. We identified that chow-fed female Pirt. We here report subtle metabolic abnormalities in female, but not male, Pirt Topics: Adipose Tissue, Brown; Animals; Calcium Channel Agonists; Carrier Proteins; Diet, Fat-Restricted; Diet, High-Fat; Energy Metabolism; Female; Gene Knockout Techniques; Glucose; Glucose Intolerance; Glucose Tolerance Test; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Pyrimidinones; Sex Factors; Thermogenesis; Transcriptome; TRPM Cation Channels	2019
Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes. Nature communications, 2018, 10-23, Volume: 9, Issue:1 Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity strategy. Here, we report that pharmacological activation of the cold receptor transient receptor potential cation channel subfamily M member 8 (TRPM8) with agonist icilin mimics the metabolic benefits of cold exposure. In diet-induced obese (DIO) mice, treatment with icilin enhances energy expenditure, and decreases body weight, without affecting food intake. To further potentiate the thermogenic action profile of icilin and add complementary anorexigenic mechanisms, we set out to identify pharmacological partners next to icilin. To that end, we specifically targeted nicotinic acetylcholine receptor (nAChR) subtype alpha3beta4 (α3β4), which we had recognized as a potential regulator of energy homeostasis and glucose metabolism. Combinatorial targeting of TRPM8 and nAChR α3β4 by icilin and dimethylphenylpiperazinium (DMPP) orchestrates synergistic anorexic and thermogenic pathways to reverse diet-induced obesity, dyslipidemia, and glucose intolerance in DIO mice. Topics: Adipose Tissue, Brown; Animals; Body Weight; Cold Temperature; Diabetes Mellitus, Type 2; Diet; Dimethylphenylpiperazinium Iodide; Energy Metabolism; Fatty Liver; Glucose Intolerance; Insulin Resistance; Male; Melanocortins; Mice, Inbred C57BL; Mice, Obese; Obesity; Pyrimidinones; Receptor, Melanocortin, Type 4; Receptors, Nicotinic; Thermogenesis; TRPM Cation Channels	2018

Article

Year

Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice.

Molecular metabolism, 2019, Volume: 23

The contribution of brown adipose tissue (BAT) to adult human metabolic control is a topic of ongoing investigation. In context, understanding the cellular events leading to BAT uncoupling, heat production, and energy expenditure is anticipated to produce significant insight into this endeavor. The phosphoinositide interacting regulator of transient receptor potentials (Pirt) was recently put forward as a key protein regulating cold sensing downstream of the transient receptor potential melastatin 8 (TRPM8). Notably, TRPM8 has been identified as a non-canonical regulator of BAT thermogenesis. The aim of this investigation was to delineate the role of Pirt in energy homeostasis and glucose metabolism - and the possible involvement of Pirt in TRPM8-elicited energy expenditure.. To this end, we metabolically phenotyped male and female Pirt deficient (Pirt. We identified that chow-fed female Pirt. We here report subtle metabolic abnormalities in female, but not male, Pirt

Topics: Adipose Tissue, Brown; Animals; Calcium Channel Agonists; Carrier Proteins; Diet, Fat-Restricted; Diet, High-Fat; Energy Metabolism; Female; Gene Knockout Techniques; Glucose; Glucose Intolerance; Glucose Tolerance Test; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Obesity; Pyrimidinones; Sex Factors; Thermogenesis; Transcriptome; TRPM Cation Channels

2019

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Nature communications, 2018, 10-23, Volume: 9, Issue:1

Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity strategy. Here, we report that pharmacological activation of the cold receptor transient receptor potential cation channel subfamily M member 8 (TRPM8) with agonist icilin mimics the metabolic benefits of cold exposure. In diet-induced obese (DIO) mice, treatment with icilin enhances energy expenditure, and decreases body weight, without affecting food intake. To further potentiate the thermogenic action profile of icilin and add complementary anorexigenic mechanisms, we set out to identify pharmacological partners next to icilin. To that end, we specifically targeted nicotinic acetylcholine receptor (nAChR) subtype alpha3beta4 (α3β4), which we had recognized as a potential regulator of energy homeostasis and glucose metabolism. Combinatorial targeting of TRPM8 and nAChR α3β4 by icilin and dimethylphenylpiperazinium (DMPP) orchestrates synergistic anorexic and thermogenic pathways to reverse diet-induced obesity, dyslipidemia, and glucose intolerance in DIO mice.

Topics: Adipose Tissue, Brown; Animals; Body Weight; Cold Temperature; Diabetes Mellitus, Type 2; Diet; Dimethylphenylpiperazinium Iodide; Energy Metabolism; Fatty Liver; Glucose Intolerance; Insulin Resistance; Male; Melanocortins; Mice, Inbred C57BL; Mice, Obese; Obesity; Pyrimidinones; Receptor, Melanocortin, Type 4; Receptors, Nicotinic; Thermogenesis; TRPM Cation Channels

2018