pyrilamine has been researched along with Hypersensitivity in 21 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Hypersensitivity: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Role of endogenous histamine in postanaphylactic phase of allergic inflammation was examined by using a rat model of allergic inflammation of air pouch type." | 7.67 | Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. ( Hirasawa, N; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1987) |
| "Role of endogenous histamine in postanaphylactic phase of allergic inflammation was examined by using a rat model of allergic inflammation of air pouch type." | 3.67 | Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats. ( Hirasawa, N; Ohuchi, K; Tsurufuji, S; Watanabe, M, 1987) |
| "Histamine has been shown to promote Th2 polarization by dendritic cells." | 1.37 | Histamine H(4) receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells. ( Borrebaeck, CA; Broos, S; Greiff, L; Lindstedt, M; Lundberg, K, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 11 (52.38) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 2 (9.52) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Menciu, C | 1 |
| Duflos, M | 1 |
| Fouchard, F | 1 |
| Le Baut, G | 1 |
| Emig, P | 1 |
| Achterrath, U | 1 |
| Szelenyi, I | 1 |
| Nickel, B | 1 |
| Schmidt, J | 1 |
| Kutscher, B | 1 |
| Günther, E | 1 |
| Riley, JP | 1 |
| Fuchs, B | 1 |
| Sjöberg, L | 1 |
| Nilsson, GP | 1 |
| Karlsson, L | 1 |
| Dahlén, SE | 1 |
| Rao, NL | 1 |
| Adner, M | 1 |
| Dev, S | 1 |
| Mizuguchi, H | 1 |
| Das, AK | 1 |
| Maeyama, K | 1 |
| Horinaga, S | 1 |
| Kato, S | 1 |
| Tamada, M | 1 |
| Hattori, M | 1 |
| Umehara, H | 1 |
| Fukui, H | 1 |
| Lundberg, K | 1 |
| Broos, S | 1 |
| Greiff, L | 1 |
| Borrebaeck, CA | 1 |
| Lindstedt, M | 1 |
| VIGLIOGLIA, PA | 1 |
| SZAMA, HE | 1 |
| Ufkes, JG | 1 |
| Ottenhof, M | 1 |
| Yakuo, I | 1 |
| Ishii, K | 1 |
| Seto, Y | 1 |
| Imano, K | 1 |
| Takeyama, K | 1 |
| Nakamura, H | 1 |
| Karasawa, T | 1 |
| Abe, T | 1 |
| Omata, T | 1 |
| Yoshida, K | 1 |
| Matsumura, T | 1 |
| Ikeda, Y | 1 |
| Segawa, Y | 1 |
| Matsuda, K | 1 |
| Nagai, H | 1 |
| Nakagawa, N | 1 |
| Obata, T | 1 |
| Kobayashi, T | 1 |
| Okada, Y | 1 |
| Nambu, F | 1 |
| Terawaki, T | 1 |
| Furuya, T | 1 |
| Muryobayashi, K | 1 |
| Sawada, M | 1 |
| Aishita, H | 1 |
| De Cock, W | 1 |
| De Cree, J | 1 |
| Verhaegen, H | 1 |
| Broder, I | 1 |
| Rogers, S | 1 |
| Chamberlain, DW | 1 |
| Milne, EN | 1 |
| Namimatsu, A | 1 |
| Go, K | 1 |
| Tanimoto, H | 1 |
| Okuda, M | 1 |
| Dini, S | 1 |
| Caselli, GF | 1 |
| Basilico, C | 1 |
| Lavezzo, A | 1 |
| Giani, R | 1 |
| Kamei, C | 1 |
| Mio, M | 1 |
| Izushi, K | 1 |
| Kitazumi, K | 1 |
| Tsujimoto, S | 1 |
| Fujisawa, K | 1 |
| Adachi, Y | 1 |
| Tasaka, K | 1 |
| Vannier, E | 1 |
| Lefort, J | 1 |
| Lellouch-Tubiana, A | 1 |
| Terlain, B | 1 |
| Vargaftig, BB | 1 |
| Watanabe, A | 1 |
| Hayashi, H | 1 |
| Vigano', T | 1 |
| Nicosia, S | 1 |
| Accomazzo, MR | 1 |
| Crivellari, MT | 1 |
| Oliva, D | 1 |
| Verga, A | 1 |
| Mezzetti, M | 1 |
| Folco, G | 1 |
| Rubinstein, I | 1 |
| Nadel, JA | 1 |
| Graf, PD | 1 |
| Caughey, GH | 1 |
| Adolphson, RL | 1 |
| Finkel, MP | 1 |
| Robichaud, LJ | 1 |
| Hirasawa, N | 1 |
| Ohuchi, K | 1 |
| Watanabe, M | 1 |
| Tsurufuji, S | 1 |
| Leon, J | 1 |
| Charap, A | 1 |
| Duzman, E | 1 |
| Shen, CD | 1 |
1 trial available for pyrilamine and Hypersensitivity
| Article | Year |
|---|---|
Efficacy of cimetidine/pyrilamine eyedrops. A dose response study with histamine challenge.
