pyrimidinones has been researched along with Ganglioglioma* in 2 studies
2 other study(ies) available for pyrimidinones and Ganglioglioma
| Article | Year |
|---|---|
Comment on: Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib.
Topics: Adolescent; Brain Neoplasms; Ganglioglioma; Humans; Imidazoles; Mitogen-Activated Protein Kinase Kinases; Oximes; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Vemurafenib | 2021 |
Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib.
Efficacy of BRAF V600E targeted therapies in brain tumors harboring the mutation has been shown in several case reports and is currently being studied in larger clinical trials. Monotherapy with vemurafenib has been associated with significant side effects, including rashes, papillomas, and squamous cell carcinomas. Here we describe an adolescent female with anaplastic ganglioglioma and significant skin reaction to vemurafenib with subsequent tumor response and tolerance to the BRAF/MEK inhibitor combination of dabrafenib and trametinib without recurrence of previous reaction. Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Drug Resistance, Neoplasm; Female; Ganglioglioma; Humans; Imidazoles; MAP Kinase Kinase 1; Mutation; Oximes; Prognosis; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Vemurafenib | 2018 |