pyrimethamine has been researched along with Leukemia in 26 studies
Maloprim: contains above 2 cpds
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy." | 9.04 | Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976) |
| "Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy." | 5.04 | Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976) |
| "At this time, methotrexate and CNS radiotherapy used together offer the best chance for prolonged remissions in children who develop overt CNS leukemia." | 4.76 | Treatment of overt CNS leukemia. ( Filler, J; Humphrey, GB; Krous, HF; Maxwell, JD; VanHoutte, JJ, 1979) |
| "CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective transport via the reduced folate carrier (RFC)." | 3.70 | A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. ( Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H, 1998) |
| "Forty-two cases of Toxoplasma gondii infection were analyzed, 25 in patients with neoplastic disease and 17 in apparently normal patients." | 1.27 | Toxoplasmosis. Problems in diagnosis and treatment. ( Armstrong, D; Hakes, TB, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (92.31) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FISCHER, GA | 1 |
| VONESSEN, CF | 1 |
| Kamal, MA | 1 |
| Christopherson, RI | 1 |
| Hakes, TB | 1 |
| Armstrong, D | 1 |
| Fyfe, MJ | 2 |
| Sedwick, WD | 2 |
| Brown, OE | 2 |
| Laszlo, J | 3 |
| Jansen, G | 1 |
| Mauritz, R | 1 |
| Drori, S | 1 |
| Sprecher, H | 1 |
| Kathmann, I | 1 |
| Bunni, M | 1 |
| Priest, DG | 1 |
| Noordhuis, P | 1 |
| Schornagel, JH | 1 |
| Pinedo, HM | 1 |
| Peters, GJ | 1 |
| Assaraf, YG | 1 |
| Wiernik, PH | 2 |
| Swedwick, D | 1 |
| Lee, L | 1 |
| Brown, O | 1 |
| Kutler, M | 1 |
| Frazer, T | 1 |
| Humphrey, GB | 1 |
| Krous, HF | 1 |
| Filler, J | 1 |
| Maxwell, JD | 1 |
| VanHoutte, JJ | 1 |
| Armata, J | 3 |
| Balwierz, W | 1 |
| Cyklis, R | 1 |
| Schimpff, SC | 1 |
| Schiffer, CA | 1 |
| Lichtenfeld, JL | 1 |
| Aisner, J | 1 |
| O'Connell, MJ | 1 |
| Fortner, C | 1 |
| Helmer, RE | 1 |
| Osieka, R | 1 |
| Schmidt, CG | 1 |
| Fernandes, DJ | 1 |
| Cranford, SK | 1 |
| Ragab, AH | 1 |
| Nichol, CA | 1 |
| Price, LA | 1 |
| Carrera Boadella, A | 1 |
| Pla Illa, RP | 1 |
| Hamers, J | 1 |
| van Hove, W | 1 |
| Baele, G | 1 |
| Wyszkowski, J | 1 |
| Krop, J | 1 |
| Jacobs, L | 1 |
| Pochedly, C | 1 |
| Scheuer-Karpin, R | 1 |
| Frick, PG | 1 |
| Israëls, MC | 1 |
2 reviews available for pyrimethamine and Leukemia
| Article | Year |
|---|---|
Treatment of overt CNS leukemia.
Topics: Adrenal Cortex Hormones; Aminopterin; Antineoplastic Agents; Asparaginase; Blood-Brain Barrier; Carm | 1979 |
Toxoplasma and toxoplasmosis.
Topics: Abortion, Habitual; Animals; Antigen-Antibody Reactions; Female; Hodgkin Disease; Humans; Intellectu | 1967 |
1 trial available for pyrimethamine and Leukemia
| Article | Year |
|---|---|
Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia.
Topics: Acute Disease; Aged; Antineoplastic Agents; Bone Marrow; Central Nervous System Diseases; Cyclophosp | 1976 |
23 other studies available for pyrimethamine and Leukemia
| Article | Year |
|---|---|
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Exper | 1965 |
Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates.
