pyrimethamine has been researched along with Cerebral Malaria in 14 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria." | 9.08 | Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995) |
| "Artemether was well tolerated." | 6.67 | Artemether in moderately severe and cerebral malaria in Nigerian children. ( Adio, R; Oduola, AM; Omokhodion, SJ; Salako, LA; Sowunmi, A; Walker, O, 1994) |
| "To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria." | 5.08 | Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995) |
| "To determine whether combining iron chelation with quinine therapy speeds the recovery of consciousness, we conducted a randomized, double-blind, placebo-controlled trial of the iron chelator deferoxamine in 83 Zambian children with cerebral malaria." | 5.07 | Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. ( Backenstose, A; Biemba, G; Brittenham, G; Gordeuk, V; Holmes, L; McKinley, E; McLaren, C; Msiska, R; Parry, D; Thuma, P, 1992) |
| " We tested whether chloroquine- and antifolate drug-resistant genotypes would be more commonly associated with cases of cerebral malaria than with cases of mild malaria in the province of Jabalpur, India, by genotyping the dhps, dhfr, pfmdr-1, and pfcrt genes using pyrosequencing, direct sequencing, and real-time PCR." | 3.76 | Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in India. ( Dash, AP; Jain, V; McCollum, AM; Mixson-Hayden, T; Nagpal, AC; Poe, A; Singh, N; Stiles, JK; Udhayakumar, V, 2010) |
| "The study population consisted of 26 Zambian children < 6 years of age who presented with cerebral malaria to a rural hospital in 1994 and who were treated with quinine for seven days." | 3.70 | Prolonged macrophage activation and persistent anaemia in children with complicated malaria. ( Biemba, G; Gordeuk, VR; Mabeza, GF; Thuma, PE; Weiss, G, 1998) |
| "United States military personnel deployed to Somalia were at risk for malaria, including chloroquine-resistant Plasmodium falciparum malaria." | 3.69 | Malaria among United States troops in Somalia. ( Batchelor, R; Burans, JP; Iriye, C; Lobel, HO; Longer, CF; Magill, AJ; Rozmajzl, P; Sharp, TW; Smoak, B; Thornton, SA; Wallace, MR, 1996) |
| "Artemether was well tolerated." | 2.67 | Artemether in moderately severe and cerebral malaria in Nigerian children. ( Adio, R; Oduola, AM; Omokhodion, SJ; Salako, LA; Sowunmi, A; Walker, O, 1994) |
| "Effective intermittent preventive treatment in pregnancy (IPTp) diminishes placental malaria (PM) and its subsequent malaria-associated morbidity." | 2.50 | Pregnancy-associated malaria and malaria in infants: an old problem with present consequences. ( Abellana, R; Cot, M; Moya-Alvarez, V, 2014) |
| "Cerebral malaria is a fatal complication of malaria." | 1.40 | Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice. ( Akai, R; Hirai, M; Hisaeda, H; Imai, T; Iwawaki, T; Okada, H; Suzue, K; Taniguchi, T, 2014) |
| "Here, we show that mice protected from cerebral malaria by CD8+ T-cell depletion have significantly fewer parasites in the brain." | 1.36 | Accumulation of Plasmodium berghei-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice. ( Baptista, FG; Mota, MM; Pamplona, A; Pena, AC; Pied, S; Vigário, AM, 2010) |
| "Twenty patients with severe malaria (17 cerebral malaria and 3 severe anaemia) were studied." | 1.29 | Severe malaria in children at Port Moresby General Hospital, Papua New Guinea. ( Brown, N, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Imai, T | 1 |
| Iwawaki, T | 1 |
| Akai, R | 1 |
| Suzue, K | 1 |
| Hirai, M | 1 |
| Taniguchi, T | 1 |
| Okada, H | 1 |
| Hisaeda, H | 1 |
| Moya-Alvarez, V | 1 |
| Abellana, R | 1 |
| Cot, M | 1 |
| Mixson-Hayden, T | 1 |
| Jain, V | 1 |
| McCollum, AM | 1 |
| Poe, A | 1 |
| Nagpal, AC | 1 |
| Dash, AP | 1 |
| Stiles, JK | 1 |
| Udhayakumar, V | 1 |
| Singh, N | 1 |
| Baptista, FG | 1 |
| Pamplona, A | 1 |
| Pena, AC | 1 |
| Mota, MM | 1 |
| Pied, S | 1 |
| Vigário, AM | 1 |
| Chen, YZ | 1 |
| Jin, T | 1 |
