pyrilamine has been researched along with Inflammation in 34 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, combinations of diclofenac and pyrilamine were used to determine their influence on nociception (formalin test), inflammation (paw inflammation produced by carrageenan), and gastric damage in rodents." | 7.85 | Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats. ( Ortiz, MI, 2017) |
| "The aim of this study was to evaluate the effect of angiotensin II on models of acute inflammation." | 7.73 | Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation. ( Alcantara, C; Brito, GA; Carvalho, RF; Cunha, FQ; Falcão, RA; Leitão, RF; Lima, RC; Ribeiro, RA; Souza, MH, 2006) |
| "15 mumol/paw) significantly reduced both bradykinin- and 5-hydroxytryptamine-induced rat paw oedema." | 7.69 | Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro. ( Antunes, E; Cirino, G; De Luca, IM; De Nucci, G; Giraldelo, CM; Hyslop, S; Muscará, MN; Zappellini, A; Zatz, R, 1994) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 7.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "The present study was undertaken to study the ability of substance P (SP) to induce inositol phospholipid (IP) hydrolysis measured as inositol mono-phosphate (IP1) accumulation, in an in vivo blister model of neurogenic inflammation in the rat hind footpad." | 7.67 | Substance P induced hydrolysis of inositol phospholipids in rat skin in an in vivo model of inflammation. ( Andrews, PV; Helme, RD; Khalil, Z; Thomas, KL, 1989) |
| "Role of endogenous histamine in postanaphylactic phase of allergic inflammation was examined by using a rat model of allergic inflammation of air pouch type." | 7.67 | Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. ( Hirasawa, N; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1987) |
| " Cortisone, mepyramine and sodium salicylate were effective in reducing histamine-induced inflammation, sodium salicylate being less active in the adrenalectomized animal." | 7.64 | Some inhibitors of histamine-induced and formaldehyde-induced inflammation in mice. ( NORTHOVER, BJ; SUBRAMANIAN, G, 1961) |
| " Here, combinations of diclofenac and pyrilamine were used to determine their influence on nociception (formalin test), inflammation (paw inflammation produced by carrageenan), and gastric damage in rodents." | 3.85 | Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats. ( Ortiz, MI, 2017) |
| "The aim of this study was to evaluate the effect of angiotensin II on models of acute inflammation." | 3.73 | Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation. ( Alcantara, C; Brito, GA; Carvalho, RF; Cunha, FQ; Falcão, RA; Leitão, RF; Lima, RC; Ribeiro, RA; Souza, MH, 2006) |
| "15 mumol/paw) significantly reduced both bradykinin- and 5-hydroxytryptamine-induced rat paw oedema." | 3.69 | Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro. ( Antunes, E; Cirino, G; De Luca, IM; De Nucci, G; Giraldelo, CM; Hyslop, S; Muscará, MN; Zappellini, A; Zatz, R, 1994) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 3.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "The actions and interactions of putative mediators of inflammation, such as substance P (SP), histamine, bradykinin and prostaglandins (PGE2) were studied in human skin." | 3.68 | Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin. ( Håkanson, R; Wallengren, J, 1992) |
| "The present study was undertaken to study the ability of substance P (SP) to induce inositol phospholipid (IP) hydrolysis measured as inositol mono-phosphate (IP1) accumulation, in an in vivo blister model of neurogenic inflammation in the rat hind footpad." | 3.67 | Substance P induced hydrolysis of inositol phospholipids in rat skin in an in vivo model of inflammation. ( Andrews, PV; Helme, RD; Khalil, Z; Thomas, KL, 1989) |
| "Role of endogenous histamine in postanaphylactic phase of allergic inflammation was examined by using a rat model of allergic inflammation of air pouch type." | 3.67 | Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. ( Hirasawa, N; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1987) |
