pyrimethamine has been researched along with Abnormalities, Drug-Induced in 46 studies
Maloprim: contains above 2 cpds
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
Excerpt | Relevance | Reference |
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"In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp)." | 9.14 | Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine. ( Ayemonna, P; Bottero, J; Briand, V; Cordel, H; Cot, M; Fayomi, B; Fievet, N; Guerra, J; Kossou, H; Masse, V; Massougbodji, A; Noël, H, 2009) |
"Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy." | 7.70 | Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998) |
" This review evaluates the toxicity data of sulfadoxine/pyrimethamine, including severe cutaneous adverse reactions, teratogenicity and alterations in bilirubin metabolism." | 6.44 | Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment. ( Newman, RD; Parise, ME; Peters, PJ; Thigpen, MC, 2007) |
"In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp)." | 5.14 | Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine. ( Ayemonna, P; Bottero, J; Briand, V; Cordel, H; Cot, M; Fayomi, B; Fievet, N; Guerra, J; Kossou, H; Masse, V; Massougbodji, A; Noël, H, 2009) |
"Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy." | 3.70 | Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998) |
"Intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine is contraindicated in the first trimester and provides imperfect chemoprevention because of inadequate dosing, poor (few and late) antenatal clinic attendance, increasing antimalarial drug resistance, and decreasing naturally acquired maternal immunity due to the decreased incidence of malaria." | 2.66 | Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs. ( Briand, V; McGready, R; Min, AM; Saito, M, 2020) |
" This review evaluates the toxicity data of sulfadoxine/pyrimethamine, including severe cutaneous adverse reactions, teratogenicity and alterations in bilirubin metabolism." | 2.44 | Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment. ( Newman, RD; Parise, ME; Peters, PJ; Thigpen, MC, 2007) |
"Pyrimethamine (PY) was mixed with mashed feed and given to the Göttingen miniature pig (G-mini) during gestional days 11-35." | 1.26 | Teratogenic activity of pyrimethamine in Göttingen minipig. ( Aoyama, H; Hayama, T; Iwasaki, T; Kanda, S; Kaneda, M; Kokue, E; Misawa, J; Teramoto, S, 1982) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 40 (86.96) | 18.7374 |
1990's | 2 (4.35) | 18.2507 |
2000's | 3 (6.52) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 1 (2.17) | 2.80 |
Authors | Studies |
---|---|
Saito, M | 1 |
Briand, V | 2 |
Min, AM | 1 |
McGready, R | 1 |
Bottero, J | 1 |
Noël, H | 1 |
Masse, V | 1 |
Cordel, H | 1 |
Guerra, J | 1 |
Kossou, H | 1 |
Fayomi, B | 1 |
Ayemonna, P | 1 |
Fievet, N | 1 |
Massougbodji, A | 1 |
Cot, M | 1 |
SAND, BJ | 1 |
SHANEDLING, PD | 1 |
DELERUE, J | 1 |
HICKL, EJ | 1 |
MOHR, U | 1 |
MARTIUS, G | 1 |
COLEMAN, RD | 1 |
Peters, PJ | 1 |
Thigpen, MC | 1 |
Parise, ME | 1 |
Newman, RD | 2 |
Dyban, AP | 5 |
Akimova, IM | 5 |
Udalova, LD | 2 |
Pozhidaev, EA | 1 |
Stanzhevskaya, TI | 1 |
Harpey, JP | 2 |
Darbois, Y | 1 |
Lefèbvre, G | 1 |
Smithells, RW | 1 |
Sheppard, S | 1 |
Shao, BR | 1 |
Zhan, CQ | 1 |
Ha, SH | 1 |
Ni, YC | 1 |
Izumi, H | 1 |
Kokue, E | 4 |
Hayama, T | 3 |
Misawa, J | 1 |
Kanda, S | 1 |
Teramoto, S | 1 |
Aoyama, H | 1 |
Kaneda, M | 1 |
Iwasaki, T | 1 |
Feberwee, JD | 1 |
Kudo, G | 1 |
Tsunematsu, K | 1 |
Shimoda, M | 1 |
Phillips-Howard, PA | 1 |
Steffen, R | 1 |
Kerr, L | 1 |
Vanhauwere, B | 1 |
Schildknecht, J | 1 |
Fuchs, E | 1 |
Edwards, R | 1 |
Parise, M | 1 |
Nahlen, B | 1 |
Popov, VB | 1 |
Puchkov, VF | 1 |
Bariliak, IR | 1 |
Tikhodeeva, II | 1 |
Chebotar', NA | 2 |
Golinskiĭ, GF | 1 |
Baranov, VS | 1 |
Shtenberg, AI | 1 |
Torchinskiĭ, AM | 1 |
Kotin, AM | 2 |
Petter, C | 3 |
Bourbon, J | 1 |
Tangapregassom, AM | 1 |
Tangapregassom, MJ | 1 |
Horvath, C | 2 |
Trecul, M | 1 |
Boucher-Ehrensperger, M | 1 |
Compagnon, A | 1 |
Kotb, MM | 1 |
Repin, VS | 1 |
Egolinskiĭ, AI | 1 |
Hengst, P | 1 |
Malakhovskiĭ, VG | 2 |
Prozorovskiĭ, VB | 1 |
Pap, AG | 1 |
Tarakhovskiĭ, ML | 1 |
Stanzhevskaia, TI | 1 |
Svetlova, VA | 1 |
Krahe, M | 1 |
Anderson, I | 1 |
Morse, LM | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Intermittent Preventive Treatment During Pregnancy in Benin: a Randomized, Open, and Equivalent Trial Comparing Sulfadoxine-Pyrimethamine With Mefloquine[NCT00274235] | Phase 3 | 1,600 participants (Anticipated) | Interventional | 2005-07-31 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
4 reviews available for pyrimethamine and Abnormalities, Drug-Induced
Article | Year |
---|---|
Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs.
