pyrimidine dimers has been researched along with Skin Neoplasms in 176 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (7.39) | 18.7374 |
1990's | 39 (22.16) | 18.2507 |
2000's | 63 (35.80) | 29.6817 |
2010's | 51 (28.98) | 24.3611 |
2020's | 10 (5.68) | 2.80 |
Authors | Studies |
---|---|
Albrecht, AV; Bohm, KA; Emehiser, RG; Hrdlicka, PJ; Mao, P; Poon, GMK; Roberts, SA; Sivapragasam, S; Stark, B; Wyrick, JJ | 1 |
Conigrave, AD; De Silva, WGM; Dixon, KM; Holland, AJA; Mason, RS; Matthews, J; Rybchyn, MS; Yang, C | 1 |
Dorr, MM; Rochette, PJ | 1 |
Poon, GMK; Selvam, K; Sivapragasam, S; Wyrick, JJ | 1 |
Brash, DE; Han, L; Knight, J; Kornacker, K; Mehta, S; Palmatier, MA; Premi, S; Zhao, D | 1 |
Burke, KE; Wang, Y; Wei, H; Zhou, X | 1 |
Hung, KF; Kawasumi, M; Lee, JW; Ratnakumar, K; Rokunohe, D | 1 |
Mao, P; Wyrick, JJ | 1 |
Frigola, J; Gonzalez-Perez, A; Lopez-Bigas, N; Sabarinathan, R | 1 |
Emri, G; Fidrus, E; Hegedűs, C; Janka, EA; Paragh, G; Remenyik, É | 1 |
De Silva, WGM; Dixon, KM; Gordon-Thomson, C; Halliday, GM; Mason, RS; McCarthy, BY; Reeve, VE; Rybchyn, MS; Tongkao-On, W; Yang, C | 1 |
Gutierrez-Bayona, NE; Lu, C; Taylor, JS | 1 |
Bérubé, R; Douki, T; Drigeard Desgarnier, MC; Lechasseur, A; Rochette, PJ | 1 |
Balbo Pogliano, C; Garajovà, Z; Gatti, M; Naegeli, H; Penengo, L; Rüthemann, P | 1 |
Duoji, G; Grigalavicius, M; Jie, D; Juzeniene, A; Pudroma, X | 1 |
Baker, R; Diffey, BL; Fajuyigbe, D; Lwin, SM; Sarkany, RPE; Tobin, DJ; Young, AR | 1 |
Cadet, J; Douki, T | 1 |
Baczynska, K; Chlebna-Sokol, D; Harrison, GI; Heydenreich, J; Lesiak, A; Narbutt, J; Olsen, P; Pearson, A; Philipsen, PA; Rogowski-Tylman, M; Sandberg Liljendahl, T; Segerbäck, D; Wulf, HC; Young, AR | 1 |
Braun, SA; Bruhs, A; Douki, T; Esser, C; Frauenstein, K; Haarmann-Stemmann, T; Homey, B; Kaveh, M; Krutmann, J; Meller, S; Mescher, M; Pollet, M; Schwarz, A; Shaik, S; Sondenheimer, K; Tigges, J; Vogel, CFA | 1 |
Mullenders, LHF | 1 |
Beesetti, S; Rayala, SK; Surabhi, RP; Venkatraman, G | 1 |
Brown, AJ; Mao, P; Roberts, SA; Smerdon, MJ; Wyrick, JJ | 1 |
Boström, M; Clausen, AR; Elliott, K; Filges, S; Larsson, E; Lindberg, M; Ståhlberg, A; Van den Eynden, J | 1 |
Lim, HW; Yeager, DG | 1 |
Chen, Y; Sugiyama, T | 1 |
Ibuki, Y; Toyooka, T; Zhao, X | 1 |
Basagaña, X; Dadvand, P; Harrison, GI; Heydenreich, J; Liljendahl, TS; Nieuwenhuijsen, MJ; Olsen, P; Petersen, B; Philipsen, PA; Schmalwieser, AW; Segerbäck, D; Thieden, E; Triguero-Mas, M; Wulf, HC; Young, AR | 1 |
Taylor, JS | 1 |
Bacchiocchi, A; Bechara, EJ; Brash, DE; Douki, T; Halaban, R; Mano, CM; Premi, S; Wakamatsu, K; Wallisch, S; Weiner, AB | 1 |
Abdel-Malek, ZA; Cassidy, P | 1 |
Altabas, K; Altabas, V; Carducci, M; De Marco, G; Emanuele, E; Lovati, S; Pavone, PS | 1 |
He, YY; Qiang, L; Sample, A; Shah, P; Yang, S; Zhao, B | 1 |
Costa, ET; Espinha, G; Forti, FL; Osaki, JH | 1 |
Brash, DE | 1 |
Blasiak, J; Pawlowska, E; Wysokinski, D | 1 |
Brash, DE; Premi, S | 1 |
Berry, JL; Cooke, MS; de Gruijl, FR; Felton, SJ; Kift, R; Lam, PM; Rhodes, LE; Vail, A; Webb, AR | 1 |
Mao, P; Roberts, SA; Smerdon, MJ; Wyrick, JJ | 1 |
Kang, TH; Park, JM | 1 |
Chen, GS; Hou, PS; Huang, SM; Lai, HC; Lan, CE; Peng, YT; Wu, CH; Wu, CS; Yang, HJ | 1 |
Ellison, TI; Gilliam, AC; MacDonald, PN; Smith, MK | 1 |
Burch, JA; Hall, RP; Iannacchione, MA; Murray, JC; Pinnell, SR; Streilein, RD | 1 |
Hemminki, K; Segerbäck, D; Snellman, E; Strozyk, M | 1 |
Alekseev, S; Backendorf, C; de Gruijl, FR; Jansen, JG; Mullenders, LH; Pines, A; Vrieling, H | 1 |
Barros, SB; da Silva, VV; de Almeida, RL; Miranda, DV; Rivelli, DP; Ropke, CD; Sawada, TC | 1 |
Kay, E; Leader, M; Mabruk, MJ; Murphy, GM; Murphy, M; Toh, LK | 1 |
Fahey, P; Hacker, E; Hayward, N; Muller, HK; Walker, G | 1 |
Broyde, S; Patel, DJ | 1 |
Aggarwal, AK; Jain, R; Johnson, RE; Prakash, L; Prakash, S; Silverstein, TD | 1 |
Johnson, JL; Lloyd, RS; Lowell, BC; McCullough, AK; Ryabinina, OP | 1 |
Fernandez, AA; Mitchell, DL | 1 |
Rünger, TM | 1 |
Esser, PR; Lademann, J; Martin, SF; Schempp, CM; Simon-Haarhaus, B; Wölfle, U | 1 |
Beani, JC; Bourrain, JL; Douki, T; Leccia, MT; Mouret, S | 1 |
Fishelevich, R; Gaspari, AA; Lee, J; Liu, H; Meng, TC; Nakazono, A; Tammaro, A; Tuchinda, P; Zhao, Y | 1 |
Besaratinia, A; Pfeifer, GP | 1 |
Baldea, I; Bolfa, P; Catoi, C; Clichici, S; Daicoviciu, D; Filip, A; Gal, A; Gherman, C; Muresan, A; Postescu, ID | 1 |
Sarkany, RP; Tewari, A; Young, AR | 1 |
Agarwal, C; Agarwal, R; Deep, G; Roy, S | 1 |
Abdel-Daim, M; Funasaka, Y; Kawana, S; Nishigori, C | 1 |
Galloway, DA; Howie, HL; Robinson, K; Wallace, NA | 1 |
Kotova, N; Liljendahl, TS; Segerbäck, D | 1 |
Carati, D; Castellana, D; D'Amore, M; De Lucro, R; La Pesa, V; Lisi, S; Lofrumento, DD; Sisto, M; Zuccarello, V | 1 |
Grage, MM; Harrison, GI; Sarkany, R; Tewari, A; Young, AR | 1 |
Bernerd, F; Del Bino, S | 1 |
Andersson, EM; Barregard, L; Blomqvist, A; Liljendahl, TS; Segerbäck, D | 1 |
Damian, DL; Halliday, GM; Surjana, D | 1 |
Lebwohl, M; Wang, Y; Wei, H; Zhang, X | 1 |
Bäckvall, H; Berne, B; Ponten, F; Wassberg, C | 1 |
Alberts, D; Bair, WB; Bowden, GT; Dong, Z; Einspahr, J; Hart, N; Liu, G | 1 |
Bates, SE; Bouziane, M; O'Connor, TR; Sarasin, A; Stary, A; Zhou, NY | 1 |
Reardon, JT; Sancar, A | 2 |
Bhawan, J; Gilchrest, BA; Goukassian, DA; Helms, E; van Oostrom, C; van Steeg, H | 1 |
Agarwal, R; Dhanalakshmi, S; Mallikarjuna, GU; Singh, RP | 1 |
Andrew, SE; Campbell, MR; Thulien, KJ; Tron, VA; Young, LC | 1 |
Horio, T; Itoh, T; Kunisada, T; Matsumura, Y; Miyauchi-Hashimoto, H; Okamoto, H; Tanaka, K; Yamazaki, F | 1 |
Yarosh, DB | 1 |
Lima-Bessa, KM; Menck, CF | 1 |
de Gruijl, FR; Eker, AP; Hoeijmakers, JH; Jans, J; Nakajima, S; Rebel, H; Rijksen, Y; Schul, W; Sert, YG; van der Horst, GT; van Steeg, H; Yasui, A | 1 |
Besaratinia, A; Pfeifer, GP; You, YH | 1 |
Agarwal, R; Dhanalakshmi, S; Gu, M; Singh, RP | 1 |
Horio, T; Itoh, T; Miyauchi-Hashimoto, H; Sugihara, A; Tanaka, K | 1 |
Alekseev, S; Backendorf, C; de Gruijl, FR; Fousteri, M; Kool, H; Moser, J; Mullenders, LH; Rebel, H; Vrieling, H | 1 |
Brown, DA; Canning, MT; Nay, SL; Pena, AV; Yarosh, DB | 1 |
Iizuka, H; Ishida-Yamamoto, A; Nakajima, S; Sakata, I; Takahashi, H | 1 |
Gao, D; Lebwohl, M; Moore, JO; Phelps, R; Stebbins, WG; Wang, Y; Wei, H; Zhou, X | 1 |
Beissert, S; Kojima, M; Maeda, A; Schneider, SW; Schwarz, A; Schwarz, T | 1 |
