Page last updated: 2024-11-03

pyrimethamine and Acquired Immune Deficiency Syndrome

pyrimethamine has been researched along with Acquired Immune Deficiency Syndrome in 105 studies

Maloprim: contains above 2 cpds

Research Excerpts

ExcerptRelevanceReference
"In this international, noncomparative, randomized phase II trial, we evaluated the effectiveness and tolerance of atovaquone suspension (1500 mg orally twice daily) plus either pyrimethamine (75 mg per day after a 200-mg loading dose) or sulfadiazine (1500 mg 4 times daily) as treatment for acute disease (for 6 weeks) and as maintenance therapy (for 42 weeks) for toxoplasmic encephalitis (TE) in patients infected with human immunodeficiency virus."9.10Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche ( Andersen, J; Bosler, EM; Chirgwin, K; Hafner, R; Jayaweera, DT; Leport, C; Luft, BJ; McAuliffe, V; Morlat, P; Rajicic, N; Remington, J; Roque, C; Vilde, JL, 2002)
"Sixty-five patients intolerant of conventional toxoplasmic encephalitis therapies-pyrimethamine, sulphadiazine or clindamycin-received atovaquone as maintenance therapy after resolution of an acute episode of toxoplasmic encephalitis."9.08Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. ( Gourdon, D; Katlama, C; Lapierre, D; Mouthon, B; Rousseau, F, 1996)
"The interim results are presented of an ongoing large-scale, prospective, randomized study to determine the potential role of clindamycin in the treatment of toxoplasmic encephalitis."9.07Treatment of acute toxoplasmosis with intravenous clindamycin. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Dannemann, BR; Israelski, DM; Leport, C; Luft, BJ; McCutchan, JA; Nussbaum, JN; Orellana, M; Vildé, JL, 1991)
"A double-blind, placebo-controlled trial was set up to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis (TE) in HIV-infected patients at risk of the disorder."9.07Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS. ( Besch, CL; Child, C; Deyton, L; Hafner, R; Jacobson, MA; Matts, JP; Muth, K; Wentworth, DN, 1992)
"To compare pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfadiazine (PS) as a treatment for toxoplasmic encephalitis (TE) in patients with the acquired immunodeficiency syndrome (AIDS)."9.07Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Clumeck, N; Dannemann, B; Israelski, D; Leport, C; Luft, B; McCutchan, JA; Morlat, P; Nussbaum, J, 1992)
"Cerebral toxoplasmosis related to AIDS was treated with a combination regimen of pyrimethamine, clindamycin, and spiramycin, and in a second trial with a combination of pyrimethamine and clindamycin."7.68Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system. ( Pohle, HD; Ruf, B, 1991)
"Fourteen patients with AIDS and toxoplasmic encephalitis, who could not be treated with the standard regimen of pyrimethamine and a sulfonamide due to a previous history of bone marrow suppression and severe allergic reactions to sulfonamides, were treated with oral clindamycin and pyrimethamine."7.68A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine. ( Bini, T; Esposito, R; Foppa, CU; Gregis, G; Lazzarin, A; Moroni, M, 1991)
"The combination of pyrimethamine and clindamycin, both administered orally, was evaluated for initial and maintenance therapy of toxoplasmosis in eight AIDS patients who were either allergic to sulfonamides or unresponsive to standard therapy."7.68Treatment of acute toxoplasmosis with oral clindamycin. ( Rolston, KV, 1991)
"Thirty-five patients with the acquired immunodeficiency syndrome (AIDS) and central nervous system toxoplasmosis, seen over a 30-month period, were treated with the combination pyrimethamine/sulfadiazine."7.67Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapy. ( Katlama, C; Leport, C; Marche, C; Matheron, S; Raffi, F; Regnier, B; Saimot, AG; Vedrenne, C; Vilde, JL, 1988)
"Three patients with acquired immune deficiency syndrome (AIDS), central nervous system toxoplasmosis, and hypersensitivity to sulfadiazine were given treatment with clindamycin plus pyrimethamine."7.67Role of clindamycin in the treatment of central nervous system toxoplasmosis. ( Hoy, J; Rolston, KV, 1987)
"Toxoplasma gondii encephalitis is an important opportunistic infection in the acquired immunodeficiency syndrome, estimated to occur in 20,000 to 40,000 patients with acquired immunodeficiency syndrome in the United States by 1991."6.38Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. ( Brosius, FC; Rothstein, DM; Simon, DI, 1990)
"In this international, noncomparative, randomized phase II trial, we evaluated the effectiveness and tolerance of atovaquone suspension (1500 mg orally twice daily) plus either pyrimethamine (75 mg per day after a 200-mg loading dose) or sulfadiazine (1500 mg 4 times daily) as treatment for acute disease (for 6 weeks) and as maintenance therapy (for 42 weeks) for toxoplasmic encephalitis (TE) in patients infected with human immunodeficiency virus."5.10Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche ( Andersen, J; Bosler, EM; Chirgwin, K; Hafner, R; Jayaweera, DT; Leport, C; Luft, BJ; McAuliffe, V; Morlat, P; Rajicic, N; Remington, J; Roque, C; Vilde, JL, 2002)
"Sixty-five patients intolerant of conventional toxoplasmic encephalitis therapies-pyrimethamine, sulphadiazine or clindamycin-received atovaquone as maintenance therapy after resolution of an acute episode of toxoplasmic encephalitis."5.08Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group. ( Gourdon, D; Katlama, C; Lapierre, D; Mouthon, B; Rousseau, F, 1996)
