Page last updated: 2024-11-03

pyrimethamine and Toxoplasmosis, Animal

pyrimethamine has been researched along with Toxoplasmosis, Animal in 83 studies

Maloprim: contains above 2 cpds

Toxoplasmosis, Animal: Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.

Research Excerpts

ExcerptRelevanceReference
"A substantial reduction of brain cyst numbers could be obtained through a six week therapy with SDDS-pyrimethamine combination or a high titer anti-Toxoplasma serum."7.65The effect of chemo-immunotherapy with SDDS, pyrimethamine and anti-toxoplasma serum on toxoplasma gondii cysts in latent infected NMRI mice. ( Adusu, E; Masihi, KN; Tischer, I; Werner, H, 1977)
"Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and mortality."5.91Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis. ( Aboul Asaad, IA; Amer, BS; Carter, WG; El Maghraby, GM; El Sharazly, BM; Ismail, HIH; Mohamed, DA; Yassen, NA, 2023)
"A substantial reduction of brain cyst numbers could be obtained through a six week therapy with SDDS-pyrimethamine combination or a high titer anti-Toxoplasma serum."3.65The effect of chemo-immunotherapy with SDDS, pyrimethamine and anti-toxoplasma serum on toxoplasma gondii cysts in latent infected NMRI mice. ( Adusu, E; Masihi, KN; Tischer, I; Werner, H, 1977)
" Azithromycin is also effective against intracystic bradyzoïtes in vitro, but long term administration of azithromycin to chronically infected mice failed to reduce the mean number of brain cysts."2.39[New pathogens and mode of action of azithromycin: Toxoplasma gondii]. ( Derouin, F, 1995)
"In patients with AIDS, toxoplasmosis is the most common cause of CNS mass lesions."2.38Toxoplasmosis in AIDS patients. ( Tuazon, CU, 1989)
"Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and mortality."1.91Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis. ( Aboul Asaad, IA; Amer, BS; Carter, WG; El Maghraby, GM; El Sharazly, BM; Ismail, HIH; Mohamed, DA; Yassen, NA, 2023)
"Drug treatment for toxoplasmosis is problematic, because current drugs cannot eradicate latent infection with Toxoplasma gondii and can cause bone marrow toxicity."1.46Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites. ( Kato, K; Murata, Y; Sugi, T; Weiss, LM, 2017)
"Pyrimethamine was radioiodinated with I-131."1.39Preparation of (131)I-Pyrimethamine and evaluation for scintigraphy of experimentally Toxoplasma gondii-infected rats. ( Baykara, B; Bekis, R; Durkan, K; Inceboz, T; Surucu, E; Uner, A; Yavasoglu, A; Yilmaz, O; Yurt Lambrecht, F, 2013)
"Fluconazole is an important antifungal triazole used against others CNS related opportunistic pathogens such as Cryptococcus neoformans and Candida spp."1.39Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. ( de Souza, W; Martins-Duarte, ÉS; Vommaro, RC, 2013)
" Three doses of 200, 300 and 400 mg/kg DFO were used either alone or in combination with pyrimethamine."1.30Effect of deferoxamine alone and combined with pyrimethamine on acute toxoplasmosis in mice. ( Mahmoud, MS, 1999)
" Extending these experiments, we have now shown that roxithromycin at doses of 400 or 200 mg/kg/day combined with dapsone at doses of 5, 25 or 50 mg/kg/day completely prevented the development of T."1.30Experimental evaluation of roxithromycin combined with dapsone or sulphamethoxazole on Pneumocystis carinii and Toxoplasma gondii dual infections in a rat model. ( Brun-Pascaud, M; Chau, F; Derouin, F; Girard, PM, 1998)
"Treatment with pyrimethamine and sulfamethoxazolum combination administered via intragastric route, was started 2 hours after each mouse received an intraperitoneal injection of a lethal inoculum of 5 x 10(3) tachyzoites of RH strain toxoplasma gondii and the therapy was lasted for 52 days."1.30[Preliminary application of PCR to curative effect assessment of chemotherapy against experimental acute infection of Toxoplasma gondii in mice]. ( Ke, OY; Xiang, X; Zhang, Z, 1997)
