Page last updated: 2024-11-03

pyrimethamine and Brain Inflammation

pyrimethamine has been researched along with Brain Inflammation in 71 studies

Maloprim: contains above 2 cpds

Research Excerpts

ExcerptRelevanceReference
"In this international, noncomparative, randomized phase II trial, we evaluated the effectiveness and tolerance of atovaquone suspension (1500 mg orally twice daily) plus either pyrimethamine (75 mg per day after a 200-mg loading dose) or sulfadiazine (1500 mg 4 times daily) as treatment for acute disease (for 6 weeks) and as maintenance therapy (for 42 weeks) for toxoplasmic encephalitis (TE) in patients infected with human immunodeficiency virus."9.10Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche ( Andersen, J; Bosler, EM; Chirgwin, K; Hafner, R; Jayaweera, DT; Leport, C; Luft, BJ; McAuliffe, V; Morlat, P; Rajicic, N; Remington, J; Roque, C; Vilde, JL, 2002)
"To assess the safety, tolerance and activity of increasing doses of azithromycin in combination with pyrimethamine for the treatment of toxoplasmic encephalitis (TE) in patients with AIDS."9.09Dose-escalation, phase I/II study of azithromycin and pyrimethamine for the treatment of toxoplasmic encephalitis in AIDS. ( Bosler, EM; Farthing, C; Hafner, R; Harris, C; Holden-Wiltse, J; Jacobson, JM; Jayaweera, DT; Luft, BJ; Remington, J; Roque, C, 2001)
"An open, randomised, multicentre trial was conducted to evaluate the efficacy of thrice-weekly versus daily therapy with sulfadiazine-pyrimethamine in the prevention of relapses of toxoplasmic encephalitis in HIV-infected patients."9.09Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group. ( Arrizabalaga, J; Cosin, J; Cruceta, A; Domingo, P; Fariñas, MC; Ferrer, E; Gatell, JM; Gudiol, F; Knobel, H; Leyes, M; Martínez-Lacasa, J; Miró, JM; Podzamczer, D; Polo, R; Ramón, JM; Ribera, E; Sirera, G, 2000)
"To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)."9.08Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995)
"The aim of the present pilot study was to compare the efficacy and safety of trimethoprim (TMP) and sulfamethoxazole (SMX) with those of the standard therapy pyrimethamine (P)-sulfadiazine (S) for the treatment of toxoplasmic encephalitis in patients with AIDS."9.08Randomized trial of trimethoprim-sulfamethoxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS. Italian Collaborative Study Group. ( Angarano, G; Carosi, G; Casari, S; Chiodo, F; Donisi, A; Fiori, G; Gregis, G; Orani, A; Poggio, A; Ranieri, S; Speranza, F; Torre, D, 1998)
"Between February 1990 and June 1993, 105 patients with HIV infection were enrolled after each had had resolution of an acute episode of toxoplasmic encephalitis treated with sulfadiazine (1 g four times per day) plus pyrimethamine (50 mg/d) plus folinic acid (15 mg/d) for 4 to 8 weeks."9.08Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Spanish Toxoplasmosis Study Group. ( Bolao, F; Cosín, J; Domingo, P; Gatell, JM; Laguna, F; Miró, JM; Podzamczer, D; Santamaría, J; Sirera, G; Verdejo, J, 1995)
"Sixty-five patients intolerant of conventional toxoplasmic encephalitis therapies-pyrimethamine, sulphadiazine or clindamycin-received atovaquone as maintenance therapy after resolution of an acute episode of toxoplasmic encephalitis."9.08Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. ( Gourdon, D; Katlama, C; Lapierre, D; Mouthon, B; Rousseau, F, 1996)
"Pyrimethamine (50 mg) with folinic acid (15 mg) given three times weekly was assessed as primary prophylaxis for toxoplasmic encephalitis (TE) in 554 human immunodeficiency virus-infected patients seropositive for Toxoplasma gondii and with < 200 CD4 cells/mm3."9.08Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Gr ( Aubertin, J; Chêne, G; Hafner, R; Leport, C; Luft, BJ; Miro, J; Morlat, P; Pueyo, S; Rousseau, F; Salamon, R; Vildé, JL, 1996)
"This European multicenter study compares the efficacy and tolerance of the combination of pyrimethamine-clindamycin (Pyr-Cm) with the standard therapy pyrimethamine-sulfadiazine (Pyr-Sdz) for the treatment of toxoplasmic encephalitis (TE) in patients with AIDS."9.08Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. ( Clumeck, N; De Wit, S; Katlama, C; O'Doherty, E; Van Glabeke, M, 1996)
"A double-blind, placebo-controlled trial was set up to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis (TE) in HIV-infected patients at risk of the disorder."9.07Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS. ( Besch, CL; Child, C; Deyton, L; Hafner, R; Jacobson, MA; Matts, JP; Muth, K; Wentworth, DN, 1992)
"A prospective study was conducted to evaluate azithromycin in combination with pyrimethamine for treatment of acute Toxoplasma encephalitis in patients with AIDS."9.07Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS. ( Hazebroucq, V; Joly, V; Leport, C; Morlat, P; Raffi, F; Saba, J; Vildé, JL, 1993)
"To compare pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfadiazine (PS) as a treatment for toxoplasmic encephalitis (TE) in patients with the acquired immunodeficiency syndrome (AIDS)."9.07Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Clumeck, N; Dannemann, B; Israelski, D; Leport, C; Luft, B; McCutchan, JA; Morlat, P; Nussbaum, J, 1992)