"The interim results are presented of an ongoing large-scale, prospective, randomized study to determine the potential role of clindamycin in the treatment of toxoplasmic encephalitis."5.07Treatment of acute toxoplasmosis with intravenous clindamycin. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Dannemann, BR; Israelski, DM; Leport, C; Luft, BJ; McCutchan, JA; Nussbaum, JN; Orellana, M; Vildé, JL, 1991)
"A double-blind, placebo-controlled trial was set up to compare clindamycin and pyrimethamine as prophylaxis for toxoplasmic encephalitis (TE) in HIV-infected patients at risk of the disorder."5.07Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS. ( Besch, CL; Child, C; Deyton, L; Hafner, R; Jacobson, MA; Matts, JP; Muth, K; Wentworth, DN, 1992)
"We retrospectively examined 39 patients with AIDS and central nervous system toxoplasmosis in order to determine the efficacy and safety of two combinations: pyrimethamine-sulfadiazine and pyrimethamine-clindamycin."5.07Comparison of two medications in central nervous system toxoplasmosis in patients with AIDS. ( Ammassari, A; Antinori, A; Camilli, G; Damiano, F; Federico, G; Maiuro, G; Pizzigallo, E; Tamburrini, E, 1992)
"To compare pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfadiazine (PS) as a treatment for toxoplasmic encephalitis (TE) in patients with the acquired immunodeficiency syndrome (AIDS)."5.07Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group. ( Antoniskis, D; Chiu, J; Clumeck, N; Dannemann, B; Israelski, D; Leport, C; Luft, B; McCutchan, JA; Morlat, P; Nussbaum, J, 1992)
"The widespread emergence of chloroquine-resistant Plasmodium falciparum led to the formulation of an effective, fixed combination of two antimalarial agents, pyrimethamine and the long-acting sulfonamide sulfadoxine, for prophylaxis and treatment."4.77Use of pyrimethamine-sulfadoxine (Fansidar) in prophylaxis against chloroquine-resistant Plasmodium falciparum and Pneumocystis carinii. ( Hewlett, EL; Pearson, RD, 1987)
"In 26 AIDS patients treated for toxoplasmic encephalitis, the inhibitory effect on Toxoxplasma growth of sequential sera taken before and after initiation of therapy was determined using a culture-based immunoassay and compared with pyrimethamine blood levels."3.70Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis. ( Derouin, F; Farinotti, R; Gérard, L; Leport, C; Maslo, C, 1998)
"A proportion of patients with AIDS and toxoplasmic encephalitis (TE) sustain low plasma pyrimethamine concentrations during oral treatment, possibly because of incomplete and variable bioavailability."3.70Disposition of intravenous pyrimethamine in healthy volunteers. ( Almond, DS; Edwards, G; Lee, MG; Szwandt, IS; Winstanley, PA, 2000)
"The combination of pyrimethamine and clindamycin, both administered orally, was evaluated for initial and maintenance therapy of toxoplasmosis in eight AIDS patients who were either allergic to sulfonamides or unresponsive to standard therapy."3.68Treatment of acute toxoplasmosis with oral clindamycin. ( Rolston, KV, 1991)
"Fourteen patients with AIDS and toxoplasmic encephalitis, who could not be treated with the standard regimen of pyrimethamine and a sulfonamide due to a previous history of bone marrow suppression and severe allergic reactions to sulfonamides, were treated with oral clindamycin and pyrimethamine."3.68A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine. ( Bini, T; Esposito, R; Foppa, CU; Gregis, G; Lazzarin, A; Moroni, M, 1991)
"Cerebral toxoplasmosis related to AIDS was treated with a combination regimen of pyrimethamine, clindamycin, and spiramycin, and in a second trial with a combination of pyrimethamine and clindamycin."3.68Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system. ( Pohle, HD; Ruf, B, 1991)
"Thirty-five patients with the acquired immunodeficiency syndrome (AIDS) and central nervous system toxoplasmosis, seen over a 30-month period, were treated with the combination pyrimethamine/sulfadiazine."3.67Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapy. ( Katlama, C; Leport, C; Marche, C; Matheron, S; Raffi, F; Regnier, B; Saimot, AG; Vedrenne, C; Vilde, JL, 1988)
"The combination of pyrimethamine and sulfadoxine (Fansidar) has been reported to cause severe skin reactions including erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis."3.67Fatal toxic epidermal necrolysis during prophylaxis with pyrimethamine and sulfadoxine in a human immunodeficiency virus-infected person. ( Dinan, WA; Pablos-Mendez, A; Palagiano, A; Raviglione, MC; Sabatini, MT, 1988)
"Three patients with acquired immune deficiency syndrome (AIDS), central nervous system toxoplasmosis, and hypersensitivity to sulfadiazine were given treatment with clindamycin plus pyrimethamine."3.67Role of clindamycin in the treatment of central nervous system toxoplasmosis. ( Hoy, J; Rolston, KV, 1987)
"Cerebral toxoplasmosis is the most frequent opportunistic infection in patients with acquired immune deficiency syndrome in France."2.67[Primary prophylaxis against cerebral toxoplasmosis. Efficacy of folinic acid in the prevention of hematologic toxicity of pyrimethamine]. ( Barbeau, P; Brossard, G; Leng, B; Neau, D; Pellegrin, JL, 1994)
"Toxoplasmic encephalitis in AIDS patients was usually treated with sulfonamides combined with other drugs and the pooled CR was 49."2.52A Systematic Review and Meta-Analysis of the Efficacy of Anti-Toxoplasma gondii Medicines in Humans. ( Lindsay, DS; Peng, HJ; Wei, HX; Wei, SS, 2015)
