pyrimethamine and Central Nervous System Toxoplasmosis studies

Research Excerpts

Excerpt	Relevance	Reference
"An open, randomised, multicentre trial was conducted to evaluate the efficacy of thrice-weekly versus daily therapy with sulfadiazine-pyrimethamine in the prevention of relapses of toxoplasmic encephalitis in HIV-infected patients."	9.09	Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group. ( Arrizabalaga, J; Cosin, J; Cruceta, A; Domingo, P; Fariñas, MC; Ferrer, E; Gatell, JM; Gudiol, F; Knobel, H; Leyes, M; Martínez-Lacasa, J; Miró, JM; Podzamczer, D; Polo, R; Ramón, JM; Ribera, E; Sirera, G, 2000)
"Pyrimethamine (50 mg) with folinic acid (15 mg) given three times weekly was assessed as primary prophylaxis for toxoplasmic encephalitis (TE) in 554 human immunodeficiency virus-infected patients seropositive for Toxoplasma gondii and with < 200 CD4 cells/mm3."	9.08	Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Gr ( Aubertin, J; Chêne, G; Hafner, R; Leport, C; Luft, BJ; Miro, J; Morlat, P; Pueyo, S; Rousseau, F; Salamon, R; Vildé, JL, 1996)
"This European multicenter study compares the efficacy and tolerance of the combination of pyrimethamine-clindamycin (Pyr-Cm) with the standard therapy pyrimethamine-sulfadiazine (Pyr-Sdz) for the treatment of toxoplasmic encephalitis (TE) in patients with AIDS."	9.08	Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. ( Clumeck, N; De Wit, S; Katlama, C; O'Doherty, E; Van Glabeke, M, 1996)
"Between February 1990 and June 1993, 105 patients with HIV infection were enrolled after each had had resolution of an acute episode of toxoplasmic encephalitis treated with sulfadiazine (1 g four times per day) plus pyrimethamine (50 mg/d) plus folinic acid (15 mg/d) for 4 to 8 weeks."	9.08	Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Spanish Toxoplasmosis Study Group. ( Bolao, F; Cosín, J; Domingo, P; Gatell, JM; Laguna, F; Miró, JM; Podzamczer, D; Santamaría, J; Sirera, G; Verdejo, J, 1995)
"To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)."	9.08	Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995)
"Sixty-five patients intolerant of conventional toxoplasmic encephalitis therapies-pyrimethamine, sulphadiazine or clindamycin-received atovaquone as maintenance therapy after resolution of an acute episode of toxoplasmic encephalitis."	9.08	Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. ( Gourdon, D; Katlama, C; Lapierre, D; Mouthon, B; Rousseau, F, 1996)
"To compare pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfadiazine (PS) as a treatment for toxoplasmic encephalitis (TE) in patients with the acquired immunodeficiency syndrome (AIDS)."	9.07	Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Clumeck, N; Dannemann, B; Israelski, D; Leport, C; Luft, B; McCutchan, JA; Morlat, P; Nussbaum, J, 1992)
"A prospective study was conducted to evaluate azithromycin in combination with pyrimethamine for treatment of acute Toxoplasma encephalitis in patients with AIDS."	9.07	Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS. ( Hazebroucq, V; Joly, V; Leport, C; Morlat, P; Raffi, F; Saba, J; Vildé, JL, 1993)
"To evaluate the safety and efficacy of a fixed 25mg pyrimethamine--500mg sulfadoxine combination plus 15mg folinic acid given twice weekly for the prevention of relapses of Pneumocystis carinii pneumonia (PCP) and primary episodes of toxoplasmic encephalitis."	7.71	Twice-weekly pyrimethamine-sulfadoxine effectively prevents Pneumocystis carinii pneumonia relapse and toxoplasmic encephalitis in patients with AIDS. ( Albrecht, H; Behnsch, M; Bergmann, F; Grobusch, M; Grünewald, T; Padberg, J; Ruf, B; Schürmann, D; Suttorp, N; Vallée, M; Wünsche, T, 2001)
"The effectiveness of combinations of rifabutin with atovaquone, clindamycin, pyrimethamine, or sulfadiazine in the treatment of toxoplasmic encephalitis in a murine model was investigated."	7.69	Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice. ( Araujo, FG; Remington, JS; Suzuki, Y, 1996)
"The efficacy and safety of 25 mg pyrimethamine plus 500 mg sulfadoxine given twice a week in preventing relapses of AIDS-related toxoplasmic encephalitis was evaluated in an open study."	7.68	Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients. ( Bergmann, F; Gottschalk, HJ; Grünewald, T; Pohle, HD; Ruf, B; Schüler-Maué, W; Schürmann, D; Witt, H, 1993)
"The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP."	7.68	Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992)
"An open, randomised, multicentre trial was conducted to evaluate the efficacy of thrice-weekly versus daily therapy with sulfadiazine-pyrimethamine in the prevention of relapses of toxoplasmic encephalitis in HIV-infected patients."	5.09	Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group. ( Arrizabalaga, J; Cosin, J; Cruceta, A; Domingo, P; Fariñas, MC; Ferrer, E; Gatell, JM; Gudiol, F; Knobel, H; Leyes, M; Martínez-Lacasa, J; Miró, JM; Podzamczer, D; Polo, R; Ramón, JM; Ribera, E; Sirera, G, 2000)
"We assessed the incidence and determinants of bacteremia, pneumonia, and sinusitis/otitis in HIV-positive people receiving cotrimoxazole (CTX) or dapsone-pyrimethamine (DP) for primary prophylaxis of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) within a randomized clinical trial."	5.09	Incidence and determinants of bacterial infections in HIV-positive patients receiving anti-Pneumocystis carinii/Toxoplasma gondii primary prophylaxis within a randomized clinical trial. ( Ammassari, A; Antinori, A; Cingolani, A; De Luca, A; Grillo, R; Murri, R; Pallavicini, F; Pezzotti, P, 2001)
"This European multicenter study compares the efficacy and tolerance of the combination of pyrimethamine-clindamycin (Pyr-Cm) with the standard therapy pyrimethamine-sulfadiazine (Pyr-Sdz) for the treatment of toxoplasmic encephalitis (TE) in patients with AIDS."	5.08	Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. ( Clumeck, N; De Wit, S; Katlama, C; O'Doherty, E; Van Glabeke, M, 1996)
"Between February 1990 and June 1993, 105 patients with HIV infection were enrolled after each had had resolution of an acute episode of toxoplasmic encephalitis treated with sulfadiazine (1 g four times per day) plus pyrimethamine (50 mg/d) plus folinic acid (15 mg/d) for 4 to 8 weeks."	5.08	Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Spanish Toxoplasmosis Study Group. ( Bolao, F; Cosín, J; Domingo, P; Gatell, JM; Laguna, F; Miró, JM; Podzamczer, D; Santamaría, J; Sirera, G; Verdejo, J, 1995)
"To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)."	5.08	Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995)
"Sixty-five patients intolerant of conventional toxoplasmic encephalitis therapies-pyrimethamine, sulphadiazine or clindamycin-received atovaquone as maintenance therapy after resolution of an acute episode of toxoplasmic encephalitis."	5.08	Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. ( Gourdon, D; Katlama, C; Lapierre, D; Mouthon, B; Rousseau, F, 1996)
"Pyrimethamine (50 mg) with folinic acid (15 mg) given three times weekly was assessed as primary prophylaxis for toxoplasmic encephalitis (TE) in 554 human immunodeficiency virus-infected patients seropositive for Toxoplasma gondii and with < 200 CD4 cells/mm3."	5.08	Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Gr ( Aubertin, J; Chêne, G; Hafner, R; Leport, C; Luft, BJ; Miro, J; Morlat, P; Pueyo, S; Rousseau, F; Salamon, R; Vildé, JL, 1996)
"To compare pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfadiazine (PS) as a treatment for toxoplasmic encephalitis (TE) in patients with the acquired immunodeficiency syndrome (AIDS)."	5.07	Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Clumeck, N; Dannemann, B; Israelski, D; Leport, C; Luft, B; McCutchan, JA; Morlat, P; Nussbaum, J, 1992)
