pyrilamine has been researched along with Migraine Disorders in 4 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "histamine infusion test is a useful model for the study of experimental vascular headache." | 6.65 | Headache provocation by continuous intravenous infusion of histamine. Clinical results and receptor mechanisms. ( Krabbe, AA; Olesen, J, 1980) |
| "Twenty migraine patients received pretreatment with placebo or the histamine-H1-receptor antagonist, mepyramine, in a randomized, double blind fashion, followed in both groups by i." | 2.68 | Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine. ( Lassen, LH; Olesen, J; Thomsen, LL, 1995) |
| "It has previously been shown that in migraine sufferers infusion of glyceryl trinitrate (GTN) and histamine causes an immediate headache during the infusion and a genuine migraine attack one to several hours after the infusion." | 2.68 | Histamine-1 receptor blockade does not prevent nitroglycerin induced migraine. Support for the NO-hypothesis of migraine. ( Iversen, HK; Kruuse, C; Lassen, LH; Olesen, J; Thomsen, LL, 1996) |
| "histamine infusion test is a useful model for the study of experimental vascular headache." | 2.65 | Headache provocation by continuous intravenous infusion of histamine. Clinical results and receptor mechanisms. ( Krabbe, AA; Olesen, J, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krabbe, AA | 1 |
| Olesen, J | 3 |
| Lassen, LH | 2 |
| Thomsen, LL | 2 |
| Kruuse, C | 1 |
| Iversen, HK | 1 |
| Gonsalves, A | 1 |
| Johnson, ES | 1 |
3 trials available for pyrilamine and Migraine Disorders
| Article | Year |
|---|---|
Headache provocation by continuous intravenous infusion of histamine. Clinical results and receptor mechanisms.
Topics: Aminopyridines; Cimetidine; Headache; Histamine; Humans; Migraine Disorders; Pyrilamine | 1980 |
Histamine induces migraine via the H1-receptor. Support for the NO hypothesis of migraine.
Topics: Adolescent; Adult; Double-Blind Method; Female; Hemodynamics; Histamine; Histamine H1 Antagonists; H | 1995 |
Histamine-1 receptor blockade does not prevent nitroglycerin induced migraine. Support for the NO-hypothesis of migraine.
Topics: Adult; Analysis of Variance; Cerebrovascular Circulation; Cross-Over Studies; Female; Hemodynamics; | 1996 |
1 other study available for pyrilamine and Migraine Disorders
| Article | Year |
|---|---|
Possible mechanism of action of beta-phenethylamine in migraine.
Topics: Animals; Aorta; Atropine; Blood Pressure; Drug Synergism; Guinea Pigs; In Vitro Techniques; Male; Mi | 1977 |