"Toxoplasma gondii encephalitis is an important opportunistic infection in the acquired immunodeficiency syndrome, estimated to occur in 20,000 to 40,000 patients with acquired immunodeficiency syndrome in the United States by 1991."2.38Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome. ( Brosius, FC; Rothstein, DM; Simon, DI, 1990)
"In patients with AIDS, toxoplasmosis is the most common cause of CNS mass lesions."2.38Toxoplasmosis in AIDS patients. ( Tuazon, CU, 1989)
" Dosage must be adjusted to the results of blood counts."2.38[Usefulness of folinic acid in cytopenia induced by antiparasitic drugs in AIDS patients]. ( Leport, C; Niyongabo, T; Vildé, JL, 1991)
"The literature on toxoplasmosis in the acquired immune deficiency syndrome is reviewed with reference to more than 140 cases from various centres."2.37Toxoplasmosis and the acquired immune deficiency syndrome. ( Holliman, RE, 1988)
"We describe the course of 36 AIDS patients with cerebral toxoplasmosis and present a review of clinical signs, diagnosis, therapy, and survival times."1.31[HIV-associated cerebral toxoplasmosis -- review and retrospective analysis of 36 patients]. ( Evers, S; Fischer, A; Freund, M; Grüneberg, U; Happe, S; Heese, Ch; Husstedt, IW; Kloska, S; Reichelt, D, 2002)
"To analyse the incidence of Pneumocystis carinii pneumonia after the withdrawal of prophylaxis, in patients with AIDS who were receiving HAART (highly active antiretroviral treatment)."1.30[Withdrawal of Pneumocystis carinii pneumonia prophylaxis in patients receiving efficacious combined antiretroviral treatment. Study of 85 cases]. ( de Górgolas Hernández, M; Fernández Guerrero, ML; García Delgado, R; García Vázquez, E, 1999)
"ET was the AIDS-defining condition in 44% of the patients."1.29[Cerebral toxoplasmosis in patients with human immunodeficiency virus (HIV) infection. Clinico-radiological and therapeutic aspects in 63 patients]. ( Barrio, JL; Cadafalch, J; Domingo, P; Ferrer, S; Fuentes, I; Fuster, M; Iranzo, A; Muñoz, C; Nolla, J; Ris, J; Sambeat, MA, 1996)
"The anticryptosporidial activity of four macrolides alone and in combination with other antimicrobial agents was investigated against ten clinical isolates of Cryptosporidium parvum recovered from stools of AIDS patients."1.29In-vitro activity of macrolides alone and in combination with artemisin, atovaquone, dapsone, minocycline or pyrimethamine against Cryptosporidium parvum. ( Cirioni, O; Giacometti, A; Scalise, G, 1996)
"Nineteen cases of cerebral toxoplasmosis (CTOX) are reported from a group of Edinburgh AIDS patients."1.29Clinical features, outcome and survival from cerebral toxoplasmosis in Edinburgh AIDS patients. ( Brettle, RP; Burns, SM; Flegg, PJ; Laing, RB; Leen, CL, 1996)
"In particular, in patients with AIDS who are more susceptible for adverse drug reactions and who are simultaneously receiving a variety of drugs with a considerable potential of cutaneous side effects, therapy cannot be withhold for lack of therapeutic alternatives."1.29[Drug-induced Stevens-Johnson syndrome in a patient with AIDS]. ( Bircher, A; Haefeli, WE; Leib, SL; Lüscher, TF; Schlienger, RG, 1993)
"Pneumocystis carinii pneumonia has been the most common life-threatening opportunistic infection in patients with acquired immunodeficiency syndrome."1.29Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia. ( Glatt, AE, 1994)
"gondii cysts in their brains."1.28Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis. ( Araujo, FG; Lin, T; Prokocimer, P; Remington, JS, 1992)
"No relapse was observed in those receiving P/S, but 40% of those treated with P/C relapsed."1.28[Encephalic toxoplasmosis in patients with the acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases]. ( Alvarez, R; Gatell, JM; González-Clemente, JM; Graus, F; Guelar, A; Jiménez de Anta, MT; Mallolas, J; Mercader, JM; Miró, JM; Pedrol, E, 1990)
"Pulmonary toxoplasmosis in AIDS is rare."1.28[Pulmonary toxoplasmosis in AIDS. Report of 3 cases]. ( Bouslama, K; Cabane, J; Gonzalez Canali, G; Imbert, JC; Knani, L; Lebas, J; Varette, C, 1990)
"Eight episodes were proven Pneumocystis carinii pneumonia, 18 satisfied Centres for Disease Control criteria for presumptive Pneumocystis carinii pneumonia and 11 lacked one Centres for Disease Control criterion."1.28Experience with pneumocystis carinii pneumonia in patients with AIDS. ( Davis, R; Ellis-Pegler, RB; Ingram, RJ, 1989)
"Patients with cerebral toxoplasmosis have a low risk for subsequently developing P."1.28Treatment for cerebral toxoplasmosis protects against Pneumocystis carinii pneumonia in patients with AIDS. The Swiss HIV Cohort Study. ( Chave, JP; Flepp, M; Gabriel, V; Heald, A; Hirschel, B; Malinverni, R; Renold, C; Rüttimann, S; Sugar, A, 1991)
"In 33 consecutive AIDS patients with a first episode of Pneumocystis carinii pneumonia (PCP) we evaluated treatment, outcome, recurrence rate and pyrimethamine as chemoprophylaxis in a 1-year follow-up."1.28Pneumocystis carinii pneumonia in Stockholm, Sweden: treatment, outcome, one-year-follow-up and pyrimethamine prophylaxis. ( Bergdahl, S; Julander, I; Lidman, C; Lundbergh, P; Ortqvist, A, 1989)
"Toxoplasma encephalitis has been reported as a life-threatening opportunistic infection among patients with the acquired immune deficiency syndrome."1.27Assessment of therapy for toxoplasma encephalitis. The TE Study Group. ( Haverkos, HW, 1987)

