Page last updated: 2024-11-03

pyrilamine and Morphine Dependence

pyrilamine has been researched along with Morphine Dependence in 5 studies

Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.

Morphine Dependence: Strong dependence, both physiological and emotional, upon morphine.

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zarrindast, MR2
Assadi, E1
Oryan, S1
Torkaman-Boutorabi, A1
Sahebgharani, M1
Khalilzadeh, A1
Djahanguiri, B1
Wong, CL2
Roberts, MB3
Hui, KS1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Examination of Palonosetron and Hydroxyzine Pre-treatment as a Possible Method to Reduce the Objective Signs of Experimentally-induced Acute Opioid Withdrawal in Humans: a Double-blind, Randomized, Placebo-controlled Crossover Study[NCT00661674]10 participants (Actual)Interventional2008-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

OOWS Score

"The OOWS is a 13-item instrument documenting physically observable signs of withdrawal, which are rated as present (1) or absent (0) during the observation period. Maximum score possible = 13, minimum score possible = 0. T=15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~OOWS scores at T=180 is the primary outcome measure of the study compared with baseline OOWS scores at T=-30 (30 minutes prior to study medication administration). Reported time frames are in relation to time past since administration of study medications.~Mean post-Naloxone OOWS scores (+/- SEM) were determined for pretreatment groups" (NCT00661674)
Timeframe: Change from baseline in OOWS score at 180 minutes (15 minutes post naloxone administration)

Interventionunits on a scale (OOWS Scale) (Mean)
Placebo3.5
Palonosetron1.0
Palonosetron + Hydroxyzine0

SOWS Score

"The SOWS score is composed of 16 subjective symptoms rated on a scale of 0 to 4 (0=not at all, 4=extremely) based on what subjects were experiencing at the time of testing. 15 minutes post naloxone administration coordinates with T = 180 (min) for the entire study session.~The highest score possible (64) would indicate that the individual was experiencing every symptom of opioid withdrawal to the fullest extent possible while the lowest score (0) would indicate that the individual was not experiencing any symptoms of opioid withdrawal.~Mean post-naloxone SOWS scores (+/- SEM) were computed for pretreatment groups: Placebo, palonosetron, and palonosetron with hydroxyzine" (NCT00661674)
Timeframe: Change from baseline in SOWS score at 180 minutes (15 minutes post naloxone administration)

Interventionunits on a scale (SOWS Scale) (Mean)
Placebo6.0
Palonosetron4.0
Palonosetron + Hydroxyzine3.5

Other Studies

5 other studies available for pyrilamine and Morphine Dependence

ArticleYear
Influence of histamine, cimetidine and pyrilamine on naloxone-induced jumping in morphine-dependent mice.
    European journal of pharmacology, 2003, Jun-20, Volume: 471, Issue:2

    Topics: Animals; Atropine; Cimetidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug

2003
Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice.
    Behavioural brain research, 2006, Jan-06, Volume: 166, Issue:1

    Topics: Analgesics, Opioid; Animals; Avoidance Learning; Behavior, Animal; Dose-Response Relationship, Drug;

2006
The effects of L-histidine and of specific histamine receptor agonists, on the expression of morphine tolerance and physical dependence in mice.
    Agents and actions, 1976, Volume: 6, Issue:5

    Topics: Animals; Body Weight; Drug Interactions; Drug Tolerance; Female; Histidine; Humans; Male; Metiamide;

1976
The effect of mepyramine on the development of morphine tolerance and physical dependence in mice.
    Life sciences, 1975, Sep-15, Volume: 17, Issue:6

    Topics: Animals; Brain Chemistry; Drug Tolerance; Female; Histamine; Humans; Male; Mice; Morphine; Morphine

1975
The possible role of brain histamine and H1 and H2 receptors in the development of morphine tolerance and physical dependence in mice.
    Agents and actions, 1975, Volume: 5, Issue:5

    Topics: Animals; Drug Tolerance; Female; Histidine; Humans; Male; Metiamide; Mice; Mice, Inbred Strains; Mor

1975