"The interim results are presented of an ongoing large-scale, prospective, randomized study to determine the potential role of clindamycin in the treatment of toxoplasmic encephalitis."9.07Treatment of acute toxoplasmosis with intravenous clindamycin. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Dannemann, BR; Israelski, DM; Leport, C; Luft, BJ; McCutchan, JA; Nussbaum, JN; Orellana, M; Vildé, JL, 1991)
"Prophylaxis of toxoplasmic encephalitis was performed with pyrimethamine in 6 patients with advanced HIV infection during combination therapy with protease inhibitors."7.72Drug monitoring of pyrimethamine during maintenance therapy of toxoplasmic encephalitis in patients with advanced HIV infection during HAART. ( Klinker, H; Langmann, P; Schirmer, D; Zilly, M, 2004)
"To evaluate the safety and efficacy of a fixed 25mg pyrimethamine--500mg sulfadoxine combination plus 15mg folinic acid given twice weekly for the prevention of relapses of Pneumocystis carinii pneumonia (PCP) and primary episodes of toxoplasmic encephalitis."7.71Twice-weekly pyrimethamine-sulfadoxine effectively prevents Pneumocystis carinii pneumonia relapse and toxoplasmic encephalitis in patients with AIDS. ( Albrecht, H; Behnsch, M; Bergmann, F; Grobusch, M; Grünewald, T; Padberg, J; Ruf, B; Schürmann, D; Suttorp, N; Vallée, M; Wünsche, T, 2001)
"The effectiveness of combinations of rifabutin with atovaquone, clindamycin, pyrimethamine, or sulfadiazine in the treatment of toxoplasmic encephalitis in a murine model was investigated."7.69Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice. ( Araujo, FG; Remington, JS; Suzuki, Y, 1996)
"The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP."7.68Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992)
"The efficacy and safety of 25 mg pyrimethamine plus 500 mg sulfadoxine given twice a week in preventing relapses of AIDS-related toxoplasmic encephalitis was evaluated in an open study."7.68Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients. ( Bergmann, F; Gottschalk, HJ; Grünewald, T; Pohle, HD; Ruf, B; Schüler-Maué, W; Schürmann, D; Witt, H, 1993)
"Fourteen patients with AIDS and toxoplasmic encephalitis, who could not be treated with the standard regimen of pyrimethamine and a sulfonamide due to a previous history of bone marrow suppression and severe allergic reactions to sulfonamides, were treated with oral clindamycin and pyrimethamine."7.68A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine. ( Bini, T; Esposito, R; Foppa, CU; Gregis, G; Lazzarin, A; Moroni, M, 1991)
"Toxoplasma gondii encephalitis is an important opportunistic infection in the acquired immunodeficiency syndrome, estimated to occur in 20,000 to 40,000 patients with acquired immunodeficiency syndrome in the United States by 1991."6.38Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. ( Brosius, FC; Rothstein, DM; Simon, DI, 1990)
"In this international, noncomparative, randomized phase II trial, we evaluated the effectiveness and tolerance of atovaquone suspension (1500 mg orally twice daily) plus either pyrimethamine (75 mg per day after a 200-mg loading dose) or sulfadiazine (1500 mg 4 times daily) as treatment for acute disease (for 6 weeks) and as maintenance therapy (for 42 weeks) for toxoplasmic encephalitis (TE) in patients infected with human immunodeficiency virus."5.10Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche ( Andersen, J; Bosler, EM; Chirgwin, K; Hafner, R; Jayaweera, DT; Leport, C; Luft, BJ; McAuliffe, V; Morlat, P; Rajicic, N; Remington, J; Roque, C; Vilde, JL, 2002)
"To assess the safety, tolerance and activity of increasing doses of azithromycin in combination with pyrimethamine for the treatment of toxoplasmic encephalitis (TE) in patients with AIDS."5.09Dose-escalation, phase I/II study of azithromycin and pyrimethamine for the treatment of toxoplasmic encephalitis in AIDS. ( Bosler, EM; Farthing, C; Hafner, R; Harris, C; Holden-Wiltse, J; Jacobson, JM; Jayaweera, DT; Luft, BJ; Remington, J; Roque, C, 2001)
"We assessed the incidence and determinants of bacteremia, pneumonia, and sinusitis/otitis in HIV-positive people receiving cotrimoxazole (CTX) or dapsone-pyrimethamine (DP) for primary prophylaxis of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) within a randomized clinical trial."5.09Incidence and determinants of bacterial infections in HIV-positive patients receiving anti-Pneumocystis carinii/Toxoplasma gondii primary prophylaxis within a randomized clinical trial. ( Ammassari, A; Antinori, A; Cingolani, A; De Luca, A; Grillo, R; Murri, R; Pallavicini, F; Pezzotti, P, 2001)
"An open, randomised, multicentre trial was conducted to evaluate the efficacy of thrice-weekly versus daily therapy with sulfadiazine-pyrimethamine in the prevention of relapses of toxoplasmic encephalitis in HIV-infected patients."5.09Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group. ( Arrizabalaga, J; Cosin, J; Cruceta, A; Domingo, P; Fariñas, MC; Ferrer, E; Gatell, JM; Gudiol, F; Knobel, H; Leyes, M; Martínez-Lacasa, J; Miró, JM; Podzamczer, D; Polo, R; Ramón, JM; Ribera, E; Sirera, G, 2000)