Research

Studies (105)

TimeframeStudies, this research(%)All Research%
pre-199037 (35.24)18.7374
1990's59 (56.19)18.2507
2000's6 (5.71)29.6817
2010's2 (1.90)24.3611
2020's1 (0.95)2.80

Authors

AuthorsStudies
Li, Y1
Zeng, YM1
Lu, YQ1
Qin, YY1
Chen, YK1
Wei, HX1
Wei, SS1
Lindsay, DS1
Peng, HJ1
Pfeffer, G1
Prout, A1
Hooge, J1
Maguire, J1
Faucher, B1
Moreau, J1
Zaegel, O1
Franck, J1
Piarroux, R1
Hill, D1
Dubey, JP1
Happe, S1
Fischer, A1
Heese, Ch1
Reichelt, D1
Grüneberg, U1
Freund, M1
Kloska, S1
Evers, S1
Husstedt, IW1
Soto-Hernández, JL1
Moreno-Andrade, T1
Góngora-Rivera, F1
Ramírez-Crescencio, MA1
Gottlieb, MS2
Knight, S1
Mitsuyasu, R1
Weisman, J1
Roth, M1
Young, LS2
Langmann, P1
Klinker, H1
Richter, E1
Potter, JL1
Kofron, WG1
Jurado, R1
Garcia-Herola, A1
Garcia-Lazaro, M1
Kindelan, JM1
Villanueva, JL1
Torre-Cisneros, J1
Brossard, G1
Neau, D1
Barbeau, P1
Pellegrin, JL2
Leng, B1
Glatt, AE1
Schlienger, RG1
Haefeli, WE1
Bircher, A1
Leib, SL1
Lüscher, TF1
Ragnaud, JM1
Morlat, P4
Dupon, M1
Lacoste, D1
Chene, G1
Murray-Pulsifer, K1
Winstanley, P1
Khoo, S1
Szwandt, S1
Edwards, G2
Wilkins, E1
Tija, J1
Coker, R1
McKane, W1
Beeching, N1
Watkin, S1
Halme, M1
Jokipii, L1
Jokipii, AM1
Ristola, M1
Lähdevirta, J1
Antinori, A2
Murri, R1
Ammassari, A2
De Luca, A1
Linzalone, A1
Cingolani, A1
Damiano, F2
Maiuro, G2
Vecchiet, J1
Scoppettuolo, G1
Ferrer, S1
Fuentes, I1
Domingo, P1
Muñoz, C1
Iranzo, A1
Barrio, JL1
Fuster, M1
Ris, J1
Sambeat, MA1
Cadafalch, J1
Nolla, J1
Wei, ME1
Campbell, SH1
Taylor, C1
Moreno García, M1
Fernández González, F1
Fernández Rodríguez, E1
Portús de Marco, MV1
Katlama, C4
Mouthon, B1
Gourdon, D1
Lapierre, D1
Rousseau, F1
Laing, RB1
Flegg, PJ1
Brettle, RP1
Leen, CL1
Burns, SM1
Giacometti, A1
Cirioni, O1
Scalise, G1
Ebrahimzadeh, A1
Bottone, EJ1
de Luis, DA1
Fortun, J1
Pintado, V1
Aller de la Fuente, R1
Schmidt-Westhausen, A1
Grünewald, T1
Reichart, PA1
Pohle, HD2
Derouin, F3
Gérard, L1
Farinotti, R1
Maslo, C1
Leport, C12
Payen, MC1
De Wit, S1
Sommereijns, B1
Clumeck, N2
García Vázquez, E1
de Górgolas Hernández, M1
García Delgado, R1
Fernández Guerrero, ML1
Almond, DS1
Szwandt, IS1
Lee, MG1
Winstanley, PA1
Chirgwin, K1
Hafner, R4
Remington, J1
Andersen, J1
Bosler, EM1
Roque, C1
Rajicic, N1
McAuliffe, V1
Jayaweera, DT1
Vilde, JL10
Luft, BJ4
Jacobson, MA2
Besch, CL2
Child, C2
Matts, JP1
Muth, K2
Wentworth, DN1
Deyton, L2
Meulemans, A1
Robine, D1
Dameron, G1
Camilli, G1
Federico, G1
Pizzigallo, E1
Tamburrini, E1
Araujo, FG1
Prokocimer, P1
Lin, T1
Remington, JS5
Iannucci, AA1
Hart, LL1
Hardy, WD2
Mallolas, J3
Zamora, L1
Gatell, JM3
Miró, JM3
Soriano, E1
Dannemann, B1
McCutchan, JA2
Israelski, D1
Antoniskis, D2
Luft, B1
Nussbaum, J1
Chiu, J2
de Gans, J1
Portegies, P1
Reiss, P1
Troost, D1
van Gool, T1
Lange, JM1
Poizot-Martin, I1
Lafeuillade, A1
Dhiver, C1
Xeri, L1
Bouabdallah, R1
Gamby, T1
Gastaut, JA1
Niyongabo, T2
Fernandez-Martin, J2
Meyohas, MC2
Chauvin, JP1
Vinogradov, NA1
Clotet, B1
Sirera, G1
Romeu, J1
Gimeno, JM1
Jou, A1
Condom, MJ1
Tor, J1
Foz, M1
Heald, A1
Flepp, M1
Chave, JP1
Malinverni, R1
Rüttimann, S1
Gabriel, V1
Renold, C1
Sugar, A1
Hirschel, B1
Díaz Benito, JA1
Rodríguez García, JC1
Piñeiro Gómez-Durán, L1
Rolston, KV3
Ruf, B1
Foppa, CU1
Bini, T1
Gregis, G1
Lazzarin, A1
Esposito, R1
Moroni, M1
Tournerie, C1
Raguin, G1
Dannemann, BR2
Israelski, DM1
Nussbaum, JN1
Orellana, M1
Holliman, RE2
González-Clemente, JM2
Pedrol, E2
Alvarez, R2
Graus, F2
Mercader, JM2
Guelar, A1
Jiménez de Anta, MT2
Lucey, DR1
Lucey, CR1
Simon, DI1
Brosius, FC1
Rothstein, DM1
Knani, L1
Bouslama, K1
Varette, C1
Gonzalez Canali, G1
Cabane, J1
Lebas, J1
Imbert, JC1
Chakroun, M1
Pelosse, B1
Zazoun, L1
Vacherot, B1
Boudes, P1
Zittoun, J1
Sobel, A1
Mitchell, CD1
Erlich, SS1
Mastrucci, MT1
Hutto, SC1
Parks, WP1
Scott, GB1
Grange, F1
Kinney, EL1
Monsuez, JJ1
Rybojad, M1
Khuong, MA1
Janier, M1
Bhatti, N1
Larson, E1
Berenguer, J1
Kassirer, JP1
Kopelman, RI1
Caumes, E1
Feyeux, C1
Garrouste, MT1
Schlemmer, B1
Wallach, D1
Carrazana, EJ1
Rossitch, E1
Samuels, MA1
Lidman, C1
Ortqvist, A1
Lundbergh, P1
Julander, I1
Bergdahl, S1
Altés, J1
Salas, A1
Ricart, C1
Villalonga, C1
Riera, M1
Casquero, P1
Gilman, TM1
Boylen, CT1
Sattler, FR1
Tuazon, CU2
Cohn, JA1
McMeeking, A1
Cohen, W1
Jacobs, J1
Holzman, RS1
Ventura, MG1
Wybran, J1
Farber, CM1
Bastuji-Garin, S1
Perronne, C1
Salmon, D1
Marche, C2
Briçaire, F1
Ingram, RJ1
Davis, R1
Ellis-Pegler, RB1
Navin, TR1
Miller, KD1
Satriale, RF1
Lobel, HO1
Pape, JW1
Verdier, RI1
Johnson, WD1
Kovacs, JA1
Masur, H1
Bonaventura, I1
Romero, F1
Ortega, A1
Navarro, C1
Juste, C1
Codina Puiggrós, A1
Frissen, PH1
Stronkhorst, A1
Eeftinck Schattenkerk, JK1
Danner, SA1
Raviglione, MC1
Dinan, WA1
Pablos-Mendez, A1
Palagiano, A1
Sabatini, MT1
Raffi, F1
Matheron, S2
Regnier, B2
Saimot, AG2
Vedrenne, C1
Weiss, LM1
Harris, C1
Berger, M1
Tanowitz, HB1
Wittner, M1
Fischl, MA1
Dickinson, GM1
Wanke, C1
Kovacs, A1
Dina, T1
Davis, DO1
Barton, N1
Katz, D1
Lunde, M1
Levy, C1
Conley, FK1
Bath, PM1
Lillicrap, DA1
Winter, M1
Pearson, RD1
Hewlett, EL1
Haverkos, HW1
Hoy, J1
Reinert, P1
Bernaudin, F1
Catterall, JR1
Potasman, I1
Navia, BA1
Petito, CK1
Gold, JW1
Cho, ES1
Jordan, BD1
Price, RW1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Randomized Open-Label Trial of Atovaquone Plus Pyrimethamine and Atovaquone Plus Sulfadiazine for the Treatment of Acute Toxoplasmic Encephalitis[NCT00000794]Phase 2100 participants InterventionalCompleted
A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection[NCT00000666]600 participants InterventionalCompleted
Dihydroartemisinin-Piperaquine or Sulphadoxine-Pyrimethamine for the Chemoprevention of Malaria in Children With Sickle Cell Anaemia in Eastern and Southern Africa: a Double Blind Randomised Trial (CHEMCHA)[NCT04844099]Phase 3723 participants (Actual)Interventional2021-04-09Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

