pyrimidine has been researched along with Disease Models, Animal in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 16 (66.67) | 24.3611 |
| 2020's | 7 (29.17) | 2.80 |
| Authors | Studies |
|---|---|
| Czech, J; Ding-Pfennigdorff, D; Dreyer, MK; Halland, N; Li, Z; Nazare, M; Saas, J; Schmidt, F; Strübing, C; Weiss, T | 1 |
| Hiraoka, W; Iizuka, D; Inanami, O; Kuwabara, M; Matsuda, A; Yasui, H | 1 |
| Dulubova, I; Eken, Y; Ferguson, DA; Hotema, M; Jiang, X; Lee, CI; Liu, L; McCauley, L; Reisman, SA; Trevino, I; Visnick, M; Wigley, WC; Wilson, AK | 1 |
| Athineos, D; Blanco, GR; Blyth, K; Brunton, H; Dhayade, S; Fernandez-de-Cossio-Diaz, J; Lilla, S; Mackay, GM; Meiser, J; Oizel, K; Pietzke, M; Sumpton, D; Tait-Mulder, J; Vazquez, A; Zanivan, SR | 1 |
| Carraway, H; Durkin, L; Grabowski, D; Gu, X; Hamilton, B; Hasipek, M; Hong, C; Hsi, ED; Jha, BK; Maciejewski, J; Patel, B; Radivoyevitch, T; Sakre, N; Saunthararajah, Y; Schuerger, C; Sobecks, R; Tohme, R; Tomlinson, B; Zidan, AM | 1 |
| Chen, LZ; Huang, X; Liu, MM; Liu, XH; Ma, D; Shi, JB; Shu, HY; Wu, J; Yu, YL | 1 |
| Bendele, AM; Neelagiri, M; Neelagiri, V; Sucholeiki, I | 1 |
| Dong, S; Ehrhart, J; Ferguson, R; Frie, J; Fu, Q; Gu, X; Guo, ZZ; Haimbach, RE; Hampton, C; Hu, M; Liu, J; Margulis, M; Morissette, P; Owens, K; Pai, LY; Pasternak, A; Priest, BT; Roy, S; Shi, ZC; Sullivan, K; Tang, H; Thomas-Fowlkes, B; Tong, V; VanGelder, K; Weinglass, A; Wu, Z; Xu, S; Yu, Y; Zingaro, GJ | 1 |
| Aizawa, Y; Akamoto, S; Aoki, M; Enomoto, A; Fujishita, T; Fukuda, S; Haba, R; Hirayama, A; Igarashi, K; Ishikawa, T; Kajino-Sakamoto, R; Kato, K; Kojima, Y; Kushida, Y; Nakagawa, T; Okano, K; Oshima, M; Saitoh, K; Sato, S; Satoh, K; Soga, T; Sugimoto, M; Suzuki, Y; Tabata, S; Taketo, MM; Tomita, M; Yachida, S | 1 |
| Abbosh, PH; Dai, J; El-Deiry, WS; Finnberg, NK; Gokare, P; Murphy, ME | 1 |
| Asami, T; Irie, T; Kawahata, W; Sawa, M | 1 |
| Distelmaier, F; Herebian, D; López, LC | 1 |
| Chen, P; Cong, X; Gui, L; Huang, W; Liu, F; Luo, H; Wang, J; Wang, Y; Xin, M; Zhao, X; Zhu, X | 1 |
| Allen, MD; Avril, N; Beltran, L; Bomalaski, JS; Chelala, C; Chmielewska-Kassassir, M; Crook, T; Cutts, R; Delage, B; Foster, J; Frezza, C; Ghazaly, E; Hudson, C; Jackson, RC; Jones, LJ; Lattanzio, L; Lemoine, NR; Leyton, J; Li, CF; Lo Nigro, C; Lu, YJ; Luong, P; Mather, S; Neal, D; Roylance, R; Sosabowski, J; Syed, N; Szlosarek, PW; Tomlinson, I; Warren, AY; Whitaker, HC; Wu, BW; Yuan, M | 1 |
| Deekshith, V; Semwal, A; Sharma, M; Sriram, D; Yogeeswari, P | 1 |
| Apodaca, RL; Breitenbucher, JG; Chambers, A; Chang, L; Chaplan, SR; Hawryluk, N; Karbarz, MJ; Keith, JM; Luo, L; Palmer, JA; Pierce, JM; Rizzolio, M; Scott, BP; Seierstad, M; Webb, M; Wennerholm, ML; Wilson, SJ | 1 |
| Bai, M; Bard, J; Beconi, M; Clayton, B; Clifton, S; Conlon, MP; Deupree, S; Dominguez, C; Duffy, BC; Freeman, E; Haber, J; Hultman, M; Irigoyen, M; Ismail, J; Khmelnitsky, Y; Kiselyov, A; Kitchen, DB; Kuok, ID; Lamers, M; Leonard, P; Luche, M; Lynch, M; Lyons, K; Manning, DD; Matthews, K; McGee, KF; Mead, T; Michels, P; Muñoz-Sanjuan, I; Newell, R; Ongeri, L; Song, RH; Toledo-Sherman, L; Wang, G; Webster, J; Wheelan, P; Wilson, C; Wityak, J; Yates, D | 1 |
| Piao, GC; Quan, ZS; Wang, SB; Zhang, HJ | 1 |
| Contamin, H; Dauzonne, D; Grandin, C; Hourani, ML; Janin, YL; Munier-Lehmann, H; Paturet, A; Taborik, F; Tangy, F; Vabret, A; Vidalain, PO | 1 |
| Alvarez-Martinez, MT; Ayrolles-Torro, A; Duarte Rodrigues, A; Imberdis, T; Kovacs, GG; Perrier, V; Robitzer, M; Torrent, J; Verdier, JM | 1 |
| Grishin, NV; Hu, Z; Kinch, LN; Kohler, JJ; Leija, C; Nischan, N; Phillips, MA; Rijo-Ferreira, F | 1 |
| Adair, RM; Altenbach, RJ; Bettencourt, BM; Brioni, JD; Cowart, MD; Drizin, I; Esbenshade, TA; Fix-Stenzel, SR; Honore, P; Hsieh, GC; Liu, H; Marsh, KC; McPherson, MJ; Milicic, I; Miller, TR; Sullivan, JP; Wetter, JM; Wishart, N; Witte, DG | 1 |
