pyrilamine has been researched along with Disease Models, Animal in 59 studies
Pyrilamine: A histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies (including skin eruptions) both parenterally and locally. It is a common ingredient of cold remedies.
mepyramine : An ethylenediamine derivative that is ethylenediamine in which one of the amino nitrogens is substituted by two methyl groups and the remaining amino nitrogen is substituted by a 4-methoxybenzyl and a pyridin-2-yl group.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine is a biogenic amine that is widely distributed and has multiple functions, but the role it plays in acute myocardial infarction (AMI) remains unclear." | 7.81 | Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis. ( Chen, J; Deng, L; Ding, S; Ge, J; Hong, T; Huang, Z; Jia, J; Lin, J; Wang, TC; Yang, X; Zou, Y, 2015) |
| "The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist) in separate and combined treatments." | 7.77 | Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats. ( Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E, 2011) |
| " In the present study, the effect of repeated administration of histamine on amnesia induced by post-training administration of the drug was examined." | 7.76 | Repeated histamine pretreatment decreased amnesia induced by post-training administration of the drug in a step-down inhibitory avoidance test in mice. ( Ahmadi, S; Malekmohammadi, N; Zarrindast, MR, 2010) |
| "Combination therapy blocking both PAF and histamine markedly reduces the severity of peanut-induced anaphylaxis, and thus it may be a potential life-saving therapeutic approach in peanut and, likely, other food-induced anaphylaxis." | 7.75 | Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. ( Arias, K; Baig, M; Chu, D; Colangelo, M; Coyle, A; Goncharova, S; Jordana, M; Vadas, P; Walker, T; Waserman, S, 2009) |
| "Oral administration for 6 days of 100 mg/kg MMK-1, an agonist peptide selective for the FPRL1 receptor, suppressed alopecia induced by the anticancer drug etoposide in neonatal rats." | 7.73 | Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1. ( Tsuruki, T; Yoshikawa, M, 2006) |
| " A selective and potent 5-LO inhibitor, zileuton (N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) was evaluated in models of airway anaphylaxis, where leukotrienes are a major component." | 7.69 | The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. ( Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB, 1994) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 7.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| "The role of the central histaminergic system in depression was studied by using swimming despair test in mice - a behavioural model of depression." | 7.67 | Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice. ( Dhawan, KN; Gulati, A; Gupta, GP; Nath, C, 1988) |
| "Regional myocardial ischemia was induced by occlusion of a diagonal branch of left anterior descending coronary artery of anesthetized cats." | 5.35 | Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2? ( Fu, LW; Longhurst, JC; Phan, A, 2008) |
| "Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells." | 5.33 | Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005) |
| "Histamine is a biogenic amine that is widely distributed and has multiple functions, but the role it plays in acute myocardial infarction (AMI) remains unclear." | 3.81 | Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis. ( Chen, J; Deng, L; Ding, S; Ge, J; Hong, T; Huang, Z; Jia, J; Lin, J; Wang, TC; Yang, X; Zou, Y, 2015) |
| "The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist) in separate and combined treatments." | 3.77 | Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats. ( Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E, 2011) |
