pyrimethamine has been researched along with Stevens-Johnson Syndrome in 38 studies
Maloprim: contains above 2 cpds
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A fatal case of Stevens-Johnson syndrome associated with Fansidar and chloroquine is reported in a 5-year-old boy." | 7.67 | Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine. ( Bamber, MG; Elder, AT; Gray, JA; Minns, RA, 1986) |
| "A 12-year-old boy developed a phototoxic rash with subsequent progression to Stevens-Johnson syndrome due to prophylactic ingestion of antimalarials (chloroquine and sulfadoxine-pyrimethamine; Fansidar)." | 3.67 | An unusual combination of phototoxicity and Stevens-Johnson syndrome due to antimalarial therapy. ( Hönigsmann, H; Ortel, B; Sivayathorn, A, 1989) |
| "The combination of pyrimethamine and sulfadoxine (Fansidar) has been reported to cause severe skin reactions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis." | 3.67 | Fatal toxic epidermal necrolysis during prophylaxis with pyrimethamine and sulfadoxine in a human immunodeficiency virus-infected person. ( Dinan, WA; Pablos-Mendez, A; Palagiano, A; Raviglione, MC; Sabatini, MT, 1988) |
| "A fatal case of Stevens-Johnson syndrome associated with Fansidar and chloroquine is reported in a 5-year-old boy." | 3.67 | Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine. ( Bamber, MG; Elder, AT; Gray, JA; Minns, RA, 1986) |
| "Other conditions seen were two (9%) Staphylococcal Scalded Skin Syndrome, three (13%) had Necrotizing Faciitis, one of whom was HIV positive and died." | 1.35 | A 12-year retrospective study of non-burn skin loss (burn-like syndromes) at a tertiary burns unit in a developing country. ( Ilombu, CA; Temiye, EO; Ugburo, AO, 2008) |
| "In particular, in patients with AIDS who are more susceptible for adverse drug reactions and who are simultaneously receiving a variety of drugs with a considerable potential of cutaneous side effects, therapy cannot be withhold for lack of therapeutic alternatives." | 1.29 | [Drug-induced Stevens-Johnson syndrome in a patient with AIDS]. ( Bircher, A; Haefeli, WE; Leib, SL; Lüscher, TF; Schlienger, RG, 1993) |
| "Six cases of drug-induced toxic epidermal necrolysis treated in a burns unit are presented." | 1.28 | Treatment of toxic epidermal necrolysis and a review of six cases. ( Krzeminska, EC; Tanner, NS; Ward, DJ, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (63.16) | 18.7374 |
| 1990's | 10 (26.32) | 18.2507 |
| 2000's | 2 (5.26) | 29.6817 |
| 2010's | 1 (2.63) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Phillips-Howard, PA | 2 |
| Warwick Buckler, J | 1 |
| Chang, MA | 1 |
| Fouché, B | 1 |
| LaFortune, W | 1 |
| Holmes, K | 1 |
| Rigodon, J | 1 |
| Juin, S | 1 |
| Marseille, S | 1 |
| Rogier, E | 1 |
| Green, M | 1 |
| Kheradmand, T | 1 |
| Moore, SG | 1 |
| Gaul, DA | 1 |
| Boncy, J | 1 |
