pyrimethamine has been researched along with Deficiency of Glucose-6-Phosphate Dehydrogenase in 20 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children." | 9.20 | Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. ( Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E, 2015) |
| "Sulphadoxine-Pyrimethamine (SP) is still the only recommended antimalarial for use in intermittent preventive treatment of malaria during pregnancy (IPTp) in some malaria endemic countries including Ghana." | 7.81 | Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin Drop after Sulphadoxine-Pyrimethamine Use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana - A Cohort Study. ( Amu, A; Anyorigiya, T; Asante, KP; Awini, E; Bart-Plange, C; Dosoo, D; Gyapong, M; Hodgson, A; Jakpa, G; Mahama, E; Oduro, AR; Ofei, E; Owusu, R; Owusu-Agyei, S; Segbaya, S, 2015) |
| "Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children." | 5.20 | Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants. ( Alifrangis, M; Baraka, V; Carneiro, I; Chandramohan, D; Gesase, S; Gosling, R; Hashim, R; Ishengoma, D; Mosha, J; Poirot, E; Vittinghoff, E, 2015) |
| "Sulphadoxine-Pyrimethamine (SP) is still the only recommended antimalarial for use in intermittent preventive treatment of malaria during pregnancy (IPTp) in some malaria endemic countries including Ghana." | 3.81 | Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin Drop after Sulphadoxine-Pyrimethamine Use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana - A Cohort Study. ( Amu, A; Anyorigiya, T; Asante, KP; Awini, E; Bart-Plange, C; Dosoo, D; Gyapong, M; Hodgson, A; Jakpa, G; Mahama, E; Oduro, AR; Ofei, E; Owusu, R; Owusu-Agyei, S; Segbaya, S, 2015) |
| "falciparum malaria was evaluated according to G6PD deficiency in a secondary analysis of an open-label, randomized clinical trial." | 2.73 | High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. ( Avellino, P; Bancone, G; d'Alessandro, U; Fanello, CI; Karema, C; Lee, SJ; Modiano, D; Uwimana, A, 2008) |
| "Twenty-one cases of agranulocytosis following dosage with one tablet of Maloprim given once or twice weekly are reviewed." | 1.27 | Agranulocytosis associated with maloprim: review of cases. ( Farquhar, JA; Hutchinson, DB; Whiteman, PD, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (45.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hutchinson, DB | 1 |
| Whiteman, PD | 1 |
| Farquhar, JA | 1 |
| Graves, PM | 4 |
| Choi, L | 1 |
| Gelband, H | 4 |
| Garner, P | 4 |
| Rochford, R | 1 |
| Ohrt, C | 1 |
| Baresel, PC | 1 |
| Campo, B | 1 |
| Sampath, A | 1 |
| Magill, AJ | 1 |
| Tekwani, BL | 1 |
| Walker, LA | 1 |
| Owusu, R | 1 |
| Asante, KP | 1 |
| Mahama, E | 1 |
| Awini, E | 1 |
| Anyorigiya, T | 1 |
| Dosoo, D | 1 |
| Amu, A | 1 |
| Jakpa, G | 1 |
| Ofei, E | 1 |
| Segbaya, S | 1 |
| Oduro, AR | 1 |
| Gyapong, M | 1 |
| Hodgson, A | 1 |
| Bart-Plange, C | 1 |
| Owusu-Agyei, S | 1 |
| Poirot, E | 1 |
| Vittinghoff, E | 1 |
| Ishengoma, D | 1 |
| Alifrangis, M | 1 |
| Carneiro, I | 1 |
| Hashim, R | 1 |
| Baraka, V | 1 |
| Mosha, J | 1 |
| Gesase, S | 1 |
| Chandramohan, D | 1 |
| Gosling, R | 1 |
| Fanello, CI | 1 |
| Karema, C | 1 |
| Avellino, P | 1 |
| Bancone, G | 1 |
| Uwimana, A | 1 |
| Lee, SJ | 1 |
| d'Alessandro, U | 1 |
| Modiano, D | 1 |
| Shekalaghe, SA | 1 |
| ter Braak, R | 1 |
| Daou, M | 1 |
| Kavishe, R | 1 |
| van den Bijllaardt, W | 1 |
| van den Bosch, S | 1 |
| Koenderink, JB | 1 |
| Luty, AJ | 1 |
| Whitty, CJ | 1 |
| Drakeley, C | 1 |
| Sauerwein, RW | 1 |
| Bousema, T | 1 |
| Khoo, KK | 1 |
| Ponnampalam, JT | 1 |
| Cultrera, R | 1 |
| Contini, C | 1 |
| Everett, WD | 1 |
| Shanks, GD | 1 |
| Edstein, MD | 1 |
| Suriyamongkol, V | 1 |
| Timsaad, S | 1 |
| Webster, HK | 1 |
| Maronpot, RR | 1 |
| Chin, W | 1 |
| Bear, DM | 1 |
| Colwell, EJ | 1 |
| Kosakal, S | 1 |
| Dube, B | 1 |
| Chawla, SC | 1 |
| Vaish, SK | 1 |
| Somani, PN | 1 |
| Srivastava, PK | 1 |
| Onadeko, BO | 1 |
| Bademosi, O | 1 |
| Welt, SI | 1 |
| Jackson, EH | 1 |
| Kirkman, HN | 1 |
| Parker, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Development of Safer Drugs for Malaria in U.S. Troops, Civilian Personnel, and Travelers: Clinical Evaluation of Primaquine Enantiomer[NCT02898779] | Phase 1 | 36 participants (Actual) | Interventional | 2017-05-01 | Completed | ||
| Open Study on the Tolerability and Efficacy of the Combination Chlorproguanil-Dapsone+Artesunate Compared to Amodiaquine+Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria in Rwandan Children[NCT00461578] | 800 participants | Interventional | 2005-04-30 | Completed | |||
| Mass-Drug Administration With a Gametocytocidal Drug Combination, a Model for a Transmission Blocking Vaccine[NCT00509015] | 6,000 participants (Anticipated) | Interventional | 2008-02-29 | Completed | |||
| Evaluation of the Efficacy and Safety of Primaquine for Clearance of Gametocytes in Uncomplicated Falciparum Malaria in Uganda[NCT01365598] | Phase 3 | 468 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| Phase 2a Dose Escalation Study of the Efficacy, Safety, and Pharmacokinetics of Low Dose Primaquine for Gametocytocidal Activity Against P. Falciparum in Sub-Saharan Africa and South East Asia[NCT01743820] | Phase 2 | 81 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for pyrimethamine and Deficiency of Glucose-6-Phosphate Dehydrogenase
| Article | Year |
|---|---|
Primaquine or other 8-aminoquinolines for reducing Plasmodium falciparum transmission.