"The aim of the present pilot study was to compare the efficacy and safety of trimethoprim (TMP) and sulfamethoxazole (SMX) with those of the standard therapy pyrimethamine (P)-sulfadiazine (S) for the treatment of toxoplasmic encephalitis in patients with AIDS."5.08Randomized trial of trimethoprim-sulfamethoxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS. Italian Collaborative Study Group. ( Angarano, G; Carosi, G; Casari, S; Chiodo, F; Donisi, A; Fiori, G; Gregis, G; Orani, A; Poggio, A; Ranieri, S; Speranza, F; Torre, D, 1998)
"Pyrimethamine (50 mg) with folinic acid (15 mg) given three times weekly was assessed as primary prophylaxis for toxoplasmic encephalitis (TE) in 554 human immunodeficiency virus-infected patients seropositive for Toxoplasma gondii and with < 200 CD4 cells/mm3."5.08Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Gr ( Aubertin, J; Chêne, G; Hafner, R; Leport, C; Luft, BJ; Miro, J; Morlat, P; Pueyo, S; Rousseau, F; Salamon, R; Vildé, JL, 1996)
"Between February 1990 and June 1993, 105 patients with HIV infection were enrolled after each had had resolution of an acute episode of toxoplasmic encephalitis treated with sulfadiazine (1 g four times per day) plus pyrimethamine (50 mg/d) plus folinic acid (15 mg/d) for 4 to 8 weeks."5.08Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Spanish Toxoplasmosis Study Group. ( Bolao, F; Cosín, J; Domingo, P; Gatell, JM; Laguna, F; Miró, JM; Podzamczer, D; Santamaría, J; Sirera, G; Verdejo, J, 1995)
"To evaluate combined prophylaxis for Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis, 533 patients with symptomatic human immunodeficiency virus infection and/or CD4 lymphocyte counts of < 200/microL were randomized to receive dapsone/pyrimethamine (200/75 mg once weekly) or aerosolized pentamidine (300 mg every 4 weeks)."5.08Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients. ( Heald, A; Hirschel, B; Iten, A; Lazzarin, A; Oertle, D; Opravil, M; Pechère, M; Praz, G; Rüttimann, S; von Overbeck, J, 1995)
"This European multicenter study compares the efficacy and tolerance of the combination of pyrimethamine-clindamycin (Pyr-Cm) with the standard therapy pyrimethamine-sulfadiazine (Pyr-Sdz) for the treatment of toxoplasmic encephalitis (TE) in patients with AIDS."5.08Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS. ( Clumeck, N; De Wit, S; Katlama, C; O'Doherty, E; Van Glabeke, M, 1996)
"Sixty-five patients intolerant of conventional toxoplasmic encephalitis therapies-pyrimethamine, sulphadiazine or clindamycin-received atovaquone as maintenance therapy after resolution of an acute episode of toxoplasmic encephalitis."5.08Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. ( Gourdon, D; Katlama, C; Lapierre, D; Mouthon, B; Rousseau, F, 1996)
"A quantifiable neurologic assessment was used prospectively to evaluate the clinical outcome of patients with AIDS and toxoplasmic encephalitis who were treated with oral clindamycin (600 mg four times a day) and pyrimethamine (75 mg every day) for six weeks."5.07Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome. Members of the ACTG 077p/ANRS 009 Study Team. ( Antoniskis, D; Bosler, EM; Bourland, DD; Fuhrer, J; Hafner, R; Jacobson, J; Korzun, AH; Leport, C; Luft, BJ; Uttamchandani, R, 1993)
"A double-blind, placebo-controlled trial was set up to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis (TE) in HIV-infected patients at risk of the disorder."5.07Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS. ( Besch, CL; Child, C; Deyton, L; Hafner, R; Jacobson, MA; Matts, JP; Muth, K; Wentworth, DN, 1992)
"A prospective study was conducted to evaluate azithromycin in combination with pyrimethamine for treatment of acute Toxoplasma encephalitis in patients with AIDS."5.07Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS. ( Hazebroucq, V; Joly, V; Leport, C; Morlat, P; Raffi, F; Saba, J; Vildé, JL, 1993)
"The interim results are presented of an ongoing large-scale, prospective, randomized study to determine the potential role of clindamycin in the treatment of toxoplasmic encephalitis."5.07Treatment of acute toxoplasmosis with intravenous clindamycin. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Dannemann, BR; Israelski, DM; Leport, C; Luft, BJ; McCutchan, JA; Nussbaum, JN; Orellana, M; Vildé, JL, 1991)
"To compare pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfadiazine (PS) as a treatment for toxoplasmic encephalitis (TE) in patients with the acquired immunodeficiency syndrome (AIDS)."5.07Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Clumeck, N; Dannemann, B; Israelski, D; Leport, C; Luft, B; McCutchan, JA; Morlat, P; Nussbaum, J, 1992)
"In a meta-analysis, we examined the efficacy of aerosolized pentamidine, trimethoprim-sulfamethoxazole, and dapsone or dapsone/pyrimethamine for the prevention of Pneumocystis carinii pneumonia and toxoplasma encephalitis in patients with HIV infection."4.79Meta-analysis of prophylactic treatments against Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients. ( Bucher, HC; Griffith, L; Guyatt, GH; Opravil, M, 1997)