Topics: Abnormalities, Drug-Induced; Antimalarials; Drug Administration Schedule; Drug Combinations; Female; | 2020 |
Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment.
Topics: Abnormalities, Drug-Induced; Africa; Animals; Antimalarials; Drug Administration Schedule; Drug Comb | 2007 |
[Theoretical and applied aspects of experimental teratology].
Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dactinomycin; DNA Replication; Dose-Response Rela | 1977 |
Use of the Goettingen miniature pig for studying pyrimethamine teratogenesis.
Topics: Abnormalities, Drug-Induced; Animal Feed; Animals; Animals, Newborn; Female; Housing, Animal; Pregna | 1985 |
1 trial available for pyrimethamine and Abnormalities, Drug-Induced
Article | Year |
---|---|
Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Antimalarials; Drug Combinations; Female; | 2009 |
41 other studies available for pyrimethamine and Abnormalities, Drug-Induced
Article | Year |
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TETRAGENESIS FROM DARAPRIM.
Topics: Abnormalities, Drug-Induced; Eye; Female; Humans; Pregnancy; Pyrimethamine; Toxicology; Toxoplasmosi | 1963 |
[TERATOGENIC ACTION OF DRUGS IN THE PREGNANT WOMAN].
Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Avitaminosis; Chlorpromazine; Cortisone; Female; | 1963 |
[ANIMAL EXPERIMENTAL STUDIES ON THE PROBLEM OF FETAL DAMAGE BY PYRIMETHAMINE].
Topics: Abnormalities, Drug-Induced; Animal Experimentation; Animals; Female; Fetal Diseases; Humans; Matern | 1964 |
DEVELOPMENT OF THE RAT PALATE.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Diet; Embryology; Female; Humans; Palate; Pathol | 1965 |
[The significance of group B vitamins and genetic factors on the reaction of the rat embryo to thalidomide].
Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Animals; Diet; Drug Hypersensitivity; E | 1966 |
[Relationship between the teratogenic effect and the chemical structure of drugs. Experiments with chloridine and bigumal].
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetus; Pregnancy; Proguanil; Pyrimethamin | 1966 |
[Disorder of embryogenesis after the application of myelosan and chloridin on the female and male gametes in the rat].
Topics: Abnormalities, Drug-Induced; Animals; Busulfan; Embryo, Mammalian; Female; Fetal Death; Gestational | 1966 |
[Effect of chloridin on chick embryogenesis].
Topics: Abnormalities, Drug-Induced; Animals; Brain; Chick Embryo; Ectromelia; Heart Defects, Congenital; Mi | 1966 |
Teratogenicity of pyrimethamine.
Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Malaria; Maternal-Fetal Exchange; Pregnancy; Pyr | 1983 |
Teratogenicity of debendox and pyrimethamine.
Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy; | 1983 |
Pyrimethamine combinations in pregnancy.
Topics: Abnormalities, Drug-Induced; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Infectious | 1983 |
Pyrimethamine in pregnancy.
Topics: Abnormalities, Drug-Induced; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Infectious | 1983 |
[Embryotoxicity of chloroquine and pyrimethamine in rats].
Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Chloroquine; Embryo, Mammalian; F | 1983 |
The critical period of pyrimethamine teratogenesis in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Female; Gestational Age; Pregnancy; Pyrimethamine; Rats; Rats, | 1984 |
Teratogenic activity of pyrimethamine in Göttingen minipig.
Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Pyrimethamine; Swine | 1982 |
A pyrimethamine-chloroquine combination for malaria prophylaxis during pregnancy.
Topics: Abnormalities, Drug-Induced; Chloroquine; Drug Combinations; Female; Fetus; Humans; Malaria; Pregnan | 1982 |
Effects of folic acid on pyrimethamine teratogenesis in rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Drug Synergism; Embryo, Mammalian; Femal | 1993 |
Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy.
