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pyrimethamine and Brain Diseases

pyrimethamine has been researched along with Brain Diseases in 34 studies

Maloprim: contains above 2 cpds

Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Research Excerpts

ExcerptRelevanceReference
"Cerebral toxoplasmosis related to AIDS was treated with a combination regimen of pyrimethamine, clindamycin, and spiramycin, and in a second trial with a combination of pyrimethamine and clindamycin."7.68Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system. ( Pohle, HD; Ruf, B, 1991)
"A substantial reduction of brain cyst numbers could be obtained through a six week therapy with SDDS-pyrimethamine combination or a high titer anti-Toxoplasma serum."7.65The effect of chemo-immunotherapy with SDDS, pyrimethamine and anti-toxoplasma serum on toxoplasma gondii cysts in latent infected NMRI mice. ( Adusu, E; Masihi, KN; Tischer, I; Werner, H, 1977)
"Cerebral toxoplasmosis related to AIDS was treated with a combination regimen of pyrimethamine, clindamycin, and spiramycin, and in a second trial with a combination of pyrimethamine and clindamycin."3.68Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system. ( Pohle, HD; Ruf, B, 1991)
"A substantial reduction of brain cyst numbers could be obtained through a six week therapy with SDDS-pyrimethamine combination or a high titer anti-Toxoplasma serum."3.65The effect of chemo-immunotherapy with SDDS, pyrimethamine and anti-toxoplasma serum on toxoplasma gondii cysts in latent infected NMRI mice. ( Adusu, E; Masihi, KN; Tischer, I; Werner, H, 1977)
"The activity of the macrolide antibiotic clarithromycin was examined alone or in combination with other drugs for the treatment of acute or chronic infections with Toxoplasma gondii in mice."1.28Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis. ( Araujo, FG; Lin, T; Prokocimer, P; Remington, JS, 1992)
"No relapse was observed in those receiving P/S, but 40% of those treated with P/C relapsed."1.28[Encephalic toxoplasmosis in patients with the acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases]. ( Alvarez, R; Gatell, JM; González-Clemente, JM; Graus, F; Guelar, A; Jiménez de Anta, MT; Mallolas, J; Mercader, JM; Miró, JM; Pedrol, E, 1990)
" Reappraisal of quinine therapy has led to important modifications in dosage recommendations and recognition of a major complication of severe malaria associated with its use--hypoglycaemia."1.27Management of Plasmodium falciparum malaria. ( Phillips, RE, 1984)
"Treatment with sulfadiazine, pyrimethamine, and steroids brought about a prompt resolution."1.26Acute acquired toxoplasmosis. ( Reese, LT; Shafer, DM; Zweifach, P, 1981)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199023 (67.65)18.7374
1990's10 (29.41)18.2507
2000's0 (0.00)29.6817
2010's1 (2.94)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chuang, YC1
Chen, JY1
Ji, DD1
Su, PH1
GOLIAS-MAKOWSKA, A1
DUC, G1
JUNGO, O1
GUGLER, E1
Phillips, RE1
Reese, LT1
Shafer, DM1
Zweifach, P1
Santucci, A1
Aguglia, F1
Federico, M1
De Mattia, G1
Montero, A1
Cohen, JE1
Martínez, DP1
Giovannoni, AG1
Foulon, W1
Villena, I1
Stray-Pedersen, B1
Decoster, A1
Lappalainen, M1
Pinon, JM1
Jenum, PA1
Hedman, K1
Naessens, A1
Schlenska, GK1
Werner, H1
Masihi, KN1
Tischer, I1
Adusu, E1
Yoeli, M1
Masson, R1
Fière, D1
Lahnèche, B1
Cordat, C1
Berger, F1
Revol, L1
Araujo, FG1
Prokocimer, P1
Lin, T1
Remington, JS1
Clotet, B1
Sirera, G1
Romeu, J1
Gimeno, JM1
Jou, A1
Condom, MJ1
Tor, J1
Foz, M1
Díaz Benito, JA1
Rodríguez García, JC1
Piñeiro Gómez-Durán, L1
Ruf, B1
Pohle, HD1
González-Clemente, JM1
Miró, JM1
Pedrol, E1
Alvarez, R1
Gatell, JM1
Mallolas, J1
Graus, F1
Mercader, JM1
Guelar, A1
Jiménez de Anta, MT1
Chakroun, M1
Meyohas, MC1
Pelosse, B1
Zazoun, L1
Vacherot, B1
Derouin, F1
Leport, C3
Boudes, P1
Zittoun, J1
Sobel, A1
Bhatti, N1
Larson, E1
Kassirer, JP1
Kopelman, RI1
Altés, J1
Salas, A1
Ricart, C1
Villalonga, C1
Riera, M1
Casquero, P1
Ventura, MG1
Wybran, J1
Farber, CM1
Bastuji-Garin, S1
Perronne, C1
Salmon, D1
Marche, C1
Briçaire, F1
Vilde, JL2
Bonaventura, I1
Romero, F1
Ortega, A1
Navarro, C1
Juste, C1
Codina Puiggrós, A1
Rolston, KV1
Katlama, C1
Regnier, B1
Mathéron, S1
Saimot, AG1
Navia, BA1
Petito, CK1
Gold, JW1
Cho, ES1
Jordan, BD1
Price, RW1
Diop Mar, I1
Sow, A1
Gyr, K1
Speck, B1
Ritz, R1
Cornu, P1
Buckner, CD1
Doutlik, S1
Kouba, K1
Geils, GF1
Scott, CW1
Baugh, CM1
Blount, RE1
Verdrager, J1