Garinis, GA; Jans, J; van der Horst, GT | 1 |
Essen, LO; Klar, T | 1 |
Conney, AH; Lin, Y; Lou, YR; Lu, YP; Peng, QY; Shih, WJ; Xie, JG; Zhou, S | 1 |
Calcagnile, A; D'Errico, M; Dogliotti, E; Lemma, T; Proietti De Santis, L | 1 |
Mitchell, D | 1 |
de Gruijl, FR; Garinis, GA; Hoeijmakers, JH; Jans, J; Leenen, PJ; Moorhouse, M; Rijksen, Y; Schul, W; Sert, YG; Smid, M; van der Horst, GT; van der Spek, PJ; van der Velde, A; van Oudenaren, A; Yasui, A | 1 |
de Gruijl, FR; Mitchell, DL; Mulder, AA; Mullenders, LH; Nijhof, JG; van Pelt, C | 1 |
Béani, JC; Cadet, J; Douki, T; Favier, A; Leccia, MT; Mouret, S | 1 |
Gaube, S; Gilbertz, KP; Kerkmann, U; Placzek, M; Przybilla, B | 1 |
Ishizaki, K; Kumimoto, H; Kunisada, M; Nakabeppu, Y; Nishigori, C; Sakumi, K | 1 |
Arad, S; Epstein, EH; Gilchrest, BA; Goukassian, DA; Hebert, J; Zattra, E | 1 |
Cafardi, JA; Elmets, CA | 1 |
Kripke, ML | 1 |
DiPaolo, JA; Doniger, J; Jacobson, ED; Krell, K | 1 |
Granstein, RD; Sober, AJ | 1 |
Berg, RJ; de Gruijl, FR; de Laat, A; Roza, L; van der Leun, JC | 1 |
Epe, B; Möller, K; Rünger, TM | 1 |
Bourre, F; Chevallier-Lagente, O; Eker, AP; Eveno, E; Hoeijmakers, JH; Kleijer, WJ; Nikaido, O; Quilliet, X; Roza, L; Stefanini, M | 1 |
Baan, RA; Berg, RJ; de Gruijl, FR; Lohman, PH; Roza, L; Vink, AA | 1 |
Bergman, W; Darroudi, F; Noz, KC; Roza, L; Schothorst, AA | 1 |
Pfeifer, GP; Tornaletti, S | 2 |
Pfeifer, GP; Rozek, D; Tornaletti, S | 1 |
Kripke, ML; Yarosh, DB | 1 |
Calcagnile, A; D'errico, M; Dogliotti, E | 1 |
Hattori, Y; Hiai, H; Imamura, S; Nikaido, O; Nishigori, C; Osawa, T; Tanaka, T; Toyokuni, S; Uchida, K | 1 |
Sutherland, BM | 1 |
Cleaver, JE | 1 |
Ahrens, C; Arlett, CF; Krutmann, J; Roza, L | 1 |
Agarwal, R; Chatterjee, ML; Mukhtar, H | 1 |
Artuso, M; English, DR; Hall, J | 1 |
Gao, S; Holmquist, GP | 1 |
Hill, HZ; Li, W; Mitchell, DL; Xin, P | 1 |
Berton, TR; Fischer, SM; Locniskar, MF; Mitchell, DL | 1 |
Denissenko, MF; Pfeifer, GP; Tommasi, S | 1 |
Drouin, R; Therrien, JP | 1 |
Kvam, E; Tyrrell, RM | 1 |
Alberts, D; Barthelman, M; Chen, W; Gensler, HL; Martinez, J | 1 |
Bykov, VJ; Hemminki, K; Jansen, CT | 1 |
Applegate, LA; Burren, R; Frenk, E; Panizzon, RG; Scaletta, C | 1 |
Berg, RJ; de Gruijl, FR; Mullenders, LH; Ruven, HJ; Sands, AT | 1 |
Bykov, VJ; Hemminki, K; Lindgren, C; Tobin, D | 1 |
Berg, RJ; de Gruijl, FR | 1 |
Lloyd, RS | 1 |
Dammann, R; Pfeifer, GP; Tu, Y | 1 |
Drobetsky, EA; Drouin, R; Rouabhia, M; Therrien, JP | 1 |
Brooks, L; Crook, T; Crossland, S; Fraser-Andrews, EA; McGregor, JM; Rozycka, M; Whittaker, SJ | 1 |
Liebler, DC; McVean, M | 1 |
Johnson, RE; Kondratick, CM; Prakash, L; Prakash, S | 1 |
Li, C; Pfeifer, GP; You, YH | 1 |
Bykov, VJ; Hemminki, K; Jansen, CT; Snellman, E; Xu, G | 1 |
Wallin, H | 1 |
Ahmed, NU; Bito, T; Budiyanto, A; Ichihashi, M; Osawa, T; Ueda, M; Wu, A | 1 |
Kusewitt, DF; Ley, RD; Reeve, VE | 1 |
Ichihashi, M; Kawasaki, K; Reguer, G; Suzuki1, T; Ueda, M; Yamasaki, H | 1 |
Hemminki, K; Jansen, CT; Snellman, E; Xu, G | 1 |
Meador, JA; Mitchell, DL; Walter, RB | 1 |
Birch-Machin, MA; Nikaido, O; Ray, AJ; Rees, JL; Turner, R | 1 |
Cooke, MS; Herbert, KE; Ladapo, A; Lunec, J; Mistry, N | 1 |
Ahmed, NU; Bito, T; Budiyanto, A; Ichihashi, M; Nikaido, O; Osawa, T; Ueda, M; Wu, A | 1 |
Pfeifer, GP; Szabó, PE; You, YH | 1 |
Boguhn, O; Breitbart, EW; Greinert, R; Harder, D; Mitchell, DL; Volkmer, B | 1 |
Horiki, S; Horio, T; Miyauchi-Hashimoto, H; Nikaido, O; Tanaka, K | 1 |
Pfeifer, GP; You, YH | 1 |
Barnard, A; Burd, RM; Cooke, MS; Evans, MD; Hutchinson, PE; Lunec, J; Patel, K | 1 |
Byrom, M; Chiarello, S; Lowery, MG; Mitchell, DL | 1 |
Cadet, J; Douki, T; Pouget, JP; Ravanat, JL; Sauvaigo, S | 1 |
Itakura, E; Iwamoto, Y; Nikaido, O; Oda, Y; Oshiro, Y; Sakamoto, A; Tsuneyoshi, M | 1 |
Chouinard, N; Drouin, R; Mitchell, DL; Robert, M; Rouabhia, M; Therrien, JP | 1 |
Galendo, D; Hergenhahn, M; Hollstein, M; Koomagi, R; Luo, JL; Pfeifer, GP; Tong, WM; Wang, ZQ; Yang, Q; Yoon, JH | 1 |
Roza, L; Vink, AA | 1 |
Bergamo, BM; Elmets, CA; Katiyar, SK; Vyalil, PK | 1 |
Hemminki, K; Jansen, CT; Snellman, E; Zhao, C | 2 |
Carrier, WL; Lee, WH; Regan, JD; Smith, DP; Waters, R | 1 |
Johnson, BE | 1 |
Hori, M; Ihara, M; Koike, K; Udono, MU; Urata, Y; Yoshida, H | 1 |
Alas, LG; Citron, M; Kibitel, JT; Mitchell, D; Oberyszyn, A; Rosenstein, R; Spinowitz, A; Yarosh, D; Yee, V | 1 |
Applegate, LA; Fry, RJ; Ley, RD; Sanchez, AB | 1 |
Alcalay, J; Freeman, SE; Goldberg, LH; Wolf, JE | 1 |
Carter, DM | 1 |
Bootsma, D; Bos, JL; Hoeijmakers, JH; Keijzer, W; Langeveld, JC; Mulder, MP; Smit, EM | 1 |
Strickland, PT | 2 |
Boyle, JM; Müller, H; Roth, M | 1 |
Mitchell, DL; Nairn, RS | 1 |
Jung, EG | 1 |
Applegate, LA; Ley, RD; Stuart, TD | 1 |
34 review(s) available for pyrimidine dimers and Skin Neoplasms
Article | Year |
---|---|
Deciphering UV-induced DNA Damage Responses to Prevent and Treat Skin Cancer.
Topics: Ataxia Telangiectasia Mutated Proteins; DNA Damage; DNA Repair; DNA Replication; Humans; Pyrimidine Dimers; Skin; Skin Neoplasms; Transcription, Genetic; Ultraviolet Rays | 2020 |
Molecular Mechanisms of UVA-Induced Melanoma.
Topics: DNA Damage; Female; Humans; Male; Melanins; Melanoma; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2017 |
Formation of UV-induced DNA damage contributing to skin cancer development.
Topics: Animals; DNA Adducts; DNA Damage; DNA Repair; Guanine; Humans; Melanins; Proto-Oncogene Mas; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2018 |
Solar UV damage to cellular DNA: from mechanisms to biological effects.
Topics: Animals; DNA Damage; DNA Repair; Humans; Pyrimidine Dimers; Signal Transduction; Skin Neoplasms; Ultraviolet Rays | 2018 |
What's New in Photoprotection: A Review of New Concepts and Controversies.
Topics: Antioxidants; Benzophenones; Cholecalciferol; Coral Reefs; Deoxyribodipyrimidine Photo-Lyase; Endocrine Disruptors; Environment; Free Radicals; Humans; Pyrimidine Dimers; Skin Aging; Skin Neoplasms; Sun Protection Factor; Sunburn; Sunlight; Sunscreening Agents; Titanium; Ultraviolet Rays; Vitamins; Zinc Oxide | 2019 |
Nucleotide Excision Repair and Vitamin D--Relevance for Skin Cancer Therapy.
Topics: Animals; DNA Damage; DNA Repair; Humans; Melanoma; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays; Vitamin D; Vitamins | 2016 |
Chemical excitation of electrons: A dark path to melanoma.
