pyrimethamine has been researched along with Epilepsy in 5 studies
Maloprim: contains above 2 cpds
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of metoprine, an inhibitor of histamine N-methyltransferase, on open field activity and brain regional histamine (HA) content were examined in rats with mixed, absence and audiogenic, epilepsy (WAG/Rij-AGS), rats with audiogenic epilepsy (Wistar-AGS) and in non-epileptic control rats (Wistar-nAGS)." | 3.78 | Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats. ( Bazyan, AS; Birioukova, LM; Kuznetsova, GD; Midzyanovskaya, IS; Samotaeva, IS; Tuomisto, L, 2012) |
| "A treatment with valproic acid was started, obtaining control of the neurological disease." | 1.43 | Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa. ( Bassetti, M; Beltrame, A; Buonfrate, D; Crichiutti, G; Meroni, V; Venturini, S, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beltrame, A | 1 |
| Venturini, S | 1 |
| Crichiutti, G | 1 |
| Meroni, V | 1 |
| Buonfrate, D | 1 |
| Bassetti, M | 1 |
| Samotaeva, IS | 1 |
| Birioukova, LM | 1 |
| Midzyanovskaya, IS | 1 |
| Kuznetsova, GD | 1 |
| Bazyan, AS | 1 |
| Tuomisto, L | 1 |
| GRISHAM, RS | 1 |
| SULLI, G | 1 |
| VARRONE, F | 1 |
| Yawata, I | 1 |
| Tanaka, K | 1 |
| Nakagawa, Y | 1 |
| Watanabe, Y | 1 |
| Murashima, YL | 1 |
| Nakano, K | 1 |
1 review available for pyrimethamine and Epilepsy
| Article | Year |
|---|---|
[EXTRAMALARIAL THERAPUETIC APPLICATIONS OF ANTIMALARIAL DRUGS. 1. CLINICAL UTILIZATIONS].
Topics: Amodiaquine; Antimalarials; Chloroquine; Collagen Diseases; Dermatology; Drug Utilization; Epilepsy; | 1963 |
4 other studies available for pyrimethamine and Epilepsy
| Article | Year |
|---|---|
Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa.
Topics: Adolescent; Antibodies, Protozoan; Anticonvulsants; Antiprotozoal Agents; Epilepsy; Ethiopia; Humans | 2016 |
Metoprine induced behavioral modifications and brain regional histamine increase in WAG/Rij and Wistar rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Electroencephalography; Enzyme Inhibitors; Epilepsy; Epi | 2012 |
Central nervous system toxicity of pyrimethamine (daraprim) in man.
Topics: Epilepsy; Epilepsy, Tonic-Clonic; Humans; Male; Pyrimethamine | 1962 |
Role of histaminergic neurons in development of epileptic seizures in EL mice.
Topics: Animals; Brain; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Epilepsy; Epil | 2004 |