"The efficacy of roxithromycin alone or in combination with pyrimethamine or sulphadiazine was examined in vitro and in a murine model of acute toxoplasmosis."1.29In-vitro and in-vivo activities of roxithromycin in combination with pyrimethamine or sulphadiazine against Toxoplasma gondii. ( Bryskier, A; Derouin, F; Moutot, M; Romand, S, 1995)
" The dosage regimen for pyrimethamine and sulfadiazine was established by pharmacokinetic studies in two monkeys."1.29Study of treatment of congenital Toxoplasma gondii infection in rhesus monkeys with pyrimethamine and sulfadiazine. ( Baars, I; Camps, W; Eskes, T; Galama, J; Melchers, W; Meuwissen, J; Schoondermark-van de Ven, E; Vree, T, 1995)
"Treatment with pyrimethamine at 12."1.29Treatment of acute Toxoplasma gondii infections in mice with diclazuril or a combination of diclazuril and pyrimethamine. ( Blagburn, BL; Lindsay, DS; Rippey, NS, 1995)
"The efficacy of atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, and minocycline was examined in vitro and in a murine model of acute toxoplasmosis."1.29In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii. ( Derouin, F; Pudney, M; Romand, S, 1993)
"The activity of atovaquone in the treatment of murine toxoplasmosis was greatly enhanced when administered in combination with pyrimethamine or sulfadiazine."1.29The activity of atovaquone (566C80) in murine toxoplasmosis is markedly augmented when used in combination with pyrimethamine or sulfadiazine. ( Araujo, FG; Lin, T; Remington, JS, 1993)
"Treatment with pyrimethamine plus sulfadiazine produced clinical cures in 100% of the infected mice 1 month after infection."1.29A clinical-parasitological monotherapy cure in the treatment of experimental infection by a highly virulent strain of Toxoplasma gondii. ( Arribas, JR; de Diego, JA; Penin, P; Vázquez, E; Vázquez, JJ, 1996)
"The activity of the macrolide antibiotic clarithromycin was examined alone or in combination with other drugs for the treatment of acute or chronic infections with Toxoplasma gondii in mice."1.28Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis. ( Araujo, FG; Lin, T; Prokocimer, P; Remington, JS, 1992)
"Pyrimethamine was administered in mouse chow at concentrations of 0, 0."1.28Pyrimethamine concentrations in serum during treatment of acute murine experimental toxoplasmosis. ( Luft, BJ; Tanowitz, HB; Weiss, LM; Wittner, M, 1992)
"Dapsone alone, which was administered at 100 mg/kg/day for 10 days from day 1 after infection, was unable to prevent parasite dissemination and only delayed the time to death of treated mice compared with the time of death of untreated controls."1.28Anti-Toxoplasma effects of dapsone alone and combined with pyrimethamine. ( Chastang, C; Chau, F; Derouin, F; Piketty, C; Pocidalo, JJ; Rouveix, B, 1991)
"The activity of recombinant gamma interferon (rIFN-gamma) in combination with either pyrimethamine or clindamycin was examined in a murine model of acute toxoplasmosis."1.28Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis. ( Israelski, D; Remington, J, 1990)
"When pyrimethamine was administered from day 1, 7 of 11 mice died within 25 days; by determination of parasitic loads, the effect of pyrimethamine was only demonstrable from day 6, and a relapse was constantly observed after the cessation of therapy."1.28In vivo assessment of antimicrobial agents against Toxoplasma gondii by quantification of parasites in the blood, lungs, and brain of infected mice. ( Derouin, F; Piketty, C; Pocidalo, JJ; Rouveix, B, 1990)
"Zidovudine was found to antagonize the toxoplasmacidal effect of low concentrations of pyrimethamine in vitro, and in vitro synergism of pyrimethamine and sulfadiazine against T."1.28Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii. ( Israelski, DM; Remington, JS; Tom, C, 1989)
"Five drug regimens for the treatment of acute toxoplasmosis were compared in a monkey model."1.27Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys. ( Harper, JS; London, WT; Sever, JL, 1985)
"Trimethoprim was found to have no effect."1.25Chemotherapy in experimental toxoplasmosis: comparison of the efficacy of trimethoprim-sulfur and pyrimethamine-sulfur combinations. ( Seah, SK, 1975)