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Adverse Drug Reaction Reporting Systems; | 1998 |
Folic acid antagonists during pregnancy and risk of birth defects.
Topics: Abnormalities, Drug-Induced; Antimalarials; Drug Combinations; Female; Folic Acid Antagonists; Human | 2001 |
[Comparison of the effect of chloridin on rat embryos during postimplantation periods of development in vivo and in vitro].
Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Embryonic Development; Female; Fetal Death | 1977 |
[Correlation of tetratogenic and antimitotic activity of a number of derivatives of 2,4-diaminopyrimidine].
Topics: Abnormalities, Drug-Induced; Animals; Cornea; Embryo, Mammalian; Female; Liver; Mitosis; Mitotic Ind | 1976 |
[Postimplantation development of rat embryos following application of injurious agents to male gametes].
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Embryo Implantation; Female; Fetal D | 1976 |
[Mechanism of the damaging effect of chloridine on white rat embryos].
Topics: Abnormalities, Drug-Induced; Animals; Decidua; Female; Pregnancy; Pyrimethamine; Rats | 1976 |
[Evaluation of experimental data on teratogenic properties of substances foreign to the body in their combined effect].
Topics: Abnormalities, Drug-Induced; Animals; Benomyl; DDT; Drug Antagonism; Drug Synergism; Embryo, Mammali | 1976 |
[Effect of 2,4-diamino-5-chlorphenyl-6-ethylpyrimidine on the oncorporation of P32-phosphate into adenylic nucleotides of rat embryo and placenta].
Topics: Abnormalities, Drug-Induced; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antimalarials; | 1976 |
Foetal red cell macrocytosis induced by pyrimethamine; its teratogenic role.
Topics: Abnormalities, Drug-Induced; Animals; Erythrocytes; Erythrocytes, Abnormal; Female; Fetal Diseases; | 1975 |
Vascular anomalies and pyrimethamine-induced malformations in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Extremities; Female; Fetus; Gestational Age | 1985 |
[Teratogenic effect of pyrimethamine in the rat. In vivo prevention by calcium folinate].
Topics: Abnormalities, Drug-Induced; Animals; Drug Combinations; Female; Leucovorin; Pyrimethamine; Rats; Ra | 1988 |
[Characteristics of the injurious effects of a structural analog of the antimalarial drug chloridin (preparation IEM-687) on various stages of white rat embryogenesis].
Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Abnormalities, Multiple; Amines; Animals; Bone and B | 1972 |
[Disturbance in the development of rat embryos resulting from the effects of chloridin in the preimplantation period].
Topics: Abnormalities, Drug-Induced; Animals; Cell Division; Dose-Response Relationship, Drug; Embryo, Mamma | 1974 |
[Anomalies in the development of rat embryo skeletons consequent to chlorid in (pyrimethamine) administration].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Female; Fetal Death; | 1972 |
Influence of 2,4-diamino-5-chlorophenyl-6-ethylpyrimidine (chloridyn) on the nucleic acid metabolism of embryos of white rats.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Radioisotopes; DNA; Female; Fetus; Formates; Phosphorus | 1974 |
[Proteins and enzymes of fetal blood and liver following administration of the teratogenic drug chloridine to pregnant rats].
Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Female; Isoenzymes; L-Lactate Dehydrogenase; L | 1972 |
[Teratogenicity of daraprim (pyrimethamine) in man].
Topics: Abnormalities, Drug-Induced; Adult; Female; Gestational Age; Humans; Pregnancy; Pregnancy Complicati | 1972 |
[The prenatal influence of chloridin and vitamin A on the behavior of the progeny of rats].
Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Central Nervous System Diseases; Female; Hum | 1971 |
[Range of teratogenic action as an indication of danger in using a medicinal preparation during pregnancy].
Topics: Abnormalities, Drug-Induced; Animals; Busulfan; Female; Pregnancy; Pregnancy Complications; Pyrimeth | 1970 |
[Effect of several drugs on the fetus].
Topics: Abnormalities, Drug-Induced; Aminopyrine; Animals; Aspirin; Benzimidazoles; Chlorpromazine; Cortison | 1967 |
[Histological changes in the rudiments of the extremities in the chick embryo caused by chloridin].
Topics: Abnormalities, Drug-Induced; Animals; Bone Development; Cartilage; Chick Embryo; Gestational Age; Hi | 1968 |
[Embryonal development of rats acted upon with 2,4-diamino-5-chlorphenyl-6-ethylpyrimidine].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Pregnancy; Pyrimethamine; Rats | 1965 |
[Studies on the teratogenic effect of drugs in the treatment of toxoplasmosis during pregnancy].
Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Female; Humans; Pregnancy; Pregnancy Complicatio | 1965 |
The influence of solvent on the teratogenic effect of folic acid antagonist in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Folic Acid Antagonists; Pyrimethamine; Rats; Solvents | 1966 |