Compounds > pyrimidine
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pyrimidine and Lung Neoplasms

pyrimidine has been researched along with Lung Neoplasms in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's0 (0.00)18.2507
2000's3 (20.00)29.6817
2010's8 (53.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Beytagh, MC; Bhutkar, A; Colón, CI; Drapkin, BJ; Dyson, NJ; Farago, AF; Hsu, PP; Jacks, T; Lewis, CA; Li, L; Li, Z; Mercer, KL; Muzumdar, MD; Myers, DT; Nabel, CS; Ng, SR; Phat, S; Romero, R; Vander Heiden, MG; Westcott, PMK1
Cao, H; Wang, H; Wang, X; Xu, L; Zhang, J1
Bhaskaran, S; Bhat, SA; D, P; M, SAP; Nallajennugari, V; Pajaniradje, S; Rajagopalan, R; Subramanian, S1
Chang, GD; Chen, IC; Chuang, YH; Del Caño-Ochoa, F; Ho, CC; Ko, CJ; Ku, CC; Lan, SW; Lee, CF; Lee, CT; Lee, DY; Lee, MS; Lin, HH; Lin, HY; Ramón-Maiques, S; Tu, HF1
Agarwal, SM; Gupta, M; Pal, D; Saini, R1
Bezwada, D; Byers, LA; Cai, L; Castrillon, DH; Chen, BPC; Choi, E; DeBerardinis, RJ; Faubert, B; Girard, L; Heymach, JV; Hu, Z; Huffman, KE; Kim, J; Lambrechts, D; Li, K; Lin, YF; Minna, JD; Ni, M; Peña, CG; Rodriguez-Canales, J; Unsal-Kacmaz, K; Vansteenkiste, J; Villalobos, P; Wauters, E; Wistuba, I; Xu, J1
Choowongkomon, K; Gleeson, MP; Hannongbua, S; Suphakun, P; Toviwek, B1
Collins, C; D'Alessandro, A; Daniels, MW; Danis, E; DeGregori, J; Gao, D; Gehrke, S; Paola, JTD; Pham-Danis, C; Rozhok, AI1
Cheng, P; Goggi, JL; Haslop, A; Jiang, L; Ramasamy, B; Robins, EG; Soh, V1
Kim, D; Kwon, A; Lee, BY; Min, KH; Nguyen, HK; Song, J; Suh, W; Yoo, J1
Broekhuizen, AJ; Giovannetti, E; Hubeek, I; Kaspers, GJ; Pastor-Anglada, M; Peters, GJ1
Bast, A; Buss, I; Dagnelie, PC; Jaehde, U; Swennen, EL; Ummels, V1
ROGERS, S1
Ali, YM; El-Saidi, MM; Elnagdi, MH; Mohamed, NR1
Rew, DA; Wilson, GD1

Reviews

2 review(s) available for pyrimidine and Lung Neoplasms

ArticleYear
Insight into Discovery of Next Generation Reversible TMLR Inhibitors Targeting EGFR Activating and Drug Resistant T790M Mutants.
    Current cancer drug targets, 2017, Volume: 17, Issue:7

    Topics: Antineoplastic Agents; Binding Sites; Carcinoma, Non-Small-Cell Lung; Drug Discovery; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Purines; Pyridones; Pyrimidines; Quinazolines; Structure-Activity Relationship

2017
Cell production rates in human tissues and tumours and their significance. Part II: clinical data.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2000, Volume: 26, Issue:4

    Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Central Nervous System Neoplasms; DNA; Esophageal Neoplasms; Female; Flow Cytometry; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Hematologic Neoplasms; Humans; Lasers; Lung Neoplasms; Melanoma; Neoplasms; Prognosis; Pyrimidines; S Phase; Time Factors

2000

Other Studies

13 other study(ies) available for pyrimidine and Lung Neoplasms

ArticleYear
Identification of DHODH as a therapeutic target in small cell lung cancer.
    Science translational medicine, 2019, 11-06, Volume: 11, Issue:517

    Topics: Adenocarcinoma; Animals; Biphenyl Compounds; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; DCMP Deaminase; Dihydroorotate Dehydrogenase; Disease Progression; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Molecular Targeted Therapy; Oxidoreductases Acting on CH-CH Group Donors; Pancreatic Neoplasms; Pyrimidines; Small Cell Lung Carcinoma; Survival Analysis; Xenograft Model Antitumor Assays