"Although the price increase of pyrimethamine in 2015 received heavy media coverage, there are little data regarding specific implications to hospitals and the total costs of treating inpatients with toxoplasmosis encephalitis (TE)."4.12Brief Report: Financial Burden of Toxoplasmosis Encephalitis Treatment at a Safety Net Hospital. ( Bogard, SN; Kempker, RR; Lee, JT; Patel, M, 2022)
"Prophylaxis of toxoplasmic encephalitis was performed with pyrimethamine in 6 patients with advanced HIV infection during combination therapy with protease inhibitors."3.72Drug monitoring of pyrimethamine during maintenance therapy of toxoplasmic encephalitis in patients with advanced HIV infection during HAART. ( Klinker, H; Langmann, P; Schirmer, D; Zilly, M, 2004)
"To evaluate the safety and efficacy of a fixed 25mg pyrimethamine--500mg sulfadoxine combination plus 15mg folinic acid given twice weekly for the prevention of relapses of Pneumocystis carinii pneumonia (PCP) and primary episodes of toxoplasmic encephalitis."3.71Twice-weekly pyrimethamine-sulfadoxine effectively prevents Pneumocystis carinii pneumonia relapse and toxoplasmic encephalitis in patients with AIDS. ( Albrecht, H; Behnsch, M; Bergmann, F; Grobusch, M; Grünewald, T; Padberg, J; Ruf, B; Schürmann, D; Suttorp, N; Vallée, M; Wünsche, T, 2001)
"In 26 AIDS patients treated for toxoplasmic encephalitis, the inhibitory effect on Toxoxplasma growth of sequential sera taken before and after initiation of therapy was determined using a culture-based immunoassay and compared with pyrimethamine blood levels."3.70Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis. ( Derouin, F; Farinotti, R; Gérard, L; Leport, C; Maslo, C, 1998)
"A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability."3.70Disposition of intravenous pyrimethamine in healthy volunteers. ( Almond, DS; Edwards, G; Lee, MG; Szwandt, IS; Winstanley, PA, 2000)
" We illustrate all of our comparisons with a dataset from an AIDS clinical trial that compared the effectiveness of the drug pyrimethamine and a placebo in preventing toxoplasmic encephalitis."3.69Robust Bayesian approaches for clinical trial monitoring. ( Carlin, BP; Sargent, DJ, 1996)
"The effectiveness of combinations of rifabutin with atovaquone, clindamycin, pyrimethamine, or sulfadiazine in the treatment of toxoplasmic encephalitis in a murine model was investigated."3.69Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice. ( Araujo, FG; Remington, JS; Suzuki, Y, 1996)
"The efficacy and safety of 25 mg pyrimethamine plus 500 mg sulfadoxine given twice a week in preventing relapses of AIDS-related toxoplasmic encephalitis was evaluated in an open study."3.68Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients. ( Bergmann, F; Gottschalk, HJ; Grünewald, T; Pohle, HD; Ruf, B; Schüler-Maué, W; Schürmann, D; Witt, H, 1993)
"Fourteen patients with AIDS and toxoplasmic encephalitis, who could not be treated with the standard regimen of pyrimethamine and a sulfonamide due to a previous history of bone marrow suppression and severe allergic reactions to sulfonamides, were treated with oral clindamycin and pyrimethamine."3.68A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine. ( Bini, T; Esposito, R; Foppa, CU; Gregis, G; Lazzarin, A; Moroni, M, 1991)
"The incidence of Pneumocystis carinii pneumonia (PCP) and toxoplasmic encephalitis (TE) was analyzed in 83 human immunodeficiency virus (HIV)-infected patients who inhaled aerosolized pentamidine (AP) either for primary prophylaxis (group Ia) or secondary prophylaxis (group IIa) of PCP."3.68Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine. ( Gottschalk, J; Grünewald, T; Jautzke, G; Köppen, S; Pohle, HD; Ruf, B, 1992)
" The weekly dosage of pyrimethamine ranged from 25 to 1,400 mg; one patient with severe diarrhea received 2,100 mg/week."2.68Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS. ( Klinker, H; Langmann, P; Richter, E, 1996)
"Toxoplasma gondii encephalitis is an important opportunistic infection in the acquired immunodeficiency syndrome, estimated to occur in 20,000 to 40,000 patients with acquired immunodeficiency syndrome in the United States by 1991."2.38Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. ( Brosius, FC; Rothstein, DM; Simon, DI, 1990)
"Toxoplasmosis is usually an asymptomatic infection, but symptomatic cases are becoming more common with the rise in AIDS cases and the increased number of patients receiving immunosuppressive therapy."1.27Toxoplasmosis of the central nervous system. ( Meredith, JT, 1987)
"Toxoplasma encephalitis has been reported as a life-threatening opportunistic infection among patients with the acquired immune deficiency syndrome."1.27Assessment of therapy for toxoplasma encephalitis. The TE Study Group. ( Haverkos, HW, 1987)
"Toxoplasma encephalitis has a high mortality, and active treatment is recommended."1.27Acquired toxoplasma encephalitis. ( Cottrell, AJ, 1986)

