Compounds > pyrimethamine
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pyrimethamine and Agranulocytosis

pyrimethamine has been researched along with Agranulocytosis in 18 studies

Maloprim: contains above 2 cpds

Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).

Research Excerpts

ExcerptRelevanceReference
"A case of agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone) is described."7.67Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone). ( Barker, LC; Barton, CJ; Booth, F; Naik, RB, 1984)
"We report a patient who developed agranulocytosis following exposure to three drugs: amodiaquine, pyrimethamine and dipyrone."7.67Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum. ( Douer, D; Ramot, B; Schwartz, E; Shaked, N, 1985)
"Generally, agranulocytosis is associated with older individuals (>60 years) and those of non-Caucasian descent."6.41Dapsone-mediated agranulocytosis: risks, possible mechanisms and prevention. ( Coleman, MD, 2001)
"We report a patient who developed agranulocytosis following exposure to three drugs: amodiaquine, pyrimethamine and dipyrone."3.67Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum. ( Douer, D; Ramot, B; Schwartz, E; Shaked, N, 1985)
"Generally, agranulocytosis is associated with older individuals (>60 years) and those of non-Caucasian descent."2.41Dapsone-mediated agranulocytosis: risks, possible mechanisms and prevention. ( Coleman, MD, 2001)
"Twenty-one cases of agranulocytosis following dosage with one tablet of Maloprim given once or twice weekly are reviewed."1.27Agranulocytosis associated with maloprim: review of cases. ( Farquhar, JA; Hutchinson, DB; Whiteman, PD, 1986)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199017 (94.44)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rée, GH1
Friman, G1
Nyström-Rosander, C1
Jonsell, G1
Björkman, A1
Lekås, G1
Svendsrup, B1
Bruce-Chwatt, LJ1
Hutchinson, DB2
Booth, F1
Barker, LC1
Barton, CJ1
Naik, RB1
Vergara, RV1
Coleman, MD1
Whiteman, PD1
Farquhar, JA1
Olsen, VV2
Loft, S2
Christensen, KD1
Whitfield, D1
Ligthelm, RJ1
van Zwienen, J1
Stuiver, PC1
Djajadiningrat, AP1
Christensen, PK1
Douer, D1
Schwartz, E1
Shaked, N1
Ramot, B1
Sheehy, TW1
Reba, RC1
Parks, GR1
Scheuer-Karpin, R1
Weissbach, G1

Reviews

1 review available for pyrimethamine and Agranulocytosis

ArticleYear
Dapsone-mediated agranulocytosis: risks, possible mechanisms and prevention.
    Toxicology, 2001, Apr-12, Volume: 162, Issue:1

    Topics: Agranulocytosis; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antimalarials; Daps

2001

Other Studies

17 other studies available for pyrimethamine and Agranulocytosis

ArticleYear
Reactions to dapsone.
    Lancet (London, England), 1981, Sep-12, Volume: 2, Issue:8246

    Topics: Agranulocytosis; Dapsone; Drug Combinations; Humans; Malaria; Medication Errors; Pyrimethamine

1981
Chemoprophylaxis of malaria in Africa.
    British medical journal (Clinical research ed.), 1983, Feb-12, Volume: 286, Issue:6364

    Topics: Agranulocytosis; Antimalarials; Dapsone; Drug Combinations; Humans; Malaria; Male; Middle Aged; Pyri

1983
Agranulocytosis associated with malaria prophylaxis with Maloprim.
    British medical journal (Clinical research ed.), 1983, Apr-16, Volume: 286, Issue:6373

    Topics: Adult; Aged; Agranulocytosis; Antimalarials; Dapsone; Drug Combinations; Female; Humans; Malaria; Ma

1983
Agranulocytosis associated with Maloprim.
    British medical journal (Clinical research ed.), 1983, May-07, Volume: 286, Issue:6376

    Topics: Aged; Agranulocytosis; Dapsone; Drug Combinations; Female; Humans; Malaria; Middle Aged; Pyrimethami

