pyrimethamine has been researched along with Leucocythaemia in 26 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy." | 9.04 | Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976) |
| "Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy." | 5.04 | Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976) |
| "At this time, methotrexate and CNS radiotherapy used together offer the best chance for prolonged remissions in children who develop overt CNS leukemia." | 4.76 | Treatment of overt CNS leukemia. ( Filler, J; Humphrey, GB; Krous, HF; Maxwell, JD; VanHoutte, JJ, 1979) |
| "CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective transport via the reduced folate carrier (RFC)." | 3.70 | A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. ( Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H, 1998) |
| "Forty-two cases of Toxoplasma gondii infection were analyzed, 25 in patients with neoplastic disease and 17 in apparently normal patients." | 1.27 | Toxoplasmosis. Problems in diagnosis and treatment. ( Armstrong, D; Hakes, TB, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (92.31) | 18.7374 |
| 1990's | 1 (3.85) | 18.2507 |
| 2000's | 1 (3.85) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| FISCHER, GA | 1 |
| VONESSEN, CF | 1 |
| Kamal, MA | 1 |
| Christopherson, RI | 1 |
| Hakes, TB | 1 |
| Armstrong, D | 1 |
| Fyfe, MJ | 2 |
| Sedwick, WD | 2 |
| Brown, OE | 2 |
| Laszlo, J | 3 |
| Jansen, G | 1 |
| Mauritz, R | 1 |
| Drori, S | 1 |
| Sprecher, H | 1 |
| Kathmann, I | 1 |
| Bunni, M | 1 |
| Priest, DG | 1 |
| Noordhuis, P | 1 |
| Schornagel, JH | 1 |
| Pinedo, HM | 1 |
| Peters, GJ | 1 |
| Assaraf, YG | 1 |
| Wiernik, PH | 2 |
| Swedwick, D | 1 |
| Lee, L | 1 |
| Brown, O | 1 |
| Kutler, M | 1 |
| Frazer, T | 1 |
| Humphrey, GB | 1 |
| Krous, HF | 1 |
| Filler, J | 1 |
| Maxwell, JD | 1 |
| VanHoutte, JJ | 1 |
| Armata, J | 3 |
| Balwierz, W | 1 |
| Cyklis, R | 1 |
| Schimpff, SC | 1 |
| Schiffer, CA | 1 |
| Lichtenfeld, JL | 1 |
| Aisner, J | 1 |
| O'Connell, MJ | 1 |
| Fortner, C | 1 |
| Helmer, RE | 1 |
| Osieka, R | 1 |
| Schmidt, CG | 1 |
| Fernandes, DJ | 1 |
| Cranford, SK | 1 |
| Ragab, AH | 1 |
| Nichol, CA | 1 |
| Price, LA | 1 |
| Carrera Boadella, A | 1 |
| Pla Illa, RP | 1 |
| Hamers, J | 1 |
| van Hove, W | 1 |
| Baele, G | 1 |
| Wyszkowski, J | 1 |
| Krop, J | 1 |
| Jacobs, L | 1 |
| Pochedly, C | 1 |
| Scheuer-Karpin, R | 1 |
| Frick, PG | 1 |
| Israëls, MC | 1 |
2 reviews available for pyrimethamine and Leucocythaemia
| Article | Year |
|---|---|
Treatment of overt CNS leukemia.
Topics: Adrenal Cortex Hormones; Aminopterin; Antineoplastic Agents; Asparaginase; Blood-Brain Barrier; Carm | 1979 |
Toxoplasma and toxoplasmosis.
Topics: Abortion, Habitual; Animals; Antigen-Antibody Reactions; Female; Hodgkin Disease; Humans; Intellectu | 1967 |
1 trial available for pyrimethamine and Leucocythaemia
| Article | Year |
|---|---|
Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia.
Topics: Acute Disease; Aged; Antineoplastic Agents; Bone Marrow; Central Nervous System Diseases; Cyclophosp | 1976 |
23 other studies available for pyrimethamine and Leucocythaemia
| Article | Year |
|---|---|
THE COMPARISON OF RADIATION AND ANTIMETABOLITE RESPONSES OF GENETICALLY ALTERED MURINE LEUKEMIC CELLS.
Topics: Animals; Antimetabolites; Chromosomes; Floxuridine; Genetics; Idoxuridine; Leukemia; Leukemia, Exper | 1965 |
Accumulation of 5-phosphoribosyl-1-pyrophosphate in human CCRF-CEM leukaemia cells treated with antifolates.
