Page last updated: 2024-11-03

pyrimethamine and Schistosomiasis mansoni

pyrimethamine has been researched along with Schistosomiasis mansoni in 6 studies

Maloprim: contains above 2 cpds

Schistosomiasis mansoni: Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.

Research Excerpts

ExcerptRelevanceReference
" In a small study in eastern Sudan, the effects of the treatment of uncomplicated, Plasmodium falciparum malaria with artesunate-sulfamethoxypyrazine-pyrimethamine (AS-SMP) and artemether-lumefantrine (AT-LU) on co-infections with Schistosoma mansoni were therefore investigated."9.13The antischistosomal efficacies of artesunate-sulfamethoxypyrazine-pyrimethamine and artemether-lumefantrine administered as treatment for uncomplicated, Plasmodium falciparum malaria. ( Abdalla, E; Adam, I; Elhadi, MO; Elhardello, OA; Elmardi, KA; Jansen, FH, 2008)
"The efficacy and safety of oral artesunate+sulfadoxine/pyrimethamine (AS+SP) (4 mg/kg AS for 3 consecutive days+25 mg sulfadoxine on Day 0) in the treatment of Schistosoma mansoni infections were compared with those of praziquantel (PZQ) (40 mg/kg) among infected schoolchildren (46 in each study arm) in eastern Sudan."5.14Artesunate plus sulfadoxine/pyrimethamine versus praziquantel in the treatment of Schistosoma mansoni in eastern Sudan. ( Adam, I; Ahmed, Ael A; Eldein, WN; Gasim, GI; Magzoub, M; Mahgoub, HM; Mohamed, AA, 2009)
" In a small study in eastern Sudan, the effects of the treatment of uncomplicated, Plasmodium falciparum malaria with artesunate-sulfamethoxypyrazine-pyrimethamine (AS-SMP) and artemether-lumefantrine (AT-LU) on co-infections with Schistosoma mansoni were therefore investigated."5.13The antischistosomal efficacies of artesunate-sulfamethoxypyrazine-pyrimethamine and artemether-lumefantrine administered as treatment for uncomplicated, Plasmodium falciparum malaria. ( Abdalla, E; Adam, I; Elhadi, MO; Elhardello, OA; Elmardi, KA; Jansen, FH, 2008)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mohamed, AA1
Mahgoub, HM1
Magzoub, M1
Gasim, GI1
Eldein, WN1
Ahmed, Ael A1
Adam, I2
Utzinger, J1
Tanner, M1
Keiser, J1
Obonyo, CO1
Muok, EM1
Mwinzi, PN1
Fortin, A1
Jansen, FH2
Elhardello, OA1
Elhadi, MO1
Abdalla, E1
Elmardi, KA1
Miller, JM1
Boyd, HA1
Ostrowski, SR1
Cookson, ST1
Parise, ME1
Gonzaga, PS1
Addiss, DG1
Wilson, M1
Nguyen-Dinh, P1
Wahlquist, SP1
Weld, LH1
Wainwright, RB1
Gushulak, BD1
Cetron, MS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Open-label, Randomized Clinical Trial in Kenya to Determine the Effectiveness of Artesunate + Sulfamethoxypyrazine/Pyrimethamine Vs. Praziquantel in the Treatment of S. Mansoni in Children[NCT01054651]Phase 3212 participants (Actual)Interventional2009-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for pyrimethamine and Schistosomiasis mansoni

ArticleYear
Artesunate plus sulfadoxine/pyrimethamine versus praziquantel in the treatment of Schistosoma mansoni in eastern Sudan.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2009, Volume: 103, Issue:10

    Topics: Adolescent; Animals; Anthelmintics; Antimalarials; Artemisinins; Artesunate; Child; Drug Combination

2009
Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial.
    The Lancet. Infectious diseases, 2010, Volume: 10, Issue:9

    Topics: Adolescent; Amebicides; Animals; Antiprotozoal Agents; Artemisinins; Artesunate; Child; Child, Presc

2010
The antischistosomal efficacies of artesunate-sulfamethoxypyrazine-pyrimethamine and artemether-lumefantrine administered as treatment for uncomplicated, Plasmodium falciparum malaria.
    Annals of tropical medicine and parasitology, 2008, Volume: 102, Issue:1

    Topics: Adolescent; Adult; Animals; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins;

2008

Other Studies

3 other studies available for pyrimethamine and Schistosomiasis mansoni

ArticleYear
ACTs for schistosomiasis: do they act?
    The Lancet. Infectious diseases, 2010, Volume: 10, Issue:9

    Topics: Adolescent; Adult; Animals; Anthelmintics; Child; Child, Preschool; Herbal Medicine; Humans; Infant;

2010
ACTs for the treatment of schistosomiasis.
    The Lancet. Infectious diseases, 2011, Volume: 11, Issue:7

    Topics: Animals; Anthelmintics; Artemisinins; Artesunate; Humans; Pyrimethamine; Schistosoma mansoni; Schist

2011
Malaria, intestinal parasites, and schistosomiasis among Barawan Somali refugees resettling to the United States: a strategy to reduce morbidity and decrease the risk of imported infections.
    The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:1

    Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Child, Preschool; Coccidiosis; Cryptosporidi

2000