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pyrimethamine and Acute Myelogenous Leukemia

pyrimethamine has been researched along with Acute Myelogenous Leukemia in 13 studies

Maloprim: contains above 2 cpds

Research Excerpts

ExcerptRelevanceReference
"Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy."9.04Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976)
"Sixty-six newly diagnosed patients with acute nonlymphocytic leukemia received either daunorubicin alone or a combination of daunorubicin, cytosine arabinoside, 6-thioguanine, and pyrimethamine for remission-induction therapy."5.04Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia. ( Aisner, J; Fortner, C; Lichtenfeld, JL; O'Connell, MJ; Schiffer, CA; Schimpff, SC; Wiernik, PH, 1976)
"Oral pyrimethamine treatment was effective in two xenograft mouse models and specifically targeted leukemic cells in human AML cell lines and primary patient cells, while CD34+ cells from healthy donors were unaffected."1.43Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening. ( Blanchard, JE; Brown, E; Chaturvedi, A; Gabdoulline, R; Ganser, A; Görlich, K; Hassell, JA; Heuser, M; Humphries, RK; Jyotsana, N; Lai, CK; Morgan, M; Murphy, C; Sharma, A, 2016)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-199010 (76.92)18.7374
1990's1 (7.69)18.2507
2000's0 (0.00)29.6817
2010's2 (15.38)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miyagi, T1
Itonaga, H1
Aosai, F1
Taguchi, J1
Norose, K1
Mochizuki, K1
Fujii, H1
Furumoto, A1
Ohama, M1
Karimata, K1
Yamanoha, A1
Taniguchi, H1
Sato, S1
Taira, N1
Moriuchi, Y1
Fukushima, T1
Masuzaki, H1
Miyazaki, Y1
Sharma, A1
Jyotsana, N1
Lai, CK1
Chaturvedi, A1
Gabdoulline, R1
Görlich, K1
Murphy, C1
Blanchard, JE1
Ganser, A1
Brown, E1
Hassell, JA1
Humphries, RK1
Morgan, M1
Heuser, M1
Ferrante, A1
Goh, DH1
Kumar, A1
Kapoor, AK1
Lal, B1
Dutta, GP1
Swaroop, A1
Price, LA1
Goldie, JH1
Hill, BT1
Laszlo, J1
Fyfe, MJ1
Swedwick, D1
Lee, L1
Brown, O1
Renoux, M1
Bernard, JF1
Brousse, N1
Henin, D1
Wiernik, PH1
Schimpff, SC1
Schiffer, CA1
Lichtenfeld, JL1
Aisner, J1
O'Connell, MJ1
Fortner, C1
Rose, MS1
Black, PJ1
Barkhan, P1
Hamers, J1
van Hove, W1
Baele, G1
Carey, RM1
Kimball, AC1
Armstrong, D1
Lieberman, PH1
Geils, GF1
Scott, CW1
Baugh, CM1

Reviews

1 review available for pyrimethamine and Acute Myelogenous Leukemia

ArticleYear
Successful treatment of toxoplasmic encephalitis diagnosed early by polymerase chain reaction after allogeneic hematopoietic stem cell transplantation: two case reports and review of the literature.
    Transplant infectious disease : an official journal of the Transplantation Society, 2015, Volume: 17, Issue:4

    Topics: Adult; Antiprotozoal Agents; Drug Therapy, Combination; Early Diagnosis; Hematopoietic Stem Cell Tra

2015

Trials

1 trial available for pyrimethamine and Acute Myelogenous Leukemia

ArticleYear
Randomized clinical comparison of daunorubicin (NSC-82151) alone with a combination of daunorubicin, cytosine arabinoside (NSC-63878), 6-thioguanine (NSC-752), and pyrimethamine (NSC-3061) for the treatment of acute nonlymphocytic leukemia.
    Cancer treatment reports, 1976, Volume: 60, Issue:1

    Topics: Acute Disease; Aged; Antineoplastic Agents; Bone Marrow; Central Nervous System Diseases; Cyclophosp

1976

Other Studies

11 other studies available for pyrimethamine and Acute Myelogenous Leukemia

ArticleYear
Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening.
    Current cancer drug targets, 2016, Volume: 16, Issue:9

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Folic Acid Antagonists; High-Throughput

2016
The effect of anti-malarial drugs on human natural killer cells in vitro.
    Parasite immunology, 1984, Volume: 6, Issue:6

    Topics: Antimalarials; Cell Line; Chloroquine; Cytotoxicity, Immunologic; Humans; Killer Cells, Natural; Leu

1984
Plasmodium falciparum: drug-resistant malaria complicating leukemias and lymphomas in children.
    Experimental parasitology, 1999, Volume: 93, Issue:1

    Topics: Adolescent; Animals; Antimalarials; Child; Child, Preschool; Chloroquine; Drug Resistance; Drug Ther

1999
Methodichlorophen as anti-tumor drug.
    British medical journal, 1975, Apr-05, Volume: 2, Issue:5961

    Topics: Adenocarcinoma; Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Small Cell; Carcinoma,

1975
Comparison of metoprine (DDMP) and etoprine (DDEP) by measuring the inhibition of deoxyuridine incorporation into the DNA of human leukemic cells 1,2,3.
    Cancer treatment reports, 1978, Volume: 62, Issue:3

    Topics: Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Humans; L

1978
[Letter: Blastic meningitis of myeloproliferative syndromes in the acute phase].
    La Nouvelle presse medicale, 1976, May-15, Volume: 5, Issue:20

    Topics: Humans; Intracranial Pressure; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Meningitis; Pyr

1976
Fatal outcome after combined therapy for myeloblastic leukaemia and toxoplasmosis.
    Lancet (London, England), 1973, Mar-31, Volume: 1, Issue:7805

    Topics: Autopsy; Bone Marrow; Bone Marrow Cells; Cytarabine; Daunorubicin; Humans; Leucovorin; Leukemia, Mye

1973
Fatal outcome after combined therapy for myeloblastic leukaemia and toxoplasmosis.
    Lancet (London, England), 1973, Mar-17, Volume: 1, Issue:7803

    Topics: Aged; Antineoplastic Agents; Bone Marrow Diseases; Cytarabine; Daunorubicin; Humans; Leukemia, Myelo

1973
Letter: Pyrimethamine in prophylaxis of meningeal leukaemia.
    Lancet (London, England), 1974, Feb-23, Volume: 1, Issue:7852

    Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Humans; Leukemia; Leukemia, Erythroblastic, Acu

1974
Toxoplasmosis. Clinical experiences in a cancer hospital.
    The American journal of medicine, 1973, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Aged; Child; Complement Fixation Tests; Diagnosis, Differential; Female; Hodgkin

1973
Treatment of meningeal leukemia with pyrimethamine.
    Blood, 1971, Volume: 38, Issue:2

    Topics: Adult; Brain Diseases; Folic Acid; Hallucinations; Humans; Leukemia, Myeloid, Acute; Male; Meninges;

1971