| Felczak, K; Hedstrom, L; Mead, J; Mudeppa, DG; Muthalagi, M; Pankiewicz, KW; Rathod, PK; Sharling, L; Striepen, B; Sun, XE | 1 |
| Bonavia, A; Bushell, S; Compton, T; Dong, H; Florez de Sessions, P; Goh, A; Hoffmaster, K; Jones, S; Kramer, L; Nilar, S; Niyomrattanakit, P; Nunes, S; Poh, MK; Qing, M; Schul, W; Shi, PY; Wang, QY; Xu, HY; Zhou, J | 1 |
1 review(s) available for pyrimidine and Disease Models, Animal
| Article | Year |
|---|---|
Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Models, Animal; DNA Damage; DNA Repair; Humans; Molecular Structure; Nucleosides; Purines; Pyrimidines; Radiation-Sensitizing Agents; Radiation, Ionizing; Radiotherapy; Xenograft Model Antitumor Assays | 2020 |
23 other study(ies) available for pyrimidine and Disease Models, Animal
| Article | Year |
|---|---|
Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis.
Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Immediate-Early Proteins; Ligands; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Osteoarthritis; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Rats; Rats, Sprague-Dawley | 2022 |
A novel series of cysteine-dependent, allosteric inverse agonists of the nuclear receptor RORγt.
Topics: Allosteric Site; Animals; Arthritis, Rheumatoid; Cell Differentiation; Collagen; Cysteine; Disease Models, Animal; Humans; Hydroxycholesterols; Interleukin-17; Ligands; Mice; Molecular Dynamics Simulation; Mutagenesis; Nuclear Receptor Subfamily 1, Group F, Member 3; Protein Binding; Protein Conformation; Pyrimidines; Structure-Activity Relationship; Th17 Cells | 2020 |
Formate induces a metabolic switch in nucleotide and energy metabolism.
Topics: Adenosine Triphosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Energy Metabolism; Female; Formates; Humans; Mice, Inbred C57BL; Models, Biological; Models, Genetic; Nucleotides; Orotic Acid; Pyrimidines; Ribonucleotides | 2020 |
Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network.
Topics: Animals; Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Decitabine; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Metabolic Networks and Pathways; Mice; Pyrimidines; Uridine Kinase | 2021 |
Discovery and development of novel pyrimidine and pyrazolo/thieno-fused pyrimidine derivatives as potent and orally active inducible nitric oxide synthase dimerization inhibitor with efficacy for arthritis.
Topics: Administration, Oral; Animals; Arthritis; Cells, Cultured; Dimerization; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Development; Enzyme Inhibitors; Freund's Adjuvant; Humans; Lipopolysaccharides; Male; Mice; Molecular Structure; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Pyrimidines; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Structure-Activity Relationship | 2021 |
Development of a selective matrix metalloproteinase 13 (MMP-13) inhibitor for the treatment of Osteoarthritis.
Topics: Amides; Animals; Disease Models, Animal; Half-Life; Humans; Isoenzymes; Joints; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Osteoarthritis; Pyrimidines; Rats; Structure-Activity Relationship | 2021 |
Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Topics: Animals; Disease Models, Animal; Dogs; ERG1 Potassium Channel; Half-Life; Hypertension; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyrimidines; Rats; Rats, Inbred SHR; Spiro Compounds; Structure-Activity Relationship; Thiadiazoles | 2017 |
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC.
Topics: Adenoma; Animals; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; Female; Genes, myc; Humans; Male; Metabolomics; Mice; Proto-Oncogene Proteins c-myc; Pyrimidines; Transcriptome | 2017 |
P53 represses pyrimidine catabolic gene dihydropyrimidine dehydrogenase (DPYD) expression in response to thymidylate synthase (TS) targeting.
