pyrilamine has been researched along with Pruritus in 12 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Pruritus: An intense itching sensation that produces the urge to rub or scratch the skin to obtain relief.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated whether 3-iodothyroacetic acid (TA1), by releasing histamine, induces itch and increases sensitization to noxious and painful heat stimuli." | 7.81 | 3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice. ( De Siena, G; Laurino, A; Masi, A; Musilli, C; Raimondi, L; Resta, F; Zucchi, R, 2015) |
| "Endothelin-1 (ET-1) has recently been identified to evoke pruritus/itching sensation in both humans and animals." | 7.76 | Molecular signaling of pruritus induced by endothelin-1 in mice. ( Ji, W; Kawamata, T; Liang, J, 2010) |
| "5mg and histamine 2 micrograms in 11 healthy black subjects who experienced generalised pruritus with oral chloroquine." | 5.07 | Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers. ( Abila, B; Ambakederemo, AW; Asomugha, L; Ezeamuzie, IC; Igbigbi, PS, 1994) |
| " We investigated whether 3-iodothyroacetic acid (TA1), by releasing histamine, induces itch and increases sensitization to noxious and painful heat stimuli." | 3.81 | 3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice. ( De Siena, G; Laurino, A; Masi, A; Musilli, C; Raimondi, L; Resta, F; Zucchi, R, 2015) |
| "Endothelin-1 (ET-1) has recently been identified to evoke pruritus/itching sensation in both humans and animals." | 3.76 | Molecular signaling of pruritus induced by endothelin-1 in mice. ( Ji, W; Kawamata, T; Liang, J, 2010) |
| "Itch and pain were scored on a visual analogue scale at regular intervals." | 2.70 | Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study. ( Benfeldt, E; Jensen, SB; Menné, T; Serup, J; Thomsen, JS, 2002) |
| "The histamine-independent allergic conjunctivitis may be useful for analyzing mechanisms underlying chronic conjunctivitis." | 1.32 | Multiple cedar pollen challenge diminishes involvement of histamine in allergic conjunctivitis of Guinea pigs. ( Fukushima, Y; Kohno, S; Mizutani, N; Nabe, T; Nakata, K, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (25.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Laurino, A | 1 |
| De Siena, G | 1 |
| Resta, F | 1 |
| Masi, A | 1 |
| Musilli, C | 1 |
| Zucchi, R | 1 |
| Raimondi, L | 1 |
| Liang, J | 1 |
| Kawamata, T | 1 |
| Ji, W | 1 |
| ROBINSON, RC | 1 |
| Fukushima, Y | 1 |
| Nabe, T | 2 |
| Mizutani, N | 1 |
| Nakata, K | 1 |
| Kohno, S | 2 |
| Shimada, SG | 1 |
| Shimada, KA | 1 |
| Collins, JG | 1 |
| Fujii, M | 1 |
| Tomozawa, J | 1 |
| Gibbs, CJ | 1 |
| Coutts, II | 1 |
| Jackson, SM | 1 |
| White, RJ | 1 |
| Abila, B | 1 |
| Ezeamuzie, IC | 1 |
| Igbigbi, PS | 1 |
| Ambakederemo, AW | 1 |
| Asomugha, L | 1 |
| Takizawa, T | 1 |
| Matsumoto, J | 1 |
| Tohma, T | 1 |
| Kanke, T | 1 |
| Wada, Y | 1 |
| Nagao, M | 1 |
| Inagaki, N | 1 |
| Nagai, H | 1 |
| Zhang, MQ | 1 |
| Timmerman, H | 1 |
| Thomsen, JS | 1 |
| Benfeldt, E | 1 |
| Jensen, SB | 1 |
| Serup, J | 1 |
| Menné, T | 1 |
| Fjellner, B | 1 |
| Hägermark, O | 1 |
4 trials available for pyrilamine and Pruritus
| Article | Year |
|---|---|
Skin test wheal size and erythema not reduced by topical antihistamine.
Topics: Administration, Topical; Aminopyridines; Clinical Trials as Topic; Double-Blind Method; Erythema; Hi | 1983 |
Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Black People; Chloroquine; Clemastine | 1994 |
Topically applied aspirin decreases histamine-induced wheal and flare reactions in normal and SLS-inflamed skin, but does not decrease itch. A randomized, double-blind and placebo-controlled human study.
Topics: Administration, Topical; Adult; Analysis of Variance; Aspirin; Dermatitis, Irritant; Double-Blind Me | 2002 |
Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin.
Topics: Adult; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Female; Histamine; Humans; M | 1985 |
8 other studies available for pyrilamine and Pruritus
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
3-iodothyroacetic acid, a metabolite of thyroid hormone, induces itch and reduces threshold to noxious and to painful heat stimuli in mice.
Topics: Animals; Ganglia, Spinal; Histamine H1 Antagonists; Histidine Decarboxylase; Hot Temperature; Male; | 2015 |
Molecular signaling of pruritus induced by endothelin-1 in mice.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cyclic AMP-Dependent Protein Kinases; Endot | 2010 |
Pyrilamine maleate in the treatment of pruritic dermatoses.
Topics: Anti-Allergic Agents; Histamine H1 Antagonists; Pruritus; Pyrilamine; Skin Diseases | 1954 |
Multiple cedar pollen challenge diminishes involvement of histamine in allergic conjunctivitis of Guinea pigs.
Topics: Administration, Oral; Administration, Topical; Albumins; Allergens; Animals; Conjunctivitis, Allergi | 2003 |
Scratching behavior in mice induced by the proteinase-activated receptor-2 agonist, SLIGRL-NH2.
Topics: Animals; Behavior, Animal; Histamine H1 Antagonists; Male; Mice; Mice, Inbred Strains; Oligopeptides | 2006 |
Involvement of skin barrier dysfunction in itch-related scratching in special diet-fed hairless mice.
Topics: Animals; Behavior, Animal; Dermatitis, Atopic; Dose-Response Relationship, Drug; Epidermis; Erythema | 2006 |
VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities.
Topics: Animals; Anti-Allergic Agents; Behavior, Animal; Benzimidazoles; Capillary Permeability; Guinea Pigs | 2001 |