2019
High expression levels of pyrimidine metabolic rate-limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.
    Purinergic signalling, 2020, Volume: 16, Issue:3

    Topics: Adenocarcinoma of Lung; Biomarkers, Tumor; Databases, Genetic; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lung; Lung Neoplasms; Prognosis; Pyrimidines; Signal Transduction

2020
A novel anticancer chromeno-pyrimidine analogue inhibits epithelial-mesenchymal transition in lung adenocarcinoma cells.
    Toxicology mechanisms and methods, 2021, Volume: 31, Issue:6

    Topics: Adenocarcinoma of Lung; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Molecular Docking Simulation; Pharmaceutical Preparations; Pyrimidines

2021
Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD.
    Cancer research, 2021, 06-15, Volume: 81, Issue:12

    Topics: Afatinib; Animals; Antineoplastic Agents; Antineoplastic Agents, Immunological; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lung; Deoxyribonucleases; Drug Therapy, Combination; Humans; Immunomodulating Agents; Lung Neoplasms; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Pyrimidines

2021
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
    Nature, 2017, 06-01, Volume: 546, Issue:7656

    Topics: Ammonia; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Proliferation; DNA; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Female; Gene Silencing; Humans; Lung Neoplasms; Male; Metabolomics; Mice; Mitochondria; Nitrogen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Purines; Pyrimidines; S Phase; Transcription, Genetic; Xenograft Model Antitumor Assays

2017
Synthesis and evaluation of the NSCLC anti-cancer activity and physical properties of 4-aryl-N-phenylpyrimidin-2-amines.
    Bioorganic & medicinal chemistry letters, 2017, 10-15, Volume: 27, Issue:20

    Topics: A549 Cells; Amines; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Humans; Lung Neoplasms; Pyrimidines; Solubility; Structure-Activity Relationship; Sulfonamides

2017
Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC.
    Molecular cancer research : MCR, 2019, Volume: 17, Issue:6

    Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Respiration; ErbB Receptors; Glycolysis; HEK293 Cells; Humans; Lung Neoplasms; Metabolomics; Mitochondria; Mutation; Prognosis; Pyrimidines; Signal Transduction; Urea

2019
Identifying nonsmall-cell lung tumours bearing the T790M EGFR TKI resistance mutation using PET imaging.
    Journal of labelled compounds & radiopharmaceuticals, 2019, Volume: 62, Issue:9

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Isotope Labeling; Lung Neoplasms; Male; Mice; Mutation; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Tissue Distribution

2019
Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Angiogenesis Inhibitors; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Indazoles; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Molecular Docking Simulation; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Vascular Endothelial Growth Factor A

2015
Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:6

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cattle; Cell Line, Tumor; Equilibrative Nucleoside Transporter 1; Gene Expression Regulation; Humans; Lung Neoplasms; Membrane Transport Proteins; Pyrimidines; RNA, Messenger; Substrate Specificity

2008
ATP sensitizes H460 lung carcinoma cells to cisplatin-induced apoptosis.
    Chemico-biological interactions, 2010, Mar-30, Volume: 184, Issue:3

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Carcinoma; Caspase 3; Caspase 7; Cell Line, Tumor; Cisplatin; Glutathione Transferase; Humans; Lactate Dehydrogenases; Lung Neoplasms; Pyrimidines; Rhodamines

2010
Studies of the mechanism of action of urethane in initiating pulmonary adenomas in mice. II. Its relation to nucleic acid synthesis.
    The Journal of experimental medicine, 1957, Apr-01, Volume: 105, Issue:4

    Topics: Adenine; Adenoma; Animals; DNA; Lung Neoplasms; Mice; Neoplasms; Nucleic Acids; Orotic Acid; Pyrimidines; RNA; Thymine; Urethane

1957
Utility of 6-amino-2-thiouracil as a precursor for the synthesis of bioactive pyrimidine derivatives.
    Bioorganic & medicinal chemistry, 2007, Sep-15, Volume: 15, Issue:18

    Topics: Antifungal Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Liver Neoplasms; Lung Neoplasms; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiouracil; Tumor Cells, Cultured

2007