pyrimethamine has been researched along with Neoplasms in 21 studies
Maloprim: contains above 2 cpds
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrimethamine is an antiparasitic drug used for the treatment of malaria and toxoplasmosis with a well-documented excellent safety profile." | 2.82 | The multifaceted antineoplastic role of pyrimethamine against human malignancies. ( Ahn, KS; Mistry, JR; Mohan, CD; Naz, I; Ramchandani, S; Rangappa, KS; Su, Q, 2022) |
| "DDMP, a diaminopyrimidine folate antagonist, was given to 26 tumor patients in a dosage of 50 mg/m2 per week orally, simultaneously with 3 mg CF i." | 2.64 | Initial clinical experience with a simultaneous combination of 2,4-diamino-5(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) with folinic acid. ( Alberto, P; Beretta-Piccoli, M; Medenica, R; Peytremann, R, 1978) |
| "Suramin is an experimental anti-neoplastic agent which has shown promising activity against prostatic carcinoma and lymphoma in clinical trials." | 1.29 | Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells. ( Bustamante, A; Henderson, GB; Patel, R; Rideout, DC, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (80.95) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 3 |
| Hitosugi, T | 1 |
| Zhang, L | 3 |
| Zhang, S | 3 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 6 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 2 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 2 |
| Ramchandani, S | 1 |
| Mohan, CD | 1 |
| Mistry, JR | 1 |
| Su, Q | 2 |
| Naz, I | 1 |
| Rangappa, KS | 1 |
| Ahn, KS | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
| Buan, MEM | 1 |
| Flox, C | 1 |
| Chavan, S | 1 |
| Shi, X | 1 |
| Kauranen, P | 1 |
| Kallio, T | 1 |
| Maia, G | 1 |
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| Lymperopoulos, N | 1 |
| Carcadea, E | 1 |
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| Iranzo, A | 1 |
| M Kannan, A | 1 |
| Arunamata, A | 1 |
| Tacy, TA | 1 |
| Kache, S | 1 |
| Mainwaring, RD | 1 |
| Ma, M | 1 |
| Maeda, K | 1 |
| Punn, R | 1 |
| Noguchi, S | 1 |
| Hahn, S | 3 |
| Iwasa, Y | 3 |
| Ling, J | 2 |
| Voccio, JP | 2 |
| Kim, Y | 3 |
| Song, J | 3 |
| Bascuñán, J | 2 |
| Chu, Y | 1 |
| Tomita, M | 1 |
| Cazorla, M | 1 |
| Herrera, E | 1 |
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| Hoplock, LB | 1 |
| Lobchuk, MM | 1 |
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| Li, X | 10 |
| Henson, MA | 1 |
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| Swaroop, S | 1 |
| Nagornov, KO | 1 |
| Kozhinov, AN | 1 |
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| Kuang, S | 1 |
| Laskin, J | 1 |
| Zin, NNINM | 1 |
| Mohamad, MN | 1 |
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| Abdul Wafi, S | 1 |
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| Akbar, M | 1 |
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| Mushtaq, Z | 1 |
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| Bibi, I | 1 |
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| Irfan, M | 1 |
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| Fan, XH | 1 |
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| Zhang, D | 2 |
| Huang, W | 1 |
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| Hossein Rashidi, B | 1 |
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| Jafarabadi, M | 1 |
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| Rubagumya, F | 1 |
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| Ma, Q | 1 |
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| Zhang, E | 1 |
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| Jarrah, S | 1 |
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| Leuschner, R | 1 |
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| Nave, S | 1 |
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| Reich, H | 1 |
| Rojas, A | 1 |
| Sacchi, A | 1 |
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| Theobald, A | 1 |
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| Verani, A | 1 |
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| Li, J | 7 |
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| Meng, P | 1 |
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| Wang, YS | 1 |
| Wang, C | 3 |
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| Wang, W | 1 |
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| Zhuang, T | 1 |
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| Wang, X | 5 |
| Lee, DF | 1 |
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5 reviews available for pyrimethamine and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
The multifaceted antineoplastic role of pyrimethamine against human malignancies.