1983
Agranulocytosis associated with Maloprim.
    British medical journal (Clinical research ed.), 1984, Jan-07, Volume: 288, Issue:6410

    Topics: Agranulocytosis; Antimalarials; Dapsone; Drug Combinations; Humans; Male; Pyrimethamine

1984
Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).
    Postgraduate medical journal, 1984, Volume: 60, Issue:706

    Topics: Agranulocytosis; Antimalarials; Dapsone; Drug Combinations; Humans; Male; Middle Aged; Pyrimethamine

1984
Maloprim--general toxicity or idiosyncrasy?
    Papua and New Guinea medical journal, 1984, Volume: 27, Issue:1

    Topics: Adult; Agranulocytosis; Dapsone; Drug Combinations; Female; Humans; Malaria; Pyrimethamine

1984
Agranulocytosis associated with maloprim: review of cases.
    Human toxicology, 1986, Volume: 5, Issue:4

    Topics: Adult; Agranulocytosis; Antimalarials; Dapsone; Dose-Response Relationship, Drug; Drug Combinations;

1986
Serious reactions during malaria prophylaxis with pyrimethamine-sulfadoxine.
    Lancet (London, England), 1982, Oct-30, Volume: 2, Issue:8305

    Topics: Aged; Agranulocytosis; Antimalarials; Drug Combinations; Female; Humans; Jaundice; Malaria; Male; Mi

1982
Presumptive fatality due to pyrimethamine-sulfadoxine.
    Lancet (London, England), 1982, Dec-04, Volume: 2, Issue:8310

    Topics: Adult; Agranulocytosis; Humans; Malaria; Male; Pyrimethamine; Sulfadoxine; Sulfanilamides

1982
[Stevens-Johnson syndrome and granulopenia induced by sulfadoxine-pyrimethamine (Fansidar)].
    Nederlands tijdschrift voor geneeskunde, 1983, Sep-17, Volume: 127, Issue:38

    Topics: Adult; Agranulocytosis; Antimalarials; Drug Combinations; Female; Humans; Pyrimethamine; Stevens-Joh

1983
[Serious side effects of sulfadoxine/pyrimethamine as antimalarials].
    Ugeskrift for laeger, 1983, Jan-24, Volume: 145, Issue:4

    Topics: Aged; Agranulocytosis; Antimalarials; Chemical and Drug Induced Liver Injury; Female; Humans; Male;

1983
Agranulocytosis associated with the use of amodiaquine for malaria prophylaxis.
    MMWR. Morbidity and mortality weekly report, 1986, Mar-14, Volume: 35, Issue:10

    Topics: Agranulocytosis; Amodiaquine; Drug Combinations; Drug Therapy, Combination; Humans; Malaria; Proguan

1986
Amodiaquine-induced agranulocytosis: drug inhibition of myeloid colonies in the presence of patient's serum.
    Israel journal of medical sciences, 1985, Volume: 21, Issue:4

    Topics: Agranulocytosis; Amodiaquine; Bone Marrow Cells; Colony-Forming Units Assay; Dipyrone; Drug Interact

1985
Combined pyrimethamine-quinine therapy for chloroquine-resistant P. falciparum infections.
    Southern medical journal, 1969, Volume: 62, Issue:2

    Topics: Adolescent; Adult; Agranulocytosis; Anemia, Hemolytic; Chloroquine; Clinical Laboratory Techniques;

1969
[Distrubed granulocytopoiesis following administration of various drugs].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1969, Nov-15, Volume: 24, Issue:22

    Topics: Adult; Aged; Agranulocytosis; Anemia; Antimetabolites; Bone Marrow Examination; Drug-Related Side Ef

1969
[Effects of combined treatment of infantile toxoplasmosis with pyrimethamine (daraprim) and sulfonamides on the blood and bone marrow].
    Zeitschrift fur arztliche Fortbildung, 1965, Jan-01, Volume: 59, Issue:1

    Topics: Agranulocytosis; Anemia, Macrocytic; Drug Synergism; Folic Acid Antagonists; Humans; Infant; Infant,

1965