Compounds > pyrimidine
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pyrimidine and Cancer of Lung

pyrimidine has been researched along with Cancer of Lung in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's0 (0.00)18.2507
2000's3 (20.00)29.6817
2010's8 (53.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Beytagh, MC; Bhutkar, A; Colón, CI; Drapkin, BJ; Dyson, NJ; Farago, AF; Hsu, PP; Jacks, T; Lewis, CA; Li, L; Li, Z; Mercer, KL; Muzumdar, MD; Myers, DT; Nabel, CS; Ng, SR; Phat, S; Romero, R; Vander Heiden, MG; Westcott, PMK1
Cao, H; Wang, H; Wang, X; Xu, L; Zhang, J1
Bhaskaran, S; Bhat, SA; D, P; M, SAP; Nallajennugari, V; Pajaniradje, S; Rajagopalan, R; Subramanian, S1
Chang, GD; Chen, IC; Chuang, YH; Del Caño-Ochoa, F; Ho, CC; Ko, CJ; Ku, CC; Lan, SW; Lee, CF; Lee, CT; Lee, DY; Lee, MS; Lin, HH; Lin, HY; Ramón-Maiques, S; Tu, HF1
Agarwal, SM; Gupta, M; Pal, D; Saini, R1
Bezwada, D; Byers, LA; Cai, L; Castrillon, DH; Chen, BPC; Choi, E; DeBerardinis, RJ; Faubert, B; Girard, L; Heymach, JV; Hu, Z; Huffman, KE; Kim, J; Lambrechts, D; Li, K; Lin, YF; Minna, JD; Ni, M; Peña, CG; Rodriguez-Canales, J; Unsal-Kacmaz, K; Vansteenkiste, J; Villalobos, P; Wauters, E; Wistuba, I; Xu, J1
Choowongkomon, K; Gleeson, MP; Hannongbua, S; Suphakun, P; Toviwek, B1
Collins, C; D'Alessandro, A; Daniels, MW; Danis, E; DeGregori, J; Gao, D; Gehrke, S; Paola, JTD; Pham-Danis, C; Rozhok, AI1
Cheng, P; Goggi, JL; Haslop, A; Jiang, L; Ramasamy, B; Robins, EG; Soh, V1
Kim, D; Kwon, A; Lee, BY; Min, KH; Nguyen, HK; Song, J; Suh, W; Yoo, J1
Broekhuizen, AJ; Giovannetti, E; Hubeek, I; Kaspers, GJ; Pastor-Anglada, M; Peters, GJ1
Bast, A; Buss, I; Dagnelie, PC; Jaehde, U; Swennen, EL; Ummels, V1
ROGERS, S1
Ali, YM; El-Saidi, MM; Elnagdi, MH; Mohamed, NR1
Rew, DA; Wilson, GD1

Reviews

2 review(s) available for pyrimidine and Cancer of Lung

ArticleYear
Insight into Discovery of Next Generation Reversible TMLR Inhibitors Targeting EGFR Activating and Drug Resistant T790M Mutants.
    Current cancer drug targets, 2017, Volume: 17, Issue:7

    Topics: Antineoplastic Agents; Binding Sites; Carcinoma, Non-Small-Cell Lung; Drug Discovery; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Mutation; Protein Kinase Inhibitors; Purines; Pyridones; Pyrimidines; Quinazolines; Structure-Activity Relationship

2017
Cell production rates in human tissues and tumours and their significance. Part II: clinical data.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2000, Volume: 26, Issue:4

    Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Division; Central Nervous System Neoplasms; DNA; Esophageal Neoplasms; Female; Flow Cytometry; Gastrointestinal Neoplasms; Genital Neoplasms, Female; Head and Neck Neoplasms; Hematologic Neoplasms; Humans; Lasers; Lung Neoplasms; Melanoma; Neoplasms; Prognosis; Pyrimidines; S Phase; Time Factors

2000

Other Studies

13 other study(ies) available for pyrimidine and Cancer of Lung

ArticleYear
Identification of DHODH as a therapeutic target in small cell lung cancer.
    Science translational medicine, 2019, 11-06, Volume: 11, Issue:517

    Topics: Adenocarcinoma; Animals; Biphenyl Compounds; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; DCMP Deaminase; Dihydroorotate Dehydrogenase; Disease Progression; Enzyme Inhibitors; Humans; Lung Neoplasms; Mice; Molecular Targeted Therapy; Oxidoreductases Acting on CH-CH Group Donors; Pancreatic Neoplasms; Pyrimidines; Small Cell Lung Carcinoma; Survival Analysis; Xenograft Model Antitumor Assays

2019
High expression levels of pyrimidine metabolic rate-limiting enzymes are adverse prognostic factors in lung adenocarcinoma: a study based on The Cancer Genome Atlas and Gene Expression Omnibus datasets.
    Purinergic signalling, 2020, Volume: 16, Issue:3

