pyrilamine has been researched along with Morphine Dependence in 5 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (60.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (40.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Zarrindast, MR | 2 |
Assadi, E | 1 |
Oryan, S | 1 |
Torkaman-Boutorabi, A | 1 |
Sahebgharani, M | 1 |
Khalilzadeh, A | 1 |
Djahanguiri, B | 1 |
Wong, CL | 2 |
Roberts, MB | 3 |
Hui, KS | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Examination of Palonosetron and Hydroxyzine Pre-treatment as a Possible Method to Reduce the Objective Signs of Experimentally-induced Acute Opioid Withdrawal in Humans: a Double-blind, Randomized, Placebo-controlled Crossover Study[NCT00661674] | 10 participants (Actual) | Interventional | 2008-04-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"The OOWS is a 13-item instrument documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score possible = 13, minimum score possible = 0. T=15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~OOWS scores at T=180 is the primary outcome measure of the study compared with baseline OOWS scores at T=-30 (30 minutes prior to study medication administration). Reported time frames are in relation to time past since administration of study medications.~Mean post-Naloxone OOWS scores (+/- SEM) were determined for pretreatment groups" (NCT00661674)
Timeframe: Change from baseline in OOWS score at 180 minutes (15 minutes post naloxone administration)
Intervention | units on a scale (OOWS Scale) (Mean) |
---|---|
Placebo | 3.5 |
Palonosetron | 1.0 |
Palonosetron + Hydroxyzine | 0 |
"The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. 15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~The highest score possible (64) would indicate that the individual was experiencing every symptom of opioid withdrawal to the fullest extent possible while the lowest score (0) would indicate that the individual was not experiencing any symptoms of opioid withdrawal.~Mean post-naloxone SOWS scores (+/- SEM) were computed for pretreatment groups: Placebo, palonosetron, and palonosetron with hydroxyzine" (NCT00661674)
Timeframe: Change from baseline in SOWS score at 180 minutes (15 minutes post naloxone administration)
Intervention | units on a scale (SOWS Scale) (Mean) |
---|---|
Placebo | 6.0 |
Palonosetron | 4.0 |
Palonosetron + Hydroxyzine | 3.5 |
5 other studies available for pyrilamine and Morphine Dependence
Article | Year |
---|---|
Influence of histamine, cimetidine and pyrilamine on naloxone-induced jumping in morphine-dependent mice.
Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug | 2003 |
Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug; | 2006 |
The effects of L-histidine and of specific histamine receptor agonists, on the expression of morphine tolerance and physical dependence in mice.
Topics: Animals; Body Weight; Drug Interactions; Drug Tolerance; Female; Histidine; Humans; Male; Metiamide; | 1976 |
The effect of mepyramine on the development of morphine tolerance and physical dependence in mice.
Topics: Animals; Brain Chemistry; Drug Tolerance; Female; Histamine; Humans; Male; Mice; Morphine; Morphine | 1975 |
The possible role of brain histamine and H1 and H2 receptors in the development of morphine tolerance and physical dependence in mice.
Topics: Animals; Drug Tolerance; Female; Histidine; Humans; Male; Metiamide; Mice; Mice, Inbred Strains; Mor | 1975 |