Research

Studies (83)

TimeframeStudies, this research(%)All Research%
pre-199039 (46.99)18.7374
1990's34 (40.96)18.2507
2000's3 (3.61)29.6817
2010's6 (7.23)24.3611
2020's1 (1.20)2.80

Authors

AuthorsStudies
Rosowsky, A1
Papoulis, AT1
Forsch, RA1
Queener, SF1
Wei, S1
Daniel, BJ1
Brumlik, MJ1
Burow, ME1
Zou, W1
Khan, IA1
Wadsworth, S1
Siekierka, J1
Curiel, TJ1
El Sharazly, BM1
Aboul Asaad, IA1
Yassen, NA1
El Maghraby, GM1
Carter, WG1
Mohamed, DA1
Amer, BS1
Ismail, HIH1
Murata, Y1
Sugi, T1
Weiss, LM2
Kato, K1
Montazeri, M1
Emami, S1
Asgarian-Omran, H1
Azizi, S1
Sharif, M1
Sarvi, S1
Rezaei, F1
Sadeghi, M1
Gohardehi, S1
Daryani, A1
Silva, LA1
Fernandes, MD1
Machado, AS1
Reis-Cunha, JL1
Bartholomeu, DC1
Almeida Vitor, RW1
Pissinate, K1
dos Santos Martins-Duarte, É1
Schaffazick, SR1
de Oliveira, CP1
Vommaro, RC2
Guterres, SS1
Pohlmann, AR1
de Souza, W2
Lamberton, PH2
Donnelly, CA2
Webster, JP2
Inceboz, T1
Yurt Lambrecht, F1
Surucu, E1
Yilmaz, O1
Yavasoglu, A1
Durkan, K1
Baykara, B1
Bekis, R1
Uner, A1
Martins-Duarte, ÉS1
Mahmoud, MS1
NAKAYAMA, I1
MATSUBAYASHI, H1
FRANCOIS, J1
JADIN, J1
WERY, M1
VANDECASTEELE, J1
GILES, CL1
JACOBS, L2
MELTON, ML2
MALONEY, ED1
KAUFMAN, HE1
TSUNODA, K1
SUZUKI, K1
ITO, S1
TSUTSUMI, Y1
PETRAK, M1
CARPENTER, J1
Torrey, EF1
Garin, JP2
Paillard, B1
Nguyen, BT1
Stadtsbaeder, S1
Bonardi, R1
Tabbara, KF1
Sakuragi, S1
O'Connor, GR1
Frenkel, JK2
Smith, DD1
Blais, J1
Tardif, C1
Chamberland, S2
Romand, S2
Bryskier, A1
Moutot, M1
Derouin, F9
Mehlhorn, H1
Dankert, W1
Hartman, PG1
Then, RL1
Schoondermark-van de Ven, E1
Galama, J1
Vree, T1
Camps, W1
Baars, I1
Eskes, T1
Meuwissen, J1
Melchers, W1
Lindsay, DS1
Rippey, NS1
Blagburn, BL1
Alder, J1
Hutch, T1
Meulbroek, JA1
Clement, JC1
Brun-Pascaud, M3
Chau, F5
Simonpoli, AM1
Girard, PM3
Pocidalo, JJ4
Araujo, FG4
Slifer, T1
Remington, JS5
Pudney, M1
Lin, T2
Buxton, D1
Thomson, KM1
Maley, S1
Richards, FO1
Kovacs, JA2
Luft, BJ2
Gross, U1
Pohl, F1
Garry, L1
Jacobus, D1
de Diego, JA1
Penin, P1
Arribas, JR1
Vázquez, E1
Vázquez, JJ1
Miédougé, M1
Bessières, MH1
Cassaing, S1
Swierczynski, B1
Séguéla, JP1
Eskes, TK2
Schoondermark-van de Ven, EM1
Melchers, WJ1
Galama, JM1
Meuwissen, JH1
Aguirre-Cruz, L2
Sotelo, J2
Velasco, O1
Xiang, X1
Ke, OY1
Zhang, Z1
el-Tombary, AA1
Ismail, KA1
Aboulwafa, OM1
Omar, AM1
el-Azzouni, MZ1
el-Mansoury, ST1
Werner, H4
Matuschka, FR1
Brandenburg, I1
Thiermann, E1
Apt, W1
Atias, A1
Lorca, M1
Olguín, J1
Masihi, KN1
Tischer, I1
Adusu, E1
Moorhouse, DE1
Coradello, H1
Kretschmer, S1
Katz, D1
Dubey, JP2
Yeary, RA1
Sheffield, HG1
Seah, SK1
Almadany, R1
Rouveix, B3
Prokocimer, P1
Tanowitz, HB1
Wittner, M1
Chang, HR1
Comte, R1
Piguet, PF1
Pechère, JC1
Piketty, C2
Chastang, C1
Current, WL1
Israelski, D1
Remington, J1
Tassignon, MJ1
Brihaye, M1
De Meuter, F1
Vercruysse, A1
Van Hoof, F1
De Wilde, F1
Tuazon, CU1
Israelski, DM1
Tom, C1
Hou, XP1
Tao, F1
Yi, YY1
Wang, WL1
Allegra, CJ1
Chabner, BA1
Swan, JC1
Drake, J1
Lunde, M1
Parrillo, JE1
Masur, H1
Bakhtari, SK1
Jíra, J1
Guptill, DR1
Brossier, N1
Tran Manh Sung, R1
Moyne, T1
Harper, JS1
London, WT1
Sever, JL1
Vischer, WA1
Egger, I1
Markus, MB1
Dannemann, R1
Zigas, V1
Benfante, RJ1
Krogstad, DJ1
Juranek, DD1
Walls, KW1
Zardi, O1
Adorisio, E1
Nobili, G1
Lattanzi, MT1
Miller, NL1
Terragna, A1
La Fauci, MF1

Reviews

6 reviews available for pyrimethamine and Toxoplasmosis, Animal

ArticleYear
[New pathogens and mode of action of azithromycin: Toxoplasma gondii].
    Pathologie-biologie, 1995, Volume: 43, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Azithromycin; Drug Synergism; Drug Therapy, Combination; Humans; In

1995
Preventing toxoplasmic encephalitis in persons infected with human immunodeficiency virus.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21 Suppl 1

    Topics: AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Cats; Dapsone; Drug Therapy,

1995
Influence of antimicrobial agents on replication and stage conversion of Toxoplasma gondii.
    Current topics in microbiology and immunology, 1996, Volume: 219