Topics: Adult; Aminopyridines; Cimetidine; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug | 1986 |
20 other studies available for pyrilamine and Hypersensitivity
| Article | Year |
|---|---|
New N-(pyridin-4-yl)-(indol-3-yl)acetamides and propanamides as antiallergic agents.
Topics: Acetylcholine; Animals; Anti-Allergic Agents; Bronchoalveolar Lavage; Capillary Permeability; Carbac | 1999 |
Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
Topics: Acetates; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Cyclopropanes; Disea | 2013 |
Kujin suppresses histamine signaling at the transcriptional level in toluene 2,4-diisocyanate-sensitized rats.
Topics: Animals; Cytokines; Fabaceae; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histamine | 2009 |
Histamine H(4) receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells.
Topics: Adult; Allergens; Case-Control Studies; Dendritic Cells; Female; Gene Expression Regulation; Histami | 2011 |
[Pyranisamine and antihistamines].
Topics: Anti-Allergic Agents; Histamine; Histamine Antagonists; Humans; Hypersensitivity; Pyrilamine | 1950 |
Characterization of various antiallergic agents using a new method for inducing systemic anaphylaxis in the rat.
Topics: Anaphylaxis; Animals; Blood Pressure; Bronchodilator Agents; Chromones; Cromolyn Sodium; Disease Mod | 1984 |
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].
Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, D | 1994 |
Antiallergic effect of ZCR-2060: antihistaminic action.
Topics: Animals; Benzoates; Brain; Dermatitis, Contact; Exploratory Behavior; Guinea Pigs; Histamine; Histam | 1994 |
Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma.
Topics: Acetylcholine; Acute-Phase Reaction; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrict | 1993 |
Histamine receptor-bearing T lymphocytes in patients with allergy, autoimmune disease, or recurrent infection.
Topics: Adolescent; Adult; Aged; Autoimmune Diseases; Child; Child, Preschool; Cimetidine; Female; Humans; H | 1978 |
Model of allergic bronchoconstriction in the guinea pig. I. Characteristics of the system.
Topics: Administration, Intranasal; Aerosols; Animals; Antibodies; Antigens; Bronchi; Bronchography; Cattle; | 1978 |
Mechanism of nasal secretion mediated via nerve reflex in guinea pigs and evaluation of antiallergic drugs.
Topics: Allergens; Aminopyridines; Animals; Atropine Derivatives; Bronchodilator Agents; Capsaicin; Ganglion | 1992 |
Antihistaminic/antiallergic activity of 2-dialkylaminoalkylthio(oxy)-1-substituted benzimidazoles: evaluation "in vitro" and "in vivo".
Topics: Animals; Benzhydryl Compounds; Benzimidazoles; Blood-Brain Barrier; Brain; Clemastine; Guinea Pigs; | 1990 |
Antiallergic effects of major metabolites of astemizole in rats and guinea pigs.
Topics: Animals; Astemizole; Binding, Competitive; Bronchoconstriction; Cerebellum; Guinea Pigs; Heart Rate; | 1991 |
Lipopolysaccharide from Escherichia coli reduces antigen-induced bronchoconstriction in actively sensitized guinea pigs.
Topics: Animals; Antigens; Aspirin; Bronchoconstriction; Cell Degranulation; Endotoxins; Escherichia coli; G | 1991 |
Allergen-induced biphasic bronchoconstriction in rats.
Topics: Airway Resistance; Allergens; Aminophylline; Animals; Bronchial Spasm; Chromones; Cromolyn Sodium; D | 1990 |
Binding sites for histamine and sulfidopeptide leukotrienes in normal and hypersensitized human lung fragments.
Topics: Binding Sites; Histamine; Humans; Hypersensitivity; Immunoglobulin E; Lung; Prostaglandin D2; Pyrila | 1990 |
Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs.
Topics: Allergens; Animals; Capillary Permeability; Cell Degranulation; Chymases; Dogs; Histamine; Hypersens | 1990 |
CI-922--a novel, potent antiallergic compound--II. Activity in animal models of allergy.
Topics: Anaphylaxis; Animals; Ascaris; Azoles; Bronchial Spasm; Cromolyn Sodium; Cross Reactions; Dogs; Hist | 1987 |
Role of endogenous histamine in postanaphylactic phase of allergic inflammation in rats.
Topics: Amine Oxidase (Copper-Containing); Animals; Capillary Permeability; Histamine; Histamine H1 Antagoni | 1987 |