pyrimethamine has been researched along with Experimental Hepatoma in 4 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metoprine was capable of replacing trimetrexate and exhibits slightly greater inhibitory activity in combination than trimetrexate." | 1.27 | Synergistic growth inhibition of rat hepatoma cells exposed in vitro to N10-propargyl-5,8-dideazafolate with methotrexate or the lipophilic antifolates trimetrexate or metoprine. ( Galivan, J; Nimec, Z; Rhee, M, 1987) |
| "The presence of low concentrations of the lipophilic dihydrofolate reductase inhibitors metoprine or trimetrexate, which cause little inhibition in the growth of cultured hepatoma cells in combination with weakly inhibiting concentrations of 5,10-dideazatetrahydrofolate, exhibit greater activity than would be predicted by the activity of the individual components." | 1.27 | Antifolate drug interactions: enhancement of growth inhibition due to the antipurine 5,10-dideazatetrahydrofolic acid by the lipophilic dihydrofolate reductase inhibitors metoprine and trimetrexate. ( Boschelli, D; Galivan, J; Kerwar, SS; Nimec, Z; Oronsky, AL; Rhee, M, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Galivan, J | 4 |
| Rhee, MS | 1 |
| Johnson, TB | 1 |
| Dilwith, R | 1 |
| Nair, MG | 1 |
| Bunni, M | 1 |
| Priest, DG | 1 |
| Nimec, Z | 3 |
| Rotundo, R | 1 |
| Rhee, M | 2 |
| Boschelli, D | 1 |
| Oronsky, AL | 1 |
| Kerwar, SS | 1 |
4 other studies available for pyrimethamine and Experimental Hepatoma