"A prospective study was conducted to evaluate azithromycin in combination with pyrimethamine for treatment of acute Toxoplasma encephalitis in patients with AIDS."	5.07	Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS. ( Hazebroucq, V; Joly, V; Leport, C; Morlat, P; Raffi, F; Saba, J; Vildé, JL, 1993)
"The aim was to evaluate the safety profile of pyrimethamine-based treatment for the three main Toxoplasma manifestations: toxoplasmic encephalitis (TE), ocular toxoplasmosis, and congenital toxoplasmosis."	4.95	Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review. ( Ben-Harari, RR; Casoy, J; Goodwin, E, 2017)
"Although the price increase of pyrimethamine in 2015 received heavy media coverage, there are little data regarding specific implications to hospitals and the total costs of treating inpatients with toxoplasmosis encephalitis (TE)."	4.12	Brief Report: Financial Burden of Toxoplasmosis Encephalitis Treatment at a Safety Net Hospital. ( Bogard, SN; Kempker, RR; Lee, JT; Patel, M, 2022)
"To evaluate the safety and efficacy of a fixed 25mg pyrimethamine--500mg sulfadoxine combination plus 15mg folinic acid given twice weekly for the prevention of relapses of Pneumocystis carinii pneumonia (PCP) and primary episodes of toxoplasmic encephalitis."	3.71	Twice-weekly pyrimethamine-sulfadoxine effectively prevents Pneumocystis carinii pneumonia relapse and toxoplasmic encephalitis in patients with AIDS. ( Albrecht, H; Behnsch, M; Bergmann, F; Grobusch, M; Grünewald, T; Padberg, J; Ruf, B; Schürmann, D; Suttorp, N; Vallée, M; Wünsche, T, 2001)
"In 26 AIDS patients treated for toxoplasmic encephalitis, the inhibitory effect on Toxoxplasma growth of sequential sera taken before and after initiation of therapy was determined using a culture-based immunoassay and compared with pyrimethamine blood levels."	3.70	Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis. ( Derouin, F; Farinotti, R; Gérard, L; Leport, C; Maslo, C, 1998)
"The effectiveness of combinations of rifabutin with atovaquone, clindamycin, pyrimethamine, or sulfadiazine in the treatment of toxoplasmic encephalitis in a murine model was investigated."	3.69	Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice. ( Araujo, FG; Remington, JS; Suzuki, Y, 1996)
"Pyrimethamine is an antiparasitic agent currently used for therapy of central nervous system toxoplasmosis, a disease seen with increasing frequency in association with the AIDS epidemic."	3.69	Pyrimethamine analysis by enzyme inhibition and HPLC assays. ( Heimer, R; Jatlow, PI; Rainey, PM; Reynolds, KM; Roberts, WL, 1995)
"The efficacy and safety of 25 mg pyrimethamine plus 500 mg sulfadoxine given twice a week in preventing relapses of AIDS-related toxoplasmic encephalitis was evaluated in an open study."	3.68	Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients. ( Bergmann, F; Gottschalk, HJ; Grünewald, T; Pohle, HD; Ruf, B; Schüler-Maué, W; Schürmann, D; Witt, H, 1993)
"The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP."	3.68	Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992)
" The weekly dosage of pyrimethamine ranged from 25 to 1,400 mg; one patient with severe diarrhea received 2,100 mg/week."	2.68	Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS. ( Klinker, H; Langmann, P; Richter, E, 1996)
"Cerebral toxoplasmosis is the most frequent opportunistic infection in patients with acquired immune deficiency syndrome in France."	2.67	[Primary prophylaxis against cerebral toxoplasmosis. Efficacy of folinic acid in the prevention of hematologic toxicity of pyrimethamine]. ( Barbeau, P; Brossard, G; Leng, B; Neau, D; Pellegrin, JL, 1994)
"To identify risk factors for cerebral toxoplasmosis (CT) in HIV patients (pts) with positive serology for Toxoplasma gondii and CD4 < 200/mm3, data from the placebo group (N = 280) of a primary prophylaxis trial, were analyzed."	2.67	[Risk factors of cerebral toxoplasmosis in patients with HIV infection: data of a primary prevention trial]. ( Aubertin, J; Chene, G; Hafner, R; Leport, C; Luft, B; Morlat, P; Pueyo, S; Salamon, R; Vilde, JL, 1993)
"11), and drug discontinuation because of adverse events (P-C: RR 0."	2.55	A systematic review and meta-analysis of the relative efficacy and safety of treatment regimens for HIV-associated cerebral toxoplasmosis: is trimethoprim-sulfamethoxazole a real option? ( Benites-Zapata, VA; Deshpande, A; Hernandez, AV; Pasupuleti, V; Pellegrino, D; Penalva de Oliveira, AC; Thota, P; Vidal, JE, 2017)
" Azithromycin is also effective against intracystic bradyzoïtes in vitro, but long term administration of azithromycin to chronically infected mice failed to reduce the mean number of brain cysts."	2.39	[New pathogens and mode of action of azithromycin: Toxoplasma gondii]. ( Derouin, F, 1995)
" Dosage must be adjusted to the results of blood counts."	2.38	[Usefulness of folinic acid in cytopenia induced by antiparasitic drugs in AIDS patients]. ( Leport, C; Niyongabo, T; Vildé, JL, 1991)
"In this study, the effects of the treatment with different doses of fluconazole (FLZ) in combination with the current treatment of acute toxoplasmosis on reducing the mortality rate and the parasitic load in the murine model in vivo were studied."	1.62	Determination of parasitic burden in the brain tissue of infected mice in acute toxoplasmosis after treatment by fluconazole combined with sulfadiazine and pyrimethamine. ( Anita, M; Hadi, M; Mohammad, JM; Reza, S; Sina, S; Soudabeh, E, 2021)
"The current standard treatment for cerebral toxoplasmosis (pyrimethamine/sulfadiazine) often encounters problems of poor tolerability, adverse effects, frequent dropouts and non-availability of pyrimethamine/sulfadiazine in some parts of India."	1.42	Alternative treatment approach to cerebral toxoplasmosis in HIV/AIDS: experience from a resource-poor setting. ( Goswami, RP; Rahman, M; Ray, Y; Tripathi, SK, 2015)
"Establishing a definitive diagnosis of cerebral toxoplasmosis is difficult in resource limited settings."	1.42	Multiple intracerebral lesions in a young male. ( Basavaprabhu, A; Deepak, M; Soundarya, M, 2015)
"Atovaquone was detectable in sera, brains, livers, and lungs of infected mice by high-performance liquid chromatography and/or mass spectrometry."	1.32	Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis. ( Arasteh, K; Borner, K; Bushrab, FN; Dunay, IR; Fitzner, R; Heimesaat, MM; Kurowski, M; Liesenfeld, O; Müller, RH; Stocker, H, 2004)
"Six patients had cerebral toxoplasmosis diagnosed on the basis of neurological signs and observation of the patients' mental confusion, seizures, and typical lesions (which were assessed by computed tomography, magnetic resonance imaging, or both)."	1.31	Toxoplasmosis, a severe complication in allogeneic hematopoietic stem cell transplantation: successful treatment strategies during a 5-year single-center experience. ( Basara, N; Bischoff, M; Blau, IW; Fauser, AA; Günzelmann, S; Kiehl, MG; Kirsten, D; Roemer, E; Sanchez, H; Wocker, EL, 2001)
"We describe the course of 36 AIDS patients with cerebral toxoplasmosis and present a review of clinical signs, diagnosis, therapy, and survival times."	1.31	[HIV-associated cerebral toxoplasmosis -- review and retrospective analysis of 36 patients]. ( Evers, S; Fischer, A; Freund, M; Grüneberg, U; Happe, S; Heese, Ch; Husstedt, IW; Kloska, S; Reichelt, D, 2002)
"We report one case of successful treatment of cerebral toxoplasmosis in acquired immunodeficiency syndrome (AIDS) with azithromycin combined with pyrimethamine."	1.30	[Azithromycin combined with pyrimethamine in the treatment of neurotoxoplasmosis, in an AIDS patient]. ( Dionisio, D; Leoncini, F; Milo, D; Sterrantino, G; Trotta, M, 1997)