Topics: Amidophosphoribosyltransferase; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Folic Ac | 2004 |
Toxoplasmosis. Problems in diagnosis and treatment.
Topics: Adolescent; Adult; Central Nervous System Diseases; Drug Therapy, Combination; Female; Hodgkin Disea | 1983 |
Human plasma and amino acids as moderators of uptake and metabolic consequences of antifolates in WIL-2 and human leukemia cells.
Topics: Amino Acids; Blood; Cell Line; Culture Media; Deoxyuridine; Folic Acid Antagonists; Glutamine; Human | 1981 |
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
Topics: Affinity Labels; Biological Transport; Blotting, Northern; Carrier Proteins; Drug Resistance, Neopla | 1998 |
The therapy of acute leukemia in the adult: a progress report.
Topics: Acute Disease; Adult; Antineoplastic Agents; Azacitidine; Blood Transfusion; Cytarabine; Daunorubici | 1976 |
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
Topics: Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Humans; L | 1978 |
New dose-time relationships of folate antagonists to sustain inhibition of human lymphoblasts and leukemic cells in vitro.
Topics: Cell Line; Cell Survival; Deoxyuridine; Dose-Response Relationship, Drug; Folic Acid Antagonists; Hu | 1979 |
[Repeated cures with daraprim in the preventive therapy of meningeal leukemia (author's transl)].
Topics: Child, Preschool; Humans; Leukemia; Male; Meningeal Neoplasms; Pyrimethamine | 1978 |
Hazard of folinic acid with pyrimethamine and sulfadiazine.
Topics: Amidines; Drug Combinations; Drug Interactions; Humans; Leucovorin; Leukemia; Pentamidine; Pneumonia | 1975 |
[Diagnosis and therapy of neoplastic meningosis].
Topics: Acute Disease; Central Nervous System Diseases; Cytarabine; Humans; Injections, Spinal; Leukemia; Me | 1975 |
Dissociation of thymidylate biosynthesis from DNA biosynthesis by 5-fluoro-2'-deoxyuridine and 5,8-dideazaisofolic acid.
Topics: Deoxyguanine Nucleotides; DNA; DNA Polymerase II; Dose-Response Relationship, Drug; Floxuridine; Fol | 1986 |
Pyrimethamine in central-nervous-system leukaemia.
Topics: Adult; Central Nervous System Diseases; Humans; Leukemia; Male; Pyrimethamine | 1973 |
Long plasma half-life of pyrimethamine.
Topics: Half-Life; Humans; Leucovorin; Leukemia; Meningitis; Pyrimethamine; Time Factors | 1973 |
Pyrimethamine in central-nervous-system leukaemia.
Topics: Central Nervous System Diseases; Child; Humans; Leukemia; Pyrimethamine | 1973 |
Letter: Pyrimethamine in central-nervous-system leukaemia.
Topics: Adult; Central Nervous System Diseases; Child; Humans; Leukemia; Pyrimethamine; Remission, Spontaneo | 1973 |
Letter: Pyrimethamine in prophylaxis of meningeal leukaemia.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Humans; Leukemia; Leukemia, Erythroblastic, Acu | 1974 |
[Daraprim in leukemia of the central nervous system in children].
Topics: Adolescent; Central Nervous System; Child; Female; Humans; Leukemia; Male; Meninges; Pyrimethamine | 1972 |
Letter: Pyrimethamine poisoning.
Topics: Drug Interactions; Humans; Leukemia; Methotrexate; Pyrimethamine; Seizures | 1973 |
Management of CNS leukemia in childhood. An outline of current concepts.
Topics: Central Nervous System Diseases; Child; Child, Preschool; Cytarabine; Humans; Leukemia; Meninges; Me | 1972 |
[Distrubed granulocytopoiesis following administration of various drugs].
Topics: Adult; Aged; Agranulocytosis; Anemia; Antimetabolites; Bone Marrow Examination; Drug-Related Side Ef | 1969 |
[Possible applications of antivitamins and antimetabolites in therapy].
Topics: Aminopterin; Antimetabolites; Azaserine; Child; Child, Preschool; Choriocarcinoma; Diazooxonorleucin | 1966 |
Treatment and prognosis of polycythaemia managed by non-radioactive methods.
Topics: Blood Platelets; Busulfan; Humans; Leukemia; Phosphorus Isotopes; Polycythemia Vera; Pyrimethamine | 1966 |