| " In the present study, the effect of repeated administration of histamine on amnesia induced by post-training administration of the drug was examined." | 3.76 | Repeated histamine pretreatment decreased amnesia induced by post-training administration of the drug in a step-down inhibitory avoidance test in mice. ( Ahmadi, S; Malekmohammadi, N; Zarrindast, MR, 2010) |
| "Combination therapy blocking both PAF and histamine markedly reduces the severity of peanut-induced anaphylaxis, and thus it may be a potential life-saving therapeutic approach in peanut and, likely, other food-induced anaphylaxis." | 3.75 | Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. ( Arias, K; Baig, M; Chu, D; Colangelo, M; Coyle, A; Goncharova, S; Jordana, M; Vadas, P; Walker, T; Waserman, S, 2009) |
| "Oral administration for 6 days of 100 mg/kg MMK-1, an agonist peptide selective for the FPRL1 receptor, suppressed alopecia induced by the anticancer drug etoposide in neonatal rats." | 3.73 | Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1. ( Tsuruki, T; Yoshikawa, M, 2006) |
| " A selective and potent 5-LO inhibitor, zileuton (N-1(1-benzo[b]thien-2-ylethyl)-N-hydroxyurea, A-64077) was evaluated in models of airway anaphylaxis, where leukotrienes are a major component." | 3.69 | The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis. ( Bell, RL; Brooks, DW; Carter, GW; Malo, PE; Shaughnessy, TK; Summers, JB, 1994) |
| "The following study was performed to further characterize a primate model of asthma using classes of drugs that target allergy (pyrilamine, cetirizine), are bronchodilators for the treatment of asthma (salbutamol, salmeterol) or are anti-inflammatory (dexamethasone)." | 3.69 | Characterization of a primate model of asthma using anti-allergy/anti-asthma agents. ( Andresen, CJ; Smith, WB; Turner, CR; Watson, JW, 1996) |
| "The leukotriene synthesis inhibitor (LSI) BAY X 1005 was tested in the arachidonic acid (AA)-induced mouse ear inflammation test (AA-MEIT) alone and in combination with other representative anti-inflammatory compounds for antiedematous effects." | 3.69 | Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test. ( Burchardt, ER; Müller-Peddinghaus, R, 1997) |
| " In ovalbumin-sensitized guinea pigs, challenged with low doses of ovalbumin, we observed an immediate bronchoconstriction, a late-phase bronchopulmonary eosinophilia but no late-phase bronchoconstriction." | 3.68 | Chasing the elusive animal model of late-phase bronchoconstriction: studies in dogs, guinea pigs and rats. ( Fidler, SF; Griffin, RL; Reid, MS; Richards, IM; Shields, SK, 1992) |
| "Evans blue (EB) dye extravasation has been used as a reliable and objective parameter of the increased vascular permeability of an allergic conjunctivitis experimental rat model that closely mimics human ocular allergy." | 3.68 | Pharmacologic modulation of vascular permeability in ocular allergy in the rat. ( Calonge, MC; González, JL; Herreras, JM; Pastor, JC, 1990) |
| "The role of the central histaminergic system in depression was studied by using swimming despair test in mice - a behavioural model of depression." | 3.67 | Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice. ( Dhawan, KN; Gulati, A; Gupta, GP; Nath, C, 1988) |
| "Histamine plays significant roles in early-phase swelling via H₁ receptors and in late-phase swelling via H₃/H₄ receptors in this TPA-modified allergic dermatitis model." | 2.47 | [Roles of histamine in the exacerbated allergic dermatitis]. ( Hirasawa, N; Ohuchi, K, 2011) |
| "Furthermore, the effects of UW-MD-71 on memory deficits induced by the non-competitive N-methyl-d-aspartate (NMDA) antagonist dizocilpine (DIZ) were tested." | 1.43 | The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats. ( Darras, FH; Decker, M; Khan, N; Nurulain, SM; Saad, A; Sadek, B, 2016) |
| "Regional myocardial ischemia was induced by occlusion of a diagonal branch of left anterior descending coronary artery of anesthetized cats." | 1.35 | Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2? ( Fu, LW; Longhurst, JC; Phan, A, 2008) |
