Page last updated: 2024-11-03

pyrimethamine and Burkitt Lymphoma

pyrimethamine has been researched along with Burkitt Lymphoma in 8 studies

Maloprim: contains above 2 cpds

Burkitt Lymphoma: A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.

Research Excerpts

ExcerptRelevanceReference
"By this procedure a subline of Burkitt's lymphoma cells (RAJI) was made 290-fold resistant (RAJI/MTX-R), T-cell leukemia cells (CCRF-CEM) were obtained 210-fold resistant (CEM/MTX-R), and 3 MTX-resistant human osteosarcoma lines were selected: TE-85/MTX-R (19-fold resistant; relative to wild-type); MG-63/MTX-R (8-fold resistant); and SAOS-2/MTX-R (200-fold resistant)."5.27Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate. ( Diddens, H; Jackson, RC; Niethammer, D, 1983)
"By this procedure a subline of Burkitt's lymphoma cells (RAJI) was made 290-fold resistant (RAJI/MTX-R), T-cell leukemia cells (CCRF-CEM) were obtained 210-fold resistant (CEM/MTX-R), and 3 MTX-resistant human osteosarcoma lines were selected: TE-85/MTX-R (19-fold resistant; relative to wild-type); MG-63/MTX-R (8-fold resistant); and SAOS-2/MTX-R (200-fold resistant)."1.27Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate. ( Diddens, H; Jackson, RC; Niethammer, D, 1983)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19908 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Diddens, H1
Niethammer, D1
Jackson, RC1
Sadoff, L2
MacGregor, GA1
Hutt, MS1
Burkitt, DP1
Williams, EH1
Bruce-Chwatt, LJ1

Other Studies

8 other studies available for pyrimethamine and Burkitt Lymphoma

ArticleYear
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
    Cancer research, 1983, Volume: 43, Issue:11

    Topics: Antineoplastic Agents; Biological Transport; Burkitt Lymphoma; Cell Line; Drug Resistance; Folic Aci

1983
Etiology of Burkitt's lymphoma.
    Lancet (London, England), 1972, Dec-30, Volume: 2, Issue:7792

    Topics: Burkitt Lymphoma; Humans; Immunosuppressive Agents; Lymphoma, Large B-Cell, Diffuse; Male; Middle Ag

1972
Aetiology of Burkitt's lymphoma.
    Lancet (London, England), 1973, Jan-27, Volume: 1, Issue:7796

    Topics: Burkitt Lymphoma; Humans; Immunosuppression Therapy; Pyrimethamine

1973
Aetiology of Burkitt's lymphoma.
    Lancet (London, England), 1973, Feb-24, Volume: 1, Issue:7800

    Topics: Burkitt Lymphoma; Humans; Pyrimethamine; Uganda

1973
Aetiology of Burkitt's lymphoma.
    Lancet (London, England), 1973, May-19, Volume: 1, Issue:7812

    Topics: Burkitt Lymphoma; Humans; Pyrimethamine; Uganda

1973
Letter: Antimalarial drugs and Burkitt's lymphoma.
    Lancet (London, England), 1973, Dec-01, Volume: 2, Issue:7840

    Topics: Antimalarials; Burkitt Lymphoma; Child; Female; Fetal Diseases; Humans; Maternal-Fetal Exchange; Pre

1973
Letter: Antimalarial drugs and Burkitt's lymphoma.
    Lancet (London, England), 1974, Jan-12, Volume: 1, Issue:7846

    Topics: Africa; Burkitt Lymphoma; Humans; Pyrimethamine; Rural Population

1974
Letter: Antimalarial drugs and Burkitt's lymphoma.
    Lancet (London, England), 1974, Feb-09, Volume: 1, Issue:7850

    Topics: Adult; Africa; Animals; Burkitt Lymphoma; Carcinogens; Child; Chloroquine; Humans; Plant Extracts; P

1974