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cells, Cultured; Clindamycin; Humans; Pyrimet

1996
Toxoplasmosis.
    Comprehensive therapy, 1976, Volume: 2, Issue:5

    Topics: Animals; Child; Drug Administration Schedule; Female; Humans; Infant; Infant, Newborn; Pregnancy; Pr

1976
Toxoplasmosis in AIDS patients.
    The Journal of antimicrobial chemotherapy, 1989, Volume: 23 Suppl A

    Topics: Acquired Immunodeficiency Syndrome; Animals; Drug Therapy, Combination; Humans; Mice; Opportunistic

1989
Toxoplasma and toxoplasmosis.
    Advances in parasitology, 1967, Volume: 5

    Topics: Abortion, Habitual; Animals; Antigen-Antibody Reactions; Female; Hodgkin Disease; Humans; Intellectu

1967

Other Studies

77 other studies available for pyrimethamine and Toxoplasmosis, Animal

ArticleYear
Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
    Journal of medicinal chemistry, 1999, Mar-25, Volume: 42, Issue:6

    Topics: Animals; Antifungal Agents; Antineoplastic Agents; Antiprotozoal Agents; Cell Line; Drug Screening A

1999
Drugs designed to inhibit human p38 mitogen-activated protein kinase activation treat Toxoplasma gondii and Encephalitozoon cuniculi infection.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:12

    Topics: Animals; Antiprotozoal Agents; CD8 Antigens; Dose-Response Relationship, Drug; Drug Design; Drug Syn

2007
Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis.
    Acta tropica, 2023, Volume: 239

    Topics: Animals; Liposomes; Mefloquine; Mice; Pyrimethamine; Sulfadiazine; Toxoplasma; Toxoplasmosis; Toxopl

2023
Identification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Abietanes; Animals; Antiprotozoal Agents; Cell Line; Chlorocebus aethiops; Host-Parasite Interaction

2017
In vitro and in vivo evaluation of kojic acid against Toxoplasma gondii in experimental models of acute toxoplasmosis.
    Experimental parasitology, 2019, Volume: 200

    Topics: Animals; Antioxidants; Antiprotozoal Agents; Apoptosis; Cell Survival; Chlorocebus aethiops; Female;

2019
Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil.
    Experimental parasitology, 2019, Volume: 202

    Topics: Alcohol Dehydrogenase; Animals; Antiprotozoal Agents; Female; Genotype; Humans; Infant, Newborn; Mic

2019
Pyrimethamine-loaded lipid-core nanocapsules to improve drug efficacy for the treatment of toxoplasmosis.
    Parasitology research, 2014, Volume: 113, Issue:2

    Topics: Animals; Cell Line; Cell Survival; Coccidiostats; Female; Lipids; Macrophages, Peritoneal; Mice; Nan

2014
Specificity of the Toxoplasma gondii-altered behaviour to definitive versus non-definitive host predation risk.
    Parasitology, 2008, Volume: 135, Issue:10

    Topics: Animals; Behavior, Animal; Cats; Dapsone; Haloperidol; Pyrimethamine; Rats; Species Specificity; Tox

2008
Preparation of (131)I-Pyrimethamine and evaluation for scintigraphy of experimentally Toxoplasma gondii-infected rats.
    Journal of drug targeting, 2013, Volume: 21, Issue:2

    Topics: Animals; Antiprotozoal Agents; Disease Models, Animal; Drug Compounding; Drug Stability; Iodine Radi

2013
Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model.
    Experimental parasitology, 2013, Volume: 133, Issue:3

    Topics: Acute Disease; Animals; Antifungal Agents; Antiprotozoal Agents; Cell Line; Cell Survival; Disease M

2013
Effect of deferoxamine alone and combined with pyrimethamine on acute toxoplasmosis in mice.
    Journal of the Egyptian Society of Parasitology, 1999, Volume: 29, Issue:3

    Topics: Acute Disease; Animals; Antiprotozoal Agents; Deferoxamine; Disease Models, Animal; Drug Therapy, Co

1999
EFFECTS OF SPIRAMYCINE ON EXPERIMENTAL TOXOPLASMOSIS IN MICE.
    The Keio journal of medicine, 1963, Volume: 12

    Topics: Brain; Mice; Pyridazines; Pyrimethamine; Research; Spiramycin; Toxoplasmosis; Toxoplasmosis, Animal

1963
[TREATMENT OF TOXOPLASMOSIS. (EXPERIMENTAL STUDY)].
    Bulletin de la Societe belge d'ophtalmologie, 1963, Volume: 134

    Topics: Anilides; Animals; Anti-Bacterial Agents; Colistin; Mice; Oxytetracycline; Penicillin V; Pyrimethami

1963
EXPERIMENTAL USE OF FOLINIC ACID IN THE TREATMENT OF TOXOPLASMOSIS WITH PYRIMETHAMINE.
    Archives of ophthalmology (Chicago, Ill. : 1960), 1964, Volume: 72