| "Histamine plays significant roles in the early-phase swelling via H1 receptors, and the late-phase swelling via H3/H4 receptors in this TPA-modified allergic dermatitis model." | 1.35 | Modification of the picryl chloride-induced allergic dermatitis model in mouse ear lobes by 12-O-tetradecanoylphorbol 13-acetate, and analysis of the role of histamine in the modified model. ( Hirasawa, N; Hong, J; Ishihara, K; Katoh, G; Ohsawa, Y; Ohuchi, K; Seyama, T; Shibata, K; Tamura, S, 2009) |
| "Montelukast has not been reported to have major effects on sneezing and itching in the clinic but reduces nasal obstruction (lower nasal airway pressure or nasal patency)." | 1.35 | Differential responses to various classes of drugs in a model of allergic rhinitis in guinea pigs. ( Al Suleimani, YM; Dong, Y; Walker, MJ, 2008) |
| "Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells." | 1.33 | Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005) |
| "Focal cerebral ischemia for 2 h by occlusion of the right middle cerebral artery provoked severe brain infarction in the rat brain after 24 h." | 1.33 | Prevention of brain infarction by postischemic administration of histidine in rats. ( Adachi, N; Arai, T; Liu, K, 2005) |
| "Biphasic nasal blockage and sneezing after the challenge in Group A-2 were more severe than those in Group A-0, while those of Group B-7 were almost the same as those of Group B-0." | 1.32 | Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig. ( Kohno, S; Mizutani, N; Nabe, T; Takenaka, H, 2003) |
| "The histamine-independent allergic conjunctivitis may be useful for analyzing mechanisms underlying chronic conjunctivitis." | 1.32 | Multiple cedar pollen challenge diminishes involvement of histamine in allergic conjunctivitis of Guinea pigs. ( Fukushima, Y; Kohno, S; Mizutani, N; Nabe, T; Nakata, K, 2003) |
| "The histamine-induced increase in intranasal pressure was significantly augmented after repeated antigen challenge, indicating that nasal hyperresponsiveness was achieved." | 1.31 | Elevated nasal mucosal G protein levels and histamine receptor affinity in a guinea pig model of nasal hyperresponsiveness. ( Chiba, Y; Matsuo, K; Misawa, M; Saitoh, N, 2002) |
| "Rat IgE pleurisy was induced by the injection of di-nitrophenol-conjugated bovine serum albumin (DNP-BSA) 48 hours after the intrapleural injection of rat anti-DNP-IgE serum." | 1.27 | Roles of leukotrienes in two rat allergic inflammatory models; IgE-mediated and IgG-antigen complex-induced pleurisies. ( Katori, M; Tanaka, K; Ueno, A, 1986) |
| " The dose-response relation of the coronary diameter to histamine was not influenced by pretreatment with the nerve transmitter blockers guanethidine (3 X 10(-6) M), atropine (10(-6) M), and tetrodotoxin (3 X 10(-7) M)." | 1.27 | Pathogenesis of coronary artery spasm in miniature swine with regional intimal thickening after balloon denudation. ( Egashira, K; Kawasaki, T; Kobayashi, T; Nakamura, M; Tomoike, H; Yamamoto, Y, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (18.64) | 18.7374 |
| 1990's | 18 (30.51) | 18.2507 |
| 2000's | 16 (27.12) | 29.6817 |
| 2010's | 13 (22.03) | 24.3611 |
| 2020's | 1 (1.69) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Köchling, H | 1 |
| Schaper, K | 1 |
| Wilzopolski, J | 1 |
| Gutzmer, R | 1 |
| Werfel, T | 1 |
| Bäumer, W | 1 |
| Kietzmann, M | 1 |
| Rossbach, K | 1 |
| Sharma, HS | 1 |
| Patnaik, R | 1 |
| Muresanu, DF | 1 |
| Lafuente, JV | 1 |
| Ozkizilcik, A | 1 |
| Tian, ZR | 1 |
| Nozari, A | 1 |
| Sharma, A | 1 |
| Alachkar, A | 1 |
| Latacz, G | 1 |
| Siwek, A | 1 |
| Lubelska, A | 1 |
| Honkisz, E | 1 |
| Gryboś, A | 1 |
| Łażewska, D | 1 |
| Handzlik, J | 1 |
| Stark, H | 1 |
| Kiec-Kononowicz, K | 1 |
| Sadek, B | 2 |
| Riley, JP | 1 |
| Fuchs, B | 1 |
| Sjöberg, L | 1 |
| Nilsson, GP | 1 |
