pyrimethamine has been researched along with ALS - Amyotrophic Lateral Sclerosis in 4 studies
Maloprim: contains above 2 cpds
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyrimethamine was measured in plasma and CSF." | 6.84 | Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations. ( Ajroud-Driss, S; Andersen, PM; Appel, SH; Doretti, A; Fields, KG; Lange, DJ; Ludolph, AC; Maderna, L; Marklund, SL; Messina, S; Morelli, C; Remanan, R; Shahbazi, M; Silani, V; Weiland, U; Weishaupt, JH, 2017) |
| "Pyrimethamine was measured in plasma and CSF." | 2.84 | Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations. ( Ajroud-Driss, S; Andersen, PM; Appel, SH; Doretti, A; Fields, KG; Lange, DJ; Ludolph, AC; Maderna, L; Marklund, SL; Messina, S; Morelli, C; Remanan, R; Shahbazi, M; Silani, V; Weiland, U; Weishaupt, JH, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lange, DJ | 2 |
| Shahbazi, M | 1 |
| Silani, V | 1 |
| Ludolph, AC | 1 |
| Weishaupt, JH | 1 |
| Ajroud-Driss, S | 1 |
| Fields, KG | 1 |
| Remanan, R | 2 |
| Appel, SH | 1 |
| Morelli, C | 1 |
| Doretti, A | 1 |
| Maderna, L | 1 |
| Messina, S | 1 |
| Weiland, U | 1 |
| Marklund, SL | 1 |
| Andersen, PM | 2 |
| Wright, PD | 1 |
| Huang, M | 1 |
| Weiss, A | 1 |
| Matthews, J | 1 |
| Wightman, N | 1 |
| Glicksman, M | 1 |
| Brown, RH | 1 |
| Marklund, S | 1 |
| Benjamin, D | 1 |
| Guerrieri, D | 1 |
| Ferrari, S | 1 |
| Costi, MP | 1 |
| Michels, PA | 1 |
2 trials available for pyrimethamine and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Female; Folic Acid Antagonists; Humans; Male; Middle Age | 2017 |
Pyrimethamine decreases levels of SOD1 in leukocytes and cerebrospinal fluid of ALS patients: a phase I pilot study.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Female; Humans; Leukocytes; Male; Middle Age | 2013 |
2 other studies available for pyrimethamine and ALS - Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Screening for inhibitors of the SOD1 gene promoter: pyrimethamine does not reduce SOD1 levels in cell and animal models.
Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Drug Evaluation, Preclinical; Folic Acid | 2010 |
Biochemical effects of riluzole on Leishmania parasites.
Topics: Amyotrophic Lateral Sclerosis; Anticonvulsants; Antiprotozoal Agents; Cell Line; Enzyme Inhibitors; | 2013 |