pyrimethamine and Abnormalities, Drug-Induced studies

Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.

Research Excerpts

Excerpt	Relevance	Reference
"In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp)."	9.14	Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine. ( Ayemonna, P; Bottero, J; Briand, V; Cordel, H; Cot, M; Fayomi, B; Fievet, N; Guerra, J; Kossou, H; Masse, V; Massougbodji, A; Noël, H, 2009)
"Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy."	7.70	Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998)
" This review evaluates the toxicity data of sulfadoxine/pyrimethamine, including severe cutaneous adverse reactions, teratogenicity and alterations in bilirubin metabolism."	6.44	Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment. ( Newman, RD; Parise, ME; Peters, PJ; Thigpen, MC, 2007)
"In the context of the increasing resistance to sulfadoxine-pyrimethamine (SP), we evaluated the efficacy of mefloquine (MQ) for intermittent preventive treatment during pregnancy (IPTp)."	5.14	Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine. ( Ayemonna, P; Bottero, J; Briand, V; Cordel, H; Cot, M; Fayomi, B; Fievet, N; Guerra, J; Kossou, H; Masse, V; Massougbodji, A; Noël, H, 2009)
"Data were collected from two separate prospective cohorts to ascertain the safety of chloroquine-proguanil, sulfadoxine-pyrimethamine (SP), and mefloquine taken in the first trimester of pregnancy."	3.70	Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. ( Edwards, R; Fuchs, E; Kerr, L; Phillips-Howard, PA; Schildknecht, J; Steffen, R; Vanhauwere, B, 1998)
"Intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine is contraindicated in the first trimester and provides imperfect chemoprevention because of inadequate dosing, poor (few and late) antenatal clinic attendance, increasing antimalarial drug resistance, and decreasing naturally acquired maternal immunity due to the decreased incidence of malaria."	2.66	Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs. ( Briand, V; McGready, R; Min, AM; Saito, M, 2020)
" This review evaluates the toxicity data of sulfadoxine/pyrimethamine, including severe cutaneous adverse reactions, teratogenicity and alterations in bilirubin metabolism."	2.44	Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment. ( Newman, RD; Parise, ME; Peters, PJ; Thigpen, MC, 2007)
"Pyrimethamine (PY) was mixed with mashed feed and given to the Göttingen miniature pig (G-mini) during gestional days 11-35."	1.26	Teratogenic activity of pyrimethamine in Göttingen minipig. ( Aoyama, H; Hayama, T; Iwasaki, T; Kanda, S; Kaneda, M; Kokue, E; Misawa, J; Teramoto, S, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	40 (86.96)	18.7374
1990's	2 (4.35)	18.2507
2000's	3 (6.52)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (2.17)	2.80