| Telfort, MA | 1 |
| Velter, C | 1 |
| Hotz, C | 1 |
| Ingen-Housz-Oro, S | 1 |
| Wolkenstein, P | 1 |
| Fardet, L | 1 |
| Oduro-Boatey, C | 1 |
| Rodrigues, O | 1 |
| Ugburo, AO | 1 |
| Temiye, EO | 1 |
| Ilombu, CA | 1 |
| Olsen, VV | 3 |
| Loft, S | 2 |
| Christensen, KD | 1 |
| Ligthelm, RJ | 1 |
| van Zwienen, J | 1 |
| Stuiver, PC | 1 |
| Djajadiningrat, AP | 1 |
| Christensen, PK | 1 |
| Hornstein, OP | 1 |
| Ruprecht, KW | 1 |
| Schlienger, RG | 1 |
| Haefeli, WE | 1 |
| Bircher, A | 1 |
| Leib, SL | 1 |
| Lüscher, TF | 1 |
| Stürchler, D | 1 |
| Mittelholzer, ML | 1 |
| Kerr, L | 1 |
| Caumes, E | 2 |
| Bocquet, H | 1 |
| Guermonprez, G | 1 |
| Rogeaux, O | 1 |
| Bricaire, F | 1 |
| Katlama, C | 1 |
| Gentilini, M | 1 |
| de Luis, DA | 1 |
| Fortun, J | 1 |
| Pintado, V | 1 |
| Aller de la Fuente, R | 1 |
| Teira, R | 1 |
| Virosta, M | 1 |
| Muñoz, J | 1 |
| Zubero, Z | 1 |
| Santamaría, JM | 1 |
| Schmidt-Westhausen, A | 1 |
| Grünewald, T | 1 |
| Reichart, PA | 1 |
| Pohle, HD | 1 |
| Moussala, M | 1 |
| Binam, F | 1 |
| Nkam, M | 1 |
| Kouda Zeh, A | 1 |
| Bengono, G | 1 |
| Dorangeon, PH | 1 |
| Marx-Chemla, C | 1 |
| Quereux, C | 1 |
| Fay, R | 1 |
| Leroux, B | 1 |
| Choisy, H | 1 |
| Pinon, JM | 1 |
| Wahl, P | 1 |
| Ward, DJ | 1 |
| Krzeminska, EC | 1 |
| Tanner, NS | 1 |
| Thiel, HJ | 1 |
| Richter, U | 1 |
| Pleyer, U | 1 |
| Zierhut, M | 1 |
| Steuhl, KP | 1 |
| Feyeux, C | 1 |
| Garrouste, MT | 1 |
| Schlemmer, B | 1 |
| Wallach, D | 1 |
| Behrens, RH | 1 |
| Dunlop, J | 1 |
| Navin, TR | 1 |
| Miller, KD | 2 |
| Satriale, RF | 2 |
| Lobel, HO | 2 |
| Ortel, B | 1 |
| Sivayathorn, A | 1 |
| Hönigsmann, H | 1 |
| Steffen, R | 1 |
| Heusser, R | 1 |
| Kuritsky, JN | 1 |
| Stern, R | 1 |
| Campbell, CC | 1 |
| Lyn, PC | 1 |
| Fernandez, E | 1 |
| Hellgren, U | 1 |
| Rombo, L | 1 |
| Berg, B | 1 |
| Carlson, J | 1 |
| Wiholm, BE | 1 |
| Meseguer, MA | 1 |
| de Rafael, L | 1 |
| Vidal, ML | 1 |
| Jeffrey, RF | 1 |
| Raviglione, MC | 1 |
| Dinan, WA | 1 |
| Pablos-Mendez, A | 1 |
| Palagiano, A | 1 |
| Sabatini, MT | 1 |
| Bamber, MG | 1 |
| Elder, AT | 1 |
| Gray, JA | 1 |
| Minns, RA | 1 |
| Lenox-Smith, I | 1 |
| Gascón Brustenga, J | 1 |
| Merlos Pujol, A | 1 |
| Bada Ainsa, JL | 1 |
| Adams, SJ | 1 |
| Broadbent, J | 1 |
| Clayden, LM | 1 |
| Ridley, CM | 1 |
| Claréus, BW | 1 |
| Hammar, H | 1 |
1 review available for pyrimethamine and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
[The risks of pyrimethamine-sulfadoxine combination in the prenatal treatment of toxoplasmosis].
Topics: Antimalarials; Cleft Palate; Contraindications; Drug Combinations; Female; Humans; Kernicterus; Preg | 1992 |
37 other studies available for pyrimethamine and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Idiosyncratic reaction resembling toxic epidermal necrolysis caused by chloroquine and maloprim.
Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Humans; Male; Middle Aged; Pyrimethamine; St | 1988 |
Investigation of Four Cases of Stevens-Johnson Syndrome among Participants in a Mass Drug Administration Campaign with Sulfadoxine-Pyrimethamine and Primaquine in Haiti, 2020.
Topics: Antimalarials; COVID-19; Drug Combinations; Haiti; Humans; Malaria; Mass Drug Administration; Pandem | 2023 |
Stevens-Johnson Syndrome During Pregnancy: Case Report of a Newborn Treated With the Culprit Drug.
Topics: Adult; Cesarean Section; Female; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Pregna | 2018 |
Stevens-Johnson syndrome in two children in Ghana following anti-malarial treatment.
Topics: Antimalarials; Child; Drug Combinations; Female; Fever; Ghana; Humans; Malaria, Falciparum; Male; Py | 2005 |
A 12-year retrospective study of non-burn skin loss (burn-like syndromes) at a tertiary burns unit in a developing country.
Topics: Adolescent; Adult; Anti-Infective Agents; Bandages; Burn Units; Child; Child, Preschool; Developing | 2008 |
Serious reactions during malaria prophylaxis with pyrimethamine-sulfadoxine.
Topics: Aged; Agranulocytosis; Antimalarials; Drug Combinations; Female; Humans; Jaundice; Malaria; Male; Mi | 1982 |
[Stevens-Johnson syndrome and granulopenia induced by sulfadoxine-pyrimethamine (Fansidar)].
Topics: Adult; Agranulocytosis; Antimalarials; Drug Combinations; Female; Humans; Pyrimethamine; Stevens-Joh | 1983 |
[Serious side effects of sulfadoxine/pyrimethamine as antimalarials].
Topics: Aged; Agranulocytosis; Antimalarials; Chemical and Drug Induced Liver Injury; Female; Humans; Male; | 1983 |
Fansidar-induced Stevens-Johnson Syndrome.
Topics: Antimalarials; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrimethamine; Stevens-Johnson | 1982 |
[Drug-induced Stevens-Johnson syndrome in a patient with AIDS].
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Phenytoin; Pyrimethamine; Stevens-Joh | 1993 |
How frequent are notified severe cutaneous adverse reactions to Fansidar?
Topics: Adverse Drug Reaction Reporting Systems; Antimalarials; Drug Combinations; Drug Eruptions; Drug Util | 1993 |
Adverse cutaneous reactions to pyrimethamine/sulfadiazine and pyrimethamine/clindamycin in patients with AIDS and toxoplasmic encephalitis.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Clindamy | 1995 |
[HIV infection and Lyell syndrome: a wake-up call concerning anti-inflammatory agents].
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory | 1997 |
The safety of pyrimethamine and sulfadoxine for the prevention of Pneumocystis carinii pneumonia.
Topics: Adult; Anti-Infective Agents; Female; Humans; Incidence; Male; Pneumocystis; Pneumonia, Pneumocystis | 1997 |
Oral manifestations of toxic epidermal necrolysis (TEN) in patients with AIDS: report of five cases.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Age | 1998 |
[Ocular manifestations and sequelae of Lyell syndrome caused by sulfadoxine-pyrimethamine in Cameroon].
Topics: Adult; Antimalarials; Blepharitis; Cameroon; Diagnosis, Differential; Drug Therapy, Combination; Hum | 1998 |
Treatment of toxic epidermal necrolysis and a review of six cases.
Topics: Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Antimalarials; Chlorp | 1990 |
[Drug-induced exudative erythema multiforme major with a chronic progressive course and bilateral blindness. Clinical and immunohistologic follow-up].
