pyrimidinones and Corneal-Neovascularization

pyrimidinones has been researched along with Corneal-Neovascularization* in 2 studies

Other Studies

2 other study(ies) available for pyrimidinones and Corneal-Neovascularization

Article	Year
Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis. Cornea, 2006, Volume: 25, Issue:3 To report a case of peripheral interstitial keratitis in a patient with mastocytosis.. Clinical case description and immunohistologic examination of biopsied ocular tissue.. A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial keratitis with vascularization associated with foreign body sensation and itching. Biomicroscopy of the cornea showed deep corneal inflammatory infiltrates and midstromal vascularization adjacent to a region of superior bulbar conjunctiva, which was mildly chemotic and inflamed. Topical mast cell stabilizers and a short course of topical steroids produced dramatic resolution of the lesion. Biopsy of the erythematous conjunctiva adjacent to the area of corneal inflammation showed the presence of mast cells.. This is the first case of corneal inflammatory infiltration in a patient with mastocytosis. Therapy for this condition consists of a combination of topical mast cell stabilizers, topical steroids, and systemic antihistaminic therapy. Topics: Adult; Corneal Neovascularization; Corneal Stroma; Female; Glucocorticoids; Histamine Antagonists; Humans; Keratitis; Mast Cells; Prednisolone; Pyridines; Pyrimidinones; Urticaria Pigmentosa	2006
RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation. Bioorganic & medicinal chemistry, 2005, Aug-15, Volume: 13, Issue:16 (+/-)-1-(anti-3-Hydroxy-cyclopentyl)-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one (RO4383596) is a potent and selective inhibitor of the pro-angiogenic receptor tyrosine kinases KDR, FGFR, and PDGFR. This agent has an excellent pharmacokinetic profile and is highly efficacious in rodent models of angiogenesis upon oral administration. Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Corneal Neovascularization; Female; Humans; Immunoblotting; Mice; Mice, Inbred C57BL; Mice, Nude; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidinones; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2	2005

Article

Year

Peripheral interstitial keratitis: a novel manifestation of ocular mastocytosis.

Cornea, 2006, Volume: 25, Issue:3

To report a case of peripheral interstitial keratitis in a patient with mastocytosis.. Clinical case description and immunohistologic examination of biopsied ocular tissue.. A 22-year-old woman with biopsy-proven urticaria pigmentosa, a subset of mastocytosis, presented with an active peripheral interstitial keratitis with vascularization associated with foreign body sensation and itching. Biomicroscopy of the cornea showed deep corneal inflammatory infiltrates and midstromal vascularization adjacent to a region of superior bulbar conjunctiva, which was mildly chemotic and inflamed. Topical mast cell stabilizers and a short course of topical steroids produced dramatic resolution of the lesion. Biopsy of the erythematous conjunctiva adjacent to the area of corneal inflammation showed the presence of mast cells.. This is the first case of corneal inflammatory infiltration in a patient with mastocytosis. Therapy for this condition consists of a combination of topical mast cell stabilizers, topical steroids, and systemic antihistaminic therapy.

Topics: Adult; Corneal Neovascularization; Corneal Stroma; Female; Glucocorticoids; Histamine Antagonists; Humans; Keratitis; Mast Cells; Prednisolone; Pyridines; Pyrimidinones; Urticaria Pigmentosa

2006

RO4383596, an orally active KDR, FGFR, and PDGFR inhibitor: synthesis and biological evaluation.

Bioorganic & medicinal chemistry, 2005, Aug-15, Volume: 13, Issue:16

(+/-)-1-(anti-3-Hydroxy-cyclopentyl)-3-(4-methoxy-phenyl)-7-phenylamino-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one (RO4383596) is a potent and selective inhibitor of the pro-angiogenic receptor tyrosine kinases KDR, FGFR, and PDGFR. This agent has an excellent pharmacokinetic profile and is highly efficacious in rodent models of angiogenesis upon oral administration.

Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Corneal Neovascularization; Female; Humans; Immunoblotting; Mice; Mice, Inbred C57BL; Mice, Nude; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidinones; Rats; Rats, Wistar; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Tumor Cells, Cultured; Vascular Endothelial Growth Factor Receptor-2

2005