pyrilamine has been researched along with Liver Neoplasms in 4 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Liver Neoplasms: Tumors or cancer of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methapyrilene hydrochloride was administered at levels of 125 or 250 ppm in the diet to groups of male and female F344 rats." | 1.27 | Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats. ( Lijinsky, W, 1984) |
| "No increase in incidence of liver neoplasms was observed after treatment with any of the four compounds, thenyldiamine, chlorothen, methafurylene, or methaphenilene, although each differed structurally from methapyrilene only in one atom or one position of substitution." | 1.27 | Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats. ( Kovatch, RM; Lijinsky, W, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lijinsky, W | 2 |
| Cheng, JS | 1 |
| Lee, KC | 1 |
| Wang, JL | 1 |
| Tseng, LL | 1 |
| Chou, KJ | 1 |
| Tang, KY | 1 |
| Jan, CR | 1 |
| Kovatch, RM | 1 |
| Habs, M | 1 |
| Shubik, P | 1 |
| Eisenbrand, G | 1 |
4 other studies available for pyrilamine and Liver Neoplasms
| Article | Year |
|---|---|
Chronic toxicity tests of pyrilamine maleate and methapyrilene hydrochloride in F344 rats.
Topics: Aminopyridines; Animals; Carcinogens; Diet; Dose-Response Relationship, Drug; Female; Liver Neoplasm | 1984 |
Histamine-Induced increases in intracellular free Ca2+ levels in hepatoma cells.
Topics: Biological Transport; Calcium; Carcinoma, Hepatocellular; Cimetidine; Cytosol; Extracellular Space; | 2000 |
Carcinogenicity studies of some analogs of the carcinogen methapyrilene in F344 rats.
Topics: Aminopyridines; Animals; Female; Histamine H1 Antagonists; Liver Neoplasms; Male; Methapyrilene; Pyr | 1986 |
Carcinogenicity of methapyrilene hydrochloride, mepyramine hydrochloride, thenyldiamine hydrochloride, and pyribenzamine hydrochloride in Sprague-Dawley rats.
Topics: Adenoma; Adrenal Gland Neoplasms; Aminopyridines; Animals; Dose-Response Relationship, Drug; Female; | 1986 |