pyrilamine has been researched along with Epilepsy in 4 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Excerpt | Relevance | Reference |
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", ip) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both 22a and its metabolite(s) are active, compensating probably low bioavailability of the parent molecule." | 1.43 | Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents. ( Bednarski, M; Gunia-Krzyżak, A; Marona, H; Nitek, W; Pękala, E; Powroźnik, B; Słoczyńska, K; Walczak, M; Waszkielewicz, AM; Żesławska, E, 2016) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 3 (75.00) | 29.6817 |
2010's | 1 (25.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Waszkielewicz, AM | 1 |
Gunia-Krzyżak, A | 1 |
Powroźnik, B | 1 |
Słoczyńska, K | 1 |
Pękala, E | 1 |
Walczak, M | 1 |
Bednarski, M | 1 |
Żesławska, E | 1 |
Nitek, W | 1 |
Marona, H | 1 |
Fujii, Y | 1 |
Tanaka, T | 1 |
Harada, C | 1 |
Hirai, T | 1 |
Kamei, C | 1 |
Nishida, N | 1 |
Huang, ZL | 1 |
Mikuni, N | 1 |
Miura, Y | 1 |
Urade, Y | 1 |
Hashimoto, N | 1 |
Chen, Z | 1 |
Li, WD | 1 |
Zhu, LJ | 1 |
Shen, YJ | 1 |
Wei, EQ | 1 |
4 other studies available for pyrilamine and Epilepsy
Article | Year |
---|---|
Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents.
Topics: Amino Alcohols; Animals; Anticonvulsants; Chemistry, Physical; Dose-Response Relationship, Drug; Dru | 2016 |
Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.
Topics: Amygdala; Animals; Cetirizine; Diphenhydramine; Electroencephalography; Epilepsy; Histamine H1 Antag | 2003 |
Deep brain stimulation of the posterior hypothalamus activates the histaminergic system to exert antiepileptic effect in rat pentylenetetrazol model.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Convulsants; Cortical Synchronization; Deep Brain Stimul | 2007 |
Effects of histidine, a precursor of histamine, on pentylenetetrazole-induced seizures in rats.
Topics: Animals; Drug Synergism; Epilepsy; Histamine; Histamine Antagonists; Histamine H1 Antagonists; Histi | 2002 |