Research

Studies (71)

TimeframeStudies, this research(%)All Research%
pre-199017 (23.94)18.7374
1990's42 (59.15)18.2507
2000's9 (12.68)29.6817
2010's1 (1.41)24.3611
2020's2 (2.82)2.80

Authors

AuthorsStudies
Prosty, C1
Hanula, R1
Levin, Y1
Bogoch, II1
McDonald, EG1
Lee, TC1
Bogard, SN1
Lee, JT1
Patel, M1
Kempker, RR1
Baliu, C1
Sanclemente, G1
Cardona, M1
Castel, MA1
Perez-Villa, F1
Moreno, A1
Cervera, C1
Hill, D1
Dubey, JP1
STAHLIE, TD1
Langmann, P2
Schirmer, D1
Zilly, M1
Klinker, H2
Filice, G1
Carnevale, G1
Orsolini, P1
Soldini, L1
Meroni, V1
Comolli, G1
Carenzo, L1
Robinson, RO1
Baumann, RJ1
Katlama, C5
Podzamczer, D2
Miró, JM2
Bolao, F1
Gatell, JM2
Cosín, J2
Sirera, G2
Domingo, P2
Laguna, F1
Santamaría, J1
Verdejo, J1
Kovacs, JA2
Opravil, M2
Hirschel, B2
Lazzarin, A2
Heald, A1
Pechère, M1
Rüttimann, S1
Iten, A1
von Overbeck, J1
Oertle, D1
Praz, G1
Oksenhendler, E1
Charreau, I1
Tournerie, C2
Azihary, M1
Carbon, C1
Aboulker, JP1
Saba, J1
Morlat, P6
Raffi, F1
Hazebroucq, V1
Joly, V1
Leport, C10
Vildé, JL8
McCabe, R1
Chirurgi, V1
Ruf, B3
Schürmann, D2
Bergmann, F2
Schüler-Maué, W1
Grünewald, T3
Gottschalk, HJ1
Witt, H1
Pohle, HD2
Luft, BJ9
Hafner, R9
Korzun, AH1
Antoniskis, D3
Bosler, EM3
Bourland, DD1
Uttamchandani, R1
Fuhrer, J1
Jacobson, J1
Girard, PM1
Landman, R1
Gaudebout, C2
Olivares, R1
Saimot, AG1
Jelazko, P1
Certain, A1
Boué, F1
Bouvet, E1
Caumes, E1
Bocquet, H1
Guermonprez, G1
Rogeaux, O1
Bricaire, F1
Gentilini, M1
Chêne, G3
Rousseau, F3
Pueyo, S3
Miro, J2
Aubertin, J3
Salamon, R3
Richards, FO1
Antinori, A2
Murri, R2
Ammassari, A2
De Luca, A2
Linzalone, A1
Cingolani, A2
Damiano, F1
Maiuro, G1
Vecchiet, J1
Scoppettuolo, G1
Caramello, P1
Brancale, T1
Forno, B1
Lucchini, A1
Pollono, AM1
Ullio, A1
Gioannini, P1
Viano, I1
Tonso, E1
Van Delden, C1
Araujo, FG1
Suzuki, Y1
Remington, JS4
Carlin, BP1
Sargent, DJ1
Richter, E1
De Wit, S1
O'Doherty, E1
Van Glabeke, M1
Clumeck, N2
Mouthon, B1
Gourdon, D1
Lapierre, D1
Derouin, F2
Letrillart, B1
Ecobichon, JL1
Luft, B2
Bucher, HC1
Griffith, L1
Guyatt, GH1
Supiot, F1
Guillaume, MP1
Hermanus, N1
Telerman-Toppet, N1
Karmali, R1
Torre, D1
Casari, S1
Speranza, F1
Donisi, A1
Gregis, G2
Poggio, A1
Ranieri, S1
Orani, A1
Angarano, G1
Chiodo, F1
Fiori, G1
Carosi, G1
Gérard, L1
Farinotti, R1
Maslo, C1
Yoshimura, K1
Hara, T1
Tsurumi, H1
Goto, H1
Tajika, M1
Fukutomi, Y1
Murakami, N1
Moriwaki, H1
Ferrer, E1
Ramón, JM1
Ribera, E1
Cruceta, A1
Knobel, H1
Polo, R1
Leyes, M1
Fariñas, MC1
Arrizabalaga, J2
Martínez-Lacasa, J1
Gudiol, F1
Almond, DS1
Szwandt, IS1
Edwards, G1
Lee, MG1
Winstanley, PA1
Lacascade, C1
Conge, AM1
Baillat, V1
Pages, I1
Huguet, MF1
Reynes, J1
Vendrell, JP1
Albrecht, H1
Padberg, J1
Behnsch, M1
Grobusch, M1
Vallée, M1
Wünsche, T1
Suttorp, N1
Jacobson, JM1
Remington, J2
Farthing, C1
Holden-Wiltse, J1
Harris, C2
Jayaweera, DT2
Roque, C2
Pezzotti, P1
Pallavicini, F1
Grillo, R1
Kupila, L1
Sonninen, V1
Peltonen, R1
Uksila, J1
Hukkanen, V1
Kotilainen, P1
Chirgwin, K1
Andersen, J1
Rajicic, N1
McAuliffe, V1
Jacobson, MA2
Besch, CL2
Child, C2
Matts, JP1
Muth, K2
Wentworth, DN1
Deyton, L2
Köppen, S1
Jautzke, G1
Gottschalk, J1
Iribarren, JA1
Garde, C1
Rodriguez-Arrondo, F1
Blanco, A1
Dannemann, B1
McCutchan, JA2
Israelski, D1
Nussbaum, J1
Chiu, J2
Foppa, CU1
Bini, T1
Esposito, R1
Moroni, M1
Raguin, G1
Fernandez-Martin, J1
Niyongabo, T1
Dannemann, BR2
Israelski, DM1
Nussbaum, JN1
Orellana, M1
Simon, DI1
Brosius, FC1
Rothstein, DM1
Carrazana, EJ1
Rossitch, E1
Samuels, MA1
Cohn, JA1
McMeeking, A1
Cohen, W1
Jacobs, J1
Holzman, RS1
Weiss, LM1
Berger, M1
Tanowitz, HB1
Wittner, M1
Wanke, C1
Tuazon, CU1
Kovacs, A1
Dina, T1
Davis, DO1
Barton, N1
Katz, D1
Lunde, M1
Levy, C1
Conley, FK1
Lim, BT1
Carbaat, PA1
van Knapen, F1
Meredith, JT1
Haverkos, HW1
Cottrell, AJ1
Payet, M1
Coulaud, JP1
Pasticier, A1
Saimot, G1
Fanghänel, M1
Meyfarth, G1
Molkentin, K1
Rieder, RT1
Granz, W1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Dose-Escalation, Phase I/II Study of Oral Azithromycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS[NCT00000966]Phase 145 participants InterventionalCompleted
A Pilot Study of Oral Clindamycin and Pyrimethamine for the Treatment of Toxoplasmic Encephalitis in Patients With AIDS[NCT00000674]30 participants InterventionalCompleted
Primary Prophylaxis of Cerebral Toxoplasmosis in HIV-Infected Patients[NCT00000643]Phase 2150 participants InterventionalCompleted
Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis[NCT00000794]Phase 2100 participants InterventionalCompleted
A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection[NCT00000666]600 participants InterventionalCompleted
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for pyrimethamine and Brain Inflammation

ArticleYear
Revisiting the Evidence Base for Modern-Day Practice of the Treatment of Toxoplasmic Encephalitis: A Systematic Review and Meta-Analysis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023, 02-08, Volume: 76, Issue:3

