Page last updated: 2024-11-03

pyrimethamine and Drug-Induced Stevens Johnson Syndrome

pyrimethamine has been researched along with Drug-Induced Stevens Johnson Syndrome in 38 studies

Maloprim: contains above 2 cpds

Research Excerpts

ExcerptRelevanceReference
"A fatal case of Stevens-Johnson syndrome associated with Fansidar and chloroquine is reported in a 5-year-old boy."7.67Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine. ( Bamber, MG; Elder, AT; Gray, JA; Minns, RA, 1986)
"A 12-year-old boy developed a phototoxic rash with subsequent progression to Stevens-Johnson syndrome due to prophylactic ingestion of antimalarials (chloroquine and sulfadoxine-pyrimethamine; Fansidar)."3.67An unusual combination of phototoxicity and Stevens-Johnson syndrome due to antimalarial therapy. ( Hönigsmann, H; Ortel, B; Sivayathorn, A, 1989)
"The combination of pyrimethamine and sulfadoxine (Fansidar) has been reported to cause severe skin reactions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis."3.67Fatal toxic epidermal necrolysis during prophylaxis with pyrimethamine and sulfadoxine in a human immunodeficiency virus-infected person. ( Dinan, WA; Pablos-Mendez, A; Palagiano, A; Raviglione, MC; Sabatini, MT, 1988)
"A fatal case of Stevens-Johnson syndrome associated with Fansidar and chloroquine is reported in a 5-year-old boy."3.67Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine. ( Bamber, MG; Elder, AT; Gray, JA; Minns, RA, 1986)
"Other conditions seen were two (9%) Staphylococcal Scalded Skin Syndrome, three (13%) had Necrotizing Faciitis, one of whom was HIV positive and died."1.35A 12-year retrospective study of non-burn skin loss (burn-like syndromes) at a tertiary burns unit in a developing country. ( Ilombu, CA; Temiye, EO; Ugburo, AO, 2008)
"In particular, in patients with AIDS who are more susceptible for adverse drug reactions and who are simultaneously receiving a variety of drugs with a considerable potential of cutaneous side effects, therapy cannot be withhold for lack of therapeutic alternatives."1.29[Drug-induced Stevens-Johnson syndrome in a patient with AIDS]. ( Bircher, A; Haefeli, WE; Leib, SL; Lüscher, TF; Schlienger, RG, 1993)
"Six cases of drug-induced toxic epidermal necrolysis treated in a burns unit are presented."1.28Treatment of toxic epidermal necrolysis and a review of six cases. ( Krzeminska, EC; Tanner, NS; Ward, DJ, 1990)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-199024 (63.16)18.7374
1990's10 (26.32)18.2507
2000's2 (5.26)29.6817
2010's1 (2.63)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Phillips-Howard, PA2
Warwick Buckler, J1
Chang, MA1
Fouché, B1
LaFortune, W1
Holmes, K1
Rigodon, J1
Juin, S1
Marseille, S1
Rogier, E1
Green, M1
Kheradmand, T1
Moore, SG1
Gaul, DA1
Boncy, J1
Telfort, MA1
Velter, C1
Hotz, C1
Ingen-Housz-Oro, S1
Wolkenstein, P1
Fardet, L1
Oduro-Boatey, C1
Rodrigues, O1
Ugburo, AO1
Temiye, EO1
Ilombu, CA1
Olsen, VV3
Loft, S2
Christensen, KD1
Ligthelm, RJ1
van Zwienen, J1
Stuiver, PC1
Djajadiningrat, AP1
Christensen, PK1
Hornstein, OP1
Ruprecht, KW1
Schlienger, RG1
Haefeli, WE1
Bircher, A1
Leib, SL1
Lüscher, TF1
Stürchler, D1
Mittelholzer, ML1
Kerr, L1
Caumes, E2
Bocquet, H1
Guermonprez, G1
Rogeaux, O1
Bricaire, F1
Katlama, C1
Gentilini, M1
de Luis, DA1
Fortun, J1
Pintado, V1
Aller de la Fuente, R1
Teira, R1
Virosta, M1
Muñoz, J1
Zubero, Z1
Santamaría, JM1
Schmidt-Westhausen, A1
Grünewald, T1
Reichart, PA1
Pohle, HD1
Moussala, M1
Binam, F1
Nkam, M1
Kouda Zeh, A1
Bengono, G1
Dorangeon, PH1
Marx-Chemla, C1
Quereux, C1
Fay, R1
Leroux, B1
Choisy, H1
Pinon, JM1
Wahl, P1
Ward, DJ1
Krzeminska, EC1
Tanner, NS1
Thiel, HJ1
Richter, U1
Pleyer, U1
Zierhut, M1
Steuhl, KP1
Feyeux, C1
Garrouste, MT1
Schlemmer, B1
Wallach, D1
Behrens, RH1
Dunlop, J1
Navin, TR1
Miller, KD2
Satriale, RF2
Lobel, HO2
Ortel, B1
Sivayathorn, A1
Hönigsmann, H1
Steffen, R1
Heusser, R1
Kuritsky, JN1
Stern, R1
Campbell, CC1
Lyn, PC1
Fernandez, E1
Hellgren, U1
Rombo, L1
Berg, B1
Carlson, J1
Wiholm, BE1
Meseguer, MA1
de Rafael, L1
Vidal, ML1
Jeffrey, RF1
Raviglione, MC1
Dinan, WA1
Pablos-Mendez, A1
Palagiano, A1
Sabatini, MT1
Bamber, MG1
Elder, AT1
Gray, JA1
Minns, RA1
Lenox-Smith, I1
Gascón Brustenga, J1
Merlos Pujol, A1
Bada Ainsa, JL1
Adams, SJ1
Broadbent, J1
Clayden, LM1
Ridley, CM1
Claréus, BW1
Hammar, H1