Authors	Studies
Saito, M	1
Briand, V	2
Min, AM	1
McGready, R	1
Bottero, J	1
Noël, H	1
Masse, V	1
Cordel, H	1
Guerra, J	1
Kossou, H	1
Fayomi, B	1
Ayemonna, P	1
Fievet, N	1
Massougbodji, A	1
Cot, M	1
SAND, BJ	1
SHANEDLING, PD	1
DELERUE, J	1
HICKL, EJ	1
MOHR, U	1
MARTIUS, G	1
COLEMAN, RD	1
Peters, PJ	1
Thigpen, MC	1
Parise, ME	1
Newman, RD	2
Dyban, AP	5
Akimova, IM	5
Udalova, LD	2
Pozhidaev, EA	1
Stanzhevskaya, TI	1
Harpey, JP	2
Darbois, Y	1
Lefèbvre, G	1
Smithells, RW	1
Sheppard, S	1
Shao, BR	1
Zhan, CQ	1
Ha, SH	1
Ni, YC	1
Izumi, H	1
Kokue, E	4
Hayama, T	3
Misawa, J	1
Kanda, S	1
Teramoto, S	1
Aoyama, H	1
Kaneda, M	1
Iwasaki, T	1
Feberwee, JD	1
Kudo, G	1
Tsunematsu, K	1
Shimoda, M	1
Phillips-Howard, PA	1
Steffen, R	1
Kerr, L	1
Vanhauwere, B	1
Schildknecht, J	1
Fuchs, E	1
Edwards, R	1
Parise, M	1
Nahlen, B	1
Popov, VB	1
Puchkov, VF	1
Bariliak, IR	1
Tikhodeeva, II	1
Chebotar', NA	2
Golinskiĭ, GF	1
Baranov, VS	1
Shtenberg, AI	1
Torchinskiĭ, AM	1
Kotin, AM	2
Petter, C	3
Bourbon, J	1
Tangapregassom, AM	1
Tangapregassom, MJ	1
Horvath, C	2
Trecul, M	1
Boucher-Ehrensperger, M	1
Compagnon, A	1
Kotb, MM	1
Repin, VS	1
Egolinskiĭ, AI	1
Hengst, P	1
Malakhovskiĭ, VG	2
Prozorovskiĭ, VB	1
Pap, AG	1
Tarakhovskiĭ, ML	1
Stanzhevskaia, TI	1
Svetlova, VA	1
Krahe, M	1
Anderson, I	1
Morse, LM	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
Intermittent Preventive Treatment During Pregnancy in Benin: a Randomized, Open, and Equivalent Trial Comparing Sulfadoxine-Pyrimethamine With Mefloquine[NCT00274235]			Phase 3	1,600 participants (Anticipated)	Interventional	2005-07-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Deleterious effects of malaria in pregnancy on the developing fetus: a review on prevention and treatment with antimalarial drugs. The Lancet. Child & adolescent health, 2020, Volume: 4, Issue:10 Topics: Abnormalities, Drug-Induced; Antimalarials; Drug Administration Schedule; Drug Combinations; Female;	2020
Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment. Drug safety, 2007, Volume: 30, Issue:6 Topics: Abnormalities, Drug-Induced; Africa; Animals; Antimalarials; Drug Administration Schedule; Drug Comb	2007
[Theoretical and applied aspects of experimental teratology]. Ontogenez, 1977, Volume: 8, Issue:6 Topics: Abnormalities, Drug-Induced; Aminopterin; Animals; Dactinomycin; DNA Replication; Dose-Response Rela	1977
Use of the Goettingen miniature pig for studying pyrimethamine teratogenesis. Critical reviews in toxicology, 1985, Volume: 14, Issue:4 Topics: Abnormalities, Drug-Induced; Animal Feed; Animals; Animals, Newborn; Female; Housing, Animal; Pregna	1985