| " Cortisone, mepyramine and sodium salicylate were effective in reducing histamine-induced inflammation, sodium salicylate being less active in the adrenalectomized animal." | 3.64 | Some inhibitors of histamine-induced and formaldehyde-induced inflammation in mice. ( NORTHOVER, BJ; SUBRAMANIAN, G, 1961) |
| "(AR) has been used to treat pain and inflammation in Korea." | 1.32 | Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways. ( Gao Zhang, C; Kim, SJ; Taek Lim, J, 2003) |
| "The histamine-induced increase in the content of VEGF protein in the conditioned medium was inhibited by the cyclic AMP antagonist Rp-cAMP (IC(50) 6." | 1.31 | Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors. ( Ghosh, AK; Hirasawa, N; Ohuchi, K, 2001) |
| "Pleurisy was induced by intrapleural injection of 1 ug of AGEPC into rats." | 1.27 | Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. ( Hayashi, M; Oh, S; Yamaki, K, 1986) |
| "Zymosan-oedema was inhibited by mepyramine and methysergide and by leucopenia." | 1.27 | Further studies of the mechanism of counter irritation by turpentine. ( Damas, J; Deflandre, E; Remacle-Volon, G, 1986) |
| "Indomethacin treatment was also ineffective." | 1.27 | Pharmacological analysis of the vascular permeability response in the anaphylactic phase of allergic inflammation in rats. ( Hirasawa, N; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (52.94) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 5 (14.71) | 29.6817 |
| 2010's | 3 (8.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Javed, S | 1 |
| Mitchell, K | 1 |
| Sidsworth, D | 1 |
| Sellers, SL | 1 |
| Reutens-Hernandez, J | 1 |
| Massicotte, HB | 1 |
| Egger, KN | 1 |
| Lee, CH | 1 |
| Payne, GW | 1 |
| Bernardes, CP | 1 |
| Menaldo, DL | 1 |
| Mamede, CC | 1 |
| Zoccal, KF | 1 |
| Cintra, AC | 1 |
| Faccioli, LH | 1 |
| Stanziola, L | 1 |
| de Oliveira, F | 1 |
| Sampaio, SV | 1 |
| Ortiz, MI | 1 |
| Kim, SJ | 1 |
| Gao Zhang, C | 1 |
| Taek Lim, J | 1 |
| NORTHOVER, BJ | 1 |
| SUBRAMANIAN, G | 1 |
| Suzuki, R | 1 |
| Edwards, M | 1 |
| Dickenson, AH | 1 |
| Carvalho, RF | 1 |
| Ribeiro, RA | 1 |
| Falcão, RA | 1 |
| Lima, RC | 1 |
| Leitão, RF | 1 |
| Alcantara, C | 1 |
| Souza, MH | 1 |
| Cunha, FQ | 1 |
| Brito, GA | 1 |
| Liu, T | 1 |
| Bai, ZT | 1 |
| Pang, XY | 1 |
| Chai, ZF | 1 |
| Jiang, F | 1 |
| Ji, YH | 1 |
| Owen, DA | 2 |
| Poy, E | 1 |
| Woodward, DF | 2 |
| Daniel, D | 1 |
| Pipkin, MA | 1 |
| Raval, P | 1 |
| Lundberg, C | 1 |
| Gerdin, B | 1 |
| Giraldelo, CM | 1 |
| Zappellini, A | 1 |
| Muscará, MN | 1 |
| De Luca, IM | 1 |
| Hyslop, S | 1 |
| Cirino, G | 1 |
| Zatz, R | 1 |
| De Nucci, G | 1 |
| Antunes, E | 1 |
| Wilsoncroft, P | 1 |
| Euzger, H | 1 |
| Brain, SD | 1 |
| Jonsson, EW | 1 |
| Dahlén, SE | 2 |
| Kakutani, M | 1 |
| Murakami, M | 1 |
| Okamoto, H | 1 |
| Kudo, I | 1 |
| Inoue, K | 1 |
| Germonpré, PR | 1 |
| Joos, GF | 1 |
| Everaert, E | 1 |
| Kips, JC | 1 |
| Pauwels, RA | 1 |
| Burchardt, ER | 1 |
| Müller-Peddinghaus, R | 1 |
| Thorlacius, H | 1 |
| Raud, J | 2 |
| Lindbom, L | 1 |
| Hedqvist, P | 2 |
| Ghosh, AK | 1 |
| Hirasawa, N | 5 |
| Ohuchi, K | 4 |
| Dunn, CJ | 2 |
| Willoughby, DA | 2 |
| Wallengren, J | 1 |
| Håkanson, R | 1 |
| Konno, S | 1 |
| Tsurufuji, S | 5 |
| Thomas, KL | 1 |
| Andrews, PV | 1 |
| Khalil, Z | 1 |
| Helme, RD | 1 |
| Kamo, I | 1 |
| Smedegård, G | 1 |
| Archer, CB | 1 |
| MacDonald, DM | 1 |
| Morley, J | 1 |
| Page, CP | 1 |
| Paul, W | 1 |
| Sanjar, S | 1 |
| Watanabe, M | 3 |
| Takahashi, C | 1 |
| Hayashi, Y | 1 |
| Fujiki, H | 1 |
| Sugimura, T | 1 |
| Oh, S | 1 |
| Hayashi, M | 1 |
| Yamaki, K | 1 |
| Damas, J | 1 |
| Remacle-Volon, G | 1 |
| Deflandre, E | 1 |
| Ekre, HP | 1 |
| Fjellner, B | 1 |
| Hägermark, O | 1 |
| Bhattacharya, SK | 1 |
| Das, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer[NCT02549534] | 29 participants (Actual) | Observational | 2015-09-30 | Completed | |||
| Study of the Measurement of Substance P in the Saliva of Patients With Low Back Pain[NCT00735735] | 40 participants (Actual) | Interventional | 2009-02-28 | Terminated | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
34 other studies available for pyrilamine and Inflammation
| Article | Year |
|---|---|
Inonotus obliquus attenuates histamine-induced microvascular inflammation.
