pyrimethamine has been researched along with Abnormalities, Autosome in 14 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "The synopsis of the in vivo test results in the first collaborative CEC Aneuploidy Project with 10 selected chemicals, colchicine (COL), econazole (EZ), chloral hydrate (CH), hydroquinone (HQ), diazepam (DZ), thiabendazole (TB), cadmium chloride (CD), thimerosal (TM), pyrimethamine (PY) and vinblastine (VBL), allowed several conclusions." | 4.78 | Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study. ( Adler, ID, 1993) |
| "Pyrimethamine is a folic acid antagonist used for the treatment of malaria and toxoplasmosis." | 1.31 | Inhibitory effects of ascorbic acid and folinic acid on chromosome aberrations induced by pyrimethamine in vitro. ( Aydemir, N; Bilaloĝlu, R; Egel, C, 2002) |
| "Induction of chromosome aberrations was investigated in cultured Chinese hamster cells treated with pyrimethamine." | 1.29 | Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells. ( Norimatsu, M; Ono, T; Yoshimura, H, 1994) |
| "Dose-related numerical chromosomal aberrations are induced by colchicine and vinblastine, the only chemicals that also induce c-mitotic effects in a wide range of doses." | 1.29 | C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons. ( Di Sibio, A; Lomi, A; Sbrana, I; Scarcelli, V, 1993) |
| "Pyrimethamine is an inhibitor of dihydrofolate reductase and is used in the treatment of malaria and toxoplasmosis." | 1.29 | The cytogenetic effects of pyrimethamine on male mouse germ cells. ( Aydemir, N; Bilaloğlu, R, 1996) |
| "Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0." | 1.28 | The clastogenic effect of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures. ( Egeli, U; Erdogan, G, 1991) |
| "The frequency of chromosome aberrations in ovulated oocytes at metaphase, II subjected to pyrimethamine and 2,4,5-T, reached 6--8% and exceeded the control value in 5--10 times." | 1.26 | [Nature of cytogenetic and morphologic disorders in rat oogenesis and embryogenesis induced by chloridin and 2,4,5-trichlorophenoxyacetic acid during the preovulatory phase of meiosis]. ( Chebotar', NA, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 8 (57.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Praveen, N | 1 |
| Saifi, MA | 1 |
| Shadab, GG | 1 |
| Egel, C | 1 |
| Bilaloĝlu, R | 3 |
| Aydemir, N | 3 |
| Tunca, B | 2 |
| Egeli, U | 3 |
| Cecener, G | 1 |
| Chebotar', NA | 1 |
| Ono, T | 1 |
| Norimatsu, M | 1 |
| Yoshimura, H | 1 |
| Natarajan, AT | 1 |
| Adler, ID | 1 |
| Sbrana, I | 1 |
| Di Sibio, A | 1 |
| Lomi, A | 1 |
| Scarcelli, V | 1 |
| Marrazzini, A | 1 |
| Betti, C | 1 |
| Bernacchi, F | 1 |
| Barrai, I | 1 |
| Barale, R | 1 |
| Erdogan, G | 1 |
| Matveeva, VG | 1 |
| Kerkis, YY | 1 |
| Osipova, LP | 1 |
| Dyban, AP | 1 |
1 review available for pyrimethamine and Abnormalities, Autosome
| Article | Year |
|---|---|
Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Chromos | 1993 |
13 other studies available for pyrimethamine and Abnormalities, Autosome
| Article | Year |
|---|---|
Cytogenetic evaluation of Fansidar on human lymphocyte chromosomes in vitro.
Topics: Antimalarials; Chromosome Aberrations; Chromosomes, Human; Drug Combinations; Humans; In Vitro Techn | 2011 |
Inhibitory effects of ascorbic acid and folinic acid on chromosome aberrations induced by pyrimethamine in vitro.
Topics: Ascorbic Acid; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Folic Acid | 2002 |
Investigation of the genotoxic effect in bone marrow of Swiss albino mice exposed long-term to pyrimethamine.
Topics: Animals; Antimalarials; Bone Marrow; Chromosome Aberrations; Chromosomes; Dose-Response Relationship | 2002 |
[Nature of cytogenetic and morphologic disorders in rat oogenesis and embryogenesis induced by chloridin and 2,4,5-trichlorophenoxyacetic acid during the preovulatory phase of meiosis].
Topics: 2,4,5-Trichlorophenoxyacetic Acid; Animals; Chromosome Aberrations; Cleavage Stage, Ovum; Embryo Los | 1980 |
Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells.
Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Dose-Response Relationship, Drug; Female; Lu | 1994 |
An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.
Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Cells, Cultured; Chloral H | 1993 |
C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons.
Topics: Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Chromosome Aberrations; Colc | 1993 |
Micronucleus test and metaphase analyses in mice exposed to known and suspected spindle poisons.
Topics: Animals; Bone Marrow Cells; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; | 1994 |
The cytogenetic effects of pyrimethamine on male mouse germ cells.
Topics: Animals; Chromosome Aberrations; Chromosome Disorders; DNA Damage; Germ Cells; Male; Mice; Mutagens; | 1996 |
Detection of fragile sites induced by pyrimethamine.
Topics: Adult; Antimalarials; Cell Culture Techniques; Chromosome Aberrations; Chromosome Banding; Chromosom | 1997 |
The clastogenic effect of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures.
Topics: Adolescent; Adult; Cell Division; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; | 1991 |
Mutagenic effect of the pesticide DDB and of chloridine in the bone marrow and germ cells of mice.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Dose-Response Relation | 1974 |
[Study of early stages of embryogenesis of mammals with induced chromosomal aberrations].
Topics: Aneuploidy; Animals; Autoradiography; Chromosome Aberrations; Diploidy; DNA; Embryo, Mammalian; Embr | 1970 |