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pyrimethamine and Abnormalities, Autosome

pyrimethamine has been researched along with Abnormalities, Autosome in 14 studies

Maloprim: contains above 2 cpds

Research Excerpts

ExcerptRelevanceReference
"The synopsis of the in vivo test results in the first collaborative CEC Aneuploidy Project with 10 selected chemicals, colchicine (COL), econazole (EZ), chloral hydrate (CH), hydroquinone (HQ), diazepam (DZ), thiabendazole (TB), cadmium chloride (CD), thimerosal (TM), pyrimethamine (PY) and vinblastine (VBL), allowed several conclusions."4.78Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study. ( Adler, ID, 1993)
"Pyrimethamine is a folic acid antagonist used for the treatment of malaria and toxoplasmosis."1.31Inhibitory effects of ascorbic acid and folinic acid on chromosome aberrations induced by pyrimethamine in vitro. ( Aydemir, N; Bilaloĝlu, R; Egel, C, 2002)
"Induction of chromosome aberrations was investigated in cultured Chinese hamster cells treated with pyrimethamine."1.29Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells. ( Norimatsu, M; Ono, T; Yoshimura, H, 1994)
"Dose-related numerical chromosomal aberrations are induced by colchicine and vinblastine, the only chemicals that also induce c-mitotic effects in a wide range of doses."1.29C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons. ( Di Sibio, A; Lomi, A; Sbrana, I; Scarcelli, V, 1993)
"Pyrimethamine is an inhibitor of dihydrofolate reductase and is used in the treatment of malaria and toxoplasmosis."1.29The cytogenetic effects of pyrimethamine on male mouse germ cells. ( Aydemir, N; Bilaloğlu, R, 1996)
"Pyrimethamine was added to in vitro lymphocyte cultures at six different concentrations: 0."1.28The clastogenic effect of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures. ( Egeli, U; Erdogan, G, 1991)
"The frequency of chromosome aberrations in ovulated oocytes at metaphase, II subjected to pyrimethamine and 2,4,5-T, reached 6--8% and exceeded the control value in 5--10 times."1.26[Nature of cytogenetic and morphologic disorders in rat oogenesis and embryogenesis induced by chloridin and 2,4,5-trichlorophenoxyacetic acid during the preovulatory phase of meiosis]. ( Chebotar', NA, 1980)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19903 (21.43)18.7374
1990's8 (57.14)18.2507
2000's2 (14.29)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Praveen, N1
Saifi, MA1
Shadab, GG1
Egel, C1
Bilaloĝlu, R3
Aydemir, N3
Tunca, B2
Egeli, U3
Cecener, G1
Chebotar', NA1
Ono, T1
Norimatsu, M1
Yoshimura, H1
Natarajan, AT1
Adler, ID1
Sbrana, I1
Di Sibio, A1
Lomi, A1
Scarcelli, V1
Marrazzini, A1
Betti, C1
Bernacchi, F1
Barrai, I1
Barale, R1
Erdogan, G1
Matveeva, VG1
Kerkis, YY1
Osipova, LP1
Dyban, AP1

Reviews

1 review available for pyrimethamine and Abnormalities, Autosome

ArticleYear
Synopsis of the in vivo results obtained with the 10 known or suspected aneugens tested in the CEC collaborative study.
    Mutation research, 1993, Volume: 287, Issue:1

    Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Chromos

1993

Other Studies

13 other studies available for pyrimethamine and Abnormalities, Autosome

ArticleYear
Cytogenetic evaluation of Fansidar on human lymphocyte chromosomes in vitro.
    Journal of environmental biology, 2011, Volume: 32, Issue:1

    Topics: Antimalarials; Chromosome Aberrations; Chromosomes, Human; Drug Combinations; Humans; In Vitro Techn

2011
Inhibitory effects of ascorbic acid and folinic acid on chromosome aberrations induced by pyrimethamine in vitro.
    Teratogenesis, carcinogenesis, and mutagenesis, 2002, Volume: 22, Issue:5

    Topics: Ascorbic Acid; Cells, Cultured; Chromosome Aberrations; Dose-Response Relationship, Drug; Folic Acid

2002
Investigation of the genotoxic effect in bone marrow of Swiss albino mice exposed long-term to pyrimethamine.
    Teratogenesis, carcinogenesis, and mutagenesis, 2002, Volume: 22, Issue:6

    Topics: Animals; Antimalarials; Bone Marrow; Chromosome Aberrations; Chromosomes; Dose-Response Relationship

2002
[Nature of cytogenetic and morphologic disorders in rat oogenesis and embryogenesis induced by chloridin and 2,4,5-trichlorophenoxyacetic acid during the preovulatory phase of meiosis].
    Genetika, 1980, Volume: 16, Issue:7

    Topics: 2,4,5-Trichlorophenoxyacetic Acid; Animals; Chromosome Aberrations; Cleavage Stage, Ovum; Embryo Los

1980
Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells.
    Mutation research, 1994, Volume: 323, Issue:4

    Topics: Animals; Cell Line; Chromosome Aberrations; Cricetinae; Dose-Response Relationship, Drug; Female; Lu

1994
An overview of the results of testing of known or suspected aneugens using mammalian cells in vitro.
    Mutation research, 1993, Volume: 287, Issue:1

    Topics: Aneuploidy; Animals; Cadmium; Cadmium Chloride; Cell Division; Cell Line; Cells, Cultured; Chloral H

1993
C-mitosis and numerical chromosome aberration analyses in human lymphocytes: 10 known or suspected spindle poisons.
    Mutation research, 1993, Volume: 287, Issue:1

    Topics: Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides; Chromosome Aberrations; Colc

1993
Micronucleus test and metaphase analyses in mice exposed to known and suspected spindle poisons.
    Mutagenesis, 1994, Volume: 9, Issue:6

    Topics: Animals; Bone Marrow Cells; Cadmium; Cadmium Chloride; Cells, Cultured; Chloral Hydrate; Chlorides;

1994
The cytogenetic effects of pyrimethamine on male mouse germ cells.
    Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer, 1996, Volume: 15, Issue:2-4

    Topics: Animals; Chromosome Aberrations; Chromosome Disorders; DNA Damage; Germ Cells; Male; Mice; Mutagens;

1996
Detection of fragile sites induced by pyrimethamine.
    Teratogenesis, carcinogenesis, and mutagenesis, 1997, Volume: 17, Issue:2

    Topics: Adult; Antimalarials; Cell Culture Techniques; Chromosome Aberrations; Chromosome Banding; Chromosom

1997
The clastogenic effect of pyrimethamine (Daraprim) on human chromosomes in lymphocyte cultures.
    Cell biology and toxicology, 1991, Volume: 7, Issue:4

    Topics: Adolescent; Adult; Cell Division; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations;

1991
Mutagenic effect of the pesticide DDB and of chloridine in the bone marrow and germ cells of mice.
    Soviet genetics, 1974, Dec-01, Volume: 9, Issue:2

    Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromosome Aberrations; Chromosomes; Dose-Response Relation

1974
[Study of early stages of embryogenesis of mammals with induced chromosomal aberrations].
    Arkhiv anatomii, gistologii i embriologii, 1970, Volume: 58, Issue:1

    Topics: Aneuploidy; Animals; Autoradiography; Chromosome Aberrations; Diploidy; DNA; Embryo, Mammalian; Embr

1970