"Neurotoxoplasmosis was the most frequent presenting symptom of AIDS (53."	1.30	[Cerebral toxoplasmosis and AIDS in Martinique]. ( Bourée, P; Dumazedier, D; Magdeleine, C; Sobesky, G, 1997)
"Cerebral toxoplasmosis is a rare late complication in allogeneic bone marrow transplanted patients."	1.30	Post-transplant cerebral toxoplasmosis diagnosed by magnetic resonance imaging. ( De Rosa, G; Di Salle, F; Pezzullo, L; Picardi, M; Raiola, A; Rotoli, B, 1998)
"Majority of patients with cerebral toxoplasmosis present with focal neurological abnormality in presence of characteristic neuroradiological abnormality and positive antitoxoplasma antibody titer."	1.30	Toxoplasmic encephalitis in acquired immunodeficiency syndrome. ( Chaddha, DS; Gupta, RM; Kalra, SP; Sanchetee, PC; Singh, AP, 1999)
" If interim results provide convincing evidence of either excessive adverse effects or significant treatment benefit, the DSMB may recommend early termination of the trial to the NIAID and the study investigators."	1.29	The data and safety monitoring board and acquired immune deficiency syndrome (AIDS) clinical trials. ( Childress, JF; DeMets, DL; Ellenberg, SS; Fleming, TR; Foulkes, M; Mayer, KH; O'Fallon, J; Pollard, RB; Rahal, JJ; Whitley, RJ, 1995)
"Three of 50 (6%) had hemichoreoathetosis."	1.29	Choreoathetosis in acquired immune deficiency syndrome patients with cerebral toxoplasmosis. ( Andreula, C; Angarano, G; Armenise, S; De Blasi, R; de Mari, M; Maggi, P; Romanelli, C; Zimatore, G, 1996)
"ET was the AIDS-defining condition in 44% of the patients."	1.29	[Cerebral toxoplasmosis in patients with human immunodeficiency virus (HIV) infection. Clinico-radiological and therapeutic aspects in 63 patients]. ( Barrio, JL; Cadafalch, J; Domingo, P; Ferrer, S; Fuentes, I; Fuster, M; Iranzo, A; Muñoz, C; Nolla, J; Ris, J; Sambeat, MA, 1996)
"In particular, in patients with AIDS who are more susceptible for adverse drug reactions and who are simultaneously receiving a variety of drugs with a considerable potential of cutaneous side effects, therapy cannot be withhold for lack of therapeutic alternatives."	1.29	[Drug-induced Stevens-Johnson syndrome in a patient with AIDS]. ( Bircher, A; Haefeli, WE; Leib, SL; Lüscher, TF; Schlienger, RG, 1993)
"The survival from AIDS or CD4 count = 50 cells/mm3 did not differ significantly between those with treated CTOX and a control group who had no toxoplasma infection, suggesting that treatment is reasonably effective."	1.29	Clinical features, outcome and survival from cerebral toxoplasmosis in Edinburgh AIDS patients. ( Brettle, RP; Burns, SM; Flegg, PJ; Laing, RB; Leen, CL, 1996)
"Treatment with pyrimethamine plus sulfadiazine produced clinical cures in 100% of the infected mice 1 month after infection."	1.29	A clinical-parasitological monotherapy cure in the treatment of experimental infection by a highly virulent strain of Toxoplasma gondii. ( Arribas, JR; de Diego, JA; Penin, P; Vázquez, E; Vázquez, JJ, 1996)
"A pregnant woman was diagnosed with central nervous system toxoplasmosis and human immunodeficiency virus infection."	1.29	Normal fetal outcome in a pregnancy with central nervous system toxoplasmosis and human immunodeficiency virus infection. A case report. ( Brown, GM; Hedriana, HL; Mitchell, JL; Williams, SB, 1993)
"Cerebral toxoplasmosis is the most common opportunistic infection of the central nervous system in AIDS patients."	1.29	[Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. ( Cardenal, C; Gatell, JM; Guelar, A; Mallolas, J; Miró, JM; Soriano, E; Zamora, L, 1994)
"Ten (91%) of these 11 patients with recurrence showed focal persistent enhancement after the initial treatment of toxoplasmosis abscess."	1.29	Persistent enhancement after treatment for cerebral toxoplasmosis in patients with AIDS: predictive value for subsequent recurrence. ( Benmelha, Z; Bouvet, E; Casalino, E; Laissy, JP; Lariven, S; Parlier, C; Servois, V; Sibert, A; Soyer, P; Vachon, F, 1994)
"Pyrimethamine was administered in mouse chow at concentrations of 0, 0."	1.28	Pyrimethamine concentrations in serum during treatment of acute murine experimental toxoplasmosis. ( Luft, BJ; Tanowitz, HB; Weiss, LM; Wittner, M, 1992)
"Ninety-nine patients with cerebral toxoplasmosis but no previous or simultaneous P."	1.28	Treatment for cerebral toxoplasmosis protects against Pneumocystis carinii pneumonia in patients with AIDS. The Swiss HIV Cohort Study. ( Chave, JP; Flepp, M; Gabriel, V; Heald, A; Hirschel, B; Malinverni, R; Renold, C; Rüttimann, S; Sugar, A, 1991)

95 other studies available for pyrimethamine and Central Nervous System Toxoplasmosis

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	93 (68.38)	18.2507
2000's	22 (16.18)	29.6817
2010's	17 (12.50)	24.3611
2020's	4 (2.94)	2.80

Trial	Phase	Enrollment	Study Type	Status
A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection[NCT00000666]		600 participants	Interventional	Completed
A Dose-Escalation, Phase I/II Study of Oral Azithromycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS[NCT00000966]	Phase 1	45 participants	Interventional	Completed
Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients[NCT00000643]	Phase 2	150 participants	Interventional	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Revisiting the Evidence Base for Modern-Day Practice of the Treatment of Toxoplasmic Encephalitis: A Systematic Review and Meta-Analysis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023, 02-08, Volume: 76, Issue:3 Topics: Encephalitis; HIV Infections; Humans; Pyrimethamine; Toxoplasmosis, Cerebral; Trimethoprim, Sulfamet	2023
Adverse Event Profile of Pyrimethamine-Based Therapy in Toxoplasmosis: A Systematic Review. Drugs in R&D, 2017, Volume: 17, Issue:4 Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Infectious Encephalitis; Pyrimethamine; Tox	2017
Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two case reports and review of the literature. Transplant infectious disease : an official journal of the Transplantation Society, 2015, Volume: 17, Issue:4 Topics: Adult; Antiprotozoal Agents; Drug Therapy, Combination; Early Diagnosis; Hematopoietic Stem Cell Tra	2015
A systematic review and meta-analysis of the relative efficacy and safety of treatment regimens for HIV-associated cerebral toxoplasmosis: is trimethoprim-sulfamethoxazole a real option? HIV medicine, 2017, Volume: 18, Issue:2 Topics: Adult; Antiprotozoal Agents; Clindamycin; Cohort Studies; Female; HIV Infections; Humans; Male; Midd	2017
Toxoplasmic encephalitis relapse rates with pyrimethamine-based therapy: systematic review and meta-analysis. Pathogens and global health, 2017, Volume: 111, Issue:1 Topics: AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiprotozoal Agents; Antiretroviral Therapy	2017
Management of toxoplasmic encephalitis in HIV-infected adults (with an emphasis on resource-poor settings). The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiretroviral Therapy, Highly	2006
[Acute kidney failure caused by sulfadiazine stones. A complication of the therapy of toxoplasmosis in AIDS]. Deutsche medizinische Wochenschrift (1946), 1993, Nov-19, Volume: 118, Issue:46 Topics: Acute Kidney Injury; AIDS-Related Opportunistic Infections; Clindamycin; Drug Therapy, Combination;	1993
Issues in toxoplasmosis. Infectious disease clinics of North America, 1993, Volume: 7, Issue:3 Topics: AIDS-Related Opportunistic Infections; Animals; Clindamycin; Drug Therapy, Combination; Encephalitis	1993
Movement disorders with cerebral toxoplasmosis and AIDS. Movement disorders : official journal of the Movement Disorder Society, 1993, Volume: 8, Issue:1 Topics: Adult; AIDS-Related Opportunistic Infections; Basal Ganglia Diseases; Cerebral Cortex; Chorea; Drug	1993