Topics: Agaricales; Animals; Arterioles; Basidiomycota; Endothelium, Vascular; Histamine; Inflammation; Inte | 2019 |
Evaluation of the local inflammatory events induced by BpirMP, a metalloproteinase from Bothrops pirajai venom.
Topics: Animals; Bothrops; Cell Degranulation; Cromolyn Sodium; Crotalid Venoms; Cyclooxygenase Inhibitors; | 2015 |
Synergistic interaction between diclofenac and pyrilamine on nociception, inflammation, and gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Diclofenac; Dose-Response Relationshi | 2017 |
Mechanism of anti-nociceptive effects of Asarum sieboldii Miq. radix: potential role of bradykinin, histamine and opioid receptor-mediated pathways.
Topics: Analgesics, Non-Narcotic; Animals; Asarum; Bradykinin; Carrageenan; Edema; Guinea Pigs; Histamine; I | 2003 |
Some inhibitors of histamine-induced and formaldehyde-induced inflammation in mice.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Antipyretics; Cortisone; Edema; Formaldehyde; Histami | 1961 |
ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and
Topics: Analgesics; Animals; Disease Models, Animal; Electrophysiology; Histamine H1 Antagonists; Inflammati | 2004 |
Angiotensin II potentiates inflammatory edema in rats: Role of mast cell degranulation.
Topics: Acute Disease; Angiotensin II; Animals; Anti-Allergic Agents; Carrageenan; Cell Degranulation; Cell | 2006 |
Degranulation of mast cells and histamine release involved in rat pain-related behaviors and edema induced by scorpion Buthus martensi Karch venom.
Topics: Animals; Chlorpheniramine; Cimetidine; Dose-Response Relationship, Drug; Edema; Histamine Antagonist | 2007 |
Evaluation of the role of Histamine H1- and H2-receptors in cutaneous inflammation in the guinea-pig produced by histamine and mast cell degranulation.
Topics: Animals; Cimetidine; Dimaprit; Guinea Pigs; Histamine; Histamine Antagonists; Histamine H1 Antagonis | 1980 |
Effect of histamine H1- and H2-receptor antagonists, steroidal and non-steroidal anti-inflammatory agents on carrageenin-induced inflammation of the guinea-pig ear.
Topics: Animals; Anti-Inflammatory Agents; Body Temperature; Carrageenan; Cimetidine; Ear; Glucocorticoids; | 1982 |
The role of histamine and serotonin in the inflammatory reaction in an experimental model of open wounds in the rat.
Topics: Animals; Capillary Permeability; Cimetidine; Granulation Tissue; Histamine; Histamine Antagonists; I | 1984 |
Effect of arginine analogues on rat hind paw oedema and mast cell activation in vitro.
Topics: Animals; Arginine; Bradykinin; Edema; Hindlimb; Histamine Release; Inflammation; Male; Mast Cells; M | 1994 |
Effect of a neurokinin-1 (NK1) receptor antagonist on oedema formation induced by tachykinins, carrageenin and an allergic response in guinea-pig skin.
Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Carrageenan; Edema; Guinea Pigs; Indoles; Infl | 1994 |
Leukotrienes and other mediators of the Schultz-Dale reaction in guinea-pig lung parenchyma.
