pyrimidinones and Clostridium-Infections

pyrimidinones has been researched along with Clostridium-Infections* in 1 studies

Other Studies

1 other study(ies) available for pyrimidinones and Clostridium-Infections

Article	Year
MBX-500 is effective for treatment of Clostridium difficile infection in gnotobiotic piglets. Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8 The novel antibiotic MBX-500, dosed at 100, 200, or 400 mg/kg twice daily for 7 days, was evaluated for the treatment of Clostridium difficile infection (CDI) in the gnotobiotic pig model. MBX-500 increased survival at all doses and at high doses improved clinical signs and reduced lesion severity, similar to vancomycin. Our results show that MBX-500 is an effective antibiotic for the treatment of diarrhea associated with CDI and prevents severe systemic disease. Topics: Animals; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Colon; Diarrhea; Disease Models, Animal; Drug Evaluation, Preclinical; Fluoroquinolones; Germ-Free Life; Kaplan-Meier Estimate; Pyrimidinones; Severity of Illness Index; Swine; Treatment Outcome; Vancomycin	2013

Article

Year

MBX-500 is effective for treatment of Clostridium difficile infection in gnotobiotic piglets.

Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:8

The novel antibiotic MBX-500, dosed at 100, 200, or 400 mg/kg twice daily for 7 days, was evaluated for the treatment of Clostridium difficile infection (CDI) in the gnotobiotic pig model. MBX-500 increased survival at all doses and at high doses improved clinical signs and reduced lesion severity, similar to vancomycin. Our results show that MBX-500 is an effective antibiotic for the treatment of diarrhea associated with CDI and prevents severe systemic disease.

Topics: Animals; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Colon; Diarrhea; Disease Models, Animal; Drug Evaluation, Preclinical; Fluoroquinolones; Germ-Free Life; Kaplan-Meier Estimate; Pyrimidinones; Severity of Illness Index; Swine; Treatment Outcome; Vancomycin

2013