[New pathogens and mode of action of azithromycin: Toxoplasma gondii]. Pathologie-biologie, 1995, Volume: 43, Issue:6 Topics: Animals; Anti-Bacterial Agents; Azithromycin; Drug Synergism; Drug Therapy, Combination; Humans; In	1995
Preventing toxoplasmic encephalitis in persons infected with human immunodeficiency virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21 Suppl 1 Topics: AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Cats; Dapsone; Drug Therapy,	1995
[Cerebral toxoplasmosis]. Enfermedades infecciosas y microbiologia clinica, 1998, Volume: 16 Suppl 1 Topics: AIDS-Related Opportunistic Infections; Animals; Anti-HIV Agents; Antiprotozoal Agents; Biopsy; Diagn	1998
Parkinsonian symptoms as an initial manifestation in a Japanese patient with acquired immunodeficiency syndrome and Toxoplasma infection. Internal medicine (Tokyo, Japan), 2000, Volume: 39, Issue:12 Topics: AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Antiretroviral Therapy, Highly Active;	2000
Clindamycin in the treatment of toxoplasmosis in AIDS. The Annals of pharmacotherapy, 1992, Volume: 26, Issue:5 Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Humans; Pyrimethamine; Retrospective Studies; Sulfa	1992
[Usefulness of folinic acid in cytopenia induced by antiparasitic drugs in AIDS patients]. Presse medicale (Paris, France : 1983), 1991, Oct-26, Volume: 20, Issue:34 Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Folic Acid; Hematologic Diseases; Hum	1991

Article	Year
A study for precision diagnosing and treatment strategies in difficult-to-treat AIDS cases and HIV-infected patients with highly fatal or highly disabling opportunistic infections. Medicine, 2020, Volume: 99, Issue:20 Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; AIDS-Related Opportunistic Infections; Anti-I	2020
Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Spanish Toxoplasmosis Study Group. Annals of internal medicine, 1995, Aug-01, Volume: 123, Issue:3 Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Drug Administration Schedule; Drug Therapy, Comb	1995
Dapsone/pyrimethamine may prevent mycobacterial disease in immunosuppressed patients infected with the human immunodeficiency virus. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:2 Topics: Adult; CD4 Lymphocyte Count; Dapsone; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Huma	1995
Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:3 Topics: Administration, Inhalation; Adult; AIDS-Related Opportunistic Infections; Animals; Dapsone; Drug Adm	1995
[Risk factors of cerebral toxoplasmosis in patients with HIV infection: data of a primary prevention trial]. La Revue de medecine interne, 1993, Volume: 14, Issue:10 Topics: Double-Blind Method; HIV Infections; HIV-1; Humans; Pyrimethamine; Risk Factors; Toxoplasmosis, Cere	1993
[Primary prevention of cerebral toxoplasmosis in patients with HIV infection: results of a double-blind randomized trial, pyrimethamine versus placebo]. La Revue de medecine interne, 1993, Volume: 14, Issue:10 Topics: Double-Blind Method; HIV Infections; HIV-1; Humans; Placebos; Pyrimethamine; Toxoplasmosis, Cerebral	1993
Pyrimethamine as primary prophylaxis of toxoplasmic encephalitis in patients infected with human immunodeficiency virus: open study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1994, Volume: 18, Issue:3 Topics: AIDS-Related Opportunistic Infections; Animals; Antibodies, Protozoan; Cohort Studies; Drug Toleranc	1994
[Primary prophylaxis against cerebral toxoplasmosis. Efficacy of folinic acid in the prevention of hematologic toxicity of pyrimethamine]. Presse medicale (Paris, France : 1983), 1994, Apr-02, Volume: 23, Issue:13 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Blood Cell Count;	1994
Four different regimens for prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients. AIDS (London, England), 1994, Volume: 8, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Dapsone; Drug Therapy, Combination; Female; Follow-Up	1994
Early and longitudinal evaluations of treated infants and children and untreated historical patients with congenital toxoplasmosis: the Chicago Collaborative Treatment Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1994, Volume: 18, Issue:1 Topics: Animals; Calcinosis; Chemistry, Pharmaceutical; Child; Child, Preschool; Drug Administration Schedul	1994
Primary prophylaxis with pyrimethamine for toxoplasmic encephalitis in patients with advanced human immunodeficiency virus disease: results of a randomized trial. Terry Beirn Community Programs for Clinical Research on AIDS. The Journal of infectious diseases, 1994, Volume: 169, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Double-Blind Method; Female; HIV Infections; Humans; M	1994
Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:11 Topics: Acute Disease; Adult; AIDS-Related Opportunistic Infections; Azithromycin; Drug Administration Sched	1993
Primary prophylaxis for Pneumocystis carinii pneumonia: a randomized trial comparing cotrimoxazole, aerosolized pentamidine and dapsone plus pyrimethamine. AIDS (London, England), 1993, Volume: 7, Issue:1 Topics: Adult; Aerosols; AIDS-Related Opportunistic Infections; Antifungal Agents; Dapsone; Drug Therapy, Co	1993
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study Group. The New England journal of medicine, 1993, May-27, Volume: 328, Issue:21 Topics: Adult; AIDS-Related Complex; AIDS-Related Opportunistic Infections; Dapsone; Drug Combinations; Ence	1993
Marked variation in pyrimethamine disposition in AIDS patients treated for cerebral toxoplasmosis. The Journal of antimicrobial chemotherapy, 1995, Volume: 36, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Infective Agents; Female; Humans; Male; Middle Aged;	1995
Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Gr The Journal of infectious diseases, 1996, Volume: 173, Issue:1 Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Antibodies, Protozoan;	1996
Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. AIDS (London, England), 1995, Volume: 9, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infe	1995
Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS. Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:7 Topics: AIDS-Related Opportunistic Infections; Dose-Response Relationship, Drug; Encephalitis; Humans; Pyrim	1996
Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 22, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Clindamycin; Drug Therapy, Comb	1996
Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. AIDS (London, England), 1996, Volume: 10, Issue:10 Topics: Acquired Immunodeficiency Syndrome; Adult; Antiprotozoal Agents; Atovaquone; Clindamycin; Encephalit	1996
Increased risk of toxoplasmic encephalitis in human immunodeficiency virus-infected patients with pyrimethamine-related rash. ANRS 005-ACTG 154 Trial Group. Agence Nationale de Recherche sur le SIDA (ANRS-INSERM) and the NIAID-AIDS Clinical Trials Group. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1997, Volume: 24, Issue:3 Topics: AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Disease Progression; Double-Blind Metho	1997
Intention-to-treat vs. on-treatment analyses of clinical trial data: experience from a study of pyrimethamine in the primary prophylaxis of toxoplasmosis in HIV-infected patients. ANRS 005/ACTG 154 Trial Group. Controlled clinical trials, 1998, Volume: 19, Issue:3 Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Bias; CD4 Lymphocyte Count; Data Inter	1998
Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2000, Volume: 19, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Drug Therapy, Combination; Encep	2000