Article	Year
TETRAGENESIS FROM DARAPRIM. American journal of ophthalmology, 1963, Volume: 56 Topics: Abnormalities, Drug-Induced; Eye; Female; Humans; Pregnancy; Pyrimethamine; Toxicology; Toxoplasmosi	1963
[TERATOGENIC ACTION OF DRUGS IN THE PREGNANT WOMAN]. Journal des sciences medicales de Lille, 1963, Volume: 81 Topics: Abnormalities, Drug-Induced; Antineoplastic Agents; Avitaminosis; Chlorpromazine; Cortisone; Female;	1963
[ANIMAL EXPERIMENTAL STUDIES ON THE PROBLEM OF FETAL DAMAGE BY PYRIMETHAMINE]. Archiv fur Gynakologie, 1964, Jun-19, Volume: 199 Topics: Abnormalities, Drug-Induced; Animal Experimentation; Animals; Female; Fetal Diseases; Humans; Matern	1964
DEVELOPMENT OF THE RAT PALATE. The Anatomical record, 1965, Volume: 151 Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Diet; Embryology; Female; Humans; Palate; Pathol	1965
[The significance of group B vitamins and genetic factors on the reaction of the rat embryo to thalidomide]. Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 51, Issue:8 Topics: Abnormalities, Drug-Induced; Abnormalities, Severe Teratoid; Animals; Diet; Drug Hypersensitivity; E	1966
[Relationship between the teratogenic effect and the chemical structure of drugs. Experiments with chloridine and bigumal]. Doklady Akademii nauk SSSR, 1966, Mar-01, Volume: 167, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Female; Fetal Death; Fetus; Pregnancy; Proguanil; Pyrimethamin	1966
[Disorder of embryogenesis after the application of myelosan and chloridin on the female and male gametes in the rat]. Arkhiv anatomii, gistologii i embriologii, 1966, Volume: 51, Issue:8 Topics: Abnormalities, Drug-Induced; Animals; Busulfan; Embryo, Mammalian; Female; Fetal Death; Gestational	1966
[Effect of chloridin on chick embryogenesis]. Biulleten' eksperimental'noi biologii i meditsiny, 1966, Volume: 61, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Brain; Chick Embryo; Ectromelia; Heart Defects, Congenital; Mi	1966
Teratogenicity of pyrimethamine. Lancet (London, England), 1983, Aug-13, Volume: 2, Issue:8346 Topics: Abnormalities, Drug-Induced; Adult; Female; Humans; Malaria; Maternal-Fetal Exchange; Pregnancy; Pyr	1983
Teratogenicity of debendox and pyrimethamine. Lancet (London, England), 1983, Sep-10, Volume: 2, Issue:8350 Topics: Abnormalities, Drug-Induced; Dicyclomine; Doxylamine; Drug Combinations; Female; Humans; Pregnancy;	1983
Pyrimethamine combinations in pregnancy. Lancet (London, England), 1983, Oct-29, Volume: 2, Issue:8357 Topics: Abnormalities, Drug-Induced; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Infectious	1983
Pyrimethamine in pregnancy. Lancet (London, England), 1983, Nov-19, Volume: 2, Issue:8360 Topics: Abnormalities, Drug-Induced; Female; Humans; Malaria; Pregnancy; Pregnancy Complications, Infectious	1983
[Embryotoxicity of chloroquine and pyrimethamine in rats]. Ji sheng chong xue yu ji sheng chong bing za zhi = Journal of parasitology & parasitic diseases, 1983, Volume: 1, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Chloroquine; Embryo, Mammalian; F	1983
The critical period of pyrimethamine teratogenesis in the rat. Nihon juigaku zasshi. The Japanese journal of veterinary science, 1984, Volume: 46, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Female; Gestational Age; Pregnancy; Pyrimethamine; Rats; Rats,	1984
Teratogenic activity of pyrimethamine in Göttingen minipig. Toxicology letters, 1982, Volume: 10, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Pyrimethamine; Swine	1982
A pyrimethamine-chloroquine combination for malaria prophylaxis during pregnancy. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Aug-21, Volume: 62, Issue:9 Topics: Abnormalities, Drug-Induced; Chloroquine; Drug Combinations; Female; Fetus; Humans; Malaria; Pregnan	1982
Effects of folic acid on pyrimethamine teratogenesis in rats. Advances in experimental medicine and biology, 1993, Volume: 338 Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Drug Synergism; Embryo, Mammalian; Femal	1993
Safety of mefloquine and other antimalarial agents in the first trimester of pregnancy. Journal of travel medicine, 1998, Volume: 5, Issue:3 Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Adverse Drug Reaction Reporting Systems;	1998
Folic acid antagonists during pregnancy and risk of birth defects. The New England journal of medicine, 2001, Mar-22, Volume: 344, Issue:12 Topics: Abnormalities, Drug-Induced; Antimalarials; Drug Combinations; Female; Folic Acid Antagonists; Human	2001
[Comparison of the effect of chloridin on rat embryos during postimplantation periods of development in vivo and in vitro]. Ontogenez, 1977, Volume: 8, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Embryonic Development; Female; Fetal Death	1977
[Correlation of tetratogenic and antimitotic activity of a number of derivatives of 2,4-diaminopyrimidine]. Ontogenez, 1976, Volume: 7, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Cornea; Embryo, Mammalian; Female; Liver; Mitosis; Mitotic Ind	1976
[Postimplantation development of rat embryos following application of injurious agents to male gametes]. Arkhiv anatomii, gistologii i embriologii, 1976, Volume: 70, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Embryo Implantation; Female; Fetal D	1976