Topics: Adult; Antimalarials; Blindness; Conjunctiva; Drug Combinations; Drug Eruptions; Epithelium; Follow- | 1990 |
[Bullous toxic skin disease with fatal outcome in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Prognosis; Pyrimethamine; Stevens-Joh | 1989 |
Stevens-Johnson syndrome due to pyrimethamine/sulfadoxine during presumptive self-therapy of malaria.
Topics: Antimalarials; Child; Child, Preschool; Drug Combinations; Female; Humans; Malaria; Medication Error | 1989 |
Adverse reactions associated with pyrimethamine-sulfadoxine prophylaxis for Pneumocystis carinii infections in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Humans; Male; Pneumonia, Pneumocystis; | 1985 |
An unusual combination of phototoxicity and Stevens-Johnson syndrome due to antimalarial therapy.
Topics: Antimalarials; Child; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Ma | 1989 |
[The reliability and side effects of malaria chemoprophylaxis].
Topics: Antimalarials; Drug Combinations; Drug Eruptions; Drug Resistance; Humans; Malaria; Plasmodium falci | 1986 |
Severe cutaneous reactions among American travelers using pyrimethamine-sulfadoxine (Fansidar) for malaria prophylaxis.
Topics: Adolescent; Adult; Aged; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Eruptions; Eryth | 1986 |
Severe cutaneous adverse reactions and sulphadoxine-pyrimethamine in Sabah, Malaysia.
Topics: Adult; Antimalarials; Drug Combinations; Drug Eruptions; Female; Humans; Malaysia; Pyrimethamine; St | 1987 |
Adverse reactions to sulphadoxine-pyrimethamine in Swedish travellers: implications for prophylaxis.
Topics: Adult; Antimalarials; Drug Combinations; Drug Eruptions; Erythema Multiforme; Female; Humans; Malari | 1987 |
Stevens-Johnson syndrome with isolation of Mycoplasma pneumoniae from skin lesions.
Topics: Humans; Infant; Male; Mycoplasma pneumoniae; Pyrimethamine; Pyrithioxin; Skin; Stevens-Johnson Syndr | 1986 |
Transient lupus anticoagulant and fansidar therapy.
Topics: Adult; Antimalarials; Blood Coagulation Factors; Drug Combinations; Humans; Lupus Coagulation Inhibi | 1986 |
Fansidar-associated fatal reaction in an HIV-infected man.
Topics: Drug Combinations; Drug Therapy, Combination; HIV Seropositivity; Homosexuality; Humans; Male; Middl | 1988 |
Leads from the MMWR. Fansidar-associated fatal reaction in an HIV-infected man.
Topics: Drug Combinations; Drug Therapy, Combination; HIV Seropositivity; Homosexuality; Humans; Male; Middl | 1988 |
Fatal toxic epidermal necrolysis during prophylaxis with pyrimethamine and sulfadoxine in a human immunodeficiency virus-infected person.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Humans; Male; Middle Aged; Pneumonia, Pneumoc | 1988 |
Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine.
Topics: Child, Preschool; Chloroquine; Drug Combinations; Humans; Malaria; Male; Pyrimethamine; Stevens-John | 1986 |
Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine.
Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Pyrimethamine; Ste | 1987 |
[Stevens-Johnson syndrome in a patient treated with quinine and pyrimethamine-sulfadoxine].
Topics: Drug Therapy, Combination; Humans; Male; Middle Aged; Pyrimethamine; Quinine; Stevens-Johnson Syndro | 1986 |
[Is the use of Fansidar as an antimalarial justified?].
Topics: Adult; Aged; Antimalarials; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; Middl | 1985 |
Erythema multiforme (Stevens-Johnson) precipitated by Fansidar.
Topics: Adult; Antimalarials; Drug Combinations; Humans; Malaria; Male; Pyrimethamine; Stevens-Johnson Syndr | 1985 |
[Malaria prevention with Fansidar as a cause of Stevens-Johnson syndrome].
Topics: Adult; Antimalarials; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrimethamine; Stevens-J | 1985 |