Incidence and determinants of bacterial infections in HIV-positive patients receiving anti-Pneumocystis carinii/Toxoplasma gondii primary prophylaxis within a randomized clinical trial. Journal of acquired immune deficiency syndromes (1999), 2001, May-01, Volume: 27, Issue:1 Topics: Adult; Animals; Anti-Infective Agents; Bacterial Infections; Dapsone; Encephalitis; Female; HIV Infe	2001
Effectiveness of twice-weekly pyrimethamine-sulfadoxine as primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in patients with advanced HIV infection. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2002, Volume: 21, Issue:5 Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Antiretroviral T	2002
Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group. Annals of internal medicine, 1992, Jan-01, Volume: 116, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Adult; Clindamycin; Drug Evaluation; Drug Therapy, Combination;	1992

Article	Year
Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii. Journal of medicinal chemistry, 2017, 12-28, Volume: 60, Issue:24 Topics: Animals; Antiprotozoal Agents; Female; Humans; Male; Mice; Protein Kinase Inhibitors; Protein Kinase	2017
Brief Report: Financial Burden of Toxoplasmosis Encephalitis Treatment at a Safety Net Hospital. Journal of acquired immune deficiency syndromes (1999), 2022, 11-01, Volume: 91, Issue:3 Topics: Encephalitis; Financial Stress; HIV Infections; Humans; Pharmaceutical Preparations; Pyrimethamine;	2022
Determination of parasitic burden in the brain tissue of infected mice in acute toxoplasmosis after treatment by fluconazole combined with sulfadiazine and pyrimethamine. European journal of medical research, 2021, Jun-30, Volume: 26, Issue:1 Topics: 14-alpha Demethylase Inhibitors; Acute Disease; Animals; Antiprotozoal Agents; Brain; Disease Models	2021
Patient and treatment pathways for toxoplasmosis in the United States: data analysis of the Vizient Health Systems Data from 2011 to 2017. Pathogens and global health, 2018, Volume: 112, Issue:8 Topics: Adolescent; Adult; Aged; Aged, 80 and over; AIDS-Related Opportunistic Infections; Antiprotozoal Age	2018
Toxoplasmosis initially presenting as neurological sequelae of chimeric antigen receptor T-cell therapy. The Lancet. Infectious diseases, 2019, Volume: 19, Issue:7 Topics: Cognitive Dysfunction; Humans; Immunotherapy, Adoptive; Leukemia, Lymphocytic, Chronic, B-Cell; Male	2019
Skin nodules in a patient with acute lymphoblastic leukaemia. BMJ case reports, 2014, Jan-09, Volume: 2014 Topics: Adolescent; Amphotericin B; Cord Blood Stem Cell Transplantation; Dermatomycoses; Diagnosis, Differe	2014
Toxoplasmic encephalitis associated with meningitis in a heart transplant recipient. Transplant infectious disease : an official journal of the Transplantation Society, 2014, Volume: 16, Issue:4 Topics: Antiprotozoal Agents; Clindamycin; Drug Therapy, Combination; Encephalitis; Heart Transplantation; H	2014
[Cerebral toxoplasmosis in a patient with Waldenström's macroglobulinemia]. Enfermedades infecciosas y microbiologia clinica, 2014, Volume: 32, Issue:8 Topics: Aged; Antiprotozoal Agents; Biopsy; Cross Infection; Drug Therapy, Combination; Fatal Outcome; Human	2014
Alternative treatment approach to cerebral toxoplasmosis in HIV/AIDS: experience from a resource-poor setting. International journal of STD & AIDS, 2015, Volume: 26, Issue:12 Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Clindamycin; Female; Huma	2015
Multiple intracerebral lesions in a young male. African health sciences, 2015, Volume: 15, Issue:3 Topics: AIDS-Related Opportunistic Infections; Antibodies, Protozoan; Brain; Drug Combinations; Humans; Immu	2015
Biopsy-proven immune reconstitution syndrome in a patient with AIDS and cerebral toxoplasmosis. Neurology, 2009, Jul-28, Volume: 73, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antiretroviral Therapy, Highly Active; Biopsy; C	2009
Failure of conventional treatment with pyrimethamine and sulfadiazine for secondary prophylaxis of cerebral toxoplasmosis in a patient with AIDS. The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:7 Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Antiprotozoal Agents; CD4 Lymphocyte Cou	2011
Toxoplasmic encephalitis in AIDS-patients before and after the introduction of highly active antiretroviral therapy (HAART). European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2011, Volume: 30, Issue:12 Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiprotozoal Agents; Antiretro	2011
[Disseminated cerebral haemorrhages in a patient with HIV infection]. Enfermedades infecciosas y microbiologia clinica, 2011, Volume: 29, Issue:9 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Antiprotozoal Agents; Antiretroviral	2011
Sulphadiazine-induced obstructive renal failure complicating treatment of HIV-associated toxoplasmosis. International journal of STD & AIDS, 2012, Volume: 23, Issue:3 Topics: Antiprotozoal Agents; Fluid Therapy; HIV Infections; Humans; Middle Aged; Nephrostomy, Percutaneous;	2012
A healthy, 81-year-old woman with toxoplasmic encephalitis. Geriatrics & gerontology international, 2012, Volume: 12, Issue:4 Topics: Aged, 80 and over; Antiprotozoal Agents; Diagnosis, Differential; Female; Humans; Pyrimethamine; Sul	2012
A possible novel mechanism of opportunistic infection in systemic lupus erythematosus, based on a case of toxoplasmic encephalopathy. Rheumatology (Oxford, England), 2002, Volume: 41, Issue:9 Topics: Adult; Animals; Anti-Infective Agents; Antibodies, Protozoan; Cerebral Cortex; Drug Combinations; Fe	2002
[HIV-associated cerebral toxoplasmosis -- review and retrospective analysis of 36 patients]. Der Nervenarzt, 2002, Volume: 73, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Opportunistic Infections; Antiretrovir	2002
A solitary brain lesion in a patient with AIDS. The AIDS reader, 2003, Volume: 13, Issue:1 Topics: Adult; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Drug Therapy, Combination; Femal	2003
Cerebral toxoplasmosis in an AIDS patient. Internal medicine (Tokyo, Japan), 2003, Volume: 42, Issue:1 Topics: Adult; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Drug Combinations; Humans; Magne	2003
Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:12 Topics: Animals; Antiprotozoal Agents; Atovaquone; Brain; Brain Chemistry; Chromatography, High Pressure Liq	2004
Cerebral toxoplasmosis in a patient with common variable immunodeficiency. Neurology, 2004, Dec-14, Volume: 63, Issue:11 Topics: Anemia, Hemolytic, Autoimmune; Antibodies, Protozoan; Antiprotozoal Agents; Biopsy; Brain; Central N	2004
[Postnatal follow-up of infants born to mothers with certain Toxoplasma gondii infection: evaluation of prenatal management]. Le infezioni in medicina, 2005, Volume: 13, Issue:2 Topics: Adolescent; Adult; Amniocentesis; Animals; Antibodies, Protozoan; Antiprotozoal Agents; Chorioretini	2005
Changing the outcome of toxoplasmosis in bone marrow transplant recipients. International journal of antimicrobial agents, 2006, Volume: 27, Issue:6 Topics: Adult; Bone Marrow Transplantation; Clindamycin; Female; Humans; Magnetic Resonance Imaging; Male; M	2006
Nocardia abscess during treatment of brain toxoplasmosis in a patient with aids, utility of proton MR spectroscopy and diffusion-weighted imaging in diagnosis. Clinical neurology and neurosurgery, 2006, Volume: 108, Issue:5 Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Anti-Retroviral Agents; Anticonvul	2006
[Opportunistic infections in HIV-infected subjects: no wonders]. Terapevticheskii arkhiv, 2006, Volume: 78, Issue:11 Topics: Adult; AIDS-Related Opportunistic Infections; Antimalarials; Drug Combinations; Early Diagnosis; Fat	2006