    Topics: Encephalitis; HIV Infections; Humans; Pyrimethamine; Toxoplasmosis, Cerebral; Trimethoprim, Sulfamet

2023
Toxoplasma gondii: transmission, diagnosis and prevention.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2002, Volume: 8, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Protozoan; Cats; Cattle; Deer; Encephalitis

2002
Issues in toxoplasmosis.
    Infectious disease clinics of North America, 1993, Volume: 7, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Animals; Clindamycin; Drug Therapy, Combination; Encephalitis

1993
Preventing toxoplasmic encephalitis in persons infected with human immunodeficiency virus.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21 Suppl 1

    Topics: AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Cats; Dapsone; Drug Therapy,

1995
Meta-analysis of prophylactic treatments against Pneumocystis carinii pneumonia and toxoplasma encephalitis in HIV-infected patients.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1997, Jun-01, Volume: 15, Issue:2

    Topics: Administration, Inhalation; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal

1997
Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome.
    Archives of internal medicine, 1990, Volume: 150, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adult; Crystallization; Drug Therapy, Combi

1990
AIDS commentary. Toxoplasmic encephalitis.
    The Journal of infectious diseases, 1988, Volume: 157, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-Bacterial Agents; Antibodies, Protozoan; Antimetab

1988

Trials

22 trials available for pyrimethamine and Brain Inflammation

ArticleYear
Twice-weekly maintenance therapy with sulfadiazine-pyrimethamine to prevent recurrent toxoplasmic encephalitis in patients with AIDS. Spanish Toxoplasmosis Study Group.
    Annals of internal medicine, 1995, Aug-01, Volume: 123, Issue:3

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Drug Administration Schedule; Drug Therapy, Comb

1995
Once-weekly administration of dapsone/pyrimethamine vs. aerosolized pentamidine as combined prophylaxis for Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus-infected patients.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 20, Issue:3

    Topics: Administration, Inhalation; Adult; AIDS-Related Opportunistic Infections; Animals; Dapsone; Drug Adm

1995
Pyrimethamine plus azithromycin for treatment of acute toxoplasmic encephalitis in patients with AIDS.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:11

    Topics: Acute Disease; Adult; AIDS-Related Opportunistic Infections; Azithromycin; Drug Administration Sched

1993
Toxoplasmic encephalitis in patients with the acquired immunodeficiency syndrome. Members of the ACTG 077p/ANRS 009 Study Team.
    The New England journal of medicine, 1993, Sep-30, Volume: 329, Issue:14

    Topics: Acute Disease; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Encephalitis; Female; Huma

1993
Dapsone-pyrimethamine compared with aerosolized pentamidine as primary prophylaxis against Pneumocystis carinii pneumonia and toxoplasmosis in HIV infection. The PRIO Study Group.
    The New England journal of medicine, 1993, May-27, Volume: 328, Issue:21

    Topics: Adult; AIDS-Related Complex; AIDS-Related Opportunistic Infections; Dapsone; Drug Combinations; Ence

1993
Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Gr
    The Journal of infectious diseases, 1996, Volume: 173, Issue:1

    Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Antibodies, Protozoan;

1996
Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
    AIDS (London, England), 1995, Volume: 9, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infe

1995
Plasma pyrimethamine concentrations during long-term treatment for cerebral toxoplasmosis in patients with AIDS.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:7

    Topics: AIDS-Related Opportunistic Infections; Dose-Response Relationship, Drug; Encephalitis; Humans; Pyrim

1996
Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1996, Volume: 22, Issue:2

    Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Clindamycin; Drug Therapy, Comb

1996
Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group.
    AIDS (London, England), 1996, Volume: 10, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiprotozoal Agents; Atovaquone; Clindamycin; Encephalit

1996
Increased risk of toxoplasmic encephalitis in human immunodeficiency virus-infected patients with pyrimethamine-related rash. ANRS 005-ACTG 154 Trial Group. Agence Nationale de Recherche sur le SIDA (ANRS-INSERM) and the NIAID-AIDS Clinical Trials Group.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1997, Volume: 24, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Disease Progression; Double-Blind Metho

1997
Randomized trial of trimethoprim-sulfamethoxazole versus pyrimethamine-sulfadiazine for therapy of toxoplasmic encephalitis in patients with AIDS. Italian Collaborative Study Group.
    Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:6

    Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infective Agents; Encephalitis; Female;

1998
Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2000, Volume: 19, Issue:2

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Drug Therapy, Combination; Encep

2000
Dose-escalation, phase I/II study of azithromycin and pyrimethamine for the treatment of toxoplasmic encephalitis in AIDS.
    AIDS (London, England), 2001, Mar-30, Volume: 15, Issue:5

    Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Bacterial Agents; Antiprotozoal Agents;

2001
TMP-SMX superior in treating Toxoplasma encephalitis.
    AIDS patient care and STDs, 1997, Volume: 11, Issue:6

    Topics: Anti-Infective Agents; Encephalitis; Humans; Pyrimethamine; Randomized Controlled Trials as Topic; S

1997
Incidence and determinants of bacterial infections in HIV-positive patients receiving anti-Pneumocystis carinii/Toxoplasma gondii primary prophylaxis within a randomized clinical trial.
    Journal of acquired immune deficiency syndromes (1999), 2001, May-01, Volume: 27, Issue:1

    Topics: Adult; Animals; Anti-Infective Agents; Bacterial Infections; Dapsone; Encephalitis; Female; HIV Infe

2001
Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, May-01, Volume: 34, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Opportunistic Infections; Ani

2002
Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS.
    Lancet (London, England), 1992, Feb-08, Volume: 339, Issue:8789

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Clindamycin; Double-Blind Method; Encephalitis;

1992
Clinical programs for clinical research on AIDS: description of a randomized prospective study of clindamycin versus pyrimethamine for prevention of Toxoplasma gondii infection.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; Clindamycin; Encephalitis; Humans; L