Topics: Amidophosphoribosyltransferase; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Folic Ac | 2004 |
Toxoplasmosis. Problems in diagnosis and treatment.
Topics: Adolescent; Adult; Central Nervous System Diseases; Drug Therapy, Combination; Female; Hodgkin Disea | 1983 |
Human plasma and amino acids as moderators of uptake and metabolic consequences of antifolates in WIL-2 and human leukemia cells.
Topics: Amino Acids; Blood; Cell Line; Culture Media; Deoxyuridine; Folic Acid Antagonists; Glutamine; Human | 1981 |
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
Topics: Affinity Labels; Biological Transport; Blotting, Northern; Carrier Proteins; Drug Resistance, Neopla | 1998 |
The therapy of acute leukemia in the adult: a progress report.
Topics: Acute Disease; Adult; Antineoplastic Agents; Azacitidine; Blood Transfusion; Cytarabine; Daunorubici | 1976 |
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
Topics: Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Humans; L | 1978 |
New dose-time relationships of folate antagonists to sustain inhibition of human lymphoblasts and leukemic cells in vitro.
Topics: Cell Line; Cell Survival; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid Antagonists; Hu | 1979 |
[Repeated cures with daraprim in the preventive therapy of meningeal leukemia (author's transl)].
Topics: Child, Preschool; Humans; Leukemia; Male; Meningeal Neoplasms; Pyrimethamine | 1978 |
Hazard of folinic acid with pyrimethamine and sulfadiazine.
Topics: Amidines; Drug Combinations; Drug Interactions; Humans; Leucovorin; Leukemia; Pentamidine; Pneumonia | 1975 |
[Diagnosis and therapy of neoplastic meningosis].
Topics: Acute Disease; Central Nervous System Diseases; Cytarabine; Humans; Injections, Spinal; Leukemia; Me | 1975 |
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Fol | 1986 |
Pyrimethamine in central-nervous-system leukaemia.
Topics: Adult; Central Nervous System Diseases; Humans; Leukemia; Male; Pyrimethamine | 1973 |
Long plasma half-life of pyrimethamine.
Topics: Half-Life; Humans; Leucovorin; Leukemia; Meningitis; Pyrimethamine; Time Factors | 1973 |
Pyrimethamine in central-nervous-system leukaemia.
Topics: Central Nervous System Diseases; Child; Humans; Leukemia; Pyrimethamine | 1973 |
Letter: Pyrimethamine in central-nervous-system leukaemia.
Topics: Adult; Central Nervous System Diseases; Child; Humans; Leukemia; Pyrimethamine; Remission, Spontaneo | 1973 |
Letter: Pyrimethamine in prophylaxis of meningeal leukaemia.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Humans; Leukemia; Leukemia, Erythroblastic, Acu | 1974 |
[Daraprim in leukemia of the central nervous system in children].
Topics: Adolescent; Central Nervous System; Child; Female; Humans; Leukemia; Male; Meninges; Pyrimethamine | 1972 |
Letter: Pyrimethamine poisoning.
Topics: Drug Interactions; Humans; Leukemia; Methotrexate; Pyrimethamine; Seizures | 1973 |
Management of CNS leukemia in childhood. An outline of current concepts.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Humans; Leukemia; Meninges; Me | 1972 |
[Distrubed granulocytopoiesis following administration of various drugs].
Topics: Adult; Aged; Agranulocytosis; Anemia; Antimetabolites; Bone Marrow Examination; Drug-Related Side Ef | 1969 |
[Possible applications of antivitamins and antimetabolites in therapy].
Topics: Aminopterin; Antimetabolites; Azaserine; Child; Child, Preschool; Choriocarcinoma; Diazooxonorleucin | 1966 |
Treatment and prognosis of polycythaemia managed by non-radioactive methods.
Topics: Blood Platelets; Busulfan; Humans; Leukemia; Phosphorus Isotopes; Polycythemia Vera; Pyrimethamine | 1966 |