16 reviews available for pyrimethamine and Acquired Immune Deficiency Syndrome

ArticleYear
A Systematic Review and Meta-Analysis of the Efficacy of Anti-Toxoplasma gondii Medicines in Humans.
    PloS one, 2015, Volume: 10, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Anti-Infective Agents; Antiprotozoal Agents; Azithromycin; Clind

2015
Toxoplasma gondii: transmission, diagnosis and prevention.
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2002, Volume: 8, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Animals; Antibodies, Protozoan; Cats; Cattle; Deer; Encephalitis

2002
Clindamycin in the treatment of toxoplasmosis in AIDS.
    The Annals of pharmacotherapy, 1992, Volume: 26, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Humans; Pyrimethamine; Retrospective Studies; Sulfa

1992
Prophylaxis of AIDS-related opportunistic infections (OIs). Current status and future strategies.
    AIDS clinical review, 1991

    Topics: Acquired Immunodeficiency Syndrome; Aerosols; Animals; Cryptococcosis; Cytomegalovirus Infections; D

1991
[Cutaneo-mucosal hyperpigmentation in AIDS. 4 cases].
    Presse medicale (Paris, France : 1983), 1991, Apr-13, Volume: 20, Issue:14

    Topics: Acquired Immunodeficiency Syndrome; Adult; Humans; Ketoconazole; Male; Middle Aged; Nail Diseases; P

1991
[Usefulness of folinic acid in cytopenia induced by antiparasitic drugs in AIDS patients].
    Presse medicale (Paris, France : 1983), 1991, Oct-26, Volume: 20, Issue:34

    Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Folic Acid; Hematologic Diseases; Hum

1991
[Diagnosis and treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome].
    Klinicheskaia meditsina, 1991, Volume: 69, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Diagnosis, Differential; Humans; Pneumonia, Pneumoc

1991
Sulfadiazine crystalluria revisited. The treatment of Toxoplasma encephalitis in patients with acquired immunodeficiency syndrome.
    Archives of internal medicine, 1990, Volume: 150, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Acute Kidney Injury; Adult; Crystallization; Drug Therapy, Combi

1990
Prophylaxis of AIDS-related opportunistic infections (OIs).
    AIDS clinical review, 1989

    Topics: Acquired Immunodeficiency Syndrome; Cryptococcosis; Cytomegalovirus Infections; Dapsone; Drug Combin

1989
Pyrimethamine-sulfadiazine for treating Pneumocystis carinii pneumonia and toxoplasmosis in AIDS.
    Clinical pharmacy, 1989, Volume: 8, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Animals; Drug Therapy, Combination; Humans; Pneumonia, Pneumocys

1989
Toxoplasmosis in AIDS patients.
    The Journal of antimicrobial chemotherapy, 1989, Volume: 23 Suppl A

    Topics: Acquired Immunodeficiency Syndrome; Animals; Drug Therapy, Combination; Humans; Mice; Opportunistic

1989
Pneumocystis carinii pneumonia: therapy and prophylaxis.
    The Journal of infectious diseases, 1988, Volume: 158, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Dapsone; Drug Combinations; Drug Therapy,

1988
Prevention of Pneumocystis carinii pneumonia.
    The Medical letter on drugs and therapeutics, 1988, Oct-07, Volume: 30, Issue:776

    Topics: Acquired Immunodeficiency Syndrome; Aerosols; Dapsone; Drug Combinations; Humans; Pentamidine; Pneum

1988
AIDS commentary. Toxoplasmic encephalitis.
    The Journal of infectious diseases, 1988, Volume: 157, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-Bacterial Agents; Antibodies, Protozoan; Antimetab

1988
Toxoplasmosis and the acquired immune deficiency syndrome.
    The Journal of infection, 1988, Volume: 16, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Africa; Animals; Antibodies, Protozoan; Drug Combinations; Human

1988
Use of pyrimethamine-sulfadoxine (Fansidar) in prophylaxis against chloroquine-resistant Plasmodium falciparum and Pneumocystis carinii.
    Annals of internal medicine, 1987, Volume: 106, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Chloroquine; Drug Combinations; Drug Resistance; Humans; Malaria

1987

Trials

17 trials available for pyrimethamine and Acquired Immune Deficiency Syndrome

ArticleYear
A study for precision diagnosing and treatment strategies in difficult-to-treat AIDS cases and HIV-infected patients with highly fatal or highly disabling opportunistic infections.
    Medicine, 2020, Volume: 99, Issue:20

    Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; AIDS-Related Opportunistic Infections; Anti-I

2020
[Primary prophylaxis against cerebral toxoplasmosis. Efficacy of folinic acid in the prevention of hematologic toxicity of pyrimethamine].
    Presse medicale (Paris, France : 1983), 1994, Apr-02, Volume: 23, Issue:13

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Blood Cell Count;

1994
Marked variation in pyrimethamine disposition in AIDS patients treated for cerebral toxoplasmosis.
    The Journal of antimicrobial chemotherapy, 1995, Volume: 36, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Infective Agents; Female; Humans; Male; Middle Aged;

1995
Aerosolized pentamidine, cotrimoxazole and dapsone-pyrimethamine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmic encephalitis.
    AIDS (London, England), 1995, Volume: 9, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Infe

1995
Atovaquone as long-term suppressive therapy for toxoplasmic encephalitis in patients with AIDS and multiple drug intolerance. Atovaquone Expanded Access Group.
    AIDS (London, England), 1996, Volume: 10, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiprotozoal Agents; Atovaquone; Clindamycin; Encephalit

1996
A controlled trial of dapsone versus pyrimethamine-sulfadoxine for primary prophylaxis of Pneumocystis carinii pneumonia and toxoplasmosis in patients with AIDS.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 1997, Volume: 51, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Opportunistic Infections; Anti-Infecti

1997
Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2002, May-01, Volume: 34, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; AIDS-Related Opportunistic Infections; Ani