[Mechanism of the damaging effect of chloridine on white rat embryos]. Biulleten' eksperimental'noi biologii i meditsiny, 1976, Volume: 81, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Decidua; Female; Pregnancy; Pyrimethamine; Rats	1976
[Evaluation of experimental data on teratogenic properties of substances foreign to the body in their combined effect]. Gigiena i sanitariia, 1976, Issue:12 Topics: Abnormalities, Drug-Induced; Animals; Benomyl; DDT; Drug Antagonism; Drug Synergism; Embryo, Mammali	1976
[Effect of 2,4-diamino-5-chlorphenyl-6-ethylpyrimidine on the oncorporation of P32-phosphate into adenylic nucleotides of rat embryo and placenta]. Biokhimiia (Moscow, Russia), 1976, Volume: 41, Issue:5 Topics: Abnormalities, Drug-Induced; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antimalarials;	1976
Foetal red cell macrocytosis induced by pyrimethamine; its teratogenic role. Experientia, 1975, Mar-15, Volume: 31, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Erythrocytes; Erythrocytes, Abnormal; Female; Fetal Diseases;	1975
Vascular anomalies and pyrimethamine-induced malformations in the rat. Teratogenesis, carcinogenesis, and mutagenesis, 1985, Volume: 5, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Extremities; Female; Fetus; Gestational Age	1985
[Teratogenic effect of pyrimethamine in the rat. In vivo prevention by calcium folinate]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1988, Volume: 182, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Drug Combinations; Female; Leucovorin; Pyrimethamine; Rats; Ra	1988
[Characteristics of the injurious effects of a structural analog of the antimalarial drug chloridin (preparation IEM-687) on various stages of white rat embryogenesis]. Arkhiv anatomii, gistologii i embriologii, 1972, Volume: 63, Issue:8 Topics: Abdominal Muscles; Abnormalities, Drug-Induced; Abnormalities, Multiple; Amines; Animals; Bone and B	1972
[Disturbance in the development of rat embryos resulting from the effects of chloridin in the preimplantation period]. Arkhiv anatomii, gistologii i embriologii, 1974, Volume: 67, Issue:8 Topics: Abnormalities, Drug-Induced; Animals; Cell Division; Dose-Response Relationship, Drug; Embryo, Mamma	1974
[Anomalies in the development of rat embryo skeletons consequent to chlorid in (pyrimethamine) administration]. Arkhiv anatomii, gistologii i embriologii, 1972, Volume: 63, Issue:8 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Bone and Bones; Female; Fetal Death;	1972
Influence of 2,4-diamino-5-chlorophenyl-6-ethylpyrimidine (chloridyn) on the nucleic acid metabolism of embryos of white rats. The Soviet journal of developmental biology, 1974, Volume: 4, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Carbon Radioisotopes; DNA; Female; Fetus; Formates; Phosphorus	1974
[Proteins and enzymes of fetal blood and liver following administration of the teratogenic drug chloridine to pregnant rats]. Biulleten' eksperimental'noi biologii i meditsiny, 1972, Volume: 13, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Blood Proteins; Female; Isoenzymes; L-Lactate Dehydrogenase; L	1972
[Teratogenicity of daraprim (pyrimethamine) in man]. Zentralblatt fur Gynakologie, 1972, Apr-29, Volume: 94, Issue:17 Topics: Abnormalities, Drug-Induced; Adult; Female; Gestational Age; Humans; Pregnancy; Pregnancy Complicati	1972
[The prenatal influence of chloridin and vitamin A on the behavior of the progeny of rats]. Biulleten' eksperimental'noi biologii i meditsiny, 1971, Volume: 71, Issue:3 Topics: Abnormalities, Drug-Induced; Animals; Behavior, Animal; Central Nervous System Diseases; Female; Hum	1971
[Range of teratogenic action as an indication of danger in using a medicinal preparation during pregnancy]. Akusherstvo i ginekologiia, 1970, Volume: 46, Issue:9 Topics: Abnormalities, Drug-Induced; Animals; Busulfan; Female; Pregnancy; Pregnancy Complications; Pyrimeth	1970
[Effect of several drugs on the fetus]. Akusherstvo i ginekologiia, 1967, Volume: 43, Issue:12 Topics: Abnormalities, Drug-Induced; Aminopyrine; Animals; Aspirin; Benzimidazoles; Chlorpromazine; Cortison	1967
[Histological changes in the rudiments of the extremities in the chick embryo caused by chloridin]. Arkhiv anatomii, gistologii i embriologii, 1968, Volume: 55, Issue:10 Topics: Abnormalities, Drug-Induced; Animals; Bone Development; Cartilage; Chick Embryo; Gestational Age; Hi	1968
[Embryonal development of rats acted upon with 2,4-diamino-5-chlorphenyl-6-ethylpyrimidine]. Doklady Akademii nauk SSSR, 1965, Aug-21, Volume: 163, Issue:6 Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Pregnancy; Pyrimethamine; Rats	1965
[Studies on the teratogenic effect of drugs in the treatment of toxoplasmosis during pregnancy]. Archiv fur Gynakologie, 1965, Volume: 202 Topics: Abnormalities, Drug-Induced; Anti-Bacterial Agents; Female; Humans; Pregnancy; Pregnancy Complicatio	1965
The influence of solvent on the teratogenic effect of folic acid antagonist in the rat. Experimental and molecular pathology, 1966, Volume: 5, Issue:2 Topics: Abnormalities, Drug-Induced; Animals; Folic Acid Antagonists; Pyrimethamine; Rats; Solvents	1966

pyrimethamine and Abnormalities, Drug-Induced

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