pyrimethamine has been researched along with Leukemia L 1210 in 10 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty-seven new acridone alkaloid derivatives (SA compounds) were tested for antimalarial activity in vitro." | 3.68 | Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro. ( Fujimura, K; Fujioka, H; Fujita, M; Kato, N; Nishiyama, Y, 1990) |
| "Metoprine resistance was further increased, and the requirement for exogenous folate during growth was decreased as well in these variants." | 1.29 | Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription. ( Mitsugi, K; Roy, K; Shane, B; Sirlin, S; Sirotnak, FM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (70.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Elslager, EF | 1 |
| Johnson, JL | 1 |
| Werbel, LM | 1 |
| Browman, GP | 2 |
| Calvert, AH | 1 |
| Taylor, GA | 1 |
| Hart, LI | 1 |
| Harrap, KR | 1 |
| Sirotnak, FM | 3 |
| Moccio, DM | 1 |
| Goutas, LJ | 1 |
| Kelleher, LE | 1 |
| Montgomery, JA | 1 |
| Gorka, C | 1 |
| Mehta, C | 1 |
| Lazarus, H | 1 |
| Abelson, HT | 1 |
| Roy, K | 1 |
| Mitsugi, K | 1 |
| Sirlin, S | 1 |
| Shane, B | 1 |
| Scheulen, ME | 1 |
| Fujioka, H | 1 |
| Kato, N | 1 |
| Fujita, M | 1 |
| Fujimura, K | 1 |
| Nishiyama, Y | 1 |
| Yang, CH | 1 |
| Mines, LS | 1 |
| Baker, BR | 1 |
| Rosowsky, A | 1 |
| Modest, EJ | 1 |
3 reviews available for pyrimethamine and Leukemia L 1210
| Article | Year |
|---|---|
Development of drug derivatives without cross-resistance to parent compounds.
Topics: Animals; Antineoplastic Agents; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance; Drug Scre | 1990 |
Active-site directed irreversible inhibitors of dihydrofolate reductase.
Topics: Aminopterin; Animals; Binding Sites; Biological Transport, Active; Carcinoma 256, Walker; Folic Acid | 1971 |
Synthesis and biological activity of tricyclic antifolate compounds with fixed geometry.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Carcinoma; Cell Line; Chickens; Enterococcus faecali | 1971 |
7 other studies available for pyrimethamine and Leukemia L 1210
| Article | Year |
|---|---|
Folate antagonists. 20. Synthesis and antitumor and antimalarial properties of trimetrexate and related 6-[(phenylamino)methyl]-2,4-quinazolinediamines.
Topics: Animals; Antimalarials; Antineoplastic Agents; Bacteria; Drug Resistance; Folic Acid Antagonists; Ha | 1983 |
The intracellular mechanism of action of metoprine (DDMP).
Topics: Animals; Cell Survival; Cells, Cultured; Deoxyuridine; Dose-Response Relationship, Drug; Drug Resist | 1980 |
Biochemical correlates of responsiveness and collateral sensitivity of some methotrexate-resistant murine tumors to the lipophilic antifolate, metoprine.
Topics: Animals; Biological Transport; Cell Line; Drug Resistance; Formyltetrahydrofolates; Kinetics; Leukem | 1982 |
Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate.
Topics: Animals; Antineoplastic Agents; Cell Line; Drug Resistance; Folic Acid Antagonists; Kinetics; Leukem | 1980 |
Different antifolate-resistant L1210 cell variants with either increased or decreased folylpolyglutamate synthetase gene expression at the level of mRNA transcription.
Topics: Amino Acid Sequence; Animals; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Gene Expr | 1995 |
Activities of new acridone alkaloid derivatives against Plasmodium yoelii in vitro.
Topics: Acridines; Acridones; Alkaloids; Animals; Antimalarials; Cell Survival; Chloroquine; Erythrocytes; I | 1990 |
Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization
Topics: Affinity Labels; Aminopterin; Animals; Biological Transport; Carrier Proteins; Cell Division; Cell M | 1988 |