2002
Toxicity of clindamycin as prophylaxis for AIDS-associated toxoplasmic encephalitis. Community Programs for Clinical Research on AIDS.
    Lancet (London, England), 1992, Feb-08, Volume: 339, Issue:8789

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Clindamycin; Double-Blind Method; Encephalitis;

1992
Comparison of two medications in central nervous system toxoplasmosis in patients with AIDS.
    Italian journal of neurological sciences, 1992, Volume: 13, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Central Nervous System Diseases; Clindamycin; Drug Combinations;

1992
Prophylaxis of AIDS-related opportunistic infections (OIs). Current status and future strategies.
    AIDS clinical review, 1991

    Topics: Acquired Immunodeficiency Syndrome; Aerosols; Animals; Cryptococcosis; Cytomegalovirus Infections; D

1991
Low-dose co-trimoxazole, aerosolised pentamidine, or dapsone plus pyrimethamine for prevention of Pneumocystis carinii pneumonia.
    Lancet (London, England), 1991, May-11, Volume: 337, Issue:8750

    Topics: Acquired Immunodeficiency Syndrome; Dapsone; Follow-Up Studies; Humans; Pentamidine; Pneumonia, Pneu

1991
Clinical programs for clinical research on AIDS: description of a randomized prospective study of clindamycin versus pyrimethamine for prevention of Toxoplasma gondii infection.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; CD4-Positive T-Lymphocytes; Clindamycin; Encephalitis; Humans; L

1991
Treatment of toxoplasmic encephalitis in patients with AIDS. A randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine. The California Collaborative Treatment Group.
    Annals of internal medicine, 1992, Jan-01, Volume: 116, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Clindamycin; Drug Evaluation; Drug Therapy, Combination;

1992
Evaluation of the efficacy and safety of clindamycin plus pyrimethamine for induction and maintenance therapy of toxoplasmic encephalitis in AIDS.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Encephalitis; Humans; Op

1991
Treatment of acute toxoplasmosis with intravenous clindamycin. The California Collaborative Treatment Group.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Encephalitis; Humans; In

1991
Treatment and prophylaxis of Isospora belli infection in patients with the acquired immunodeficiency syndrome.
    The New England journal of medicine, 1989, Apr-20, Volume: 320, Issue:16

    Topics: Acquired Immunodeficiency Syndrome; Chronic Disease; Coccidiosis; Drug Administration Schedule; Drug

1989
Pneumocystis carinii pneumonia in the patient with AIDS.
    Chest, 1985, Volume: 88, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Animals; Bronchoscopy; Clinical Trials as Topic; Dapsone; Drug C

1985

Other Studies

73 other studies available for pyrimethamine and Acquired Immune Deficiency Syndrome

ArticleYear
Biopsy-proven immune reconstitution syndrome in a patient with AIDS and cerebral toxoplasmosis.
    Neurology, 2009, Jul-28, Volume: 73, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antiretroviral Therapy, Highly Active; Biopsy; C

2009
Failure of conventional treatment with pyrimethamine and sulfadiazine for secondary prophylaxis of cerebral toxoplasmosis in a patient with AIDS.
    The Journal of antimicrobial chemotherapy, 2011, Volume: 66, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-HIV Agents; Antiprotozoal Agents; CD4 Lymphocyte Cou

2011
[HIV-associated cerebral toxoplasmosis -- review and retrospective analysis of 36 patients].
    Der Nervenarzt, 2002, Volume: 73, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; AIDS-Related Opportunistic Infections; Antiretrovir

2002
Nocardia abscess during treatment of brain toxoplasmosis in a patient with aids, utility of proton MR spectroscopy and diffusion-weighted imaging in diagnosis.
    Clinical neurology and neurosurgery, 2006, Volume: 108, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Anti-Retroviral Agents; Anticonvul

2006
Prophylaxis of Pneumocystis carinii infection in AIDS with pyrimethamine-sulfadoxine.
    Lancet (London, England), 1984, Aug-18, Volume: 2, Issue:8399

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Humans; Pneumonia, Pneumocystis; Pyrimethamin

1984
[Pyrimethamine-sulfadiazine resistant cerebral toxoplasmosis in AIDS].
    Deutsche medizinische Wochenschrift (1946), 1995, May-26, Volume: 120, Issue:21

    Topics: Acquired Immunodeficiency Syndrome; Animals; Drug Resistance; Drug Therapy, Combination; Humans; Pyr

1995
Sulfadiazine/N4-acetylsulfadiazine crystalluria in a patient with the acquired immune deficiency syndrome (AIDS)
    Clinica chimica acta; international journal of clinical chemistry, 1994, Oct-31, Volume: 230, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Hemophilia A; Huma

1994
Pyrimethamine/sulfadoxine for prevention of Pneumocystis carinii pneumonia in patients infected with the human immunodeficiency virus.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1994, Volume: 19, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Female; Humans; Male; Middle Aged; Pne

1994
Dilemmas in the prophylaxis of Pneumocystis carinii pneumonia.
    Southern medical journal, 1994, Volume: 87, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clindamycin; Dapso

1994
[Drug-induced Stevens-Johnson syndrome in a patient with AIDS].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1993, Aug-17, Volume: 82, Issue:33

    Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Phenytoin; Pyrimethamine; Stevens-Joh

1993
[Cerebral toxoplasmosis in AIDS. 73 cases. Clinical Epidemiology Group on AIDS in Aquitania].
    Presse medicale (Paris, France : 1983), 1993, May-29, Volume: 22, Issue:19

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Clarithromycin; Cl

1993
Two central nervous system infectious diseases in a patient with AIDS.
    The Journal of family practice, 1993, Volume: 36, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Amphotericin B; Hu

1993
Toxoplasma pneumonia in a patient with AIDS.
    The Journal of infection, 1995, Volume: 31, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Animals; Anti-Bact

1995
[Cerebral toxoplasmosis in patients with human immunodeficiency virus (HIV) infection. Clinico-radiological and therapeutic aspects in 63 patients].
    Anales de medicina interna (Madrid, Spain : 1984), 1996, Volume: 13, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Clind

1996
Precipitous visual loss secondary to optic nerve toxoplasmosis as an unusual presentation of AIDS.
    Australian and New Zealand journal of ophthalmology, 1996, Volume: 24, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Therap

1996
[Granulocyte colony-stimulating factor in the treatment of neutropenia associated with HIV infection].
    Medicina clinica, 1996, Jul-06, Volume: 107, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Anti-Infective Agents; Antiviral Agents; Cefta