Central nervous system toxoplasmosis in adult Ethiopians. Ethiopian medical journal, 2006, Volume: 44, Issue:2 Topics: Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Drug Combinati	2006
Treating AIDS-associated cerebral toxoplasmosis - pyrimethamine plus sulfadiazine compared with cotrimoxazole, and outcome with adjunctive glucocorticoids. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2007, Volume: 97, Issue:10 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiprotozoal Agents; Drug Ther	2007
[The impact of the prevention of cerebral toxoplasmosis]. Journal of neuroradiology = Journal de neuroradiologie, 1995, Volume: 22, Issue:3 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiprotozoal Agents; Brain Abs	1995
Drug treatment of toxoplasmic encephalitis in acquired immunodeficiency syndrome. Postgraduate medical journal, 1995, Volume: 71, Issue:837 Topics: AIDS-Related Opportunistic Infections; Atovaquone; Clindamycin; Coccidiostats; Humans; Naphthoquinon	1995
Toxoplasmosis in AIDS: keeping the lid on. Annals of internal medicine, 1995, Aug-01, Volume: 123, Issue:3 Topics: AIDS-Related Opportunistic Infections; Drug Therapy, Combination; Encephalitis; Humans; Pyrimethamin	1995
Pyrimethamine analysis by enzyme inhibition and HPLC assays. American journal of clinical pathology, 1995, Volume: 104, Issue:1 Topics: Calibration; Chromatography, High Pressure Liquid; Clinical Enzyme Tests; Drug Monitoring; Enzyme In	1995
[Pyrimethamine-sulfadiazine resistant cerebral toxoplasmosis in AIDS]. Deutsche medizinische Wochenschrift (1946), 1995, May-26, Volume: 120, Issue:21 Topics: Acquired Immunodeficiency Syndrome; Animals; Drug Resistance; Drug Therapy, Combination; Humans; Pyr	1995
Cerebral toxoplasmosis in childhood and adult HIV infection treated with 1-4 hydroxynaphthoquinone and rapid desensitization with pyrimethamine. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1995, Volume: 74, Issue:6 Topics: Adult; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Atovaquone; Child; Desensitizati	1995
[Pyrimethamine-sulfadiazine resistant cerebral toxoplasmosis in AIDS]. Deutsche medizinische Wochenschrift (1946), 1995, Jan-20, Volume: 120, Issue:3 Topics: AIDS-Related Opportunistic Infections; Clindamycin; Dexamethasone; Drug Resistance, Microbial; Drug	1995
Sulfadiazine/N4-acetylsulfadiazine crystalluria in a patient with the acquired immune deficiency syndrome (AIDS) Clinica chimica acta; international journal of clinical chemistry, 1994, Oct-31, Volume: 230, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Hemophilia A; Huma	1994
Persistent enhancement after treatment for cerebral toxoplasmosis in patients with AIDS: predictive value for subsequent recurrence. AJNR. American journal of neuroradiology, 1994, Volume: 15, Issue:9 Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Atrophy; Brain; Brain Abscess; Drug Therapy, Com	1994
Cataplexy associated with midbrain lesion. Neurology, 1995, Volume: 45, Issue:2 Topics: Adult; AIDS-Related Opportunistic Infections; Cataplexy; HIV Seropositivity; Humans; Magnetic Resona	1995
Renal alterations induced by sulfadiazine therapy in an AIDS patients. Clinical nephrology, 1994, Volume: 42, Issue:1 Topics: Adult; AIDS-Related Opportunistic Infections; Drug Therapy, Combination; Female; Humans; Kidney Calc	1994
Toxoplasma gondii infection in advanced HIV infection. AIDS (London, England), 1994, Volume: 8, Issue:4 Topics: Adult; AIDS-Related Opportunistic Infections; Dapsone; Encephalitis; Female; Humans; Male; Middle Ag	1994
[Therapeutic alternatives for cases of cerebral toxoplasmosis in patients with AIDS: clarithromycin and atovaquone]. Enfermedades infecciosas y microbiologia clinica, 1994, Volume: 12, Issue:3 Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Atovaquone; Clarithromycin; Clindamycin; Drug	1994
Levels of dapsone and pyrimethamine in serum during once-weekly dosing for prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:5 Topics: Adult; Aged; Dapsone; Drug Interactions; Female; HIV Infections; Humans; Male; Middle Aged; Phenotyp	1994
[Recurrence of cerebral toxoplasmosis in 15 AIDS patients]. Annales de medecine interne, 1994, Volume: 145, Issue:3 Topics: Adult; AIDS-Related Opportunistic Infections; Brain; Clindamycin; Drug Therapy, Combination; Female;	1994
Rifabutin is active in murine models of toxoplasmosis. Antimicrobial agents and chemotherapy, 1994, Volume: 38, Issue:3 Topics: Animals; Antiprotozoal Agents; Atovaquone; Brain; Clindamycin; Drug Therapy, Combination; Female; Mi	1994
Normal fetal outcome in a pregnancy with central nervous system toxoplasmosis and human immunodeficiency virus infection. A case report. The Journal of reproductive medicine, 1993, Volume: 38, Issue:9 Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Antibodies, Protozoan; Drug Hypersensitivity;	1993
Pyrimethamine alone as long-term suppressive therapy in cerebral toxoplasmosis. The American journal of medicine, 1994, Volume: 96, Issue:1 Topics: Adult; AIDS-Related Opportunistic Infections; Humans; Male; Pyrimethamine; Time Factors; Toxoplasmos	1994
Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:5 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Drug Administration Schedule; D	1993
[Drug-induced Stevens-Johnson syndrome in a patient with AIDS]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1993, Aug-17, Volume: 82, Issue:33 Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Phenytoin; Pyrimethamine; Stevens-Joh	1993
[Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania]. Presse medicale (Paris, France : 1983), 1993, May-29, Volume: 22, Issue:19 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clarithromycin; Cl	1993
[Acquired cerebral toxoplasmosis in an non-immunosuppressed child]. Archives francaises de pediatrie, 1993, Volume: 50, Issue:4 Topics: Child, Preschool; Drug Therapy, Combination; Female; Humans; Immunocompetence; Magnetic Resonance Im	1993
Doxycycline and pyrimethamine for toxoplasmic encephalitis. Scandinavian journal of infectious diseases, 1993, Volume: 25, Issue:1 Topics: Adult; AIDS-Related Opportunistic Infections; Doxycycline; Drug Therapy, Combination; Humans; Male;	1993
[Favorable course of cerebral toxoplasmosis treated with doxycycline and pyrimethamine]. Revista clinica espanola, 1993, Volume: 192, Issue:4 Topics: Adult; Doxycycline; Humans; Male; Pyrimethamine; Remission Induction; Toxoplasmosis, Cerebral	1993
Two central nervous system infectious diseases in a patient with AIDS. The Journal of family practice, 1993, Volume: 36, Issue:6 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Hu	1993
Symptomatic sulfadiazine crystalluria in AIDS patients: a report of two cases. Clinical nephrology, 1993, Volume: 39, Issue:5 Topics: Acute Kidney Injury; Adult; AIDS-Related Opportunistic Infections; Drug Therapy, Combination; Humans	1993
[Clarithromycin in the treatment of cerebral toxoplasmosis associated with HIV infection]. Revista clinica espanola, 1993, Volume: 192, Issue:9 Topics: Adult; Clarithromycin; Drug Therapy, Combination; Female; HIV Infections; Humans; Pyrimethamine; Tox	1993
Adverse cutaneous reactions to pyrimethamine/sulfadiazine and pyrimethamine/clindamycin in patients with AIDS and toxoplasmic encephalitis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:3 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Clindamy	1995
Relapse of Toxoplasma encephalitis and susceptibility to pyrimethamine: lack of evidence of treatment-induced resistance. Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:10 Topics: Adult; Anti-Infective Agents; Drug Resistance; Encephalitis; Humans; Pyrimethamine; Recurrence; Toxo	1995