Topics: Adult; Antimalarials; Artemisinins; Child; Chloroquine; Drug Combinations; Glucosephosphate Dehydrog | 2018 |
Primaquine or other 8-aminoquinoline for reducing P. falciparum transmission.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Glucosephosphate Dehydrogen | 2014 |
Primaquine or other 8-aminoquinoline for reducing Plasmodium falciparum transmission.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Glucosephosphate Dehydrogen | 2015 |
Primaquine for reducing Plasmodium falciparum transmission.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Drug Combinations; Glucosephosphate Dehydrogen | 2012 |
5 trials available for pyrimethamine and Deficiency of Glucose-6-Phosphate Dehydrogenase
| Article | Year |
|---|---|
Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants.
Topics: Antimalarials; Cohort Studies; Dapsone; Double-Blind Method; Drug Combinations; Female; Genotype; Gl | 2015 |
High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dapsone; Drug Combina | 2008 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
In Tanzania, hemolysis after a single dose of primaquine coadministered with an artemisinin is not restricted to glucose-6-phosphate dehydrogenase-deficient (G6PD A-) individuals.
Topics: Anemia; Anti-Infective Agents; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Dru | 2010 |
The treatment of malaria in glucose-6-phosphate dehydrogenase deficient patients in Sabah.
Topics: Adolescent; Adult; Anemia, Hemolytic; Antimalarials; Child; Chloroquine; Drug Combinations; Female; | 1981 |
Malaria chemoprophylaxis using proguanil/dapsone combinations on the Thai-Cambodian border.
Topics: Blood Cells; Cambodia; Dapsone; Doxycycline; Drug Therapy, Combination; Drug Tolerance; Glucosephosp | 1992 |
11 other studies available for pyrimethamine and Deficiency of Glucose-6-Phosphate Dehydrogenase
| Article | Year |
|---|---|
Agranulocytosis associated with maloprim: review of cases.
Topics: Adult; Agranulocytosis; Antimalarials; Dapsone; Dose-Response Relationship, Drug; Drug Combinations; | 1986 |
Humanized mouse model of glucose 6-phosphate dehydrogenase deficiency for in vivo assessment of hemolytic toxicity.
Topics: Aminoquinolines; Anemia, Hemolytic; Animals; Antimalarials; Chloroquine; Combined Modality Therapy; | 2013 |
Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin Drop after Sulphadoxine-Pyrimethamine Use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana - A Cohort Study.
Topics: Adult; Antimalarials; Cohort Studies; Drug Combinations; Female; Ghana; Glucosephosphate Dehydrogena | 2015 |
Haemoglobinuria after a single dose treatment with dapsone and pyrimethamine for falciparum malaria in a patient with glucose-6-phosphate dehydrogenase deficiency.
Topics: Child, Preschool; Dapsone; Drug Combinations; Glucosephosphate Dehydrogenase; Glucosephosphate Dehyd | 1981 |
Management of a case of chloroquine-resistant falciparum malaria in a pregnant woman with glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Topics: Adult; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Drug Therapy, Combination; F | 1999 |
Malaria and beriberi: unresolved military medical problems contributing to the fall of Cambodia.
Topics: Antimalarials; Beriberi; Cambodia; Drug Combinations; Glucosephosphate Dehydrogenase Deficiency; Hem | 1979 |
Erythrocyte glucose-6-phosphate dehydrogenase and glutathione deficiency in sheep.
Topics: Age Factors; Animals; Chromium Isotopes; Disease Models, Animal; Erythrocytes; Female; Glucosephosph | 1972 |
A comparative evaluation of sulfalene-trimethoprim and sulphormethoxine-pyrimethamine against falciparum malaria in Thailand.
Topics: Adolescent; Adult; Anti-Infective Agents; Antibodies; Antimalarials; Drug Combinations; Evaluation S | 1973 |
Consumption coagulopathy following haemolytic crisis in glucose-6-phosphate dehydrogenase deficient subjects.
Topics: Adolescent; Adult; Aspirin; Disseminated Intravascular Coagulation; Glucosephosphate Dehydrogenase D | 1972 |
Glucose-6-phosphate dehydrogenase deficiency and intravascular haemolysis.
Topics: Adolescent; Adult; Anemia, Hemolytic; Aspirin; Dapsone; Female; Glucosephosphate Dehydrogenase Defic | 1974 |
The effects of certain drugs on the hexose monophosphate shunt of human red cells.
Topics: Adult; Carbon Dioxide; Carbon Isotopes; Chromatography, Ion Exchange; Cyanides; Erythrocytes; Female | 1971 |