    Topics: Eye; Folic Acid; Injections; Injections, Intraperitoneal; Injections, Subcutaneous; Leucovorin; Mice

1964
MULTIPLICATION AND THERAPY OF TOXOPLASMA GONDII IN TISSUE CULTURE.
    Journal of bacteriology, 1964, Volume: 88

    Topics: Animals; Mice; Pharmacology; Pyrimethamine; Research; Temperature; Tissue Culture Techniques; Toxopl

1964
EFFECTS OF SULFAMONOMETHOXINE ALONE AND WITH PYRIMETHAMINE UPON PIGS EXPERIMENTALLY INFECTED WITH TOXOPLASMA.
    National Institute of Animal Health quarterly, 1965, Volume: 5

    Topics: Animals; Mice; Pharmacology; Pyrimethamine; Research; Sulfamonomethoxine; Sulfanilamide; Sulfanilami

1965
FELINE TOXOPLASMOSIS.
    Journal of the American Veterinary Medical Association, 1965, Apr-01, Volume: 146

    Topics: Animals; Anorexia Nervosa; Blood; Cat Diseases; Cats; Drug Therapy; Dyspnea; Iritis; Pathology; Pyri

1965
Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii's ability to alter host behaviour.
    Proceedings. Biological sciences, 2006, Apr-22, Volume: 273, Issue:1589

    Topics: Animals; Antimanic Agents; Antiprotozoal Agents; Antipsychotic Agents; Behavior, Animal; Cats; Dapso

2006
[Experimental toxoplasmosis in mice. Comparative activity of clindamycin, midecamycin, josamycin, spiramycin, pyrimethamine-sulfadoxine, and trimethoprim-sulfamethoxazole].
    Annales de pediatrie, 1984, Volume: 31, Issue:10

    Topics: Animals; Clindamycin; Drug Combinations; Leucomycins; Mice; Pyrimethamine; Sulfadoxine; Sulfamethoxa

1984
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole), pyrimethamine-sulphadiazine and spiramycin during avirulent infection with Toxoplasma gondii (Beverley strain) in mice.
    British journal of pharmacology, 1983, Volume: 79, Issue:4

    Topics: Animals; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Leucomyci

1983
[Toxoplasmosis].
    Minerva medica, 1980, Feb-11, Volume: 71, Issue:4

    Topics: Adult; Animals; Antibodies; Antimalarials; Drug Therapy, Combination; Female; Humans; Immunologic Te

1980
Minocycline in the chemotherapy of murine toxoplasmosis.
    Parasitology, 1982, Volume: 84, Issue:Pt 2

    Topics: Animals; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Male; Mice; Minocycline; P

1982
Immunization of cats against shedding of Toxoplasma oocysts.
    The Journal of parasitology, 1982, Volume: 68, Issue:5

    Topics: Animals; Antibodies; Cat Diseases; Cats; Feces; Immunization; Mice; Monensin; Parasite Egg Count; Py

1982
Effect of clindamycin on intracellular replication, protein synthesis, and infectivity of Toxoplasma gondii.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:12

    Topics: Animals; Clindamycin; Evaluation Studies as Topic; Intracellular Fluid; Macrophages; Mice; Microbial

1993
In-vitro and in-vivo activities of roxithromycin in combination with pyrimethamine or sulphadiazine against Toxoplasma gondii.
    The Journal of antimicrobial chemotherapy, 1995, Volume: 35, Issue:6

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cells, Cultured; Drug Combinations; Female; F

1995
A pilot study on the efficacy of epiroprim against developmental stages of Toxoplasma gondii and Pneumocystis carinii in animal models.
    Parasitology research, 1995, Volume: 81, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Dapsone; Drug Therapy, Combination; Female; F

1995
Study of treatment of congenital Toxoplasma gondii infection in rhesus monkeys with pyrimethamine and sulfadiazine.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:1

    Topics: Administration, Oral; Animals; Female; Half-Life; Macaca mulatta; Maternal-Fetal Exchange; Metabolic

1995
Treatment of acute Toxoplasma gondii infections in mice with diclazuril or a combination of diclazuril and pyrimethamine.
    The Journal of parasitology, 1995, Volume: 81, Issue:2

    Topics: Acute Disease; Animals; Coccidiostats; Drug Therapy, Combination; Female; Mice; Nitriles; Pyrimetham

1995
Treatment of experimental Toxoplasma gondii infection by clarithromycin-based combination therapy with minocycline or pyrimethamine.
    Journal of acquired immune deficiency syndromes, 1994, Volume: 7, Issue:11

    Topics: AIDS-Related Opportunistic Infections; Animals; Clarithromycin; Disease Models, Animal; Dose-Respons

1994
Experimental evaluation of combined prophylaxis against murine pneumocystosis and toxoplasmosis.
    The Journal of infectious diseases, 1994, Volume: 170, Issue:3

    Topics: Animals; Antifungal Agents; Antiprotozoal Agents; Atovaquone; Brain; Dapsone; Drug Therapy, Combinat

