pyrimidinones and Airway-Obstruction

pyrimidinones has been researched along with Airway-Obstruction* in 2 studies

Other Studies

2 other study(ies) available for pyrimidinones and Airway-Obstruction

Article	Year
BL-5255. I. Activity in animal models of immediate hypersensitivity reactions. International archives of allergy and applied immunology, 1982, Volume: 67, Issue:2 BL-5255 exhibited potent activity in several models of antigen-induced immediate hypersensitivity reactions in rats and guinea pigs. The compound was effective whether administered by oral or parenteral routes and in passively and actively sensitized animals. It appeared to be readily absorbed when given orally. Localized skin and bronchoconstriction reactions in rats were inhibited by the compound by oral doses at 0.014 and 1 mg/kg, respectively. BL-5255 was protective against both IgE- and IgG-mediated reactions in the rat and guinea pig. Its effectiveness versus the systemic anaphylaxis reaction in the guinea pig appears to be due to BL-5255's ability to inhibit both the IgE and IgG1 components of the reaction. Topics: Administration, Oral; Airway Obstruction; Animals; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypersensitivity, Immediate; Immunoglobulin E; Injections, Intravenous; Kinetics; Male; Ovalbumin; Passive Cutaneous Anaphylaxis; Pyrimidinones; Rats; Rats, Inbred Strains	1982
BL-5255, a tetrazolylpyrimidinone with potent oral antiallergy activity in animals. Monographs in allergy, 1979, Volume: 14 BL-5255, 2-(2-n-propoxyphenyl)-5-(5-1 H-tetrazolyl)pyrimidin-4 (3H)-one, effectively inhibited allergic reactions in sensitized rats or guinea pigs when administered by oral or intravenous routes as the water-soluble sodium or ethanolamine monohydrate salts. In the IgE-mediated rat PCA, BL-5255 was 50 times more potent than disodium cromoglycate by intravenous administration. When administered orally in this model, BL-5255 inhibited the PCA reaction by 50% at 0.1 mg/kg. At less than 0.1 mg/kg p.o., the compound protected conscious actively sensitized guinea pigs from aerosolized antigen-induced collapse. In N. brasiliensis-sensitized rats, BL-5255 administered at 0.1--10 mg/kg p.o. inhibited antigen-induced airway constriction in a dose-related manner. BL-5255 is not a histamine or serotonin antagonist but appears to exert its antiallergic effect by inhibiting the release of mediators. Topics: Administration, Oral; Airway Obstruction; Animals; Azoles; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Hypersensitivity; Hypersensitivity, Immediate; Male; Passive Cutaneous Anaphylaxis; Pyrimidinones; Rats; Tetrazoles	1979

Article

Year

BL-5255. I. Activity in animal models of immediate hypersensitivity reactions.

International archives of allergy and applied immunology, 1982, Volume: 67, Issue:2

BL-5255 exhibited potent activity in several models of antigen-induced immediate hypersensitivity reactions in rats and guinea pigs. The compound was effective whether administered by oral or parenteral routes and in passively and actively sensitized animals. It appeared to be readily absorbed when given orally. Localized skin and bronchoconstriction reactions in rats were inhibited by the compound by oral doses at 0.014 and 1 mg/kg, respectively. BL-5255 was protective against both IgE- and IgG-mediated reactions in the rat and guinea pig. Its effectiveness versus the systemic anaphylaxis reaction in the guinea pig appears to be due to BL-5255's ability to inhibit both the IgE and IgG1 components of the reaction.

Topics: Administration, Oral; Airway Obstruction; Animals; Cromolyn Sodium; Dose-Response Relationship, Drug; Female; Guinea Pigs; Hypersensitivity, Immediate; Immunoglobulin E; Injections, Intravenous; Kinetics; Male; Ovalbumin; Passive Cutaneous Anaphylaxis; Pyrimidinones; Rats; Rats, Inbred Strains

1982

BL-5255, a tetrazolylpyrimidinone with potent oral antiallergy activity in animals.

Monographs in allergy, 1979, Volume: 14

BL-5255, 2-(2-n-propoxyphenyl)-5-(5-1 H-tetrazolyl)pyrimidin-4 (3H)-one, effectively inhibited allergic reactions in sensitized rats or guinea pigs when administered by oral or intravenous routes as the water-soluble sodium or ethanolamine monohydrate salts. In the IgE-mediated rat PCA, BL-5255 was 50 times more potent than disodium cromoglycate by intravenous administration. When administered orally in this model, BL-5255 inhibited the PCA reaction by 50% at 0.1 mg/kg. At less than 0.1 mg/kg p.o., the compound protected conscious actively sensitized guinea pigs from aerosolized antigen-induced collapse. In N. brasiliensis-sensitized rats, BL-5255 administered at 0.1--10 mg/kg p.o. inhibited antigen-induced airway constriction in a dose-related manner. BL-5255 is not a histamine or serotonin antagonist but appears to exert its antiallergic effect by inhibiting the release of mediators.

Topics: Administration, Oral; Airway Obstruction; Animals; Azoles; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Hypersensitivity; Hypersensitivity, Immediate; Male; Passive Cutaneous Anaphylaxis; Pyrimidinones; Rats; Tetrazoles

1979