1991
Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group.
    Annals of internal medicine, 1992, Jan-01, Volume: 116, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Clindamycin; Drug Evaluation; Drug Therapy, Combination;

1992
Evaluation of the efficacy and safety of clindamycin plus pyrimethamine for induction and maintenance therapy of toxoplasmic encephalitis in AIDS.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Encephalitis; Humans; Op

1991
Treatment of acute toxoplasmosis with intravenous clindamycin. The California Collaborative Treatment Group.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Encephalitis; Humans; In

1991

Other Studies

42 other studies available for pyrimethamine and Brain Inflammation

ArticleYear
Brief Report: Financial Burden of Toxoplasmosis Encephalitis Treatment at a Safety Net Hospital.
    Journal of acquired immune deficiency syndromes (1999), 2022, 11-01, Volume: 91, Issue:3

    Topics: Encephalitis; Financial Stress; HIV Infections; Humans; Pharmaceutical Preparations; Pyrimethamine;

2022
Toxoplasmic encephalitis associated with meningitis in a heart transplant recipient.
    Transplant infectious disease : an official journal of the Transplantation Society, 2014, Volume: 16, Issue:4

    Topics: Antiprotozoal Agents; Clindamycin; Drug Therapy, Combination; Encephalitis; Heart Transplantation; H

2014
[SWOLLEN CERVICAL LYMPH GLANDS].
    Nederlands tijdschrift voor geneeskunde, 1964, Apr-04, Volume: 108

    Topics: Child; Complement Fixation Tests; Diagnosis, Differential; Encephalitis; Exanthema; Hepatitis; Human

1964
Drug monitoring of pyrimethamine during maintenance therapy of toxoplasmic encephalitis in patients with advanced HIV infection during HAART.
    Medical science monitor : international medical journal of experimental and clinical research, 2004, Volume: 10, Issue:5

    Topics: Adult; Age Factors; Antiretroviral Therapy, Highly Active; Chromatography, Gas; Chromatography, High

2004
Chemotherapy of toxoplasmic encephalitis in AIDS patients.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4 Suppl

    Topics: Administration, Oral; AIDS-Related Opportunistic Infections; Antiprotozoal Agents; Encephalitis; Hum

1989
Late cerebral relapse of congenital toxoplasmosis.
    Archives of disease in childhood, 1980, Volume: 55, Issue:3

    Topics: Child; Chorioretinitis; Drug Therapy, Combination; Encephalitis; Female; Humans; Pyrimethamine; Recu

1980
[The impact of the prevention of cerebral toxoplasmosis].
    Journal of neuroradiology = Journal de neuroradiologie, 1995, Volume: 22, Issue:3

    Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antiprotozoal Agents; Brain Abs

1995
Toxoplasmosis in AIDS: keeping the lid on.
    Annals of internal medicine, 1995, Aug-01, Volume: 123, Issue:3

    Topics: AIDS-Related Opportunistic Infections; Drug Therapy, Combination; Encephalitis; Humans; Pyrimethamin

1995
Toxoplasma gondii infection in advanced HIV infection.
    AIDS (London, England), 1994, Volume: 8, Issue:4

    Topics: Adult; AIDS-Related Opportunistic Infections; Dapsone; Encephalitis; Female; Humans; Male; Middle Ag

1994
Efficacy of pyrimethamine/sulfadoxine in the prevention of toxoplasmic encephalitis relapses and Pneumocystis carinii pneumonia in HIV-infected patients.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1993, Volume: 12, Issue:5

    Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Drug Administration Schedule; D

1993
Adverse cutaneous reactions to pyrimethamine/sulfadiazine and pyrimethamine/clindamycin in patients with AIDS and toxoplasmic encephalitis.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1995, Volume: 21, Issue:3

    Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Anti-Infective Agents; Clindamy

1995
Relapse of Toxoplasma encephalitis and susceptibility to pyrimethamine: lack of evidence of treatment-induced resistance.
    Antimicrobial agents and chemotherapy, 1995, Volume: 39, Issue:10

    Topics: Adult; Anti-Infective Agents; Drug Resistance; Encephalitis; Humans; Pyrimethamine; Recurrence; Toxo

1995
Folinic acid supplements to pyrimethamine-sulfadiazine for Toxoplasma encephalitis are associated with better outcome.
    The Journal of infectious diseases, 1996, Volume: 173, Issue:5

    Topics: Antiprotozoal Agents; Drug Combinations; Drug Interactions; Drug Therapy, Combination; Encephalitis;

1996
Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1996, Volume: 15, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antiprotozoal Agents; Atovaquone; Brain; Clin

1996
Robust Bayesian approaches for clinical trial monitoring.
    Statistics in medicine, 1996, Jun-15, Volume: 15, Issue:11

    Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Bayes Theorem; Controlled Clinical Tri

1996
Predictive value of Toxoplasma gondii antibody titres on the occurrence of toxoplasmic encephalitis in HIV-infected patients. ANRS 005/ACTG 154 Trial Group.
    AIDS (London, England), 1996, Volume: 10, Issue:13

    Topics: Adolescent; Adult; AIDS-Related Opportunistic Infections; Animals; Antibodies, Protozoan; Antiprotoz

1996
Toxoplasma encephalitis in a HIV patient: unusual involvement of the corpus callosum.
    Clinical neurology and neurosurgery, 1997, Volume: 99, Issue:4

    Topics: Adult; Animals; Anti-Infective Agents; Brain Neoplasms; Corpus Callosum; Diagnosis, Differential; En

1997
Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Sep-01, Volume: 19, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Dr

1998
[Non-Hodgkin's lymphoma with Toxoplasma encephalitis].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 1999, Volume: 40, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Antiprotozoal Agents; Cyclophosphamide; Dox

