pyrimethamine has been researched along with Acute Myelogenous Leukemia in 13 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy." | 9.04 | Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976) |
| "Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy." | 5.04 | Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976) |
| "Oral pyrimethamine treatment was effective in two xenograft mouse models and specifically targeted leukemic cells in human AML cell lines and primary patient cells, while CD34+ cells from healthy donors were unaffected." | 1.43 | Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening. ( Blanchard, JE; Brown, E; Chaturvedi, A; Gabdoulline, R; Ganser, A; Görlich, K; Hassell, JA; Heuser, M; Humphries, RK; Jyotsana, N; Lai, CK; Morgan, M; Murphy, C; Sharma, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyagi, T | 1 |
| Itonaga, H | 1 |
| Aosai, F | 1 |
| Taguchi, J | 1 |
| Norose, K | 1 |
| Mochizuki, K | 1 |
| Fujii, H | 1 |
| Furumoto, A | 1 |
| Ohama, M | 1 |
| Karimata, K | 1 |
| Yamanoha, A | 1 |
| Taniguchi, H | 1 |
| Sato, S | 1 |
| Taira, N | 1 |
| Moriuchi, Y | 1 |
| Fukushima, T | 1 |
| Masuzaki, H | 1 |
| Miyazaki, Y | 1 |
| Sharma, A | 1 |
| Jyotsana, N | 1 |
| Lai, CK | 1 |
| Chaturvedi, A | 1 |
| Gabdoulline, R | 1 |
| Görlich, K | 1 |
| Murphy, C | 1 |
| Blanchard, JE | 1 |
| Ganser, A | 1 |
| Brown, E | 1 |
| Hassell, JA | 1 |
| Humphries, RK | 1 |
| Morgan, M | 1 |
| Heuser, M | 1 |
| Ferrante, A | 1 |
| Goh, DH | 1 |
| Kumar, A | 1 |
| Kapoor, AK | 1 |
| Lal, B | 1 |
| Dutta, GP | 1 |
| Swaroop, A | 1 |
| Price, LA | 1 |
| Goldie, JH | 1 |
| Hill, BT | 1 |
| Laszlo, J | 1 |
| Fyfe, MJ | 1 |
| Swedwick, D | 1 |
| Lee, L | 1 |
| Brown, O | 1 |
| Renoux, M | 1 |
| Bernard, JF | 1 |
| Brousse, N | 1 |
| Henin, D | 1 |
| Wiernik, PH | 1 |
| Schimpff, SC | 1 |
| Schiffer, CA | 1 |
| Lichtenfeld, JL | 1 |
| Aisner, J | 1 |
| O'Connell, MJ | 1 |
| Fortner, C | 1 |
| Rose, MS | 1 |
| Black, PJ | 1 |
| Barkhan, P | 1 |
| Hamers, J | 1 |
| van Hove, W | 1 |
| Baele, G | 1 |
| Carey, RM | 1 |
| Kimball, AC | 1 |
| Armstrong, D | 1 |
| Lieberman, PH | 1 |
| Geils, GF | 1 |
| Scott, CW | 1 |
| Baugh, CM | 1 |
1 review available for pyrimethamine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two case reports and review of the literature.
Topics: Adult; Antiprotozoal Agents; Drug Therapy, Combination; Early Diagnosis; Hematopoietic Stem Cell Tra | 2015 |
1 trial available for pyrimethamine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia.
Topics: Acute Disease; Aged; Antineoplastic Agents; Bone Marrow; Central Nervous System Diseases; Cyclophosp | 1976 |
11 other studies available for pyrimethamine and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Folic Acid Antagonists; High-Throughput | 2016 |
The effect of anti-malarial drugs on human natural killer cells in vitro.
Topics: Antimalarials; Cell Line; Chloroquine; Cytotoxicity, Immunologic; Humans; Killer Cells, Natural; Leu | 1984 |
Plasmodium falciparum: drug-resistant malaria complicating leukemias and lymphomas in children.
Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Ther | 1999 |
Methodichlorophen as anti-tumor drug.
Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Small Cell; Carcinoma, | 1975 |
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
Topics: Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Humans; L | 1978 |
[Letter: Blastic meningitis of myeloproliferative syndromes in the acute phase].
Topics: Humans; Intracranial Pressure; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Meningitis; Pyr | 1976 |
Fatal outcome after combined therapy for myeloblastic leukaemia and toxoplasmosis.
Topics: Autopsy; Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; Humans; Leucovorin; Leukemia, Mye | 1973 |
Fatal outcome after combined therapy for myeloblastic leukaemia and toxoplasmosis.
Topics: Aged; Antineoplastic Agents; Bone Marrow Diseases; Cytarabine; Daunorubicin; Humans; Leukemia, Myelo | 1973 |
Letter: Pyrimethamine in prophylaxis of meningeal leukaemia.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Humans; Leukemia; Leukemia, Erythroblastic, Acu | 1974 |
Toxoplasmosis. Clinical experiences in a cancer hospital.
Topics: Adolescent; Adult; Aged; Child; Complement Fixation Tests; Diagnosis, Differential; Female; Hodgkin | 1973 |
Treatment of meningeal leukemia with pyrimethamine.
Topics: Adult; Brain Diseases; Folic Acid; Hallucinations; Humans; Leukemia, Myeloid, Acute; Male; Meninges; | 1971 |