1994
Rifabutin is active in murine models of toxoplasmosis.
    Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:3

    Topics: Animals; Antiprotozoal Agents; Atovaquone; Brain; Clindamycin; Drug Therapy, Combination; Female; Mi

1994
In vitro and in vivo activities of the hydroxynaphthoquinone atovaquone alone or combined with pyrimethamine, sulfadiazine, clarithromycin, or minocycline against Toxoplasma gondii.
    Antimicrobial agents and chemotherapy, 1993, Volume: 37, Issue:11

    Topics: Animals; Antiprotozoal Agents; Atovaquone; Clarithromycin; Coccidiostats; Drug Combinations; Drug In

1993
The activity of atovaquone (566C80) in murine toxoplasmosis is markedly augmented when used in combination with pyrimethamine or sulfadiazine.
    The Journal of infectious diseases, 1993, Volume: 167, Issue:2

    Topics: Animals; Antiprotozoal Agents; Atovaquone; Drug Synergism; Drug Therapy, Combination; Female; Mice;

1993
Treatment of ovine toxoplasmosis with a combination of sulphamezathine and pyrimethamine.
    The Veterinary record, 1993, Apr-17, Volume: 132, Issue:16

    Topics: Animals; Antibodies, Protozoan; Drug Therapy, Combination; Female; Immunoglobulin G; Immunoglobulin

1993
Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Dapsone; Drug Therapy, Combination; Folic Acid

1996
A clinical-parasitological monotherapy cure in the treatment of experimental infection by a highly virulent strain of Toxoplasma gondii.
    Folia microbiologica, 1996, Volume: 41, Issue:6

    Topics: Animals; Antiprotozoal Agents; Brain; Drug Evaluation, Preclinical; Drug Therapy, Combination; Mice;

1996
Parasitemia and parasitic loads in acute infection and after anti-gamma-interferon treatment in a toxoplasmic mouse model.
    Parasitology research, 1997, Volume: 83, Issue:4

    Topics: Acute Disease; Animals; Anti-Infective Agents; Antibodies; Brain; Chronic Disease; Drug Therapy, Com

1997
Toxoplasmosis: a scenic change and a change of therapy?
    European journal of obstetrics, gynecology, and reproductive biology, 1997, Volume: 74, Issue:2

    Topics: Animals; Coccidiostats; Disease Models, Animal; Macaca mulatta; Polymerase Chain Reaction; Pyrimetha

1997
Prenatal diagnosis and treatment of congenital Toxoplasma gondii infections: an experimental study in rhesus monkeys.
    European journal of obstetrics, gynecology, and reproductive biology, 1997, Volume: 74, Issue:2

    Topics: Amniotic Fluid; Animals; Anti-Infective Agents; Disease Models, Animal; DNA, Protozoan; DNA, Ribosom

1997
Lack of therapeutic effect of colchicine on murine toxoplasmosis.
    The Journal of parasitology, 1998, Volume: 84, Issue:1

    Topics: Administration, Oral; Animals; Anti-Infective Agents; Colchicine; Diarrhea; Disease Models, Animal;

1998
Experimental evaluation of roxithromycin combined with dapsone or sulphamethoxazole on Pneumocystis carinii and Toxoplasma gondii dual infections in a rat model.
    The Journal of antimicrobial chemotherapy, 1998, Volume: 41 Suppl B

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Dapsone; Disease Models, Animal; Dose-Respons

1998
Nifurtimox plus pyrimethamine for treatment of murine toxoplasmosis.
    The Journal of parasitology, 1998, Volume: 84, Issue:5

    Topics: Administration, Oral; Animals; Antiprotozoal Agents; Disease Models, Animal; Dose-Response Relations

1998
[Preliminary application of PCR to curative effect assessment of chemotherapy against experimental acute infection of Toxoplasma gondii in mice].
    Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 1997, Volume: 22, Issue:1

    Topics: Animals; Antiprotozoal Agents; Brain; Drug Therapy, Combination; Female; Mice; Mice, Inbred BALB C;

1997
Novel triazolo[4,3-a]quinazolinone and bis-triazolo[4,3-a:4,3'-c]quinazolines: synthesis and antitoxoplasmosis effect.
    Farmaco (Societa chimica italiana : 1989), 1999, Jul-30, Volume: 54, Issue:7

    Topics: Animals; Anti-Infective Agents; Coccidiostats; Mice; Pyrimethamine; Quinazolines; Quinazolinones; To

1999
Structural changes of Toxoplasma gondii bradyzoites and cysts following therapy with sulfamethoxypyrazine-pyrimethamine: studies by light and electron microscopy. Consequences for chemotherapy.
    Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie, 1979, Volume: 245, Issue:1-2

    Topics: Animals; Brain; Drug Therapy, Combination; Female; Male; Pyrimethamine; Rodentia; Sulfalene; Sulfani