    Topics: Adenocarcinoma of Lung; Biomarkers, Tumor; Databases, Genetic; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lung; Lung Neoplasms; Prognosis; Pyrimidines; Signal Transduction

2020
A novel anticancer chromeno-pyrimidine analogue inhibits epithelial-mesenchymal transition in lung adenocarcinoma cells.
    Toxicology mechanisms and methods, 2021, Volume: 31, Issue:6

    Topics: Adenocarcinoma of Lung; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Humans; Lung Neoplasms; Molecular Docking Simulation; Pharmaceutical Preparations; Pyrimidines

2021
Afatinib Exerts Immunomodulatory Effects by Targeting the Pyrimidine Biosynthesis Enzyme CAD.
    Cancer research, 2021, 06-15, Volume: 81, Issue:12

    Topics: Afatinib; Animals; Antineoplastic Agents; Antineoplastic Agents, Immunological; Carcinoma, Lewis Lung; Carcinoma, Non-Small-Cell Lung; Deoxyribonucleases; Drug Therapy, Combination; Humans; Immunomodulating Agents; Lung Neoplasms; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Pyrimidines

2021
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
    Nature, 2017, 06-01, Volume: 546, Issue:7656

    Topics: Ammonia; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Animals; Bicarbonates; Carbamoyl-Phosphate Synthase (Ammonia); Carbamyl Phosphate; Carcinoma, Non-Small-Cell Lung; Cell Death; Cell Proliferation; DNA; DNA Damage; DNA Replication; DNA-Directed DNA Polymerase; Female; Gene Silencing; Humans; Lung Neoplasms; Male; Metabolomics; Mice; Mitochondria; Nitrogen; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins p21(ras); Purines; Pyrimidines; S Phase; Transcription, Genetic; Xenograft Model Antitumor Assays

2017
Synthesis and evaluation of the NSCLC anti-cancer activity and physical properties of 4-aryl-N-phenylpyrimidin-2-amines.
    Bioorganic & medicinal chemistry letters, 2017, 10-15, Volume: 27, Issue:20

    Topics: A549 Cells; Amines; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Humans; Lung Neoplasms; Pyrimidines; Solubility; Structure-Activity Relationship; Sulfonamides

2017
Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC.
    Molecular cancer research : MCR, 2019, Volume: 17, Issue:6

    Topics: Carbamoyl-Phosphate Synthase (Ammonia); Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Respiration; ErbB Receptors; Glycolysis; HEK293 Cells; Humans; Lung Neoplasms; Metabolomics; Mitochondria; Mutation; Prognosis; Pyrimidines; Signal Transduction; Urea

2019
Identifying nonsmall-cell lung tumours bearing the T790M EGFR TKI resistance mutation using PET imaging.
    Journal of labelled compounds & radiopharmaceuticals, 2019, Volume: 62, Issue:9

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; ErbB Receptors; Isotope Labeling; Lung Neoplasms; Male; Mice; Mutation; Positron-Emission Tomography; Protein Kinase Inhibitors; Pyrimidines; Tissue Distribution

2019
Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Angiogenesis Inhibitors; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Indazoles; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Molecular Docking Simulation; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Vascular Endothelial Growth Factor A

2015
Immunocytochemical detection of hENT1 and hCNT1 in normal tissues, lung cancer cell lines, and NSCLC patient samples.
    Nucleosides, nucleotides & nucleic acids, 2008, Volume: 27, Issue:6

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cattle; Cell Line, Tumor; Equilibrative Nucleoside Transporter 1; Gene Expression Regulation; Humans; Lung Neoplasms; Membrane Transport Proteins; Pyrimidines; RNA, Messenger; Substrate Specificity

2008
ATP sensitizes H460 lung carcinoma cells to cisplatin-induced apoptosis.
    Chemico-biological interactions, 2010, Mar-30, Volume: 184, Issue:3

    Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Carcinoma; Caspase 3; Caspase 7; Cell Line, Tumor; Cisplatin; Glutathione Transferase; Humans; Lactate Dehydrogenases; Lung Neoplasms; Pyrimidines; Rhodamines

2010
Studies of the mechanism of action of urethane in initiating pulmonary adenomas in mice. II. Its relation to nucleic acid synthesis.
    The Journal of experimental medicine, 1957, Apr-01, Volume: 105, Issue:4

    Topics: Adenine; Adenoma; Animals; DNA; Lung Neoplasms; Mice; Neoplasms; Nucleic Acids; Orotic Acid; Pyrimidines; RNA; Thymine; Urethane

1957
Utility of 6-amino-2-thiouracil as a precursor for the synthesis of bioactive pyrimidine derivatives.
    Bioorganic & medicinal chemistry, 2007, Sep-15, Volume: 15, Issue:18

    Topics: Antifungal Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Liver Neoplasms; Lung Neoplasms; Microbial Sensitivity Tests; Molecular Structure; Pyrimidines; Structure-Activity Relationship; Thiouracil; Tumor Cells, Cultured

2007