Compounds > pyrimidine
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pyrimidine and Astrocytoma, Grade IV

pyrimidine has been researched along with Astrocytoma, Grade IV in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Agnihotri, S; Bao, S; Bhargava, S; Gimple, RC; Jiang, L; Kim, LJY; Li, X; Mack, SC; Mischel, PS; Morton, AR; Prager, BC; Qiu, Z; Rich, JN; Shi, Y; Tao, W; Wang, X; Wu, Q; Yang, K; Zhang, G; Zhao, L; Zhou, W; Zhu, Z1
Barnes, S; Burma, S; Buszczak, M; Conacci-Sorrell, M; Han, J; Kanji, S; Kilgore, JA; Lafita-Navarro, MC; Venkateswaran, N; Williams, NS1
Bristow, CA; Chen, P; Chin, L; Colla, S; DePinho, RA; Gorman, CE; Ho, YW; Hu, B; Jiang, S; Jin, EJ; Koul, D; Marchesini, M; Monasterio, MM; Multani, AS; Nezi, L; Ong, DST; Sauvé, CG; Spring, DJ; Sulman, EP; Verhaak, RGW; Wang, Q; Wang, YA; Yung, WA1
Ai, J; Chen, Y; Gao, X; Geng, M; Wang, Y; Zhang, A; Zhao, A1

Other Studies

4 other study(ies) available for pyrimidine and Astrocytoma, Grade IV

ArticleYear
Targeting pyrimidine synthesis accentuates molecular therapy response in glioblastoma stem cells.
    Science translational medicine, 2019, 08-07, Volume: 11, Issue:504

    Topics: Animals; Biosynthetic Pathways; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Self Renewal; Crotonates; Dihydroorotate Dehydrogenase; ErbB Receptors; Gene Deletion; Glioblastoma; Humans; Hydroxybutyrates; MAP Kinase Signaling System; Mice; Molecular Targeted Therapy; Neoplastic Stem Cells; Nitriles; Oxidoreductases Acting on CH-CH Group Donors; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Pyrimidines; Toluidines; Treatment Outcome; Up-Regulation

2019
Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells.
    PLoS genetics, 2020, Volume: 16, Issue:11

    Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Brain Neoplasms; Cell Line, Tumor; Cell Nucleolus; Dihydroorotate Dehydrogenase; Drug Screening Assays, Antitumor; Female; Glioblastoma; Humans; Mice; Multienzyme Complexes; Nucleophosmin; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Ribosomes; RNA, Ribosomal; Stress, Physiological; Transcription, Genetic; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2020
PAF promotes stemness and radioresistance of glioma stem cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 10-24, Volume: 114, Issue:43

    Topics: Animals; Brain Neoplasms; Carrier Proteins; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Green Fluorescent Proteins; Humans; Mice, SCID; Neoplastic Stem Cells; Pyrimidines; Radiation Tolerance; Xenograft Model Antitumor Assays

2017
Discovery of novel c-Met kinase inhibitors bearing a thieno[2,3-d]pyrimidine or furo[2,3-d]pyrimidine scaffold.
    Bioorganic & medicinal chemistry, 2011, Jul-01, Volume: 19, Issue:13

    Topics: Animals; Cell Line, Tumor; Drug Evaluation, Preclinical; Glioblastoma; Humans; Mice; Mice, Nude; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met; Pyrimidines; Structure-Activity Relationship; Thiophenes; Transplantation, Heterologous

2011