1996
Clinical features, outcome and survival from cerebral toxoplasmosis in Edinburgh AIDS patients.
    International journal of STD & AIDS, 1996, Volume: 7, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal

1996
In-vitro activity of macrolides alone and in combination with artemisin, atovaquone, dapsone, minocycline or pyrimethamine against Cryptosporidium parvum.
    The Journal of antimicrobial chemotherapy, 1996, Volume: 38, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Artemisin

1996
Persistent diarrhea caused by Isospora belli: therapeutic response to pyrimethamine and sulfadiazine.
    Diagnostic microbiology and infectious disease, 1996, Volume: 26, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Animals; Anti-Infective Agents; Antitrichomonal Agents; Diarrhea

1996
[HIV infection and Lyell syndrome: a wake-up call concerning anti-inflammatory agents].
    Enfermedades infecciosas y microbiologia clinica, 1997, Volume: 15, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory

1997
Oral manifestations of toxic epidermal necrolysis (TEN) in patients with AIDS: report of five cases.
    Oral diseases, 1998, Volume: 4, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Age

1998
Determination of the inhibitory effect on Toxoplasma growth in the serum of AIDS patients during acute therapy for toxoplasmic encephalitis.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1998, Sep-01, Volume: 19, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Dr

1998
[Withdrawal of Pneumocystis carinii pneumonia prophylaxis in patients receiving efficacious combined antiretroviral treatment. Study of 85 cases].
    Medicina clinica, 1999, Jun-26, Volume: 113, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; A

1999
Disposition of intravenous pyrimethamine in healthy volunteers.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Antimalarials; Encephalitis; Humans; Infusions, Intravenous; Mal

2000
Levels of pyrimethamine in serum and penetration into brain tissue in humans.
    AIDS (London, England), 1992, Volume: 6, Issue:9

    Topics: Acquired Immunodeficiency Syndrome; Brain; Dose-Response Relationship, Drug; Humans; Pyrimethamine;

1992
Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis.
    Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:11

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Animals; Brain Diseases; Chronic Disease; Clarith

1992
Clindamycin for toxoplasma encephalitis in AIDS.
    Lancet (London, England), 1991, Nov-02, Volume: 338, Issue:8775

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Combinations; Encephalitis; Humans; Pyrimetham

1991
Pyrimethamine alone as maintenance therapy for central nervous system toxoplasmosis in 38 patients with AIDS.
    Journal of acquired immune deficiency syndromes, 1992, Volume: 5, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Therapy, Combination; Female; Humans; Male; Opportun

1992
Pyrimethamine-clarithromycin combination for therapy of acute Toxoplasma encephalitis in patients with AIDS.
    Antimicrobial agents and chemotherapy, 1991, Volume: 35, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Brain; Clarithromycin; Drug Therapy, Combination; Erythromycin;

1991
Twice-weekly dapsone-pyrimethamine for preventing PCP and cerebral toxoplasmosis.
    AIDS (London, England), 1991, Volume: 5, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Dapsone; Drug Administration Schedule; Drug Ther

1991
Treatment for cerebral toxoplasmosis protects against Pneumocystis carinii pneumonia in patients with AIDS. The Swiss HIV Cohort Study.
    Annals of internal medicine, 1991, Nov-15, Volume: 115, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Clindamycin; Cohort Studies; Drug Therapy, Combinat

1991
[Cerebral toxoplasmosis as a cause of treatable dementia in an aged patient].
    Medicina clinica, 1991, Apr-20, Volume: 96, Issue:15

    Topics: Acquired Immunodeficiency Syndrome; Aged; Brain; Brain Diseases; Dementia; Humans; Male; Pyrimethami

1991
Treatment of acute toxoplasmosis with oral clindamycin.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Administration, Oral; Adult; Clindamycin; Drug Th

1991
Role of clindamycin in the treatment of acute toxoplasmosis of the central nervous system.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Brain Diseases; Clindamycin; Drug Therapy, Combin

1991
A retrospective study of primary and maintenance therapy of toxoplasmic encephalitis with oral clindamycin and pyrimethamine.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Clindamycin; Drug Therapy, Combinat

1991
Long-term follow-up of patients with AIDS on maintenance therapy for toxoplasmosis.
    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 1991, Volume: 10, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Drug Therapy, Combination; Encephalitis; Follow-Up

1991
Clinical and diagnostic findings in 20 patients with toxoplasmosis and the acquired immune deficiency syndrome.
    Journal of medical microbiology, 1991, Volume: 35, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Drug Therapy, Combination; England; Enzyme-Linke

1991
[Encephalic toxoplasmosis in patients with the acquired immunodeficiency syndrome. A clinico-radiological study and the therapeutic results in 78 cases].
    Medicina clinica, 1990, Oct-13, Volume: 95, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Biopsy; Brain; Brain Diseases; Clindamycin; Drug

1990
Infectious disease emergencies in persons with HIV/AIDS: an update.
    The Journal of the Arkansas Medical Society, 1990, Volume: 87, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Amphotericin B; Clindamycin; Communicable Diseases; Fluconazole;

1990
[Pulmonary toxoplasmosis in AIDS. Report of 3 cases].
    Annales de medecine interne, 1990, Volume: 141, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Bronchoalveolar Lavage Fluid; Drug Therapy, Combination;

1990
[Ocular toxoplasmosis in AIDS].
    Annales de medecine interne, 1990, Volume: 141, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Humans; Male; Middle Aged; Opportunistic

1990
[Acute pancytopenia induced by pyrimethamine during treatment of cerebral toxoplasmosis associated with AIDS. Role of dihydrofolate reductase inhibitors].
    Annales de medecine interne, 1990, Volume: 141, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Adult; Brain Diseases; Folic Acid Antagonists; Fo

1990
Congenital toxoplasmosis occurring in infants perinatally infected with human immunodeficiency virus 1.
    The Pediatric infectious disease journal, 1990, Volume: 9, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Animals; Central Nervous System Diseases; Family Health; Female;

1990
Successful therapy for Toxoplasma gondii myocarditis in acquired immunodeficiency syndrome.
    American heart journal, 1990, Volume: 120, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Aged; Clindamycin; Humans; Male; Myocarditis; Pyrimethamine; Tox

1990
Low-dose alternate-day pyrimethamine for maintenance therapy in cerebral toxoplasmosis complicating AIDS.
    The Journal of infection, 1990, Volume: 21, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Brain Diseases; Drug Administratio

