pyrimethamine has been researched along with Hemolysis in 10 studies
Maloprim: contains above 2 cpds
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children." | 9.20 | Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. ( Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E, 2015) |
| "Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children." | 5.20 | Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. ( Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E, 2015) |
| "Untreated and pyrimethamine-treated controls showed decreasing %Hct." | 1.40 | Protective effect of Thunbergia laurifolia extract on hemolysis during Plasmodium berghei infection. ( Jaihan, U; Khobjai, W; Somsak, V; Watcharasamphankul, W, 2014) |
| " A few potent chalcones were selected for their antimalarial interaction in combination with artemisinin in vitro." | 1.35 | Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro. ( Awasthi, SK; Bhasin, VK; Bhattacharya, A; Mishra, LC; Sharma, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bhattacharya, A | 1 |
| Mishra, LC | 1 |
| Sharma, M | 1 |
| Awasthi, SK | 1 |
| Bhasin, VK | 1 |
| Bekhit, AA | 1 |
| Saudi, MN | 1 |
| Hassan, AMM | 1 |
| Fahmy, SM | 1 |
| Ibrahim, TM | 1 |
| Ghareeb, D | 1 |
| El-Seidy, AM | 1 |
| Nasralla, SN | 1 |
| Bekhit, AEA | 1 |
| Khobjai, W | 1 |
| Jaihan, U | 1 |
| Watcharasamphankul, W | 1 |
| Somsak, V | 1 |
| Poirot, E | 1 |
| Vittinghoff, E | 1 |
| Ishengoma, D | 1 |
| Alifrangis, M | 1 |
| Carneiro, I | 1 |
| Hashim, R | 1 |
| Baraka, V | 1 |
| Mosha, J | 1 |
| Gesase, S | 1 |
| Chandramohan, D | 1 |
| Gosling, R | 1 |
| Shekalaghe, SA | 1 |
| ter Braak, R | 1 |
| Daou, M | 1 |
| Kavishe, R | 1 |
| van den Bijllaardt, W | 1 |
| van den Bosch, S | 1 |
| Koenderink, JB | 1 |
| Luty, AJ | 1 |
| Whitty, CJ | 1 |
| Drakeley, C | 1 |
| Sauerwein, RW | 1 |
| Bousema, T | 1 |
| Anaba, FC | 1 |
| Ahiante, BO | 1 |
| Pepple, DJ | 1 |
| MOLENAAR, JC | 1 |
| VOORS, AW | 1 |
| Ahlqvist, J | 1 |
| Maronpot, RR | 1 |
| Fleming, AF | 1 |
| Hendrickse, JP | 1 |
| Allan, NC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mass-Drug Administration With a Gametocytocidal Drug Combination, a Model for a Transmission Blocking Vaccine[NCT00509015] | 6,000 participants (Anticipated) | Interventional | 2008-02-29 | Completed | |||
| Evaluation of the Efficacy and Safety of Primaquine for Clearance of Gametocytes in Uncomplicated Falciparum Malaria in Uganda[NCT01365598] | Phase 3 | 468 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Phase 2a Dose Escalation Study of the Efficacy, Safety, and Pharmacokinetics of Low Dose Primaquine for Gametocytocidal Activity Against P. Falciparum in Sub-Saharan Africa and South East Asia[NCT01743820] | Phase 2 | 81 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for pyrimethamine and Hemolysis
8 other studies available for pyrimethamine and Hemolysis
| Article | Year |
|---|---|
Antimalarial pharmacodynamics of chalcone derivatives in combination with artemisinin against Plasmodium falciparum in vitro.
Topics: Animals; Antimalarials; Artemisinins; Chalcone; Drug Combinations; Drug Synergism; Erythrocytes; Hem | 2009 |
Synthesis, in silico experiments and biological evaluation of 1,3,4-trisubstituted pyrazole derivatives as antimalarial agents.
Topics: Animals; Anti-Inflammatory Agents; Antimalarials; Computer Simulation; Hemolysis; Humans; Inhibitory | 2019 |
Protective effect of Thunbergia laurifolia extract on hemolysis during Plasmodium berghei infection.
Topics: Acanthaceae; Animals; Erythrocytes; Hemolysis; Malaria; Mice; Mice, Inbred ICR; Plant Extracts; Plan | 2014 |
In vitro hemolytic effect of sulfadoxine/pyrimethamine and artemether/lumefantrine on malaria parasitized erythrocytes of female patients.
Topics: Adult; Analysis of Variance; Antimanic Agents; Artemether, Lumefantrine Drug Combination; Artemisini | 2012 |
BLACKWATER FEVER AFTER THE USE OF CHLOROQUINE-PYRIMETHAMINE.
Topics: Blackwater Fever; Chloroquine; Hemolysis; Humans; Malaria; New Guinea; Pyrimethamine; Quinine; Toxic | 1963 |
Decreased red cell deformability and vascular obstruction in falciparum malaria illustrated by a fatal case.
Topics: Blood Viscosity; Cell Survival; Drug Combinations; Erythrocyte Deformability; Erythrocytes; Exchange | 1985 |
Erythrocyte glucose-6-phosphate dehydrogenase and glutathione deficiency in sheep.
Topics: Age Factors; Animals; Chromium Isotopes; Disease Models, Animal; Erythrocytes; Female; Glucosephosph | 1972 |
The prevention of megaloblastic anaemia in pregnancy in Nigeria.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Female; Folic Acid; Hemolysis; Humans; Malaria; Nigeria; Pr | 1968 |