Topics: Antineoplastic Agents; Apoptosis; Female; Humans; Neoplasms; Pyrimethamine; Temozolomide | 2022 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Toxoplasmosis in the compromised host.
Topics: Animals; Collagen Diseases; Hemagglutination; Humans; Immunoglobulin M; Immunosuppression Therapy; I | 1976 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biologica | 1986 |
2 trials available for pyrimethamine and Neoplasms
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Initial clinical experience with a simultaneous combination of 2,4-diamino-5(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) with folinic acid.
Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials as Topic; Drug Therapy, Combination; Female; Hum | 1978 |
15 other studies available for pyrimethamine and Neoplasms
| Article | Year |
|---|---|
ANTICANCER AGENTS.
Topics: Alkylating Agents; Aminopterin; Antineoplastic Agents; Chemotherapy, Cancer, Regional Perfusion; Cor | 1964 |
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Exper | 1965 |
Phase II study of diamino-dichlorophenyl-methylpyrimidine (DDMP) with folinic acid (CF) protection and rescue.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Child; Drug Evaluation; Drug Therapy, Combination; Folic A | 1980 |
Phase I clinical trial and pharmacology of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (metoprine) (DDMP) and folinic acid (CF).
Topics: Antineoplastic Agents; Drug Evaluation; Humans; Kinetics; Leucovorin; Neoplasms; Protein Binding; Py | 1981 |
Phase II clinical trial of DDMP (2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine) and folinic acid (CF) in solid tumors.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Drug Evaluation; Humans; Leucovorin; Neoplasms; Pyrimet | 1981 |
An experimentally designed high dose simultaneous combination of a diaminopyrimidine and folinic acid for the treatment of human malignancies.
Topics: Antineoplastic Agents; Bone Marrow Diseases; Drug Administration Schedule; Drug Therapy, Combination | 1981 |
Suramin sodium: pronounced effects on methotrexate transport and anti-folate activity in cultured tumor cells.
Topics: Antineoplastic Agents; Biological Transport; Carrier Proteins; Cell Division; Drug Synergism; Folate | 1995 |
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances.
Topics: Acriflavine; Animals; Anthralin; Aurothioglucose; Carcinogens; Chloroquine; Diazepam; Ethanolamines; | 1977 |
Methodichlorophen as anti-tumor drug.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Small Cell; Carcinoma, | 1975 |
DDMP and selective folinic acid protection in the treatment of malignant disease: a further report.
Topics: Bone Marrow; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Leucovorin; Male; Neoplasms | 1977 |
[Pneumocystis pneumonia as a complication in cytostatic therapy].
Topics: Adolescent; Antineoplastic Agents; Female; Humans; Male; Neoplasms; Pentamidine; Pneumonia, Pneumocy | 1976 |
A phase I study of meta-azidopyrimethamine ethanesulphonate (MZPES)--a new dihydrofolate reductase inhibitor.
Topics: Antineoplastic Agents; Azides; Dose-Response Relationship, Drug; Drug Evaluation; Folic Acid Antagon | 1989 |
Selective toxicity of a new lipophilic antifolate, BW301U, for methotrexate-resistant cells with reduced drug uptake.
Topics: Antineoplastic Agents; Cell Line; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Neo | 1985 |
The importance of insterstitial (plasma cell) pneumonia and its correlation with immunodeficiency.
Topics: Cross Infection; Drug Therapy, Combination; Female; Humans; Immunologic Deficiency Syndromes; Infant | 1972 |
Diagnosis and treatment of pneumocystosis and toxoplasmosis in the immunosuppressed host.
Topics: Anti-Bacterial Agents; Cerebrospinal Fluid; Drug Combinations; Fluorescent Antibody Technique; Hemag | 1973 |