Compounds > pyrimidine
Page last updated: 2024-08-21

pyrimidine and Acute Myelogenous Leukemia

pyrimidine has been researched along with Acute Myelogenous Leukemia in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Cho, SJ; Ghosh, S; Keretsu, S1
Abu-Remaileh, M; Cantor, JR; Freinkman, E; Gao, X; Kanarek, N; Lewis, CA; Louissaint, A; Sabatini, DM1
Bauser, M; Brzezinka, K; Christian, S; Eheim, A; Evans, L; Ferrara, S; Friberg, A; Gradl, S; Haegebarth, A; Janzer, A; Lejeune, P; Lesche, R; Losman, JA; Merz, C; Meyer, H; Scadden, DT; Seidel, H; Stoeckigt, D; Sykes, DB; Zimmermann, K1
Choi, Y; Han, G; Jeong, JH; Kang, JS; Kim, H; Kim, MH; Lee, C; Oh, C; Park, CH; Yang, JS; Yun, J1
Bachand, J; Clemons, PA; Clish, CB; Cobert, JM; Eheim, AL; Ferrara, SJ; Haynes, MK; Jain, E; Janzer, A; Kfoury, YS; Kotz, JD; Law, JM; Lee, D; Lewis, TA; Maxcy, KL; Mercier, FE; Meyer, H; Mukherjee, S; Pierce, KA; Sadreyev, RI; Scadden, DT; Schajnovitz, A; Schreiber, SL; Sklar, LA; Stoeckigt, D; Sykes, DB; Szekely, BA; Tolliday, NJ; Waller, A; Wawer, MJ1

Other Studies

5 other study(ies) available for pyrimidine and Acute Myelogenous Leukemia

ArticleYear
Molecular Modeling Studies of
    International journal of molecular sciences, 2021, Nov-19, Volume: 22, Issue:22

    Topics: Amines; Binding Sites; Catalytic Domain; Computer Simulation; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Kinase Inhibitors; Pyrimidines; Quantitative Structure-Activity Relationship; Signal Transduction; Structure-Activity Relationship

2021
Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase.
    Cell, 2017, Apr-06, Volume: 169, Issue:2

    Topics: Aged; Animals; Cell Culture Techniques; Cell Line, Tumor; Culture Media; Fluorouracil; Glucose; Humans; Leukemia, Myeloid, Acute; Male; Mice; Middle Aged; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Protein Domains; Pyrimidines; Uric Acid

2017
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
    Leukemia, 2019, Volume: 33, Issue:10

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Female; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; THP-1 Cells; Translocation, Genetic

2019
Synthesis and biological evaluation of novel thieno[2,3-d]pyrimidine-based FLT3 inhibitors as anti-leukemic agents.
    European journal of medicinal chemistry, 2014, Oct-06, Volume: 85

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Feasibility Studies; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship

2014
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
    Cell, 2016, Sep-22, Volume: 167, Issue:1

    Topics: Animals; Antineoplastic Agents; Cell Differentiation; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; High-Throughput Screening Assays; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Mice; Molecular Targeted Therapy; Myeloid Cells; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Small Molecule Libraries; Xenograft Model Antitumor Assays

2016