Topics: DNA Damage; Electrons; Humans; Keratinocytes; Melanins; Melanoma; NADPH Oxidases; Neoplasms, Radiation-Induced; Nitric Oxide; Nitric Oxide Synthase; Peroxynitrous Acid; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunlight; Superoxides; Ultraviolet Rays | 2016 |
UV-Induced DNA Damage and Mutagenesis in Chromatin.
Topics: Chromatin; DNA; DNA Damage; Humans; Mutagenesis; Neoplasms, Radiation-Induced; Nucleosomes; Pyrimidine Dimers; Skin Neoplasms; Transcription Factors; Ultraviolet Rays | 2017 |
Transcriptional and Posttranslational Regulation of Nucleotide Excision Repair: The Guardian of the Genome against Ultraviolet Radiation.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Chromosomal Proteins, Non-Histone; DNA Damage; DNA Repair; Guanine Nucleotide Exchange Factors; Humans; Protein Isoforms; Protein Processing, Post-Translational; Pyrimidine Dimers; Signal Transduction; Skin Neoplasms; Transcription, Genetic; Ubiquitin-Protein Ligases; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 2016 |
UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.
Topics: DNA Damage; Humans; Melanoma; Mutation; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2012 |
Effect of chemical peeling on the skin in relation to UV irradiation.
Topics: Animals; Chemexfoliation; Humans; Light; Mice; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunburn; Ultraviolet Rays | 2012 |
Thermodynamic cooperativity and kinetic proofreading in DNA damage recognition and repair.
Topics: DNA Damage; DNA Repair; Humans; Pyrimidine Dimers; Skin Neoplasms; Thermodynamics; Ultraviolet Rays | 2004 |
DNA repair, immunosuppression, and skin cancer.
Topics: Animals; Deoxyribodipyrimidine Photo-Lyase; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Humans; Immune Tolerance; Liposomes; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays; Viral Proteins | 2004 |
Mutations induced by ultraviolet light.
Topics: 5-Methylcytosine; Animals; Humans; Melanoma; Mutation; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2005 |
Photolyases: capturing the light to battle skin cancer.
Topics: Animals; Deoxyribodipyrimidine Photo-Lyase; DNA; DNA Repair; Mice; Mice, Transgenic; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2006 |
Light-driven DNA repair by photolyases.
Topics: Animals; Deoxyribodipyrimidine Photo-Lyase; DNA; DNA Repair; Forecasting; Humans; Light; Models, Biological; Models, Molecular; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2006 |
Cell type and DNA damage specific response of human skin cells to environmental agents.
Topics: Antioxidants; Apoptosis; Cell Differentiation; Cells, Cultured; DNA Damage; DNA Repair; Fibroblasts; G1 Phase; Humans; Keratinocytes; Oxidants; Pyrimidine Dimers; Skin; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2007 |
T4 endonuclease V: review and application to dermatology.
Topics: Administration, Cutaneous; Adult; Animals; Bacteriophage T4; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Clinical Trials as Topic; Deoxyribonuclease (Pyrimidine Dimer); DNA Repair; Drug Evaluation, Preclinical; Female; Genetic Predisposition to Disease; Humans; Liposomes; Male; Middle Aged; Neoplasms, Radiation-Induced; Photosensitivity Disorders; Pyrimidine Dimers; Rats; Skin Neoplasms; Sunburn; Viral Proteins; Xeroderma Pigmentosum | 2008 |
Immunologic mechanisms in UV radiation carcinogenesis.
Topics: Animals; Antibodies, Neoplasm; Antigens, Neoplasm; DNA; DNA Repair; Graft Rejection; Humans; Immunosuppression Therapy; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Neoplasms, Radiation-Induced; Nucleic Acid Denaturation; Pyrimidine Dimers; Rats; Skin Neoplasms; Sunlight; T-Lymphocytes; T-Lymphocytes, Regulatory; Ultraviolet Rays | 1981 |
Current concepts in ultraviolet carcinogenesis.
Topics: Aging; Animals; Antioxidants; beta Carotene; Carcinogens; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Carotenoids; DNA; Female; Geography; Humans; Male; Melanocytes; Melanoma; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Sex Factors; Skin Neoplasms; Ultraviolet Rays; Vitamin A | 1982 |
DNA repair and cytokines in antimutagenesis and anticarcinogenesis.
Topics: Cytokines; DNA Damage; DNA Repair; Humans; Immune Tolerance; Melanins; Mutation; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays; Virus Activation | 1996 |
Genetic alterations in skin cancer.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; Cocarcinogenesis; Disease Susceptibility; DNA Damage; DNA Ligases; DNA Repair; Epidermis; Genes, p53; Humans; Mice; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Sunlight; Ultraviolet Rays | 1996 |
UV damage and repair mechanisms in mammalian cells.
Topics: Animals; Chromatin; DNA; DNA Damage; DNA Repair; Humans; In Vitro Techniques; Neoplasms, Radiation-Induced; Photochemistry; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1996 |
Mutagenic lesions in carcinogenesis: induction and repair of pyrimidine dimers.
Topics: Animals; DNA Damage; DNA Repair; Humans; Mutation; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Sunlight | 1996 |
Mutagenic lesions in photocarcinogenesis: the fate of pyrimidine photoproducts in repair-deficient disorders.
Topics: Animals; DNA Repair; Humans; Mutation; Photobiology; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum | 1996 |
The role of DNA damage and repair in ultraviolet B radiation-induced immunomodulation: relevance for human photocarcinogenesis.
Topics: Animals; DNA Damage; DNA Repair; Humans; Immune Tolerance; Intercellular Adhesion Molecule-1; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1996 |
Molecular epidemiology of skin cancers: DNA repair and non-melanocytic skin cancer.
Topics: Animals; Cell Transformation, Neoplastic; Cocarcinogenesis; Cockayne Syndrome; DNA Damage; DNA Repair; Humans; Incidence; Mammals; Neoplasms, Radiation-Induced; Photosensitivity Disorders; Pyrimidine Dimers; Risk Factors; Skin Neoplasms; Sunlight; Ultraviolet Rays; Xeroderma Pigmentosum | 1996 |
Somatic mutation theory, DNA repair rates, and the molecular epidemiology of p53 mutations.
Topics: Animals; DNA Repair; Genes, p53; Humans; Kinetics; Molecular Epidemiology; Mutagenesis; Mutation; Pyrimidine Dimers; Skin Neoplasms | 1997 |
Melanin: a two edged sword?
Topics: 1-Methyl-3-isobutylxanthine; Animals; Disease Susceptibility; DNA Damage; Humans; Melanins; Melanocyte-Stimulating Hormones; Melanocytes; Melanoma, Experimental; Mice; Mice, Mutant Strains; Neoplasm Proteins; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Racial Groups; Reactive Oxygen Species; Skin Neoplasms; Skin Pigmentation; Sunlight; Ultraviolet Rays | 1997 |
Base excision repair of cyclobutane pyrimidine dimers.
Topics: Antineoplastic Agents; Base Pairing; Carbon-Oxygen Lyases; Cyclobutanes; Deoxyribonuclease IV (Phage T4-Induced); DNA Glycosylases; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Humans; N-Glycosyl Hydrolases; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1998 |
Photobiology of Monodelphis domestica.
Topics: Animals; Cornea; Dermatitis, Contact; Dinitrofluorobenzene; Disease Models, Animal; DNA Repair; Eye Neoplasms; Melanoma; Mice; Mice, Nude; Opossums; Oxazolone; Photobiology; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays; Urocanic Acid | 2000 |
Effects of UV and visible radiations on cellular DNA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Biomarkers; Deoxyguanosine; DNA; DNA Adducts; DNA Damage; DNA Ligases; Forecasting; Humans; Light; Neoplasms, Radiation-Induced; Oxidation-Reduction; Oxidative Stress; Photochemistry; Photosensitivity Disorders; Pyrimidine Dimers; Radiation-Sensitizing Agents; Reactive Oxygen Species; Skin Neoplasms; Ultraviolet Rays | 2001 |
Biological consequences of cyclobutane pyrimidine dimers.
Topics: Animals; DNA Damage; Erythema; Humans; Immune Tolerance; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2001 |
Green tea polyphenols: DNA photodamage and photoimmunology.
Topics: Animals; DNA Damage; Flavonoids; Humans; Immune Tolerance; Phenols; Polymers; Polyphenols; Pyrimidine Dimers; Skin; Skin Neoplasms; Tea; Ultraviolet Rays | 2001 |
4 trial(s) available for pyrimidine dimers and Skin Neoplasms
Article | Year |
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Comparative Effects of Sunscreens Alone vs Sunscreens Plus DNA Repair Enzymes in Patients With Actinic Keratosis: Clinical and Molecular Findings from a 6-Month, Randomized, Clinical Study.
Topics: Aged; Aged, 80 and over; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Deoxyribodipyrimidine Photo-Lyase; Drug Combinations; Endonucleases; Female; Humans; Keratosis, Actinic; Male; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunscreening Agents | 2015 |
A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation.
Topics: Administration, Cutaneous; Adult; alpha-Tocopherol; Antioxidants; Ascorbic Acid; Coumaric Acids; Cytokines; DNA Damage; DNA Primers; Drug Combinations; Erythema; Humans; Immunohistochemistry; Polymerase Chain Reaction; Pyrimidine Dimers; Radiation Dosage; RNA, Messenger; Skin; Skin Neoplasms; Statistics, Nonparametric; Sunburn; Tumor Suppressor Protein p53; Ultraviolet Rays | 2008 |
Induction and excretion of ultraviolet-induced 8-oxo-2'-deoxyguanosine and thymine dimers in vivo: implications for PUVA.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Case-Control Studies; Deoxyguanosine; DNA Damage; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Pilot Projects; Psoriasis; PUVA Therapy; Pyrimidine Dimers; Reproducibility of Results; Skin Neoplasms; Ultraviolet Rays | 2001 |
Excision repair of pyrimidine dimers induced by simulated solar radiation in the skin of patients with basal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; DNA Repair; DNA, Neoplasm; Dose-Response Relationship, Radiation; Female; Humans; Male; Middle Aged; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1990 |
138 other study(ies) available for pyrimidine dimers and Skin Neoplasms
Article | Year |
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CTCF binding modulates UV damage formation to promote mutation hot spots in melanoma.