Reviews

1 review available for pyrimethamine and Brain Diseases

ArticleYear
[Empirical anti-toxoplasma therapy in cerebral AIDS and Chagas disease. Presentation of 2 cases, review of the literature and proposal of an algorithm].
    Medicina, 1998, Volume: 58, Issue:5 Pt 1

    Topics: Adult; AIDS-Related Opportunistic Infections; Algorithms; Antiprotozoal Agents; Brain Diseases; Chag

1998

Other Studies

33 other studies available for pyrimethamine and Brain Diseases

ArticleYear
Congenital toxoplasmosis in a neonate with significant neurologic manifestations.
    Journal of the Formosan Medical Association = Taiwan yi zhi, 2012, Volume: 111, Issue:4

    Topics: Adult; Antibodies, Protozoan; Antiprotozoal Agents; Brain Diseases; Female; Fetal Growth Retardation

2012
[2 CASES OF CONGENITAL TOXOPLASMOSIS].
    Klinika oczna, 1964, Volume: 34

    Topics: Adrenal Cortex Hormones; Brain Diseases; Calcinosis; Child; Chlortetracycline; Drug Therapy; Erythro

1964
[BILATERAL FACIAL PARALYSIS AND ACQUIRED TOXOPLASMOSIS IN A 4-YEAR-OLD CHILD].
    Helvetica paediatrica acta, 1964, Volume: 19

    Topics: Brain Diseases; Child; Drug Therapy; Facial Paralysis; Humans; Paralysis; Pyrimethamine; Sulfisoxazo

1964
Management of Plasmodium falciparum malaria.
    The Medical journal of Australia, 1984, Oct-13, Volume: 141, Issue:8

    Topics: Amodiaquine; Anemia; Antimalarials; Brain Diseases; Chloroquine; Drug Resistance; Female; Humans; Hy

1984
Acute acquired toxoplasmosis.
    Annals of ophthalmology, 1981, Volume: 13, Issue:4

    Topics: Brain Diseases; Drug Therapy, Combination; Endophthalmitis; Female; Humans; Middle Aged; Pyrimethami

1981
[Neuroendocrine syndromes with toxoplasmic origin: clinical and therapeutic considerations].
    La Clinica terapeutica, 1980, Jul-15, Volume: 94, Issue:1

    Topics: Adult; Brain Diseases; Child; Chloroquine; Female; Fenfluramine; Humans; Pyrimethamine; Sulfamethoxy

1980
Treatment of toxoplasmosis during pregnancy: a multicenter study of impact on fetal transmission and children's sequelae at age 1 year.
    American journal of obstetrics and gynecology, 1999, Volume: 180, Issue:2 Pt 1

    Topics: Animals; Antibodies, Protozoan; Antiprotozoal Agents; Brain Diseases; Calcinosis; Choroid Diseases;

1999
[Symptomatology, diagnosis, and treatment of nervous tissue affecting toxoplasmosis in adult (author's transl)].
    Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1978, Volume: 46, Issue:5

    Topics: Adult; Brain Diseases; Diagnosis, Differential; Female; Humans; Immunosuppression Therapy; Male; Mul

1978
The effect of chemo-immunotherapy with SDDS, pyrimethamine and anti-toxoplasma serum on toxoplasma gondii cysts in latent infected NMRI mice.
    Tropenmedizin und Parasitologie, 1977, Volume: 28, Issue:4

    Topics: Animals; Brain Diseases; Cysts; Dapsone; Female; Immunotherapy; Mice; Mice, Inbred Strains; Pyrimeth

1977
Chadwick lecture. Cerebral malaria--the quest for suitable experimental models in parasitic diseases of man.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1976, Volume: 70, Issue:1

    Topics: Africa; Animals; Brain; Brain Diseases; Disease Models, Animal; Drug Resistance; Haplorhini; Humans;

1976
[Encephalic pseudotumoral toxoplasmosis in the course of blood diseases].
    La Nouvelle presse medicale, 1975, Oct-18, Volume: 4, Issue:35

    Topics: Brain; Brain Diseases; Drug Therapy, Combination; Female; Hodgkin Disease; Humans; Immunosuppression