Folinic acid supplements to pyrimethamine-sulfadiazine for Toxoplasma encephalitis are associated with better outcome. The Journal of infectious diseases, 1996, Volume: 173, Issue:5 Topics: Antiprotozoal Agents; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Encephalitis;	1996
Prophylaxis of pneumocystis pneumonia and toxoplasmosis. Annals of internal medicine, 1996, Jun-15, Volume: 124, Issue:12 Topics: Anti-Infective Agents; Dapsone; Drug Therapy, Combination; Humans; Pneumonia, Pneumocystis; Pyrimeth	1996
Resolution of intracranial calcifications in infants with treated congenital toxoplasmosis. Radiology, 1996, Volume: 199, Issue:2 Topics: Anti-Infective Agents; Brain; Calcinosis; Follow-Up Studies; Humans; Infant; Infant, Newborn; Leucov	1996
[Cerebral toxoplasmosis in patients with human immunodeficiency virus (HIV) infection. Clinico-radiological and therapeutic aspects in 63 patients]. Anales de medicina interna (Madrid, Spain : 1984), 1996, Volume: 13, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Clind	1996
The data and safety monitoring board and acquired immune deficiency syndrome (AIDS) clinical trials. Controlled clinical trials, 1995, Volume: 16, Issue:6 Topics: Advisory Committees; Anti-Infective Agents; Clinical Trials as Topic; Clinical Trials Data Monitorin	1995
Precipitous visual loss secondary to optic nerve toxoplasmosis as an unusual presentation of AIDS. Australian and New Zealand journal of ophthalmology, 1996, Volume: 24, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Therap	1996
Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:5 Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Atovaquone; Brain; Clin	1996
Choreoathetosis in acquired immune deficiency syndrome patients with cerebral toxoplasmosis. Movement disorders : official journal of the Movement Disorder Society, 1996, Volume: 11, Issue:4 Topics: Adult; AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Athetosi	1996
Clinical features, outcome and survival from cerebral toxoplasmosis in Edinburgh AIDS patients. International journal of STD & AIDS, 1996, Volume: 7, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal	1996
Predictive value of Toxoplasma gondii antibody titres on the occurrence of toxoplasmic encephalitis in HIV-infected patients. ANRS 005/ACTG 154 Trial Group. AIDS (London, England), 1996, Volume: 10, Issue:13 Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Animals; Antibodies, Protozoan; Antiprotoz	1996
A clinical-parasitological monotherapy cure in the treatment of experimental infection by a highly virulent strain of Toxoplasma gondii. Folia microbiologica, 1996, Volume: 41, Issue:6 Topics: Animals; Antiprotozoal Agents; Brain; Drug Evaluation, Preclinical; Drug Therapy, Combination; Mice;	1996
[Azithromycin combined with pyrimethamine in the treatment of neurotoxoplasmosis, in an AIDS patient]. Minerva medica, 1997, Volume: 88, Issue:3 Topics: AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Azithromycin; D	1997
Penetration of 3'-amino-3'-deoxythymidine, a cytotoxic metabolite of zidovudine, into the cerebrospinal fluid of HIV-1-infected patients. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1997, Jun-01, Volume: 15, Issue:2 Topics: Administration, Oral; Adult; Anti-HIV Agents; Anti-Infective Agents; Antidotes; Dideoxynucleosides;	1997
[HIV infection and Lyell syndrome: a wake-up call concerning anti-inflammatory agents]. Enfermedades infecciosas y microbiologia clinica, 1997, Volume: 15, Issue:4 Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory	1997
Toxoplasma encephalitis in a HIV patient: unusual involvement of the corpus callosum. Clinical neurology and neurosurgery, 1997, Volume: 99, Issue:4 Topics: Adult; Animals; Anti-Infective Agents; Brain Neoplasms; Corpus Callosum; Diagnosis, Differential; En	1997
[Cerebral toxoplasmosis and AIDS in Martinique]. Medecine tropicale : revue du Corps de sante colonial, 1997, Volume: 57, Issue:3 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Drug Therapy, Combination; Fema	1997
Neuropsychiatric lupus? Annals of the rheumatic diseases, 1998, Volume: 57, Issue:1 Topics: Anti-Infective Agents; Antibodies, Protozoan; Drug Therapy, Combination; Humans; Lupus Erythematosus	1998
Toxoplasma retinitis/encephalitis 9 months after allogeneic bone marrow transplantation. Bone marrow transplantation, 1998, Volume: 21, Issue:6 Topics: Adult; Anti-Infective Agents; Bone Marrow Transplantation; Clindamycin; Female; Graft vs Host Diseas	1998
Post-transplant cerebral toxoplasmosis diagnosed by magnetic resonance imaging. Haematologica, 1998, Volume: 83, Issue:6 Topics: Adult; Anti-Infective Agents; Bone Marrow Transplantation; Hodgkin Disease; Humans; Male; Pyrimetham	1998
Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis. Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Sep-01, Volume: 19, Issue:1 Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Dr	1998
Approaches for optimal sequential decision analysis in clinical trials. Biometrics, 1998, Volume: 54, Issue:3 Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Bayes Theorem; Biometry; Clinical Tria	1998
Long-term course and outcome in AIDS patients with cerebral toxoplasmosis. Acta neurologica Scandinavica, 1999, Volume: 100, Issue:3 Topics: Adult; AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Antiprot	1999
[Non-Hodgkin's lymphoma with Toxoplasma encephalitis]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 1999, Volume: 40, Issue:7 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiprotozoal Agents; Cyclophosphamide; Dox	1999
Toxoplasmic encephalitis in acquired immunodeficiency syndrome. The Journal of the Association of Physicians of India, 1999, Volume: 47, Issue:7 Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiprotozoal Agents; Drug Ther	1999
In vitro anti-Toxoplasma gondii antibody production by peripheral blood mononuclear cells in the diagnosis and the monitoring of toxoplasmic encephalitis in AIDS-related brain lesions. Journal of acquired immune deficiency syndromes (1999), 2000, Nov-01, Volume: 25, Issue:3 Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antibodies, Protozoan; Antiprotozoal Agents; Enc	2000
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Twice-weekly pyrimethamine-sulfadoxine effectively prevents Pneumocystis carinii pneumonia relapse and toxoplasmic encephalitis in patients with AIDS. The Journal of infection, 2001, Volume: 42, Issue:1 Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Cohort Studies; Drug Comb	2001
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pyrimethamine and Central Nervous System Toxoplasmosis

Research Excerpts

Research

Studies (136)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Rutaganira, FU	1
Barks, J	1
Dhason, MS	1
Wang, Q	1
Lopez, MS	1
Long, S	1
Radke, JB	1
Jones, NG	1
Maddirala, AR	1
Janetka, JW	1
El Bakkouri, M	1
Hui, R	1
Shokat, KM	1
Sibley, LD	1
Prosty, C	1
Hanula, R	1
Levin, Y	1
Bogoch, II	1
McDonald, EG	1
Lee, TC	1
Bogard, SN	1
Lee, JT	1
Patel, M	1
Kempker, RR	1
Li, Y	1
Zeng, YM	1
Lu, YQ	1
Qin, YY	1
Chen, YK	1
Sina, S	1
Mohammad, JM	1
Reza, S	1
Anita, M	1
Soudabeh, E	1
Hadi, M	1
Ben-Harari, RR	2
Goodwin, E	2
Casoy, J	1
Belk, K	1
Connolly, MP	2
Schlesinger, L	1
Marzolini, MAV	1
Jaunmuktane, Z	1
Roddie, C	1
O'Reilly, M	1
Chiodini, P	1
Peggs, KS	1
Le Clech, L	1
Hutin, P	1
Le Gal, S	1
Guillerm, G	1
Baliu, C	1
Sanclemente, G	1
Cardona, M	1
Castel, MA	1
Perez-Villa, F	1
Moreno, A	1
Cervera, C	1
Olmos Soto, S	1
Reus Bañuls, S	1
Mora Castera, E	1
Villarubia Lor, MB	1
Goswami, RP	2
Rahman, M	1
Ray, Y	1
Tripathi, SK	1
Miyagi, T	1
Itonaga, H	1
Aosai, F	1
Taguchi, J	1
Norose, K	1
Mochizuki, K	1
Fujii, H	1
Furumoto, A	1
