pyrilamine has been researched along with Seizures in 7 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of systemic injection of H3R ligands 1-13 on MES-induced and PTZ-kindled seizures were screened and evaluated against the reference antiepileptic drug (AED) Phenytoin (PHT) and the standard histamine H3R inverse agonist/antagonist Thioperamide (THP) to determine their potential as new antiepileptic drugs." | 3.79 | Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanol. ( Adem, A; Kieć-Kononowicz, K; Sadek, B; Shafiullah, M; Shehab, S; Subramanian, D; Więcek, M, 2013) |
| " The centrally acting histamine H1 antagonists including pyrilamine (mepyramine) and ketotifen showed an acceleration in the rate of electrical stimulation to develop fully kindled convulsive seizures." | 3.69 | Centrally acting histamine H1 antagonists promote the development of amygdala kindling in rats. ( Iinuma, K; Onodera, K; Sato, M; Watanabe, T; Yokoyama, H, 1996) |
| "One month after the last kindled seizure, the decreased K(D) value was sustained in the kindled nonstimulated amygdala." | 1.30 | Histamine H1 receptor binding capacities in the amygdalas of the amygdaloid kindled rat. ( Ito, C; Sato, M; Toyota, H; Watanabe, T; Yanai, K, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sadek, B | 2 |
| Shehab, S | 1 |
| Więcek, M | 1 |
| Subramanian, D | 1 |
| Shafiullah, M | 1 |
| Kieć-Kononowicz, K | 2 |
| Adem, A | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Alachkar, A | 1 |
| Latacz, G | 1 |
| Siwek, A | 1 |
| Lubelska, A | 1 |
| Honkisz, E | 1 |
| Gryboś, A | 1 |
| Łażewska, D | 1 |
| Handzlik, J | 1 |
| Stark, H | 1 |
| Zhang, LS | 1 |
| Chen, Z | 1 |
| Huang, YW | 1 |
| Hu, WW | 1 |
| Wei, EQ | 1 |
| Yanai, K | 2 |
| Midzyanovskaya, I | 1 |
| Kopilov, M | 1 |
| Fedotova, E | 1 |
| Kuznetsova, G | 1 |
| Tuomisto, L | 1 |
| Yokoyama, H | 1 |
| Sato, M | 2 |
| Iinuma, K | 1 |
| Onodera, K | 1 |
| Watanabe, T | 2 |
| Toyota, H | 1 |
| Ito, C | 1 |
7 other studies available for pyrilamine and Seizures
| Article | Year |
|---|---|
Anticonvulsant properties of histamine H3 receptor ligands belonging to N-substituted carbamates of imidazopropanol.
Topics: 1-Propanol; Animals; Anticonvulsants; Carbamates; Electroshock; Histamine Agonists; Histamine Antago | 2013 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats.
Topics: Animals; Anticonvulsants; Benzothiazoles; Disease Models, Animal; Dose-Response Relationship, Drug; | 2018 |
Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Histamine; Histamine Release; Histidine; | 2003 |
Dual effect of pyrilamine on absence seizures in WAG/Rij rats.
Topics: Animals; Epilepsy, Absence; Male; Pyrilamine; Rats; Seizures | 2005 |
Centrally acting histamine H1 antagonists promote the development of amygdala kindling in rats.
Topics: Amygdala; Animals; Dibenzazepines; Electroencephalography; Histamine H1 Antagonists; Imidazoles; Ket | 1996 |
Histamine H1 receptor binding capacities in the amygdalas of the amygdaloid kindled rat.
Topics: Amygdala; Animals; Disease Susceptibility; Dominance, Cerebral; Histamine H1 Antagonists; Kindling, | 1999 |