Topics: Binding Sites; Binding, Competitive; CCCTC-Binding Factor; Cell Line, Tumor; DNA Damage; DNA Repair; Gene Expression; Humans; Melanoma; Molecular Dynamics Simulation; Mutation; Protein Binding; Protein Serine-Threonine Kinases; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2021 |
The CaSR Modulator NPS-2143 Reduced UV-Induced DNA Damage in Skh:hr1 Hairless Mice but Minimally Inhibited Skin Tumours.
Topics: Animals; DNA Damage; Female; Humans; Mice; Mice, Hairless; Pyrimidine Dimers; Receptors, Calcium-Sensing; Skin; Skin Neoplasms; Ultraviolet Rays | 2023 |
Reduction of DNA damage repair efficiency and accumulation of residual damage following chronic UVB-irradiation of HaCaT cells.
Topics: DNA Damage; DNA Repair; HaCaT Cells; Humans; Keratinocytes; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2023 |
Detecting recurrent passenger mutations in melanoma by targeted UV damage sequencing.
Topics: DNA Damage; Humans; Melanocytes; Melanoma; Mutation; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2023 |
Genomic sites hypersensitive to ultraviolet radiation.
Topics: 5' Untranslated Regions; Cells, Cultured; DNA Damage; Fibroblasts; Gene Expression Regulation; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Melanocytes; Melanoma; Mutation; Promoter Regions, Genetic; Protein Biosynthesis; Pyrimidine Dimers; Pyrimidine Nucleotides; Skin Neoplasms; TOR Serine-Threonine Kinases; Ultraviolet Rays | 2019 |
Dietary Lycopene Protects SKH-1 Mice Against Ultraviolet B-Induced Photocarcinogenesis
Topics: Animals; Antioxidants; Dietary Supplements; Female; Lycopene; Mice; Mice, Hairless; Proliferating Cell Nuclear Antigen; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2019 |
Genome-Wide Mapping of UV-Induced DNA Damage with CPD-Seq.
Topics: Cell Line; Chromosome Mapping; Computational Biology; DNA Damage; Fibroblasts; High-Throughput Nucleotide Sequencing; Humans; Pyrimidine Dimers; Saccharomyces cerevisiae; Skin Neoplasms; Ultraviolet Rays | 2020 |
Variable interplay of UV-induced DNA damage and repair at transcription factor binding sites.
Topics: Binding Sites; Chromosome Mapping; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Melanoma; Mutagenesis; Mutation; Pyrimidine Dimers; Skin Neoplasms; Transcription Factors; Ultraviolet Rays; Whole Genome Sequencing | 2021 |
Inhibitors of Nucleotide Excision Repair Decrease UVB-Induced Mutagenesis-An In Vitro Study.
Topics: Animals; Arsenic Trioxide; Autophagy; Benzimidazoles; Cell Cycle Checkpoints; Cell Line, Transformed; Cell Survival; CHO Cells; Cricetulus; DNA Damage; DNA Repair; HaCaT Cells; Humans; Hypoxanthine Phosphoribosyltransferase; Melanoma; Mutation Rate; Pyrimidine Dimers; Resveratrol; Skin; Skin Neoplasms; Spironolactone; Ultraviolet Rays | 2021 |
Sex Differences in Photoprotective Responses to 1,25-Dihydroxyvitamin D3 in Mice Are Modulated by the Estrogen Receptor-β.
Topics: Administration, Cutaneous; Animals; Calcitriol; Dermatitis, Contact; Disease Models, Animal; Estrogen Receptor beta; Female; Immune Tolerance; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrimidine Dimers; Sex Factors; Signal Transduction; Skin; Skin Neoplasms; Sunburn; Sunscreening Agents; Ultraviolet Rays | 2021 |
The effect of flanking bases on direct and triplet sensitized cyclobutane pyrimidine dimer formation in DNA depends on the dipyrimidine, wavelength and the photosensitizer.
Topics: 3' Flanking Region; 5' Flanking Region; Base Sequence; Cytosine; DNA; Humans; Melanocytes; Mutagenesis; Mutation; Photosensitizing Agents; Pyrimidine Dimers; Skin Neoplasms; Thymine; Ultraviolet Rays | 2021 |
Persistence and Tolerance of DNA Damage Induced by Chronic UVB Irradiation of the Human Genome.
Topics: Adult; Biopsy; DNA Damage; DNA Repair; DNA Replication; Dose-Response Relationship, Radiation; Female; Fibroblasts; Genome, Human; Genomic Instability; Heterochromatin; Humans; Primary Cell Culture; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays; Young Adult | 2018 |
ASH1L histone methyltransferase regulates the handoff between damage recognition factors in global-genome nucleotide excision repair.
Topics: Cell Line; DNA Damage; DNA Repair; DNA-Binding Proteins; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Nucleosomes; Protein Interaction Domains and Motifs; Pyrimidine Dimers; RNA, Small Interfering; Skin Neoplasms; Transcription Factors; Ultraviolet Rays | 2017 |
Melanin distribution in human epidermis affords localized protection against DNA photodamage and concurs with skin cancer incidence difference in extreme phototypes.
Topics: Adult; Black People; DNA Damage; Epidermis; Humans; Melanins; Pyrimidine Dimers; Skin Neoplasms; Skin Pigmentation; Sunlight; White People | 2018 |
Children sustain high levels of skin DNA photodamage, with a modest increase of serum 25-hydroxyvitamin D
Topics: Bathing Beaches; Calcifediol; Child; Diaries as Topic; DNA Damage; Dose-Response Relationship, Radiation; Female; Holidays; Humans; Male; Poland; Pyrimidine Dimers; Seasons; Skin; Skin Neoplasms; Sunbathing; Sunlight; Sunscreening Agents; Ultraviolet Rays | 2018 |
The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line; Cyclin-Dependent Kinase Inhibitor p27; DNA Breaks, Double-Stranded; DNA Repair; Humans; Keratinocytes; Mice; Mice, Hairless; Mice, Knockout; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Receptors, Aryl Hydrocarbon; RNA Interference; RNA, Small Interfering; Skin Neoplasms; Ultraviolet Rays | 2018 |
Mechanics of PAK1-A new molecular player in the arena of skin cancer.
Topics: Ataxia Telangiectasia Mutated Proteins; Biomarkers, Tumor; DNA Damage; DNA Repair; ErbB Receptors; Humans; Keratinocytes; p21-Activated Kinases; Precancerous Conditions; Pyrimidine Dimers; Signal Transduction; Skin; Skin Neoplasms; Ultraviolet Rays | 2018 |
Nucleosome positions establish an extended mutation signature in melanoma.
Topics: Chromatin; DNA Repair; DNA, Neoplasm; Female; Genome, Human; Histone Code; Humans; Male; Melanoma; Models, Genetic; Mutation; Neoplasms, Radiation-Induced; Nucleosomes; Prostatic Neoplasms; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2018 |
Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers.
Topics: Base Sequence; Binding Sites; Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Humans; Melanoma; Mutation; Neoplasms, Radiation-Induced; Promoter Regions, Genetic; Proto-Oncogene Proteins c-ets; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays; Whole Genome Sequencing | 2018 |
Biochemical reconstitution of UV-induced mutational processes.
Topics: 5-Methylcytosine; Cell-Free System; Cytosine; Deamination; DNA Damage; DNA Replication; DNA-Cytosine Methylases; DNA-Directed DNA Polymerase; DNA, Neoplasm; DNA, Single-Stranded; Humans; Melanoma; Models, Genetic; Mutagenesis; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Transcriptome; Ultraviolet Rays | 2019 |
Silver ions enhance UVB-induced phosphorylation of histone H2AX.
Topics: Anti-Bacterial Agents; Biomarkers; Cell Cycle; Cell Survival; Cell-Free System; DNA Breaks, Double-Stranded; Flow Cytometry; Histones; Humans; Ions; Keratinocytes; Mutagens; Phosphorylation; Pyrimidine Dimers; Pyrimidines; Silver; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2014 |
Sun and ski holidays improve vitamin D status, but are associated with high levels of DNA damage.
Topics: Adult; Bathing Beaches; DNA Damage; Female; Holidays; Humans; Male; Middle Aged; Pyrimidine Dimers; Skiing; Skin; Skin Neoplasms; Sunlight; Time Factors; Ultraviolet Rays; Vitamin D; Vitamin D Deficiency | 2014 |
Biomolecules. The dark side of sunlight and melanoma.
Topics: Animals; DNA; DNA Damage; Humans; Melanins; Melanocytes; Melanoma; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms | 2015 |
Photochemistry. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Topics: Animals; Cells, Cultured; Cytosine; DNA; DNA Damage; Energy Transfer; Humans; Melanins; Melanocytes; Melanoma; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Neoplasms, Radiation-Induced; Photons; Pyrimidine Dimers; Receptor, Melanocortin, Type 1; Skin Neoplasms; Sunlight; Thymine; Ultraviolet Rays | 2015 |
Dark CPDs and photocarcinogenesis: the party continues after the lights go out.
Topics: Animals; DNA; DNA Damage; Humans; Melanins; Melanocytes; Melanoma; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms | 2015 |
Autophagy positively regulates DNA damage recognition by nucleotide excision repair.
Topics: Animals; Autophagy; Carcinogenesis; DNA Damage; DNA Repair; DNA-Binding Proteins; Down-Regulation; E1A-Associated p300 Protein; HEK293 Cells; Humans; Mice; Models, Biological; Nuclear Proteins; Proto-Oncogene Proteins c-akt; Pyrimidine Dimers; Skin Neoplasms; Transcription, Genetic; Twist-Related Protein 1; Ultraviolet Rays | 2016 |
Inhibition of the RhoA GTPase Activity Increases Sensitivity of Melanoma Cells to UV Radiation Effects.