Reviews

1 review available for pyrimethamine and Drug-Induced Stevens Johnson Syndrome

ArticleYear
[The risks of pyrimethamine-sulfadoxine combination in the prenatal treatment of toxoplasmosis].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 1992, Volume: 21, Issue:5

    Topics: Antimalarials; Cleft Palate; Contraindications; Drug Combinations; Female; Humans; Kernicterus; Preg

1992

Other Studies

37 other studies available for pyrimethamine and Drug-Induced Stevens Johnson Syndrome

ArticleYear
Idiosyncratic reaction resembling toxic epidermal necrolysis caused by chloroquine and maloprim.
    British medical journal (Clinical research ed.), 1988, Jun-04, Volume: 296, Issue:6636

    Topics: Antimalarials; Chloroquine; Dapsone; Drug Combinations; Humans; Male; Middle Aged; Pyrimethamine; St

1988
Investigation of Four Cases of Stevens-Johnson Syndrome among Participants in a Mass Drug Administration Campaign with Sulfadoxine-Pyrimethamine and Primaquine in Haiti, 2020.
    The American journal of tropical medicine and hygiene, 2023, 06-07, Volume: 108, Issue:6

    Topics: Antimalarials; COVID-19; Drug Combinations; Haiti; Humans; Malaria; Mass Drug Administration; Pandem

2023
Stevens-Johnson Syndrome During Pregnancy: Case Report of a Newborn Treated With the Culprit Drug.
    JAMA dermatology, 2018, 02-01, Volume: 154, Issue:2

    Topics: Adult; Cesarean Section; Female; Follow-Up Studies; Gestational Age; Humans; Infant, Newborn; Pregna

2018
Stevens-Johnson syndrome in two children in Ghana following anti-malarial treatment.
    Tropical doctor, 2005, Volume: 35, Issue:2

    Topics: Antimalarials; Child; Drug Combinations; Female; Fever; Ghana; Humans; Malaria, Falciparum; Male; Py

2005
A 12-year retrospective study of non-burn skin loss (burn-like syndromes) at a tertiary burns unit in a developing country.
    Burns : journal of the International Society for Burn Injuries, 2008, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Anti-Infective Agents; Bandages; Burn Units; Child; Child, Preschool; Developing

2008
Serious reactions during malaria prophylaxis with pyrimethamine-sulfadoxine.
    Lancet (London, England), 1982, Oct-30, Volume: 2, Issue:8305

    Topics: Aged; Agranulocytosis; Antimalarials; Drug Combinations; Female; Humans; Jaundice; Malaria; Male; Mi

1982
[Stevens-Johnson syndrome and granulopenia induced by sulfadoxine-pyrimethamine (Fansidar)].
    Nederlands tijdschrift voor geneeskunde, 1983, Sep-17, Volume: 127, Issue:38

