Compounds > pyrimethamine
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pyrimethamine and Amaurotic Familial Idiocy

pyrimethamine has been researched along with Amaurotic Familial Idiocy in 2 studies

Maloprim: contains above 2 cpds

Amaurotic Familial Idiocy: An outdated term for Tay-Sachs disease.

Research Excerpts

ExcerptRelevanceReference
"Pyrimethamine (PMT) was previously shown to act as a HexA chaperone in human fibroblasts in vitro carrying some (e."2.80Effect of cyclic, low dose pyrimethamine treatment in patients with Late Onset Tay Sachs: an open label, extended pilot study. ( Elstein, D; Fattal-Valevski, A; Lerman-Sagie, T; Navon, R; Osher, E; Peleg, L; Sagie, L; Sagiv, N; Stern, N; Urshanski, N; Valevski, A; Zimran, A, 2015)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Osher, E2
Fattal-Valevski, A2
Sagie, L2
Urshanski, N2
Sagiv, N1
Peleg, L2
Lerman-Sagie, T2
Zimran, A2
Elstein, D2
Navon, R2
Valevski, A2
Stern, N2
Amir-Levi, Y1
Katzburg, S1

Trials

2 trials available for pyrimethamine and Amaurotic Familial Idiocy

ArticleYear
Effect of cyclic, low dose pyrimethamine treatment in patients with Late Onset Tay Sachs: an open label, extended pilot study.
    Orphanet journal of rare diseases, 2015, Apr-17, Volume: 10

    Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation, E

2015
Pyrimethamine increases β-hexosaminidase A activity in patients with Late Onset Tay Sachs.
    Molecular genetics and metabolism, 2011, Volume: 102, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Dose-Response Relationship, Drug; Enzyme Activation; Female; Folic A

2011