Topics: Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Comet Assay; DNA Damage; DNA Repair; Glutathione Transferase; GTP-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; Melanoma; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Pyrimidine Dimers; rhoA GTP-Binding Protein; Skin Neoplasms; Ultraviolet Rays | 2016 |
UV-induced Melanin Chemiexcitation: A New Mode of Melanoma Pathogenesis.
Topics: Animals; DNA Damage; Humans; Melanins; Melanocytes; Melanoma; Mice; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2016 |
Concurrent beneficial (vitamin D production) and hazardous (cutaneous DNA damage) impact of repeated low-level summer sunlight exposures.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adolescent; Adult; Asia, Southeastern; Biomarkers; Deoxyguanosine; Diet; DNA Damage; DNA Repair; Environmental Exposure; Female; Humans; Male; Middle Aged; Pyrimidine Dimers; Seasons; Skin; Skin Neoplasms; Skin Pigmentation; Sunlight; Vitamin D; Vitamin D Deficiency; Young Adult | 2016 |
Irradiance-dependent UVB Photocarcinogenesis.
Topics: Adult; Animals; Bromodeoxyuridine; Butadienes; Carcinogenesis; Cell Count; Cell Survival; Cells, Cultured; Dermatitis, Contact; DNA Damage; Extracellular Signal-Regulated MAP Kinases; G2 Phase; Humans; Immunosuppression Therapy; Keratinocytes; Mice, Hairless; Mitosis; Mutation; Nitriles; Protein Kinase Inhibitors; Pyrimidine Dimers; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2016 |
Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis.
Topics: Adaptation, Physiological; Animals; Apoptosis; Disease Susceptibility; Epidermis; Keratinocytes; Mice; Mice, Knockout; Neoplasms, Radiation-Induced; Penetrance; Pyrimidine Dimers; Receptors, Calcitriol; Skin; Skin Neoplasms; Ultraviolet Rays; Vitamin D | 2008 |
Repair of UV dimers in skin DNA of patients with basal cell carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Buttocks; Carcinoma, Basal Cell; Case-Control Studies; Chromatography, High Pressure Liquid; DNA Damage; DNA Repair; DNA, Neoplasm; Female; Humans; Male; Middle Aged; Pyrimidine Dimers; Risk; Skin; Skin Neoplasms; Sunlight | 2008 |
Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.
Topics: Animals; Disease Susceptibility; DNA Repair; DNA-Binding Proteins; Fibroblasts; Humans; Keratinocytes; Kinetics; Mice; Mice, Hairless; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2009 |
Photoprotective effect of Pothomorphe umbellata on UVB radiation-induced biomarkers involved in carcinogenesis of hairless mouse epidermis.
Topics: Administration, Cutaneous; Animals; Apoptosis; Biomarkers; Carcinogenicity Tests; Epidermis; Female; Hyperplasia; Immunohistochemistry; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Piperaceae; Plant Extracts; Proliferating Cell Nuclear Antigen; Pyrimidine Dimers; Radiation-Protective Agents; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2009 |
Investigation of the effect of UV irradiation on DNA damage: comparison between skin cancer patients and normal volunteers.
Topics: Adult; Aged; Carcinoma, Basal Cell; DNA Damage; Dose-Response Relationship, Radiation; Erythema; Female; Humans; Keratinocytes; Male; Middle Aged; Pyrimidine Dimers; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2009 |
Enhancement of DNA repair using topical T4 endonuclease V does not inhibit melanoma formation in Cdk4(R24C/R24C)/Tyr-Nras(Q61K) mice following neonatal UVR.
Topics: Administration, Topical; Animals; Animals, Newborn; Antineoplastic Agents; Cell Proliferation; Cyclin-Dependent Kinase 4; Deoxyribonuclease (Pyrimidine Dimer); Disease Models, Animal; DNA Damage; DNA Repair; Keratinocytes; Melanocytes; Melanoma; Mice; Mice, Transgenic; Pyrimidine Dimers; Skin; Skin Neoplasms; Time; Treatment Outcome; Ultraviolet Rays; Up-Regulation; Viral Proteins | 2010 |
DNA repair: How to accurately bypass damage.
Topics: Biocatalysis; Crystallography, X-Ray; DNA; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Humans; Models, Molecular; Mutation, Missense; Pyrimidine Dimers; Saccharomyces cerevisiae; Skin Neoplasms; Structure-Activity Relationship; Xeroderma Pigmentosum | 2010 |
Structural basis for the suppression of skin cancers by DNA polymerase eta.
Topics: Biocatalysis; Catalytic Domain; Crystallography, X-Ray; DNA; DNA Damage; DNA-Directed DNA Polymerase; Humans; Kinetics; Models, Molecular; Mutation, Missense; Nucleic Acid Conformation; Protein Structure, Tertiary; Pyrimidine Dimers; Saccharomyces cerevisiae; Skin Neoplasms; Structure-Activity Relationship; Xeroderma Pigmentosum | 2010 |
TAT-mediated delivery of a DNA repair enzyme to skin cells rapidly initiates repair of UV-induced DNA damage.
Topics: Administration, Topical; Cell Line; Cell Nucleus; Chlorella; DNA; DNA Damage; DNA Glycosylases; DNA Repair; Fibroblasts; Humans; Keratinocytes; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2011 |
Different types of DNA damage play different roles in the etiology of sunlight-induced melanoma.
Topics: Animals; Cyprinodontiformes; Disease Models, Animal; DNA Damage; Humans; Melanoma; Models, Biological; Mutation; Pyrimidine Dimers; Reactive Oxygen Species; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2011 |
Is UV-induced mutation formation in melanocytes different from other skin cells?
Topics: Animals; DNA Damage; DNA Repair; Fibroblasts; Humans; Keratinocytes; Melanocytes; Melanoma; Mutagenesis; Mutation; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2011 |
UVB-induced DNA damage, generation of reactive oxygen species, and inflammation are effectively attenuated by the flavonoid luteolin in vitro and in vivo.
Topics: Acetylcysteine; Antioxidants; Cell Line; Chromans; Cyclooxygenase 2; Cytoprotection; Dinoprostone; DNA Damage; Erythema; Extracellular Signal-Regulated MAP Kinases; Fluoresceins; Gene Expression; Humans; Inflammation; Inhibitory Concentration 50; Keratinocytes; Luteolin; Organ Culture Techniques; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pyrimidine Dimers; Reactive Oxygen Species; Skin; Skin Neoplasms; Ultraviolet Rays | 2011 |
Individual photosensitivity of human skin and UVA-induced pyrimidine dimers in DNA.
Topics: Adult; Erythema; Humans; Male; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Radiation Tolerance; Skin; Skin Neoplasms; Ultraviolet Rays | 2011 |
Imiquimod-induced TLR7 signaling enhances repair of DNA damage induced by ultraviolet light in bone marrow-derived cells.
Topics: Aminoquinolines; Animals; Antineoplastic Agents; Bone Marrow Cells; Cell Line; DNA Damage; DNA Repair; Female; Gene Expression Regulation, Neoplastic; Imiquimod; Membrane Glycoproteins; Mice; Mice, Knockout; Myeloid Differentiation Factor 88; Pyrimidine Dimers; Signal Transduction; Skin Neoplasms; Toll-Like Receptor 7; Ultraviolet Rays; Xeroderma Pigmentosum Group A Protein | 2011 |
Chemopreventive effects of Calluna vulgaris and Vitis vinifera extracts on UVB-induced skin damage in SKH-1 hairless mice.
Topics: Animals; Apoptosis; Biphenyl Compounds; Calluna; Cytokines; Disease Models, Animal; Female; Free Radical Scavengers; Humans; Mice; Mice, Hairless; Phytotherapy; Picrates; Plant Extracts; Pyrimidine Dimers; Random Allocation; Seeds; Skin; Skin Neoplasms; Sunburn; Ultraviolet Rays; Vitis | 2011 |
UVA1 induces cyclobutane pyrimidine dimers but not 6-4 photoproducts in human skin in vivo.
Topics: DNA Repair; Dose-Response Relationship, Radiation; Erythema; Humans; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2012 |
Silibinin prevents ultraviolet B radiation-induced epidermal damages in JB6 cells and mouse skin in a p53-GADD45α-dependent manner.
Topics: Animals; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Mice; Mice, Hairless; Nuclear Proteins; Pyrimidine Dimers; RNA Interference; RNA, Small Interfering; S Phase Cell Cycle Checkpoints; Silybin; Silymarin; Skin; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2012 |
HPV 5 and 8 E6 abrogate ATR activity resulting in increased persistence of UVB induced DNA damage.
Topics: Ataxia Telangiectasia Mutated Proteins; Betapapillomavirus; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cells, Cultured; DNA Breaks, Double-Stranded; Humans; Oncogene Proteins, Viral; p300-CBP Transcription Factors; Protein Serine-Threonine Kinases; Pyrimidine Dimers; RNA Interference; RNA, Messenger; RNA, Small Interfering; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2012 |
Quantification of ultraviolet radiation-induced DNA damage in the urine of Swedish adults and children following exposure to sunlight.
Topics: Adult; Biomarkers; Child; Child, Preschool; DNA Damage; Environmental Exposure; Female; Humans; Male; Middle Aged; Pyrimidine Dimers; Risk Factors; Skin Neoplasms; Statistics, Nonparametric; Sunbathing; Sunlight; Sweden; Ultraviolet Rays; Young Adult | 2012 |
Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Disease Progression; DNA Repair; Epidermal Cells; Gene Expression Regulation; Humans; Keratinocytes; NF-kappa B; Pyrimidine Dimers; Saponins; Signal Transduction; Skin Neoplasms; Tribulus; Ultraviolet Rays | 2012 |
UVA1 is skin deep: molecular and clinical implications.
Topics: Animals; DNA Damage; Erythema; Humans; Mice; Mutation; Pyrimidine Dimers; Reactive Oxygen Species; Skin; Skin Neoplasms; Ultraviolet Rays | 2013 |
Relationship between skin color and skin response to ultraviolet light.
Topics: Black People; Dose-Response Relationship, Radiation; Humans; Melanins; Pyrimidine Dimers; Radiation Dosage; Radiation Injuries; Skin; Skin Neoplasms; Skin Pigmentation; Ultraviolet Rays | 2012 |
Urinary levels of thymine dimer as a biomarker of exposure to ultraviolet radiation in humans during outdoor activities in the summer.