Ohama, M	1
Karimata, K	1
Yamanoha, A	1
Taniguchi, H	1
Sato, S	1
Taira, N	1
Moriuchi, Y	1
Fukushima, T	1
Masuzaki, H	1
Miyazaki, Y	1
Deepak, M	1
Basavaprabhu, A	1
Soundarya, M	1
Hernandez, AV	1
Thota, P	1
Pellegrino, D	1
Pasupuleti, V	1
Benites-Zapata, VA	1
Deshpande, A	1
Penalva de Oliveira, AC	1
Vidal, JE	1
Schey, C	1
Zummo, J	1
Pfeffer, G	1
Prout, A	1
Hooge, J	1
Maguire, J	1
Faucher, B	1
Moreau, J	1
Zaegel, O	1
Franck, J	1
Piarroux, R	1
Kiderlen, TR	1
Liesenfeld, O	2
Schürmann, D	4
Schneider, T	1
Diz, S	1
Barbolla, I	1
Egea, M	1
de Luna, G	1
Allinson, J	1
Topping, W	1
Edwards, SG	1
Miller, RF	1
Kanno, A	1
Suzuki, Y	2
Minami, M	1
Ogawa, K	1
Oishi, M	1
Kamei, S	1
Seta, N	1
Shimizu, T	1
Nawata, M	1
Wada, R	1
Mori, K	1
Sekigawa, I	1
Iida, N	1
Maeda, M	1
Hashimoto, H	1
Happe, S	1
Fischer, A	1
Heese, Ch	1
Reichelt, D	1
Grüneberg, U	1
Freund, M	1
Kloska, S	1
Evers, S	1
Husstedt, IW	1
Ball, SC	1
Saito, T	1
Takeuchi, S	1
Taguchi, H	1
Miyoshi, I	1
Dunay, IR	1
Heimesaat, MM	1
Bushrab, FN	1
Müller, RH	1
Stocker, H	1
Arasteh, K	1
Kurowski, M	1
Fitzner, R	1
Borner, K	1
Holtkamp, M	1
Okuducu, AF	1
Klingebiel, R	1
Ploner, CJ	1
Di Carlo, P	1
Mazzola, A	1
Romano, A	1
Schimmenti, MG	1
Colicchia, P	1
Bellipanni, P	1
Titone, L	1
Aoun, M	1
Georgala, A	1
Mboumi, K	1
De Bruyne, JM	1
Duchateau, V	1
Lemort, M	1
Martiat, P	1
Soto-Hernández, JL	1
Moreno-Andrade, T	1
Góngora-Rivera, F	1
Ramírez-Crescencio, MA	1
Dedicoat, M	1
Livesley, N	1
Ermak, TN	1
Peregudova, AV	1
Gruzdev, BM	1
Amogne, W	1
Teshager, G	1
Zenebe, G	1
Arens, J	1
Barnes, K	1
Crowley, N	1
Maartens, G	1
Katlama, C	4
Winstanley, P	2
Podzamczer, D	2
Miró, JM	4
Bolao, F	1
Gatell, JM	5
Cosín, J	2
Sirera, G	2
Domingo, P	3
Laguna, F	2
Santamaría, J	1
Verdejo, J	1
Kovacs, JA	2
Roberts, WL	1
Reynolds, KM	1
Heimer, R	1
Jatlow, PI	1
Rainey, PM	1
Opravil, M	3
Pechère, M	2
Lazzarin, A	2
Heald, A	3
Rüttimann, S	3
Iten, A	2
Furrer, H	1
Oertle, D	2
Praz, G	2
Vuitton, DA	1
Hirschel, B	3
von Overbeck, J	1
Langmann, P	2
Klinker, H	2
Richter, E	2
Bouboulis, DA	1
Rubinstein, A	1
Shliozberg, J	1
Madden, J	1
Frieri, M	1
Huber, W	1
Bautz, W	1
Classen, M	1
Schepp, W	1
Potter, JL	1
Kofron, WG	1
Laissy, JP	1
Soyer, P	1
Parlier, C	1
Lariven, S	1
Benmelha, Z	1
Servois, V	1
Casalino, E	1
Bouvet, E	2
Sibert, A	1
Vachon, F	1
Fernandez, JM	1
Sadaba, F	1
Villaverde, FJ	1
Alvaro, LC	1
Cortina, C	1
Marques, LP	1
Madeira, EP	1
Santos, OR	1
Pueyo, S	4
Leport, C	13
Chene, G	7
Morlat, P	10
Hafner, R	7
Vilde, JL	12
Luft, B	5
Salamon, R	6
Aubertin, J	6
Rousseau, F	4
Oksenhendler, E	1
Charreau, I	2
Tournerie, C	1
Azihary, M	1
Carbon, C	1
Aboulker, JP	2
Guelar, A	1
Mallolas, J	3
Zamora, L	3
Cardenal, C	1
Soriano, E	2
Bachmeyer, C	1
Gorin, I	1
Deleuze, J	1
Morini, JP	1
Escande, JP	1
Brossard, G	1
Neau, D	1
Barbeau, P	1
Pellegrin, JL	2
Leng, B	1
Tocchetti, A	1
Tambini, R	1
Allegro, A	1
Longoni, E	1
Rinaldi, E	1
McAuley, J	1
Boyer, KM	2
Patel, D	1
Mets, M	1
Swisher, C	1
Roizen, N	1
Wolters, C	1
Stein, L	1
Stein, M	1
Schey, W	1
Joos, B	1
Lüthy, R	1
Walckenaer, G	1
Longuet, P	1
Perronne, C	1
Lacassin, F	1
Jacobson, MA	1
Besch, CL	1
Child, C	1
Matts, JP	1
Muth, K	1
Wentworth, DN	1
Neaton, JD	1
Abrams, D	1
Rimland, D	1
Saba, J	1
Raffi, F	1
Hazebroucq, V	1
Joly, V	1
Araujo, FG	2
Slifer, T	1
Remington, JS	4
Kronawitter, U	1
Jakob, K	1
Zoller, WG	1
Rauh, G	1
Goebel, FD	1
McCabe, R	1
Chirurgi, V	1
Hedriana, HL	1
Mitchell, JL	1
Brown, GM	1
Williams, SB	1
Murphy, K	1
Groarke, M	1
O'Shaughnessy, E	1
Buckley, A	1
Mitchell, T	1
Ruf, B	4
Bergmann, F	3
Schüler-Maué, W	1
Grünewald, T	4
Gottschalk, HJ	1
Witt, H	1
Pohle, HD	2
Schlienger, RG	1
Haefeli, WE	1
Bircher, A	1
Leib, SL	1
Lüscher, TF	1
Ragnaud, JM	1
Dupon, M	1
Lacoste, D	1
Desguerre, I	1
Pedespan, JM	1
Buissonnière, R	1
Couvreur, J	1
Ponsot, G	1
Nath, A	1
Hobson, DE	1
Russell, A	1
Vernet, E	1
Valls, ME	1
SanMiguel, JG	1
Hagberg, L	1
Palmertz, B	1
Lindberg, J	1
Girard, PM	1
Landman, R	1
Gaudebout, C	2
Olivares, R	1
Saimot, AG	1
Jelazko, P	1
Certain, A	1
Boué, F	1
Valencia, ME	1
Soriano, V	1
González Lahoz, J	1
Murray-Pulsifer, K	1
Hein, R	1
Brunkhorst, R	1
Thon, WF	1
Schedel, I	1
Schmidt, RE	1
Alba, D	1
Molina, F	1
Ripoll, MM	1
del Arco, A	1
Khoo, S	1
Szwandt, S	1
Edwards, G	1
Wilkins, E	1
Tija, J	1
Coker, R	1
McKane, W	1
Beeching, N	1
Watkin, S	1
Caumes, E	1
Bocquet, H	1
Guermonprez, G	1
Rogeaux, O	1
Bricaire, F	1
Gentilini, M	1
Luft, BJ	4
Miro, J	2
Derouin, F	3
Richards, FO	1
Antinori, A	2
Murri, R	2
Ammassari, A	2
De Luca, A	2
Linzalone, A	1
Cingolani, A	2
Damiano, F	1
Maiuro, G	1
Vecchiet, J	1
Scoppettuolo, G	1
Caramello, P	1
Brancale, T	1
Forno, B	1
Lucchini, A	1
Pollono, AM	1
Ullio, A	1
Gioannini, P	1
Viano, I	1
Tonso, E	1
Van Delden, C	1
Patel, DV	1
Holfels, EM	1
Vogel, NP	1
Mets, MB	1
Swisher, CN	1
Roizen, NJ	1
Stein, LK	1
Stein, MA	1
Hopkins, J	1
Withers, SE	1
Mack, DG	1
Luciano, RA	1
Meier, P	1
McLeod, RL	1
Ferrer, S	1
Fuentes, I	1
Muñoz, C	1
Iranzo, A	1
Barrio, JL	1
Fuster, M	1
Ris, J	1
Sambeat, MA	1
Cadafalch, J	1
Nolla, J	1
DeMets, DL	1
Fleming, TR	1
Whitley, RJ	1
Childress, JF	1
Ellenberg, SS	1
Foulkes, M	1
Mayer, KH	1
O'Fallon, J	1
Pollard, RB	1
Rahal, JJ	1
Wei, ME	1
Campbell, SH	1
Taylor, C	1
Maggi, P	1
de Mari, M	1
De Blasi, R	1
Armenise, S	1
Romanelli, C	1
Andreula, C	1
Zimatore, G	1
Angarano, G	1
De Wit, S	1
O'Doherty, E	1
Van Glabeke, M	1
Clumeck, N	2
Mouthon, B	1
Gourdon, D	1
Lapierre, D	1
Laing, RB	1
Flegg, PJ	1
Brettle, RP	1
Leen, CL	1
Burns, SM	1
Letrillart, B	1
Ecobichon, JL	1
de Diego, JA	1
Penin, P	1
Arribas, JR	1
Vázquez, E	1
Vázquez, JJ	1
Trotta, M	1
Sterrantino, G	1
Milo, D	1
Dionisio, D	1
Leoncini, F	1
Hoetelmans, RM	1
Kraaijeveld, CL	1
Meenhorst, PL	1
Mulder, JW	1
Burger, DM	1
Koks, CH	1
Beijnen, JH	1
de Luis, DA	1
Fortun, J	1
Pintado, V	1
Aller de la Fuente, R	1
Supiot, F	1
Guillaume, MP	1
Hermanus, N	1
Telerman-Toppet, N	1
Karmali, R	1
Bourée, P	1
Dumazedier, D	1
Magdeleine, C	1
Sobesky, G	1
Sillevis Smitt, P	1
Swaak, T	1
Brinkman, K	1
Debast, S	1
Sauerwein, R	1
Ooyman, F	1
Hiel, J	1
Raemaekers, J	1
Dequae, L	1
Picardi, M	1
De Rosa, G	1
Di Salle, F	1
Pezzullo, L	1
Raiola, A	1
Rotoli, B	1
Gérard, L	1
Farinotti, R	1
Maslo, C	1
Carlin, BP	1
Kadane, JB	1
Gelfand, AE	1
Ribera Pascuet, E	1
López Aldeguer, J	1
Pérez Elías, MJ	1
Podzamczer Palter, D	1
Arendt, G	1
von Giesen, HJ	1
Hefter, H	1
Neuen-Jacob, E	1
Roick, H	1
Jablonowski, H	1
Yoshimura, K	1
Hara, T	1
Tsurumi, H	1
Goto, H	1
Tajika, M	1
Fukutomi, Y	1
Murakami, N	1
Moriwaki, H	1
Ferrer, E	1
Ramón, JM	1
Ribera, E	1
Cruceta, A	1
Knobel, H	1
Polo, R	1
Leyes, M	1
Fariñas, MC	1
Arrizabalaga, J	2
Martínez-Lacasa, J	1
Gudiol, F	1
Chaddha, DS	1
Kalra, SP	1
Singh, AP	1
Gupta, RM	1
Sanchetee, PC	1
Lacascade, C	1
Conge, AM	1
Baillat, V	1
Pages, I	1
Huguet, MF	1
Reynes, J	1
Vendrell, JP	1
Roemer, E	1
Blau, IW	1
Basara, N	1
Kiehl, MG	1
Bischoff, M	1
Günzelmann, S	1
Kirsten, D	1
Sanchez, H	1
Wocker, EL	1
Fauser, AA	1
Murakami, T	1
Nakajima, M	1
Nakamura, T	1
Hara, A	1
Uyama, E	1
Mita, S	1
Matsushita, S	1
Uchino, M	1
Albrecht, H	2
Padberg, J	2
Behnsch, M	1
Grobusch, M	2
Vallée, M	2
Wünsche, T	2
Suttorp, N	2
Pezzotti, P	1
Pallavicini, F	1
Grillo, R	1
Kupila, L	1
Sonninen, V	1
Peltonen, R	1
Uksila, J	1
Hukkanen, V	1
Kotilainen, P	1
Kociecka, W	1
Schürmann, M	1
Köppen, S	1
Jautzke, G	1
Gottschalk, J	1
Meulemans, A	1
Robine, D	1
Dameron, G	1
Iribarren, JA	1
Garde, C	1
Rodriguez-Arrondo, F	1
Blanco, A	1
Weiss, LM	1
Tanowitz, HB	1
Wittner, M	1
Lüscher, C	1
Horber, FF	1
Iannucci, AA	1
Hart, LL	1
Dannemann, B	1
McCutchan, JA	1
Israelski, D	1
Antoniskis, D	1
Nussbaum, J	1
Chiu, J	1
de Gans, J	1
Portegies, P	1
Reiss, P	1
Troost, D	1
van Gool, T	1
Lange, JM	1
Niyongabo, T	1
Fernandez-Martin, J	1
Meyohas, MC	1
Chauvin, JP	1
Flepp, M	1
Chave, JP	1
Malinverni, R	1
Gabriel, V	1
Renold, C	1
Sugar, A	1