1979
A comparative study of some combined treatment regimens in acute toxoplasmosis in mice.
    The American journal of tropical medicine and hygiene, 1978, Volume: 27, Issue:4

    Topics: Acute Disease; Animals; Clindamycin; Drug Therapy, Combination; Humans; Leucomycins; Mice; Pyrimetha

1978
The effect of chemo-immunotherapy with SDDS, pyrimethamine and anti-toxoplasma serum on toxoplasma gondii cysts in latent infected NMRI mice.
    Tropenmedizin und Parasitologie, 1977, Volume: 28, Issue:4

    Topics: Animals; Brain Diseases; Cysts; Dapsone; Female; Immunotherapy; Mice; Mice, Inbred Strains; Pyrimeth

1977
Toxoplasmosis.
    Australian family physician, 1977, Volume: 6, Issue:12

    Topics: Animals; Cats; Cattle; Female; Humans; Meat; Pregnancy; Pyrimethamine; Sheep; Sulfonamides; Swine; T

1977
[A comparison of Ultrax, Diazil, Bactrim and Spiramycin in experimental toxoplasmosis in mice (author's transl)].
    Wiener klinische Wochenschrift, 1978, Jan-06, Volume: 90, Issue:1

    Topics: Animals; Injections, Subcutaneous; Leucomycins; Mice; Pyrimethamine; Sulfameter; Sulfamethazine; Sul

1978
Anticoccidial activity of 2-sulfamoyl-4,4-diaminodiphenylsulfone, sulfadiazine, pyrimethamine and clindamycin in cats infected with Toxoplasma gondii.
    The Canadian veterinary journal = La revue veterinaire canadienne, 1977, Volume: 18, Issue:3

    Topics: Animals; Cat Diseases; Cats; Clindamycin; Coccidiostats; Pyrimethamine; Sulfadiazine; Sulfonamides;

1977
Effects of pyrimethamine and sulfadiazine on the intestinal development of Toxoplasma gondii in cats.
    The American journal of tropical medicine and hygiene, 1976, Volume: 25, Issue:3

    Topics: Animals; Antibody Formation; Cat Diseases; Cats; Immunization; Intestines; Parasite Egg Count; Pyrim

1976
Chemotherapy in experimental toxoplasmosis: comparison of the efficacy of trimethoprim-sulfur and pyrimethamine-sulfur combinations.
    The Journal of tropical medicine and hygiene, 1975, Volume: 78, Issue:7

    Topics: Animals; Drug Combinations; Drug Evaluation; Female; Mice; Pyrimethamine; Sulfadiazine; Sulfamethoxa

1975
Synergistic activity of azithromycin and pyrimethamine or sulfadiazine in acute experimental toxoplasmosis.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:5

    Topics: Animals; Azithromycin; Brain; Drug Synergism; Drug Therapy, Combination; Erythromycin; Female; Lung;

1992
Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Animals; Brain Diseases; Chronic Disease; Clarith

1992
Pyrimethamine concentrations in serum during treatment of acute murine experimental toxoplasmosis.
    The American journal of tropical medicine and hygiene, 1992, Volume: 46, Issue:3

    Topics: Acute Disease; Animals; Biological Availability; Mice; Pyrimethamine; Toxoplasmosis, Animal; Toxopla

1992
Activity of minocycline against Toxoplasma gondii infection in mice.
    The Journal of antimicrobial chemotherapy, 1991, Volume: 27, Issue:5

    Topics: Acute Disease; Animals; Chronic Disease; Drug Evaluation, Preclinical; Female; Mice; Minocycline; Py

1991
Anti-Toxoplasma effects of dapsone alone and combined with pyrimethamine.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:2

    Topics: Animals; Cells, Cultured; Dapsone; Drug Combinations; Fibroblasts; Immunoenzyme Techniques; Mice; Mo

1991
Use of mouse macrophage cell lines for in vitro propagation of Toxoplasma gondii RH tachyzoites.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1991, Volume: 197, Issue:2

    Topics: Animals; Cell Line; Electrophoresis, Polyacrylamide Gel; Kinetics; Macrophages; Mice; Protozoan Prot

1991
Activity of gamma interferon in combination with pyrimethamine or clindamycin in treatment of murine toxoplasmosis.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1990, Volume: 9, Issue:5

    Topics: Animals; Clindamycin; Drug Combinations; Female; Interferon-gamma; Mice; Pyrimethamine; Recombinant

1990
In vivo assessment of antimicrobial agents against Toxoplasma gondii by quantification of parasites in the blood, lungs, and brain of infected mice.
    Antimicrobial agents and chemotherapy, 1990, Volume: 34, Issue:8

    Topics: Animals; Anti-Infective Agents; Brain; Clindamycin; Female; Kinetics; Lung; Mice; Pyrimethamine; Sul

1990
[Efficacy of treatments in experimental toxoplasmosis].
    Bulletin de la Societe belge d'ophtalmologie, 1989, Volume: 230

    Topics: Animals; Blood-Retinal Barrier; Clindamycin; Doxycycline; Drug Therapy, Combination; Female; Male; P