Topics: Adolescent; Adult; Biomarkers; Environmental Exposure; Female; Humans; Male; Middle Aged; Pyrimidine Dimers; Radiation Dosage; Seasons; Skin Neoplasms; Sunlight; Time Factors; Ultraviolet Rays; Young Adult | 2013 |
Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Line; Deoxyguanosine; DNA; DNA Damage; DNA Glycosylases; DNA Repair; Humans; Keratinocytes; Niacinamide; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2013 |
Inhibition of ultraviolet light-induced oxidative events in the skin and internal organs of hairless mice by isoflavone genistein.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anticarcinogenic Agents; Brain; Cattle; Deoxyguanosine; DNA Damage; Female; Genistein; Hydrogen Peroxide; In Vitro Techniques; Kidney; Liver; Malondialdehyde; Mice; Mice, Hairless; Oxidation-Reduction; Oxidative Stress; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2002 |
Similar UV responses are seen in a skin organ culture as in human skin in vivo.
Topics: Adult; Aged; Aged, 80 and over; DNA Damage; DNA Repair; Female; Humans; Kinetics; Male; Middle Aged; Models, Biological; Neoplasms, Radiation-Induced; Organ Culture Techniques; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunscreening Agents; Tumor Suppressor Protein p53; Ultraviolet Rays | 2002 |
Inhibitory effects of sodium salicylate and acetylsalicylic acid on UVB-induced mouse skin carcinogenesis.
Topics: Administration, Topical; Animals; Anticarcinogenic Agents; Aspirin; Biopsy, Needle; Cell Transformation, Neoplastic; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Mice; Mice, Hairless; Neoplasms, Experimental; Pyrimidine Dimers; Random Allocation; Reference Values; Sensitivity and Specificity; Skin Neoplasms; Sodium Salicylate; Ultraviolet Rays | 2002 |
Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells.
Topics: Cell Line; Databases, Nucleic Acid; DNA Damage; DNA Repair; DNA, Complementary; Exons; Fibroblasts; Genes, p53; Genetic Therapy; Hair Diseases; Humans; Mutation; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum | 2003 |
Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease.
Topics: Deoxyribodipyrimidine Photo-Lyase; DNA Ligases; DNA Repair; Humans; Models, Molecular; Protein Structure, Tertiary; Pyrimidine Dimers; Skin Neoplasms | 2003 |
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.
Topics: Administration, Topical; Animals; Antimutagenic Agents; DNA Repair; Mice; Mice, Hairless; Mutation; Neoplasms; Oligodeoxyribonucleotides; Pyrimidine Dimers; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays; Up-Regulation | 2004 |
Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Cell Division; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dimerization; DNA Damage; Epidermis; Female; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Hairless; Models, Biological; Proliferating Cell Nuclear Antigen; Pyrimidine Dimers; Silybin; Silymarin; Skin; Skin Neoplasms; Time Factors; Tumor Suppressor Protein p53; Ultraviolet Rays; Up-Regulation | 2004 |
DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; DNA Adducts; DNA Repair; DNA-Binding Proteins; Epidermal Cells; Epidermis; Humans; Mice; Mice, Knockout; Microsatellite Repeats; MutS Homolog 2 Protein; Neoplasm Invasiveness; Neoplasms, Radiation-Induced; Proto-Oncogene Proteins; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2004 |
XPA gene-deficient, SCF-transgenic mice with epidermal melanin are resistant to UV-induced carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Dermatitis; DNA Damage; DNA-Binding Proteins; Epidermis; Immunity, Innate; In Situ Nick-End Labeling; Langerhans Cells; Melanins; Melanocytes; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Pyrimidine Dimers; Skin Neoplasms; Stem Cell Factor; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 2004 |
Skin cancer: lights on genome lesions.
Topics: Animals; DNA Damage; DNA Repair Enzymes; Mice; Mice, Transgenic; Models, Biological; Mutagenesis; Pyrimidine Dimers; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2005 |
Powerful skin cancer protection by a CPD-photolyase transgene.
Topics: Animals; Apoptosis; Carcinoma; Cell Line; Deoxyribodipyrimidine Photo-Lyase; DNA Damage; DNA Repair; Gene Expression; Mice; Mice, Transgenic; Pyrimidine Dimers; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Ultraviolet Rays | 2005 |
Dietary feeding of silibinin prevents early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.
Topics: Animals; Apoptosis; Cell Proliferation; Chemoprevention; Dietary Supplements; DNA Damage; DNA Repair; Epidermis; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Hairless; Models, Animal; Pyrimidine Dimers; Silybin; Silymarin; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2005 |
The photocarcinogenesis of antibiotic lomefloxacin and UVA radiation is enhanced in xeroderma pigmentosum group A gene-deficient mice.
Topics: Animals; Anti-Bacterial Agents; Carcinogens; DNA Damage; DNA-Binding Proteins; Fluoroquinolones; Mice; Mice, Mutant Strains; Mutation; Neoplasms, Radiation-Induced; Photosensitizing Agents; Pyrimidine Dimers; Quinolones; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum Group A Protein | 2005 |
Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation.
Topics: Animals; Apoptosis; DNA Repair; DNA-Binding Proteins; Female; Fibroblasts; Male; Mice; Mice, Hairless; Mice, Transgenic; Oligopeptides; Peptides; Pyrimidine Dimers; Radiation Tolerance; Skin; Skin Neoplasms; Ultraviolet Rays | 2005 |
Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation.
Topics: Active Transport, Cell Nucleus; Apoptosis; Calcineurin Inhibitors; Cell Nucleus; Cyclosporine; DNA; DNA Damage; DNA Repair; Enzyme Inhibitors; Humans; Keratinocytes; NFATC Transcription Factors; Pyrimidine Dimers; Skin Neoplasms; Tacrolimus; Ultraviolet Rays | 2005 |
ATX-S10(Na)-photodynamic therapy is less carcinogenic for mouse skin compared with ultraviolet B irradiation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Cell Transformation, Neoplastic; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Radiation; Female; Keratinocytes; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Photochemotherapy; Porphyrins; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Therapy | 2005 |
Photoprotective effect of isoflavone genistein on ultraviolet B-induced pyrimidine dimer formation and PCNA expression in human reconstituted skin and its implications in dermatology and prevention of cutaneous carcinogenesis.
Topics: Anticarcinogenic Agents; Cells, Cultured; Dermatology; Epidermis; Genistein; Humans; Proliferating Cell Nuclear Antigen; Pyrimidine Dimers; Skin; Skin Neoplasms; Skin, Artificial; Ultraviolet Rays | 2006 |
Enhanced photocarcinogenesis in interleukin-12-deficient mice.
Topics: Animals; Cell Growth Processes; Cocarcinogenesis; Electric Impedance; Genes, p53; Interleukin-10; Interleukin-12; Interleukin-12 Subunit p40; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Neoplasm Invasiveness; Protein Subunits; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunburn; Ultraviolet Rays | 2006 |
Caffeine and caffeine sodium benzoate have a sunscreen effect, enhance UVB-induced apoptosis, and inhibit UVB-induced skin carcinogenesis in SKH-1 mice.
Topics: Administration, Topical; Animals; Antimutagenic Agents; Apoptosis; Benzoates; Caffeine; Cell Transformation, Neoplastic; Central Nervous System Stimulants; Drug Combinations; Female; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunburn; Sunscreening Agents; Ultraviolet Rays | 2007 |
Revisiting the photochemistry of solar UVA in human skin.
Topics: Environment; Humans; Photochemistry; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2006 |
Differential role of basal keratinocytes in UV-induced immunosuppression and skin cancer.
Topics: Animals; Apoptosis; Carcinoma; Carnitine; Cluster Analysis; Deoxyribodipyrimidine Photo-Lyase; Hyperplasia; Immunosuppression Therapy; Keratin-14; Keratinocytes; Mice; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Pyrimidine Dimers; Radiation Tolerance; Skin; Skin Neoplasms; Transcription, Genetic; Ultraviolet Rays | 2006 |
Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency.
Topics: Animals; Antigens, Surface; Bromodeoxyuridine; DNA Damage; DNA Repair; DNA-Binding Proteins; Epidermal Cells; Fibroblasts; Humans; Membrane Glycoproteins; Mice; Mice, Hairless; Mice, Knockout; Mice, Transgenic; Photobiology; Pyrimidine Dimers; Radiation Tolerance; Skin Neoplasms; Stem Cells; Tumor Suppressor Protein p53; Ultraviolet Rays | 2007 |
[Harmful effects of solar UVA radiation: new indices in DNA].
Topics: Adolescent; Adult; Biomarkers; Child; DNA; DNA Damage; Humans; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Sunlight; Sunscreening Agents; Ultraviolet Rays | 2007 |
Effect of ultraviolet (UV) A, UVB or ionizing radiation on the cell cycle of human melanoma cells.
Topics: Cell Cycle; DNA Damage; Humans; Melanoma; Pyrimidine Dimers; Radiation, Ionizing; Skin Neoplasms; Ultraviolet Rays | 2007 |
Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer.
Topics: Animals; Cell Transformation, Neoplastic; Cyclobutanes; DNA Glycosylases; Epidermis; Guanosine; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Photochemistry; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2007 |
Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Cutaneous; Animals; Anticarcinogenic Agents; Apoptosis; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Cell Nucleus; Cell Size; Deoxyguanosine; Humans; Mice; Patched Receptors; Patched-1 Receptor; Pyrimidine Dimers; Receptors, Cell Surface; Skin; Skin Neoplasms; Thymine Nucleotides; Ultraviolet Rays | 2008 |
Ultraviolet light action spectra for neoplastic transformation and lethality of Syrian hamster embryo cells correlate with spectrum for pyrimidine dimer formation in cellular DNA.
Topics: Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Models, Biological; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Spectrum Analysis; Ultraviolet Rays | 1981 |
Substitution of equally carcinogenic UV-A for UV-B irradiations lowers epidermal thymine dimer levels during skin cancer induction in hairless mice.