Topics: Animals; Guinea Pigs; Inflammation; Leukotriene B4; Leukotrienes; Lung; Male; Metiamide; Ovalbumin; | 1995 |
Role of type II phospholipase A2 in the inflammatory process of carrageenan-induced pleurisy in rats.
Topics: Animals; Antibodies, Monoclonal; Carrageenan; Indomethacin; Inflammation; Male; Phospholipases A; Ph | 1994 |
Characterization of neurogenic inflammation in the airways of two highly inbred rat strains.
Topics: Animals; Benzamides; Blood Pressure; Bronchi; Capillary Permeability; Capsaicin; Cimetidine; Colorin | 1995 |
Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, Animal; Drug The | 1997 |
Histamine potentiates leukotriene B4-induced leukocyte adhesion: a potential role of histamine1-receptor antagonism in allergic leukocyte recruitment.
Topics: Animals; Blood Proteins; Cell Adhesion; Cheek; Cricetinae; Drug Synergism; Histamine; Histamine H1 A | 1997 |
Enhancement by histamine of vascular endothelial growth factor production in granulation tissue via H(2) receptors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, Cultured; Cimetidine; Cyclic A | 2001 |
The response of the newborn rat to injury. I. Vascular and humoral aspects.
Topics: Age Factors; Albumins; Animals; Animals, Newborn; Bradykinin; Capillary Permeability; Carrageenan; C | 1975 |
The response of the newborn rat to intraleural dextran: vascular and cellular aspects.
Topics: Aging; Animals; Animals, Newborn; Cyproheptadine; Dextrans; Edema; Exudates and Transudates; Hindlim | 1975 |
Effects of capsaicin, bradykinin and prostaglandin E2 in the human skin.
Topics: Adult; Axons; Bradykinin; Capsaicin; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomet | 1992 |
Analysis of the factor(s) involved in pathogenesis of zymosan-induced inflammation in rats.
Topics: Animals; Capillary Permeability; Complement System Proteins; Histamine; Histamine Release; Inflammat | 1985 |
Substance P induced hydrolysis of inositol phospholipids in rat skin in an in vivo model of inflammation.
Topics: Animals; Blister; Capillary Permeability; Capsaicin; Histamine; Hydrolysis; Inflammation; Phosphatid | 1989 |
Analysis of the effects of cyclooxygenase and lipoxygenase inhibitors on leukocyte accumulation in the inflammatory site.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Movement; Cimetidine; Cyclooxygenase Inhibito | 1989 |
An intravital microscopic model for mast cell-dependent inflammation in the hamster cheek pouch.
Topics: Acute-Phase Reaction; Allergens; Animals; Antigens; Cheek; Cricetinae; Inflammation; Male; Mast Cell | 1989 |
Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man.
Topics: Adult; Animals; Blood Proteins; Chlorpheniramine; Guinea Pigs; Histamine H1 Antagonists; Humans; Ind | 1985 |
Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Capillary Permeability; Histamine; Histamine H1 Antagoni | 1987 |
Analysis of tumor-promoter-induced inflammation in rats: participation of histamine and prostaglandin E2.
Topics: Animals; Capillary Permeability; Dinoprostone; Edema; Histamine; Indomethacin; Inflammation; Lyngbya | 1987 |
Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats.
Topics: Animals; Azo Compounds; Bradykinin; Capillary Permeability; Dexamethasone; Guinea Pigs; Histamine; I | 1986 |
Further studies of the mechanism of counter irritation by turpentine.
Topics: Animals; Blood Sedimentation; Captopril; Carrageenan; Edema; Female; Inflammation; Kininogens; Leuko | 1986 |
Inhibition of complement dependent experimental inflammation in human skin by different heparin fractions.
Topics: Animals; Complement Inactivator Proteins; Heparin; Histamine; Humans; Inflammation; Kinetics; Pyrila | 1986 |
Pharmacological analysis of the vascular permeability response in the anaphylactic phase of allergic inflammation in rats.
Topics: Anaphylaxis; Animals; Capillary Permeability; Chromones; Dexamethasone; Histamine; Indomethacin; Inf | 1985 |
Anti-inflammatory effect of intraventricularly administered histamine in rats.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Female; Histamine; Inflammation; Injections, Intrave | 1985 |