pyrimethamine has been researched along with Aneuploid in 14 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "The synopsis of the in vivo test results in the first collaborative CEC Aneuploidy Project with 10 selected chemicals, colchicine (COL), econazole (EZ), chloral hydrate (CH), hydroquinone (HQ), diazepam (DZ), thiabendazole (TB), cadmium chloride (CD), thimerosal (TM), pyrimethamine (PY) and vinblastine (VBL), allowed several conclusions." | 4.78 | Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study. ( Adler, ID, 1993) |
| "Aneuploidy is a major cause of human reproductive failure and an important contributor to cancer and it is therefore important that any increase in its frequency due to chemical exposures should be recognized and controlled." | 2.41 | Detection and characterization of mechanisms of action of aneugenic chemicals. ( Corso, C; Doherty, A; Haddad, F; Hermine, TF; Johnson, G; Kayani, M; Parry, EM; Parry, JM; Quick, E; Warr, T; Williamson, J, 2002) |
| "Pyrimethamine did not inhibit the assembly of microtubules, but produced aberrant forms." | 1.29 | Effects of potential aneuploidy inducing agents on microtubule assembly in vitro. ( Hartley-Asp, B; Wallin, M, 1993) |
| "The test chemicals included in the EC Aneuploidy Project were evaluated for their ability to induce aneuploidy or aneuploidy related endpoints in assays using in vitro tubulin polymerisation, fungi and wheat." | 1.29 | An evaluation of the use of in vitro tubulin polymerisation, fungal and wheat assays to detect the activity of potential chemical aneugens. ( Parry, JM, 1993) |
| "Cadmium chloride was negative in the chromosome enumeration assay and hydroquinone yielded inconclusive results." | 1.29 | A comparison of two in vitro mammalian cell cytogenetic assays for the detection of mitotic aneuploidy using 10 known or suspected aneugens. ( Parry, EM; Parry, JM; Warr, TJ, 1993) |
| "Mitomycin-C (MMC) was used as a positive control for the induction of micronuclei." | 1.29 | The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens. ( Lynch, AM; Parry, JM, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 12 (85.71) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parry, EM | 2 |
| Parry, JM | 5 |
| Corso, C | 1 |
| Doherty, A | 1 |
| Haddad, F | 1 |
| Hermine, TF | 1 |
| Johnson, G | 1 |
| Kayani, M | 1 |
| Quick, E | 1 |
| Warr, T | 1 |
| Williamson, J | 1 |
| Natarajan, AT | 2 |
| Leopardi, P | 1 |
| Zijno, A | 1 |
| Bassani, B | 1 |
| Pacchierotti, F | 1 |
| Adler, ID | 1 |
| Wallin, M | 1 |
| Hartley-Asp, B | 1 |
| Warr, TJ | 1 |
| Sors, A | 1 |
| Duivenvoorden, WC | 1 |
| Meijers, M | 1 |
| Zwanenburg, TS | 1 |
| Lynch, AM | 1 |
| Gibson, DP | 1 |
| Aardema, MJ | 2 |
| Kerckaert, GA | 1 |
| Carr, GJ | 1 |
| Brauninger, RM | 1 |
| LeBoeuf, RA | 1 |
| Mailhes, JB | 1 |
| Marchetti, F | 1 |
| Crebelli, R | 1 |
| Conti, G | 1 |
| Conti, L | 1 |
| Carere, A | 1 |
| Dyban, AP | 1 |
3 reviews available for pyrimethamine and Aneuploid
| Article | Year |
|---|---|
Detection and characterization of mechanisms of action of aneugenic chemicals.
Topics: Aneuploidy; Animals; Benzhydryl Compounds; Cell Line; DNA Helicases; DNA-Binding Proteins; Folic Aci | 2002 |
Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Chromos | 1993 |
The detection and assessment of the aneugenic potential of environmental chemicals: the European Community Aneuploidy Project.
Topics: Aneuploidy; Animals; Aspergillus; Cadmium; Cadmium Chloride; Cell Cycle; Cells, Cultured; Chloral Hy | 1993 |
11 other studies available for pyrimethamine and Aneuploid
| Article | Year |
|---|---|
An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Cells, Cultured; Chloral H | 1993 |
In vivo studies on chemically induced aneuploidy in mouse somatic and germinal cells.
Topics: Aneuploidy; Animals; Bone Marrow; Cadmium; Cadmium Chloride; Chloral Hydrate; Chlorides; Colchicine; | 1993 |
Effects of potential aneuploidy inducing agents on microtubule assembly in vitro.
Topics: Aneuploidy; Animals; Brain; Cadmium; Cadmium Chloride; Cattle; Chloral Hydrate; Chlorides; Colchicin | 1993 |
An evaluation of the use of in vitro tubulin polymerisation, fungal and wheat assays to detect the activity of potential chemical aneugens.
Topics: Aneuploidy; Animals; Aspergillus nidulans; Cadmium; Cadmium Chloride; Chloral Hydrate; Chlorides; Co | 1993 |
A comparison of two in vitro mammalian cell cytogenetic assays for the detection of mitotic aneuploidy using 10 known or suspected aneugens.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Centromere; Chloral Hydrat | 1993 |
Induction of mitotic aneuploidy using Chinese hamster primary embryonic cells. Test results of 10 chemicals.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Colchic | 1993 |
The cytochalasin-B micronucleus/kinetochore assay in vitro: studies with 10 suspected aneugens.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Centromere; Chloral Hydrat | 1993 |
Detection of aneuploidy-inducing carcinogens in the Syrian hamster embryo (SHE) cell transformation assay.
Topics: Aneuploidy; Animals; Asbestos; Benomyl; Cadmium; Cadmium Chloride; Carcinogenicity Tests; Carcinogen | 1995 |
Investigation of aneuploidy induction in mouse oocytes following exposure to vinblastine-sulfate, pyrimethamine, diethylstilbestrol diphosphate, or chloral hydrate.
Topics: Aneuploidy; Animals; Chloral Hydrate; Diethylstilbestrol; Dose-Response Relationship, Drug; Female; | 1993 |
In vitro studies with nine known or suspected spindle poisons: results in tests for chromosome malsegregation in Aspergillus nidulans.
Topics: Aneuploidy; Aspergillus nidulans; Cadmium; Cadmium Chloride; Chloral Hydrate; Chromosomes, Fungal; C | 1991 |
[Study of early stages of embryogenesis of mammals with induced chromosomal aberrations].
Topics: Aneuploidy; Animals; Autoradiography; Chromosome Aberrations; Diploidy; DNA; Embryo, Mammalian; Embr | 1970 |