| JONES, SA | 1 |
| Brown, N | 1 |
| Gordeuk, VR | 3 |
| Thuma, PE | 3 |
| McLaren, CE | 2 |
| Biemba, G | 4 |
| Zulu, S | 1 |
| Poltera, AA | 1 |
| Askin, JE | 1 |
| Brittenham, GM | 1 |
| Salako, LA | 1 |
| Walker, O | 1 |
| Sowunmi, A | 1 |
| Omokhodion, SJ | 1 |
| Adio, R | 1 |
| Oduola, AM | 1 |
| Wallace, MR | 1 |
| Sharp, TW | 1 |
| Smoak, B | 1 |
| Iriye, C | 1 |
| Rozmajzl, P | 1 |
| Thornton, SA | 1 |
| Batchelor, R | 1 |
| Magill, AJ | 1 |
| Lobel, HO | 1 |
| Longer, CF | 1 |
| Burans, JP | 1 |
| Mabeza, GF | 2 |
| Weiss, G | 1 |
| Dolmans, DE | 1 |
| Parry, D | 2 |
| Vogel, G | 1 |
| Gordeuk, V | 1 |
| Thuma, P | 1 |
| Brittenham, G | 1 |
| McLaren, C | 1 |
| Backenstose, A | 1 |
| Msiska, R | 1 |
| Holmes, L | 1 |
| McKinley, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations[NCT04333550] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2020-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for pyrimethamine and Cerebral Malaria
| Article | Year |
|---|---|
Pregnancy-associated malaria and malaria in infants: an old problem with present consequences.
Topics: Adult; Africa South of the Sahara; Antimalarials; Comorbidity; Complement Activation; Developmental | 2014 |
4 trials available for pyrimethamine and Cerebral Malaria
| Article | Year |
|---|---|
Transferrin saturation and recovery from coma in cerebral malaria.
Topics: Chelation Therapy; Child, Preschool; Cohort Studies; Coma; Deferoxamine; Double-Blind Method; Drug T | 1995 |
Artemether in moderately severe and cerebral malaria in Nigerian children.
Topics: Antimalarials; Antiprotozoal Agents; Artemether; Artemisinins; Child; Child, Preschool; Drug Combina | 1994 |
A prospective study of combination antimalarial therapy and of anaemia in Zambian children with cerebral malaria.
Topics: Anemia; Antimalarials; Child; Child, Preschool; Drug Therapy, Combination; Follow-Up Studies; Humans | 1999 |
Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria.
Topics: Child, Preschool; Coma; Consciousness; Deferoxamine; Double-Blind Method; Drug Therapy, Combination; | 1992 |
9 other studies available for pyrimethamine and Cerebral Malaria
| Article | Year |
|---|---|
Evaluating experimental cerebral malaria using oxidative stress indicator OKD48 mice.
Topics: Animals; Antimalarials; Brain; Luminescent Measurements; Malaria, Cerebral; Mice; Mice, Inbred Strai | 2014 |
Evidence of selective sweeps in genes conferring resistance to chloroquine and pyrimethamine in Plasmodium falciparum isolates in India.
Topics: Animals; Antimalarials; Chloroquine; Drug Resistance; Genes, Protozoan; Genotype; Humans; India; Mal | 2010 |
Accumulation of Plasmodium berghei-infected red blood cells in the brain is crucial for the development of cerebral malaria in mice.
Topics: Animals; Blood-Brain Barrier; Brain; CD8-Positive T-Lymphocytes; Erythrocytes; Malaria, Cerebral; Ma | 2010 |
[Diagnosis and treatment of a case with cerebral falciparum malaria].
Topics: Adult; Antimalarials; Drug Combinations; Humans; Malaria, Cerebral; Malaria, Falciparum; Male; Pyrim | 2001 |
Malaria treated with daraprim, including cerebral malaria and high parasitaemia.
Topics: Malaria; Malaria, Cerebral; Parasitemia; Pyrimethamine; Pyrimidines | 1952 |
Severe malaria in children at Port Moresby General Hospital, Papua New Guinea.
Topics: Antimalarials; Child; Child, Preschool; Drug Combinations; Female; Glasgow Coma Scale; Hospitals, Ge | 1995 |
Malaria among United States troops in Somalia.
Topics: Anti-Bacterial Agents; Antimalarials; Chemoprevention; Chloroquine; Clothing; Cohort Studies; Doxycy | 1996 |
Prolonged macrophage activation and persistent anaemia in children with complicated malaria.
Topics: Analysis of Variance; Anemia; Antimalarials; Child, Preschool; Deferoxamine; Drug Therapy, Combinati | 1998 |
African research. Traditional and modern medicine merge to save lives.
Topics: Antimalarials; Child; Child, Preschool; Drug Combinations; Humans; Infusions, Intravenous; Malaria, | 2000 |