Topics: Animals; Cell Line, Tumor; Cell Survival; Chromatography, Liquid; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Disease Models, Animal; DNA-Activated Protein Kinase; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Humans; Male; Mice; Mice, Knockout; Models, Biological; Nuclear Proteins; Polymorphism, Genetic; Protein Binding; Pyrimidines; Signal Transduction; Tandem Mass Spectrometry; Thymidylate Synthase; Tumor Suppressor Protein p53 | 2017 |
Design and synthesis of novel pyrimidine analogs as highly selective, non-covalent BTK inhibitors.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Ether-A-Go-Go Potassium Channels; Humans; Mice; Molecular Structure; Passive Cutaneous Anaphylaxis; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Structure-Activity Relationship | 2018 |
Bypassing human CoQ
Topics: Animals; Apoptosis; Ataxia; Biosynthetic Pathways; Cytochrome P-450 Enzyme System; Disease Models, Animal; Humans; Hydroxybenzoates; Mice; Mitochondria; Mitochondrial Diseases; Muscle Weakness; Pyrimidines; Solubility; Treatment Outcome; Ubiquinone; Vitamins | 2018 |
Discovery of potent anti-inflammatory 4-(4,5,6,7-tetrahydrofuro[3,2-c]pyridin-2-yl) pyrimidin-2-amines for use as Janus kinase inhibitors.
Topics: Administration, Oral; Amines; Animals; Anti-Inflammatory Agents; Arthritis; Binding Sites; Disease Models, Animal; Drug Evaluation, Preclinical; Half-Life; Humans; Janus Kinase Inhibitors; Janus Kinases; Molecular Docking Simulation; Protein Isoforms; Pyrimidines; Rats; Structure-Activity Relationship | 2019 |
Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging.
Topics: Animals; Antimetabolites, Antineoplastic; Argininosuccinate Synthase; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA Methylation; Drug Synergism; Female; Glutamates; Guanine; Humans; Hydrolases; Immunohistochemistry; Mice; Neoplasm Invasiveness; Pemetrexed; Polyethylene Glycols; Positron-Emission Tomography; Prognosis; Pyrimidines; Urinary Bladder Neoplasms; X-Ray Microtomography | 2014 |
Discovery of tetrahydropyrido[4,3-d]pyrimidine derivatives for the treatment of neuropathic pain.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Discovery; Edema; Female; Hyperalgesia; Male; Mice; Neuralgia; Pyrimidines; Sciatic Nerve | 2014 |
1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.
Topics: Amidohydrolases; Amino Alcohols; Analgesics; Animals; Binding Sites; Brain; Catalytic Domain; Disease Models, Animal; Enzyme Inhibitors; Half-Life; Humans; Molecular Docking Simulation; Neuralgia; Protein Binding; Pyrimidines; Rats; Structure-Activity Relationship | 2014 |
Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
Topics: Animals; Blood-Brain Barrier; Chemistry Techniques, Synthetic; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Half-Life; Humans; Huntington Disease; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Mice; Microsomes, Liver; Mitogen-Activated Protein Kinase 10; Molecular Structure; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Structure-Activity Relationship | 2015 |
Synthesis of 5-alkoxythieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives and evaluation of their anticonvulsant activities.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Molecular Structure; Pyrimidines; Seizures; Structure-Activity Relationship | 2015 |
Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors.
Topics: Administration, Intranasal; Animals; Antimetabolites; Antiviral Agents; Dihydroorotate Dehydrogenase; Disease Models, Animal; Hep G2 Cells; Humans; Macaca; Oxidoreductases Acting on CH-CH Group Donors; Palivizumab; Pyrimidines; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Virus Replication | 2016 |
A Fluorescent Oligothiophene-Bis-Triazine ligand interacts with PrP fibrils and detects SDS-resistant oligomers in human prion diseases.
Topics: Animals; Blotting, Western; Brain; Disease Models, Animal; Fluorescent Dyes; Humans; Mice; Prion Diseases; Prions; PrPC Proteins; Pyrimidines | 2016 |
Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei.
Topics: Animals; Blotting, Western; Chromatography, Liquid; Disease Models, Animal; Humans; Mice; Mice, Inbred C57BL; Nucleotides; Polymerase Chain Reaction; Pyrimidines; Tandem Mass Spectrometry; Thymidine Kinase; Transfection; Trypanosoma brucei brucei; Trypanosomiasis, African | 2016 |
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
Topics: Amines; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Histamine Antagonists; Ligands; Mice; Molecular Structure; Pain; Pyrimidines; Rats; Receptors, Histamine | 2008 |
Prodrug activation by Cryptosporidium thymidine kinase.
Topics: Animals; Antiprotozoal Agents; Cell Line, Tumor; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Floxuridine; Genome, Protozoan; Humans; Mice; Mice, Knockout; Prodrugs; Protozoan Proteins; Pyrimidines; Recombinant Proteins; Thymidine Kinase | 2010 |
Inhibition of dengue virus through suppression of host pyrimidine biosynthesis.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Dengue; Dengue Virus; Dihydroorotate Dehydrogenase; Disease Models, Animal; High-Throughput Screening Assays; Humans; Mice; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Sigmodontinae; Treatment Outcome; Vero Cells; Virus Replication | 2011 |