1975
Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Animals; Brain Diseases; Chronic Disease; Clarith

1992
Twice-weekly dapsone-pyrimethamine for preventing PCP and cerebral toxoplasmosis.
    AIDS (London, England), 1991, Volume: 5, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Dapsone; Drug Administration Schedule; Drug Ther

1991
[Cerebral toxoplasmosis as a cause of treatable dementia in an aged patient].
    Medicina clinica, 1991, Apr-20, Volume: 96, Issue:15

    Topics: Acquired Immunodeficiency Syndrome; Aged; Brain; Brain Diseases; Dementia; Humans; Male; Pyrimethami

1991
Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Brain Diseases; Clindamycin; Drug Therapy, Combin

1991
[Encephalic toxoplasmosis in patients with the acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases].
    Medicina clinica, 1990, Oct-13, Volume: 95, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Biopsy; Brain; Brain Diseases; Clindamycin; Drug

1990
[Ocular toxoplasmosis in AIDS].
    Annales de medecine interne, 1990, Volume: 141, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Humans; Male; Middle Aged; Opportunistic

1990
[Acute pancytopenia induced by pyrimethamine during treatment of cerebral toxoplasmosis associated with AIDS. Role of dihydrofolate reductase inhibitors].
    Annales de medecine interne, 1990, Volume: 141, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; Brain Diseases; Folic Acid Antagonists; Fo

1990
Low-dose alternate-day pyrimethamine for maintenance therapy in cerebral toxoplasmosis complicating AIDS.
    The Journal of infection, 1990, Volume: 21, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Brain Diseases; Drug Administratio

1990
Interpreting negative test results.
    Hospital practice (Office ed.), 1989, Aug-15, Volume: 24, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Diagnosis, Differential; False Negative R

1989
[Cerebral toxoplasmosis in patients with AIDS].
    Archivos de neurobiologia, 1989, Volume: 52 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Drug Evaluation; Drug Therapy, Combinatio

1989
Sulfadiazine revisited.
    The Journal of infectious diseases, 1989, Volume: 160, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Brain Diseases; Crystallization; D

1989
An open study of the pyrimethamine-clindamycin combination in AIDS patients with brain toxoplasmosis.
    The Journal of infectious diseases, 1989, Volume: 160, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Clindamycin; Drug Therapy, Combination; Humans;

1989
[Cerebral toxoplasmosis in the acquired immunodeficiency syndrome. Study of the clinical, radiological, and pathological findings in 10 cases].
    Medicina clinica, 1988, May-28, Volume: 91, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Brain Abscess; Brain Diseases; Humans; Opportunistic Infections;

1988
Clindamycin in cerebral toxoplasmosis.
    The American journal of medicine, 1988, Volume: 85, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Clindamycin; Drug Therapy, Combination; Humans;

1988
[Cerebral toxoplasmosis in immunosuppressed patients: diagnosis and treatment].
    Annales de medecine interne, 1987, Volume: 138, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Drug Combinations; Female; Humans; Leucom

1987
Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients.
    Annals of neurology, 1986, Volume: 19, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Brain Diseases; Central Nervous System; Clindamyc

1986
[Treatment of cerebral malaria with a fansidar-hydergine combination].
    Bulletin de la Societe medicale d'Afrique noire de langue francaise, 1973, Volume: 18, Issue:3

    Topics: Adolescent; Adult; Antimalarials; Brain Diseases; Child; Child, Preschool; Coma; Drug Combinations;

1973
[Cerebral tropical malaria with blackwater fever. A current diagnostic and therapeutic problem].
    Schweizerische medizinische Wochenschrift, 1974, Nov-09, Volume: 104, Issue:45

    Topics: Acute Kidney Injury; Adult; Blackwater Fever; Brain Diseases; Chloroquine; Disseminated Intravascula

1974
[The neurologic manifestations of toxoplasmosis].
    Psychiatrie, Neurologie, und medizinische Psychologie, 1974, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Brain Diseases; Child; Child, Preschool; Diagnosis, Differential; Female; Humans;

1974
Treatment of meningeal leukemia with pyrimethamine.
    Blood, 1971, Volume: 38, Issue:2

    Topics: Adult; Brain Diseases; Folic Acid; Hallucinations; Humans; Leukemia, Myeloid, Acute; Male; Meninges;

1971
Management of chloroquine resistant falciparum malaria.
    Transactions of the American Clinical and Climatological Association, 1967, Volume: 78

    Topics: Adult; Brain Diseases; Chloroquine; Dapsone; Dexamethasone; Drug Resistance, Microbial; Edema; Human

1967
Cerebral malaria following blood transfusion.
    The Journal of tropical medicine and hygiene, 1969, Volume: 72, Issue:6

    Topics: Adult; Brain Diseases; Chloroquine; Communicable Disease Control; Disease Reservoirs; Humans; Malari

1969
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