Topics: Animals; Cell Cycle; Dactinomycin; Epidermis; Female; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1995 |
Processing of directly and indirectly ultraviolet-induced DNA damage in human cells.
Topics: Cell Line, Transformed; Cell Transformation, Neoplastic; Chloramphenicol O-Acetyltransferase; DNA; DNA Damage; DNA Repair; DNA, Bacterial; DNA, Recombinant; Genetic Vectors; Herpesvirus 4, Human; Humans; Lymphocytes; Methylene Blue; Neoplasms, Radiation-Induced; Oxidative Stress; Oxygen; Plasmids; Pyrimidine Dimers; Radiation-Sensitizing Agents; Recombinant Fusion Proteins; Singlet Oxygen; Skin Neoplasms; Tissue Extracts; Ultraviolet Rays; Xeroderma Pigmentosum | 1995 |
Different removal of ultraviolet photoproducts in genetically related xeroderma pigmentosum and trichothiodystrophy diseases.
Topics: Cell Line; Chloramphenicol O-Acetyltransferase; DNA Repair; Genes, Reporter; Hair; Humans; Luciferases; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum | 1995 |
Detection of thymine dimers in suprabasal and basal cells of chronically UV-B exposed hairless mice.
Topics: Animals; Dose-Response Relationship, Radiation; Epidermal Cells; Female; Fluorescence; Immunohistochemistry; Mice; Mice, Hairless; Pyrimidine Dimers; Skin; Skin Neoplasms; Staining and Labeling; Time Factors; Ultraviolet Rays | 1993 |
UV induction of cyclobutane thymine dimers in the DNA of cultured melanocytes from foreskin, common melanocytic nevi and dysplastic nevi.
Topics: Cells, Cultured; DNA; Dysplastic Nevus Syndrome; Humans; Male; Melanocytes; Nevus, Pigmented; Pyrimidine Dimers; Skin Neoplasms; Tumor Cells, Cultured; Ultraviolet Rays | 1994 |
Slow repair of pyrimidine dimers at p53 mutation hotspots in skin cancer.
Topics: Cells, Cultured; DNA Repair; Exons; Genes, p53; HeLa Cells; Humans; Mutation; Phosphoglycerate Kinase; Polymerase Chain Reaction; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 1994 |
The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer.
Topics: Base Sequence; Codon; DNA Damage; Exons; Genes, p53; Humans; Male; Molecular Sequence Data; Mutation; Photochemistry; Polymerase Chain Reaction; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1993 |
8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Deoxyguanosine; Male; Mice; Mice, Hairless; Pyrimidine Dimers; Skin; Skin Neoplasms; Tyrosine; Ultraviolet Rays | 1996 |
Ultraviolet B radiation-induced DNA lesions in mouse epidermis: an assessment using a novel 32P-postlabelling technique.
Topics: Animals; DNA; Epidermis; Female; Guanosine Triphosphate; Mice; Mice, Hairless; Phosphorus Radioisotopes; Pyrimidine Dimers; Silymarin; Skin Neoplasms; Sunscreening Agents; Ultraviolet Rays | 1996 |
Epidermal proliferation but not quantity of DNA photodamage is correlated with UV-induced mouse skin carcinogenesis.
Topics: Animals; Bromodeoxyuridine; Cell Division; DNA; DNA Damage; Female; Gene Expression; Genes, p53; Genetic Predisposition to Disease; Hyperplasia; Mice; Mice, Hairless; Mice, Inbred SENCAR; Neoplasms, Radiation-Induced; Ornithine Decarboxylase; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 1997 |
Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.
Topics: 5-Methylcytosine; Codon; Cytosine; Genes, p53; Humans; Keratinocytes; Methylation; Mutation; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Sunlight | 1997 |
UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53.
Topics: Base Sequence; Cells, Cultured; DNA; Genes, p53; Humans; Molecular Sequence Data; Mutation; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1997 |
Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cells, Cultured; Deoxyguanosine; DNA Damage; Dose-Response Relationship, Radiation; Fibroblasts; Humans; Melanoma; Oxidation-Reduction; Pyrimidine Dimers; Skin; Skin Neoplasms; Spectrum Analysis; Ultraviolet Rays | 1997 |
Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV-irradiated mice by alpha-tocopherol.
Topics: Administration, Cutaneous; Animals; Blotting, Southern; Female; Genes, p53; Mice; Mice, Inbred BALB C; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Specific Pathogen-Free Organisms; Time Factors; Ultraviolet Rays; Vitamin E | 1997 |
High levels of dipyrimidine dimers are induced in human skin by solar-simulating UV radiation.
Topics: Adolescent; Adult; DNA Adducts; DNA Repair; Dose-Response Relationship, Radiation; Female; Humans; Male; Middle Aged; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Risk Factors; Skin; Skin Neoplasms; Sunlight; Ultraviolet Rays | 1998 |
Sunlight and carcinogenesis: expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations.
Topics: Adult; Antibodies; DNA; DNA Damage; Gene Expression; Genes, p53; Humans; Immunohistochemistry; Middle Aged; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunlight; Tumor Suppressor Protein p53; Ultraviolet Rays | 1998 |
Defective global genome repair in XPC mice is associated with skin cancer susceptibility but not with sensitivity to UVB induced erythema and edema.
Topics: Animals; Carcinoma, Squamous Cell; DNA Repair; Dose-Response Relationship, Radiation; Edema; Erythema; Genetic Predisposition to Disease; Genome; Mice; Mice, Knockout; Photosensitivity Disorders; Pyrimidine Dimers; Radiation Injuries, Experimental; Skin Neoplasms; Transcription, Genetic; Ultraviolet Rays; Xeroderma Pigmentosum | 1998 |
Sensitive 32P-HPLC technique shows base sequence dependent differences in photolesion repair in human keratinocytes.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; DNA Adducts; DNA Damage; DNA Repair; Erythema; Humans; Keratinocytes; Phosphorus Radioisotopes; Phosphorylation; Photochemistry; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1998 |
In situ molecular dosimetry and tumor risk: UV-induced DNA damage and tumor latency time.
Topics: Animals; Cell Transformation, Neoplastic; Cells, Cultured; DNA; DNA Damage; Epidermis; Female; Hyperplasia; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1998 |
Sequence and time-dependent deamination of cytosine bases in UVB-induced cyclobutane pyrimidine dimers in vivo.
Topics: Carbon-Oxygen Lyases; Cytosine; Deamination; Deoxyribodipyrimidine Photo-Lyase; Deoxyribonuclease IV (Phage T4-Induced); DNA; DNA-(Apurinic or Apyrimidinic Site) Lyase; Fibroblasts; Genes, jun; Genes, p53; Humans; Mutagenesis; Pyrimidine Dimers; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1998 |
The multilayered organization of engineered human skin does not influence the formation of sunlight-induced cyclobutane pyrimidine dimers in cellular DNA.
Topics: Biomedical Engineering; DNA; Humans; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunlight | 1999 |
Spectrum of p53 gene mutations suggests a possible role for ultraviolet radiation in the pathogenesis of advanced cutaneous lymphomas.
Topics: Female; Genes, p53; Humans; Lymphoma; Male; Mutation; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1999 |
Prevention of DNA photodamage by vitamin E compounds and sunscreens: roles of ultraviolet absorbance and cellular uptake.
Topics: Administration, Cutaneous; alpha-Tocopherol; Animals; Anticarcinogenic Agents; Benzophenones; Biological Transport; Cell Nucleus; Cells, Cultured; Cinnamates; DNA Damage; Ethers; Female; Keratinocytes; Mice; Mice, Inbred C3H; Neoplasms, Radiation-Induced; Photochemistry; Pyrimidine Dimers; Radiation Tolerance; Radiation-Protective Agents; Salicylates; Skin; Skin Neoplasms; Sunscreening Agents; Tocopherols; Ultraviolet Rays; Vitamin E | 1999 |
hRAD30 mutations in the variant form of xeroderma pigmentosum.
Topics: Alleles; Amino Acid Sequence; Cell Line; DNA Damage; DNA Polymerase iota; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; DNA, Complementary; Frameshift Mutation; Humans; Molecular Sequence Data; Mutation; Neoplasms, Radiation-Induced; Protein Biosynthesis; Pyrimidine Dimers; Saccharomyces cerevisiae; Sequence Alignment; Sequence Deletion; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum | 1999 |
Involvement of 5-methylcytosine in sunlight-induced mutagenesis.
Topics: 5-Methylcytosine; Animals; Bacterial Proteins; Base Sequence; Cells, Cultured; CpG Islands; Cytosine; DNA Methylation; DNA Mutational Analysis; Escherichia coli Proteins; Fibroblasts; Genes, p53; Humans; Lac Repressors; Mice; Mice, Transgenic; Models, Genetic; Molecular Sequence Data; Mutagenesis; Mutation; Pyrimidine Dimers; Repressor Proteins; Skin Neoplasms; Sunlight; Transgenes; Ultraviolet Rays | 1999 |
Cutaneous melanoma patients have normal repair kinetics of ultraviolet-induced DNA repair in skin in situ.
Topics: Adult; DNA Repair; Female; Humans; Male; Melanoma; Middle Aged; Pyrimidine Dimers; Skin; Skin Neoplasms; Time Factors; Ultraviolet Rays | 2000 |
A molecular pathway for UV-induced CC to TT mutations.
Topics: DNA Repair; Genes, p53; Humans; Mutation; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum | 2000 |
Preventive effect of antioxidant on ultraviolet-induced skin cancer in mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Topical; Animals; Antioxidants; Deoxyguanosine; Female; Humans; Mice; Neoplasms, Radiation-Induced; Olive Oil; Plant Oils; Pyrimidine Dimers; Reactive Oxygen Species; Skin Neoplasms; Ultraviolet Rays | 2000 |
CC to TT mutation in the mitochondrial DNA of normal skin: relationship to ultraviolet light exposure.
Topics: Aged; Aged, 80 and over; Alleles; DNA, Mitochondrial; Dose-Response Relationship, Radiation; Female; Humans; Male; Middle Aged; Mutation; Polymerase Chain Reaction; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2000 |
Levels and repair of cyclobutane pyrimidine dimers and 6-4 photoproducts in skin of sporadic basal cell carcinoma patients.