    Topics: Adult; Agranulocytosis; Antimalarials; Drug Combinations; Female; Humans; Pyrimethamine; Stevens-Joh

1983
[Serious side effects of sulfadoxine/pyrimethamine as antimalarials].
    Ugeskrift for laeger, 1983, Jan-24, Volume: 145, Issue:4

    Topics: Aged; Agranulocytosis; Antimalarials; Chemical and Drug Induced Liver Injury; Female; Humans; Male;

1983
Fansidar-induced Stevens-Johnson Syndrome.
    The New England journal of medicine, 1982, Dec-09, Volume: 307, Issue:24

    Topics: Antimalarials; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrimethamine; Stevens-Johnson

1982
[Drug-induced Stevens-Johnson syndrome in a patient with AIDS].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1993, Aug-17, Volume: 82, Issue:33

    Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Phenytoin; Pyrimethamine; Stevens-Joh

1993
How frequent are notified severe cutaneous adverse reactions to Fansidar?
    Drug safety, 1993, Volume: 8, Issue:2

    Topics: Adverse Drug Reaction Reporting Systems; Antimalarials; Drug Combinations; Drug Eruptions; Drug Util

1993
Adverse cutaneous reactions to pyrimethamine/sulfadiazine and pyrimethamine/clindamycin in patients with AIDS and toxoplasmic encephalitis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:3

    Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Clindamy

1995
[HIV infection and Lyell syndrome: a wake-up call concerning anti-inflammatory agents].
    Enfermedades infecciosas y microbiologia clinica, 1997, Volume: 15, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory

1997
The safety of pyrimethamine and sulfadoxine for the prevention of Pneumocystis carinii pneumonia.
    Scandinavian journal of infectious diseases, 1997, Volume: 29, Issue:6

    Topics: Adult; Anti-Infective Agents; Female; Humans; Incidence; Male; Pneumocystis; Pneumonia, Pneumocystis

1997
Oral manifestations of toxic epidermal necrolysis (TEN) in patients with AIDS: report of five cases.
    Oral diseases, 1998, Volume: 4, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Age

1998
[Ocular manifestations and sequelae of Lyell syndrome caused by sulfadoxine-pyrimethamine in Cameroon].
    Journal francais d'ophtalmologie, 1998, Volume: 21, Issue:1

    Topics: Adult; Antimalarials; Blepharitis; Cameroon; Diagnosis, Differential; Drug Therapy, Combination; Hum

1998
Treatment of toxic epidermal necrolysis and a review of six cases.
    Burns : journal of the International Society for Burn Injuries, 1990, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Antimalarials; Chlorp

1990
[Drug-induced exudative erythema multiforme major with a chronic progressive course and bilateral blindness. Clinical and immunohistologic follow-up].
    Klinische Monatsblatter fur Augenheilkunde, 1990, Volume: 197, Issue:2

    Topics: Adult; Antimalarials; Blindness; Conjunctiva; Drug Combinations; Drug Eruptions; Epithelium; Follow-

1990
[Bullous toxic skin disease with fatal outcome in AIDS].
    Presse medicale (Paris, France : 1983), 1989, Oct-21, Volume: 18, Issue:34

    Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Prognosis; Pyrimethamine; Stevens-Joh

1989
Stevens-Johnson syndrome due to pyrimethamine/sulfadoxine during presumptive self-therapy of malaria.
    Lancet (London, England), 1989, Sep-30, Volume: 2, Issue:8666

    Topics: Antimalarials; Child; Child, Preschool; Drug Combinations; Female; Humans; Malaria; Medication Error

1989
Adverse reactions associated with pyrimethamine-sulfadoxine prophylaxis for Pneumocystis carinii infections in AIDS.
    Lancet (London, England), 1985, Jun-08, Volume: 1, Issue:8441

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Humans; Male; Pneumonia, Pneumocystis;

1985
An unusual combination of phototoxicity and Stevens-Johnson syndrome due to antimalarial therapy.
    Dermatologica, 1989, Volume: 178, Issue:1

    Topics: Antimalarials; Child; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Ma

1989
[The reliability and side effects of malaria chemoprophylaxis].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1986, Apr-15, Volume: 75, Issue:16

    Topics: Antimalarials; Drug Combinations; Drug Eruptions; Drug Resistance; Humans; Malaria; Plasmodium falci