1990
Central nervous system toxoplasmosis in AIDS patients: efficacy of an intermittent maintenance therapy.
    AIDS (London, England), 1990, Volume: 4, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Central Nervous System Diseases; Clindamycin; Drug Combinations;

1990
Toxoplasmic encephalitis.
    AIDS (London, England), 1990, Volume: 4, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Encephalitis; Humans; Opportunistic Infection

1990
Toxoplasmic encephalitis in AIDS.
    Hospital practice (Office ed.), 1989, Mar-15, Volume: 24, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Animals; Antibodies, Protozoan; Brain; Diagnosis, Differe

1989
Interpreting negative test results.
    Hospital practice (Office ed.), 1989, Aug-15, Volume: 24, Issue:8

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Diagnosis, Differential; False Negative R

1989
[Bullous toxic skin disease with fatal outcome in AIDS].
    Presse medicale (Paris, France : 1983), 1989, Oct-21, Volume: 18, Issue:34

    Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Prognosis; Pyrimethamine; Stevens-Joh

1989
Cerebral toxoplasmosis in the acquired immune deficiency syndrome.
    Clinical neurology and neurosurgery, 1989, Volume: 91, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Encephalitis; Female; Humans; Male; Middle Aged; Py

1989
Pneumocystis carinii pneumonia in Stockholm, Sweden: treatment, outcome, one-year-follow-up and pyrimethamine prophylaxis.
    Scandinavian journal of infectious diseases, 1989, Volume: 21, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Aged; Dapsone; Drug Evaluation; Drug Therapy, Combination

1989
[Cerebral toxoplasmosis in patients with AIDS].
    Archivos de neurobiologia, 1989, Volume: 52 Suppl 1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Drug Evaluation; Drug Therapy, Combinatio

1989
Evaluation of the policy of empiric treatment of suspected Toxoplasma encephalitis in patients with the acquired immunodeficiency syndrome.
    The American journal of medicine, 1989, Volume: 86, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Brain; Clindamycin; Encephalitis; Female; Humans;

1989
Sulfadiazine revisited.
    The Journal of infectious diseases, 1989, Volume: 160, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Bacterial Agents; Brain Diseases; Crystallization; D

1989
An open study of the pyrimethamine-clindamycin combination in AIDS patients with brain toxoplasmosis.
    The Journal of infectious diseases, 1989, Volume: 160, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Clindamycin; Drug Therapy, Combination; Humans;

1989
Experience with pneumocystis carinii pneumonia in patients with AIDS.
    The New Zealand medical journal, 1989, Sep-27, Volume: 102, Issue:876

    Topics: Acquired Immunodeficiency Syndrome; Adult; Bronchoscopy; Drug Combinations; Follow-Up Studies; Homos

1989
Adverse reactions associated with pyrimethamine-sulfadoxine prophylaxis for Pneumocystis carinii infections in AIDS.
    Lancet (London, England), 1985, Jun-08, Volume: 1, Issue:8441

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Humans; Male; Pneumonia, Pneumocystis;

1985
Adverse reactions to pyrimethamine-sulfadoxine in context of AIDS.
    Lancet (London, England), 1985, Jun-15, Volume: 1, Issue:8442

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Drug Hypersensitivity; Humans; Pyrimethamine;

1985
[Cerebral toxoplasmosis in the acquired immunodeficiency syndrome. Study of the clinical, radiological, and pathological findings in 10 cases].
    Medicina clinica, 1988, May-28, Volume: 91, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Brain Abscess; Brain Diseases; Humans; Opportunistic Infections;

1988
Fansidar and Pneumocystis carinii pneumonia.
    Annals of internal medicine, 1988, Volume: 108, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Humans; Male; Pneumonia, Pneumocystis;

1988
Fatal toxic epidermal necrolysis during prophylaxis with pyrimethamine and sulfadoxine in a human immunodeficiency virus-infected person.
    Archives of internal medicine, 1988, Volume: 148, Issue:12

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Humans; Male; Middle Aged; Pneumonia, Pneumoc

1988
Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome. Efficacy of long-term continuous therapy.
    The American journal of medicine, 1988, Volume: 84, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Central Nervous System Diseases; Drug Therapy, Combinatio

1988
Pyrimethamine concentrations in serum and cerebrospinal fluid during treatment of acute Toxoplasma encephalitis in patients with AIDS.
    The Journal of infectious diseases, 1988, Volume: 157, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Encephalitis; Humans; Pyrimethamine; Toxoplasmosi

1988
Clindamycin in cerebral toxoplasmosis.
    The American journal of medicine, 1988, Volume: 85, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Clindamycin; Drug Therapy, Combination; Humans;

1988
Fansidar prophylaxis of Pneumocystis pneumonia in the acquired immunodeficiency syndrome.
    Annals of internal medicine, 1986, Volume: 105, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Humans; Pneumonia, Pneumocystis; Pyrimethamin

1986
Toxoplasma encephalitis in patients with acquired immune deficiency syndrome: diagnosis and response to therapy.
    The American journal of tropical medicine and hygiene, 1987, Volume: 36, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antibodies; Drug Therapy, Combination; Encephalitis; Huma

1987
Fansidar--a treatment for AIDS-related pneumocystis?
    Postgraduate medical journal, 1987, Volume: 63, Issue:740

    Topics: Acquired Immunodeficiency Syndrome; Antimalarials; Drug Combinations; Humans; Pneumonia, Pneumocysti

1987
Assessment of therapy for toxoplasma encephalitis. The TE Study Group.
    The American journal of medicine, 1987, Volume: 82, Issue:5

    Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Adult; Encephalitis; Evaluation Studies

1987
[Cerebral toxoplasmosis in immunosuppressed patients: diagnosis and treatment].
    Annales de medecine interne, 1987, Volume: 138, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Diseases; Drug Combinations; Female; Humans; Leucom

1987
Role of clindamycin in the treatment of central nervous system toxoplasmosis.
    The American journal of medicine, 1987, Volume: 83, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Central Nervous System Diseases; Clindamycin; Drug Therap

1987
[Opportunistic Toxoplasma gondii infections].
    Archives francaises de pediatrie, 1985, Volume: 42 Suppl 2

    Topics: Acquired Immunodeficiency Syndrome; Child, Preschool; Drug Combinations; Humans; Immunologic Deficie

1985
Cerebral toxoplasmosis complicating the acquired immune deficiency syndrome: clinical and neuropathological findings in 27 patients.
    Annals of neurology, 1986, Volume: 19, Issue:3

    Topics: Acquired Immunodeficiency Syndrome; Adult; Biopsy; Brain Diseases; Central Nervous System; Clindamyc

1986