Topics: Aged; Carcinoma, Basal Cell; Deoxyribodipyrimidine Photo-Lyase; DNA Repair; Erythema; Humans; Middle Aged; Pyrimidine Dimers; Skin Neoplasms | 2000 |
Induction, distribution and repair of UV photodamage in the platyfish, Xiphophorus signum.
Topics: Animals; Cyprinodontiformes; DNA Repair; Melanoma; Neoplasms, Radiation-Induced; Photobiology; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2000 |
The spectrum of mitochondrial DNA deletions is a ubiquitous marker of ultraviolet radiation exposure in human skin.
Topics: Biomarkers; DNA, Mitochondrial; Gene Deletion; Genetic Complementation Test; Humans; Mutation; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum | 2000 |
Immunochemical quantitation of UV-induced oxidative and dimeric DNA damage to human keratinocytes.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Line, Transformed; Deoxyguanosine; DNA Damage; Humans; Hydrogen Peroxide; Immunohistochemistry; Keratinocytes; Nucleic Acid Denaturation; Oxidation-Reduction; Pyrimidine Dimers; Simian virus 40; Skin Neoplasms; Ultraviolet Rays | 2000 |
Protective effect of topically applied olive oil against photocarcinogenesis following UVB exposure of mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Topical; Animals; Anticarcinogenic Agents; Deoxyguanosine; Female; Mice; Mice, Hairless; Mice, Inbred BALB C; Olive Oil; Plant Oils; Pyrimidine Dimers; Skin; Skin Neoplasms; Tumor Suppressor Protein p53; Ultraviolet Rays | 2000 |
Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors.
Topics: Animals; Codon; CpG Islands; DNA Methylation; DNA Repair; Epidermis; Female; Genes, p53; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2000 |
The dose dependence of cyclobutane dimer induction and repair in UVB-irradiated human keratinocytes.
Topics: Cell Line; Dose-Response Relationship, Radiation; Humans; Keratinocytes; Neoplasms, Radiation-Induced; Photobiology; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 2000 |
Protective effects of sunscreening agents on photocarcinogenesis, photoaging, and DNA damage in XPA gene knockout mice.
Topics: Aging; Animals; Disease Models, Animal; DNA-Binding Proteins; Ear; Fluorescent Antibody Technique; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Sunscreening Agents; Ultraviolet Rays; Xeroderma Pigmentosum; Xeroderma Pigmentosum Group A Protein | 2000 |
Similarities in sunlight-induced mutational spectra of CpG-methylated transgenes and the p53 gene in skin cancer point to an important role of 5-methylcytosine residues in solar UV mutagenesis.
Topics: 5-Methylcytosine; Animals; Bacterial Proteins; Base Sequence; Cell Line; CpG Islands; Cytosine; DNA Methylation; Escherichia coli Proteins; Fibroblasts; Genes, p53; Humans; Lac Operon; Lac Repressors; Mice; Models, Genetic; Molecular Sequence Data; Mutagenesis; Pyrimidine Dimers; Repressor Proteins; Skin Neoplasms; Sunlight; Transcription Factors; Transgenes; Ultraviolet Rays; Viral Proteins | 2001 |
Attenuation of DNA damage in the dermis and epidermis of the albino hairless mouse by chronic exposure to ultraviolet-A and -B radiation.
Topics: Animals; DNA Damage; Dose-Response Relationship, Radiation; Female; Mice; Mice, Hairless; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2001 |
Immunoexpression of ultraviolet photoproducts and p53 mutation analysis in atypical fibroxanthoma and superficial malignant fibrous histiocytoma.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Base Sequence; DNA; DNA Mutational Analysis; Female; Histiocytoma, Benign Fibrous; Humans; Immunohistochemistry; Male; Middle Aged; Mutation; Polymorphism, Single-Stranded Conformational; Pyrimidine Dimers; Skin Neoplasms; Tumor Suppressor Protein p53 | 2001 |
Repeated exposures of human skin equivalent to low doses of ultraviolet-B radiation lead to changes in cellular functions and accumulation of cyclobutane pyrimidine dimers.
Topics: Adult; Cell Division; Humans; In Vitro Techniques; Microscopy, Electron; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Radioimmunoassay; Skin; Skin Neoplasms; Ultraviolet Rays | 2001 |
UV-induced DNA damage and mutations in Hupki (human p53 knock-in) mice recapitulate p53 hotspot alterations in sun-exposed human skin.
Topics: Amino Acid Sequence; Animals; Chromosome Mapping; DNA Damage; Genes, p53; Humans; Mice; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Pyrimidine Dimers; Recombinant Fusion Proteins; Skin; Skin Neoplasms; Sunlight; Ultraviolet Rays | 2001 |
Ultraviolet photoproduct levels in melanocytic nevi and surrounding epidermis in human skin in situ.
Topics: Adult; Color; Female; Humans; Male; Middle Aged; Nevus, Pigmented; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2002 |
In situ repair of cyclobutane pyrimidine dimers in skin and melanocytic nevi of cutaneous melanoma patients.
Topics: Adult; Biopsy; Chromatography, High Pressure Liquid; DNA Repair; DNA, Neoplasm; Humans; Melanoma; Middle Aged; Nevus, Pigmented; Pyrimidine Dimers; Skin; Skin Neoplasms; Ultraviolet Rays | 2002 |
Pyrimidine dimer excision in human cells and skin cancer.
Topics: Animals; Cell Line; Cricetinae; DNA Repair; DNA, Neoplasm; Fibroblasts; Humans; Mice; Neoplasms, Experimental; Pyrimidine Dimers; Skin Neoplasms; Time Factors; Ultraviolet Rays; Xeroderma Pigmentosum | 1978 |
Formation of thymine containing dimers in skin exposed to ultraviolet radiation.
Topics: Animals; DNA; DNA Repair; DNA Replication; Guinea Pigs; Mice; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1978 |
Immunochemical detection of unrepaired cyclobutane-type pyrimidine dimers of DNAs extracted from human skin tumours.
Topics: Adult; Animals; DNA; DNA Damage; DNA Repair; Fluorescent Antibody Technique; Humans; Immune Sera; Immunoblotting; Leukocytes; Pyrimidine Dimers; Rabbits; Skin Neoplasms; Ultraviolet Rays | 1992 |
Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice.
Topics: Animals; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DNA Repair; Drug Carriers; Endodeoxyribonucleases; Female; Humans; Liposomes; Mice; Mice, Hairless; Neoplasms, Radiation-Induced; Organ Culture Techniques; Pyrimidine Dimers; Skin; Skin Neoplasms; T-Phages; Tissue Distribution; Ultraviolet Rays; Viral Proteins | 1992 |
Photoreactivation of ultraviolet radiation-induced skin and eye tumors of Monodelphis domestica.
Topics: Animals; Cornea; Deoxyribodipyrimidine Photo-Lyase; DNA Repair; Eye Neoplasms; Neoplasms, Radiation-Induced; Opossums; Pyrimidine Dimers; Skin Neoplasms; Ultraviolet Rays | 1991 |
UV-mediated interaction of psoralens with the genome.
Topics: Animals; Chemical Phenomena; Chemistry; Cross-Linking Reagents; DNA; DNA Repair; Escherichia coli; Eukaryotic Cells; Furocoumarins; Humans; Neoplasms, Radiation-Induced; Nucleic Acid Conformation; Oxygen; PUVA Therapy; Pyrimidine Dimers; Pyrimidines; RNA; Skin Neoplasms; Ultraviolet Rays | 1986 |
Establishment and characterization of a melanoma cell line from a xeroderma pigmentosum patient: activation of N-ras at a potential pyrimidine dimer site.
Topics: Animals; Child; Chromosome Aberrations; DNA Repair; Genes, ras; Humans; Melanoma; Mice; Mutation; Phenotype; Pyrimidine Dimers; Skin Neoplasms; Tumor Cells, Cultured; Ultraviolet Rays; Xeroderma Pigmentosum | 1989 |
Distribution of thymine dimers induced in mouse skin by ultraviolet radiation.
Topics: Animals; Antibodies, Monoclonal; DNA Damage; Female; Fluorescent Antibody Technique; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pyrimidine Dimers; Skin; Skin Neoplasms; Species Specificity; Ultraviolet Rays | 1988 |
Immunochemical determination of an initial step in thymine dimer excision repair in xeroderma pigmentosum variant fibroblasts and biopsy material from the normal population and patients with basal cell carcinoma and melanoma.
Topics: Adult; Antibodies, Monoclonal; Carcinoma, Basal Cell; DNA; DNA Repair; Female; Fibroblasts; Humans; Immunoenzyme Techniques; Male; Melanoma; Middle Aged; Mutation; Pyrimidine Dimers; Skin Neoplasms; Xeroderma Pigmentosum | 1987 |
The (6-4) photoproduct and human skin cancer.
Topics: DNA; DNA Repair; Humans; Pyrimidine Dimers; Skin Neoplasms; Sunlight | 1988 |
Photocarcinogenesis and persistent hyperplasia in UV-irradiated SENCAR mouse skin.
Topics: Animals; Cell Division; Hyperplasia; Mice; Mice, Inbred Strains; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Skin; Skin Neoplasms; Species Specificity; Ultraviolet Rays | 1986 |
Molecular targets of UVB.
Topics: Cell Division; Cells, Cultured; Colony-Forming Units Assay; DNA; DNA Repair; Dose-Response Relationship, Radiation; Fibroblasts; Humans; Interphase; Lymphocytes; Melanocytes; Neoplasms, Radiation-Induced; Pyrimidine Dimers; Sister Chromatid Exchange; Skin; Skin Neoplasms; Ultraviolet Rays; Xeroderma Pigmentosum | 1986 |
Ultraviolet radiation-induced histopathological changes in the skin of the marsupial Monodelphis domestica. I. The effects of acute and chronic exposures and of photoreactivation treatment.
Topics: Animals; DNA Repair; Light; Neoplasms, Radiation-Induced; Opossums; Precancerous Conditions; Pyrimidine Dimers; Radiation Dosage; Skin; Skin Neoplasms; Time Factors; Ultraviolet Rays | 1985 |