1986
Severe cutaneous reactions among American travelers using pyrimethamine-sulfadoxine (Fansidar) for malaria prophylaxis.
    The American journal of tropical medicine and hygiene, 1986, Volume: 35, Issue:3

    Topics: Adolescent; Adult; Aged; Antimalarials; Child; Chloroquine; Drug Combinations; Drug Eruptions; Eryth

1986
Severe cutaneous adverse reactions and sulphadoxine-pyrimethamine in Sabah, Malaysia.
    The Medical journal of Australia, 1987, Mar-16, Volume: 146, Issue:6

    Topics: Adult; Antimalarials; Drug Combinations; Drug Eruptions; Female; Humans; Malaysia; Pyrimethamine; St

1987
Adverse reactions to sulphadoxine-pyrimethamine in Swedish travellers: implications for prophylaxis.
    British medical journal (Clinical research ed.), 1987, Aug-08, Volume: 295, Issue:6594

    Topics: Adult; Antimalarials; Drug Combinations; Drug Eruptions; Erythema Multiforme; Female; Humans; Malari

1987
Stevens-Johnson syndrome with isolation of Mycoplasma pneumoniae from skin lesions.
    European journal of clinical microbiology, 1986, Volume: 5, Issue:2

    Topics: Humans; Infant; Male; Mycoplasma pneumoniae; Pyrimethamine; Pyrithioxin; Skin; Stevens-Johnson Syndr

1986
Transient lupus anticoagulant and fansidar therapy.
    Postgraduate medical journal, 1986, Volume: 62, Issue:731

    Topics: Adult; Antimalarials; Blood Coagulation Factors; Drug Combinations; Humans; Lupus Coagulation Inhibi

1986
Fansidar-associated fatal reaction in an HIV-infected man.
    MMWR. Morbidity and mortality weekly report, 1988, Sep-23, Volume: 37, Issue:37

    Topics: Drug Combinations; Drug Therapy, Combination; HIV Seropositivity; Homosexuality; Humans; Male; Middl

1988
Leads from the MMWR. Fansidar-associated fatal reaction in an HIV-infected man.
    JAMA, 1988, Oct-21, Volume: 260, Issue:15

    Topics: Drug Combinations; Drug Therapy, Combination; HIV Seropositivity; Homosexuality; Humans; Male; Middl

1988
Fatal toxic epidermal necrolysis during prophylaxis with pyrimethamine and sulfadoxine in a human immunodeficiency virus-infected person.
    Archives of internal medicine, 1988, Volume: 148, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Humans; Male; Middle Aged; Pneumonia, Pneumoc

1988
Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine.
    The Journal of infection, 1986, Volume: 13, Issue:1

    Topics: Child, Preschool; Chloroquine; Drug Combinations; Humans; Malaria; Male; Pyrimethamine; Stevens-John

1986
Fatal Stevens-Johnson syndrome associated with Fansidar and chloroquine.
    The Journal of infection, 1987, Volume: 14, Issue:1

    Topics: Antimalarials; Chloroquine; Drug Combinations; Drug Therapy, Combination; Humans; Pyrimethamine; Ste

1987
[Stevens-Johnson syndrome in a patient treated with quinine and pyrimethamine-sulfadoxine].
    Medicina clinica, 1986, Dec-06, Volume: 87, Issue:19

    Topics: Drug Therapy, Combination; Humans; Male; Middle Aged; Pyrimethamine; Quinine; Stevens-Johnson Syndro

1986
[Is the use of Fansidar as an antimalarial justified?].
    Ugeskrift for laeger, 1985, Feb-11, Volume: 147, Issue:7

    Topics: Adult; Aged; Antimalarials; Chemical and Drug Induced Liver Injury; Drug Combinations; Humans; Middl

1985
Erythema multiforme (Stevens-Johnson) precipitated by Fansidar.
    Postgraduate medical journal, 1985, Volume: 61, Issue:713

    Topics: Adult; Antimalarials; Drug Combinations; Humans; Malaria; Male; Pyrimethamine; Stevens-Johnson Syndr

1985
[Malaria prevention with Fansidar as a cause of Stevens-Johnson syndrome].
    Lakartidningen, 1985, Nov-27, Volume: 82, Issue:48

    Topics: Adult; Antimalarials; Drug Combinations; Female; Humans; Male; Middle Aged; Pyrimethamine; Stevens-J

1985