pyrimidinones has been researched along with Cough* in 2 studies
2 other study(ies) available for pyrimidinones and Cough
| Article | Year |
|---|---|
Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs.
Phosphodiesterases (PDEs) are enzymes involved in the degradation of cAMP and cGMP. Selective PDE4 inhibitors (e.g., roflumilast) are effective in therapy of chronic obstructive pulmonary disease associated with neutrophil inflammation. The aim of this study was to evaluate the effects of a selective PDE4 inhibitor, YM976, on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity to histamine, and on inflammatory mediators in ovalbumin-sensitized guinea pigs, with experimentally induced eosinophil inflammation. The YM976 was administered intraperitoneally at a dose of 1.0 mg/kg once daily for 7 days. Sensitization with ovalbumin led to a significant increase in the number of coughs, and in vivo and in vitro airway reactivity. Also, increased plasma levels of IL-4, IL-5, and PAF were observed, with a significant increase in the differential count of eosinophils in both blood and bronchoalveolar lavage fluid. The YM976 suppressed the number of coughs, the airway reactivity in tracheal tissue strips, and the IL-4 level. The findings indicate that PDE4 inhibition by YM976 exerts antitussive and anti-inflammatory effects in guinea pigs with ovalbumin-induced eosinophilic inflammation. Topics: Animals; Bronchial Hyperreactivity; Cough; Cyclic Nucleotide Phosphodiesterases, Type 4; Guinea Pigs; Male; Ovalbumin; Phosphodiesterase 4 Inhibitors; Pyridines; Pyrimidinones; Respiratory System | 2016 |
The role of metabolic factors in the interaction between opiates and homopyrimidazoles in the central nervous system.
Both the analgesic and the antitussive effects of morphine, codeine and azidomorphine, azidocodeine and azidoethylmorphine are potentiated in rats and cats by Probon, a minor analgesic, with a homopyrimidazole structure. The analgesic effect of opiates and their toxicity are more strongly influenced by the N-methylhomopyrimidazoles than their antitussive effect. In the potentiation between Probon and morphine derivatives metabolic interference may play a role at the N-demethylation level, occuring in the liver microsomes. Topics: Analgesics; Animals; Antitussive Agents; Central Nervous System; Cough; Drug Interactions; In Vitro Techniques; Microsomes, Liver; Morphine; Narcotics; Pyrimidinones; Rats | 1980 |