1989
Zidovudine antagonizes the action of pyrimethamine in experimental infection with Toxoplasma gondii.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:1

    Topics: Animals; Cells, Cultured; Drug Interactions; Female; Fibroblasts; Humans; Male; Mice; Pyrimethamine;

1989
[Surface charged liposomes as drug carriers and in vivo tests of mice infected with toxoplasma].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1989, Volume: 24, Issue:1

    Topics: Animals; Drug Carriers; Electrochemistry; Liposomes; Mice; Pyrimethamine; Sulfadiazine; Toxoplasmosi

1989
Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
    The Journal of infectious diseases, 1987, Volume: 155, Issue:5

    Topics: Animals; Cells, Cultured; Drug Therapy, Combination; Folic Acid Antagonists; Macrophages; Mice; Mice

1987
Chemotherapy of experimental toxoplasmosis with special reference to robenidine.
    Folia parasitologica, 1988, Volume: 35, Issue:3

    Topics: Animals; Brain; Drug Administration Schedule; Drug Therapy, Combination; Female; Guanidines; Mice; P

1988
In vivo activity of piritrexim [corrected] against Toxoplasma gondii.
    The Journal of infectious diseases, 1987, Volume: 156, Issue:5

    Topics: Animals; Anti-Infective Agents; Drug Combinations; Drug Evaluation, Preclinical; Mice; Pyrimethamine

1987
[Effect of pyrimethamine sulfadoxine (Fansidar) on an avirulent cystogenic strain of Toxoplasma gondii (Prugniaud strain) in white mice].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:5 Pt 2

    Topics: Animals; Drug Combinations; Mice; Pyrimethamine; Sulfadoxine; Sulfanilamides; Toxoplasmosis, Animal

1985
Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys.
    The American journal of tropical medicine and hygiene, 1985, Volume: 34, Issue:1

    Topics: Animals; Clindamycin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leuco

1985
[Comparative study on the effect of some clinically used sulfanilamide derivatives against toxoplasmosis in the mouse].
    Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie, 1973, Volume: 223, Issue:2

    Topics: Aminobenzoates; Animals; Dapsone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Syn

1973
[Experimental study of the activity of the sulphamethoxypyrazine (Longum equals Kelfizina) with pyrimethamine (Daraprim) on the cysts development phase of Toxoplasma gondii in Mastomys natalensis. Further contribution to experimental chemotherapy of toxop
    Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie, 1974, Volume: 226, Issue:4

    Topics: Animals; Brain; Drug Therapy, Combination; Female; Male; Pyrimethamine; Rodent Diseases; Rodentia; S

1974
Symptoms, transmission, prevention and treatment of toxoplasmosis.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, Sep-08, Volume: 47, Issue:35

    Topics: Adult; Animals; Cat Diseases; Cats; Child; Dogs; Female; Humans; Infant; Infant, Newborn; Lymph Node

1973
[Experimental studies of the activity of certain drugs on zoites and cyst development of toxoplasma gondii in NMRI mice].
    Zeitschrift fur Tropenmedizin und Parasitologie, 1972, Volume: 23, Issue:1

    Topics: Animals; Brain; Female; Leucomycins; Mice; Mice, Inbred Strains; Pyrimethamine; Pyrimidines; Sulfame

1972
Human toxoplasmosis: an evaluation of current progress.
    Tropical and geographical medicine, 1972, Volume: 24, Issue:1

    Topics: Animals; Antibodies; Cats; Climate; Disease Reservoirs; Dogs; Female; Humans; Infant, Newborn; Pregn

1972
Toxoplasmosis. With comments on risk of infection from cats.
    Annals of internal medicine, 1972, Volume: 77, Issue:5

    Topics: Animals; Cat Diseases; Cats; Feces; Female; Food Contamination; Humans; Male; Meat; Pregnancy; Pregn

1972
[Action of an association of 2-sulfamido-3-methoxypyazine and 2,4-diamino-p-chlorophenyl-6-ehtylpyrimidine in experimental toxoplasmosis].
    La Clinica terapeutica, 1971, Apr-30, Volume: 57, Issue:2

    Topics: Animals; Mice; Pyrazines; Pyrimethamine; Sulfonamides; Toxoplasmosis, Animal

1971
Toxoplasma gondii life cycle in cats.
    Journal of the American Veterinary Medical Association, 1970, Dec-01, Volume: 157, Issue:11

    Topics: Animals; Antigens; Carrier State; Cat Diseases; Cats; Feces; Intestines; Isospora; Mice; Pyrimethami

1970
[The association of sulfamethoxypyrazine and pyrimethamine in the therapy of experimental toxoplasmosis in mice].
    Giornale di malattie infettive e parassitarie, 1968, Volume: 20, Issue:3

    Topics: Aniline Compounds; Animals; Drug Synergism; Male; Mice; Pyrazines; Pyrimethamine; Toxoplasmosis, Ani

1968