1999
Disposition of intravenous pyrimethamine in healthy volunteers.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Antimalarials; Encephalitis; Humans; Infusions, Intravenous; Mal

2000
In vitro anti-Toxoplasma gondii antibody production by peripheral blood mononuclear cells in the diagnosis and the monitoring of toxoplasmic encephalitis in AIDS-related brain lesions.
    Journal of acquired immune deficiency syndromes (1999), 2000, Nov-01, Volume: 25, Issue:3

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antibodies, Protozoan; Antiprotozoal Agents; Enc

2000
Twice-weekly pyrimethamine-sulfadoxine effectively prevents Pneumocystis carinii pneumonia relapse and toxoplasmic encephalitis in patients with AIDS.
    The Journal of infection, 2001, Volume: 42, Issue:1

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Cohort Studies; Drug Comb

2001
[Toxoplasma encephalitis in a previously healthy man].
    Duodecim; laaketieteellinen aikakauskirja, 1999, Volume: 115, Issue:3

    Topics: Abattoirs; Antiprotozoal Agents; Drug Therapy, Combination; Encephalitis; Humans; Male; Middle Aged;

1999
Prevention of Pneumocystis carinii pneumonia and toxoplasmic encephalitis in human immunodeficiency virus infected patients: a clinical approach comparing aerosolized pentamidine and pyrimethamine/sulfadoxine.
    The Clinical investigator, 1992, Volume: 70, Issue:6

    Topics: Adult; Aerosols; Aged; CD4-Positive T-Lymphocytes; Drug Combinations; Encephalitis; Female; HIV Infe

1992
Empiric treatment of acute Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome.
    Archives of internal medicine, 1992, Volume: 152, Issue:10

    Topics: AIDS-Related Opportunistic Infections; Encephalitis; Humans; Pyrimethamine; Sulfadiazine; Toxoplasmo

1992
Clindamycin for toxoplasma encephalitis in AIDS.
    Lancet (London, England), 1991, Nov-02, Volume: 338, Issue:8775

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Combinations; Encephalitis; Humans; Pyrimetham

1991
A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Clindamycin; Drug Therapy, Combinat

1991
Long-term follow-up of patients with AIDS on maintenance therapy for toxoplasmosis.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Encephalitis; Follow-Up

1991
Toxoplasmic encephalitis.
    AIDS (London, England), 1990, Volume: 4, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Encephalitis; Humans; Opportunistic Infection

1990
Toxoplasmic encephalitis in AIDS.
    Hospital practice (Office ed.), 1989, Mar-15, Volume: 24, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antibodies, Protozoan; Brain; Diagnosis, Differe

1989
Cerebral toxoplasmosis in the acquired immune deficiency syndrome.
    Clinical neurology and neurosurgery, 1989, Volume: 91, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Encephalitis; Female; Humans; Male; Middle Aged; Py

1989
Evaluation of the policy of empiric treatment of suspected Toxoplasma encephalitis in patients with the acquired immunodeficiency syndrome.
    The American journal of medicine, 1989, Volume: 86, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Brain; Clindamycin; Encephalitis; Female; Humans;

1989
Pyrimethamine concentrations in serum and cerebrospinal fluid during treatment of acute Toxoplasma encephalitis in patients with AIDS.
    The Journal of infectious diseases, 1988, Volume: 157, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Encephalitis; Humans; Pyrimethamine; Toxoplasmosi

1988
Toxoplasma encephalitis in patients with acquired immune deficiency syndrome: diagnosis and response to therapy.
    The American journal of tropical medicine and hygiene, 1987, Volume: 36, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies; Drug Therapy, Combination; Encephalitis; Huma

1987
[A young man with acute toxoplasmosis encephalitis].
    Nederlands tijdschrift voor geneeskunde, 1987, Nov-14, Volume: 131, Issue:46

    Topics: Acute Disease; Adult; Drug Therapy, Combination; Encephalitis; Humans; Leucovorin; Male; Pyrimethami

1987
Toxoplasmosis of the central nervous system.
    American family physician, 1987, Volume: 35, Issue:5

    Topics: Adult; Central Nervous System Diseases; Cerebellum; Encephalitis; Female; Humans; Pyrimethamine; Sul

1987
Assessment of therapy for toxoplasma encephalitis. The TE Study Group.
    The American journal of medicine, 1987, Volume: 82, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Adult; Encephalitis; Evaluation Studies

1987
Acquired toxoplasma encephalitis.
    Archives of disease in childhood, 1986, Volume: 61, Issue:1

    Topics: Child, Preschool; Drug Therapy, Combination; Encephalitis; Humans; Male; Pyrimethamine; Sulfamethazi

1986
[Tropical and parasitic diseases].
    La Revue du praticien, 1974, Nov-11, Volume: 24, Issue:51

    Topics: Acute Kidney Injury; Amebiasis; Antimalarials; Cholera; Drug Resistance, Microbial; Encephalitis; Gl

1974
[Congenital toxoplasmosis diagnosis, a cooperative effort of obstetrician and pediatrician].
    Zentralblatt fur Gynakologie, 1969, Jan-04, Volume: 91, Issue:1

    Topics: Adult; Encephalitis; Female; Humans; Infant, Newborn; Pregnancy; Pyrimethamine; Serologic Tests; Ski

1969
[Childhood toxoplasmosis in Schleswig].
    Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:6

    Topics: Child; Child, Preschool; Encephalitis; Germany, West; Humans; Infant; Infant, Newborn; Infant, Newbo

1970
[Acquired toxoplasmosis].
    Munchener medizinische Wochenschrift (1950), 1967, Mar-31, Volume: 109, Issue:13

    Topics: Animals; Complement Fixation Tests; Diagnosis, Differential; Encephalitis; Hemagglutination Tests; H

1967