| Karlsson, L | 1 |
| Dahlén, SE | 1 |
| Rao, NL | 1 |
| Adner, M | 1 |
| Deng, L | 1 |
| Hong, T | 1 |
| Lin, J | 1 |
| Ding, S | 1 |
| Huang, Z | 1 |
| Chen, J | 1 |
| Jia, J | 1 |
| Zou, Y | 1 |
| Wang, TC | 1 |
| Yang, X | 1 |
| Ge, J | 1 |
| Khan, N | 1 |
| Saad, A | 1 |
| Nurulain, SM | 1 |
| Darras, FH | 1 |
| Decker, M | 1 |
| Yu, J | 1 |
| Tang, YY | 1 |
| Wang, RR | 1 |
| Lou, GD | 1 |
| Hu, TT | 1 |
| Hou, WW | 1 |
| Yue, JX | 1 |
| Ohtsu, H | 1 |
| Shi, LY | 1 |
| Zhang, SH | 1 |
| Chen, Z | 1 |
| Fu, LW | 1 |
| Phan, A | 1 |
| Longhurst, JC | 1 |
| Hirasawa, N | 2 |
| Ohsawa, Y | 1 |
| Katoh, G | 1 |
| Shibata, K | 1 |
| Ishihara, K | 1 |
| Seyama, T | 1 |
| Tamura, S | 1 |
| Hong, J | 1 |
| Ohuchi, K | 2 |
| Arias, K | 1 |
| Baig, M | 1 |
| Colangelo, M | 1 |
| Chu, D | 1 |
| Walker, T | 1 |
| Goncharova, S | 1 |
| Coyle, A | 1 |
| Vadas, P | 1 |
| Waserman, S | 1 |
| Jordana, M | 1 |
| Ahmadi, S | 1 |
| Malekmohammadi, N | 1 |
| Zarrindast, MR | 1 |
| Tamaddonfard, E | 1 |
| Erfanparast, A | 1 |
| Farshid, AA | 1 |
| Khalilzadeh, E | 1 |
| Coruzzi, G | 1 |
| Pozzoli, C | 1 |
| Adami, M | 1 |
| Grandi, D | 1 |
| Guido, N | 1 |
| Smits, R | 1 |
| de Esch, I | 1 |
| Leurs, R | 1 |
| Fish, EW | 1 |
| Faccidomo, S | 1 |
| Gupta, S | 1 |
| Miczek, KA | 1 |
| Fukushima, Y | 1 |
| Nabe, T | 3 |
| Mizutani, N | 3 |
| Nakata, K | 1 |
| Kohno, S | 3 |
| Takenaka, H | 2 |
| Suzuki, R | 1 |
| Edwards, M | 1 |
| Dickenson, AH | 1 |
| Adachi, N | 1 |
| Liu, K | 1 |
| Arai, T | 1 |
| Sakairi, T | 1 |
| Suzuki, K | 1 |
| Makita, S | 1 |
| Wajima, T | 1 |
| Shakuto, S | 1 |
| Yoshida, Y | 1 |
| Yaguchi, M | 1 |
| Tsuruki, T | 1 |
| Yoshikawa, M | 1 |
| Tessier, J | 1 |
| Green, C | 1 |
| Padgett, D | 1 |
| Zhao, W | 1 |
| Schwartz, L | 1 |
| Hughes, M | 1 |
| Hewlett, E | 1 |
| Al Suleimani, YM | 1 |
| Dong, Y | 1 |
| Walker, MJ | 1 |
| Miyano, K | 1 |
| Chiou, GC | 1 |
| Ufkes, JG | 1 |
| Ottenhof, M | 1 |
| Yakuo, I | 1 |
| Ishii, K | 1 |
| Seto, Y | 1 |
| Imano, K | 1 |
| Takeyama, K | 1 |
| Nakamura, H | 1 |
| Karasawa, T | 1 |
| Langer, JC | 1 |
| Liebman, SM | 1 |
| Monk, PK | 1 |
| Pelletier, GJ | 1 |
| Malo, PE | 1 |
| Bell, RL | 1 |
| Shaughnessy, TK | 1 |
| Summers, JB | 1 |
| Brooks, DW | 1 |
| Carter, GW | 1 |
| Nakagawa, N | 1 |
| Obata, T | 1 |
| Kobayashi, T | 2 |
| Okada, Y | 1 |
| Nambu, F | 1 |
| Terawaki, T | 1 |
| Furuya, T | 1 |
| Muryobayashi, K | 1 |
| Sawada, M | 1 |
| Aishita, H | 1 |
| Schachter, EN | 1 |
| Zuskin, E | 1 |
| Buck, MG | 1 |
| Maayani, S | 1 |
| Marom, Z | 1 |
| Goswami, S | 1 |
| Rienzi, N | 1 |
| Turner, CR | 1 |
| Andresen, CJ | 1 |
| Smith, WB | 1 |
| Watson, JW | 1 |
| Heuer, HO | 1 |
| Wenz, B | 1 |
| Jennewein, HM | 1 |
| Urich, K | 1 |
| Burchardt, ER | 1 |
| Müller-Peddinghaus, R | 1 |
| Yang, PC | 1 |
| Liu, T | 1 |
| Zhang, TY | 1 |
| Fan, DS | 1 |
| Tohda, Y | 1 |
| Kubo, H | 1 |
| Haraguchi, R | 1 |
| Iwanaga, T | 1 |
| Fukuoka, M | 1 |
| Nakajima, S | 1 |
| Sasaki, K | 1 |
| Yuzurihara, M | 1 |
| Ikarashi, Y | 1 |
| Ishige, A | 1 |
| Sasaki, H | 1 |
| Kuribara, H | 1 |
| Maruyama, Y | 1 |
| Olsen, UB | 1 |
| Eltorp, CT | 1 |
| Ingvardsen, BK | 1 |
| Jørgensen, TK | 1 |
| Lundbaek, JA | 1 |
| Thomsen, C | 1 |
| Hansen, AJ | 1 |
| Chiba, Y | 1 |
| Saitoh, N | 1 |
| Matsuo, K | 1 |
| Misawa, M | 1 |
| Rees, WD | 1 |
| Rhodes, J | 1 |
| Wheeler, MH | 1 |
| Meek, EM | 1 |
| Newcombe, RG | 1 |
| Chand, N | 1 |
| Deroth, L | 1 |
| Eyre, P | 1 |
| Cheung, LY | 1 |
| Porterfield, G | 1 |
| Broder, I | 1 |
| Rogers, S | 1 |
| Chamberlain, DW | 1 |
| Milne, EN | 1 |
| Richards, IM | 1 |
| Griffin, RL | 1 |
| Shields, SK | 1 |
| Reid, MS | 1 |
| Fidler, SF | 1 |
| Yeadon, M | 1 |
| Wilkinson, D | 1 |
| Darley-Usmar, V | 1 |
| O'Leary, VJ | 1 |
| Payne, AN | 1 |
| Noguchi, S | 1 |
| Fukuda, Y | 1 |
| Inukai, T | 1 |
| Iwama, T | 1 |
| Shikada, K | 1 |
| Yamamoto, A | 1 |
| Sakashita, M | 1 |
| Hibi, M | 1 |
| Tanaka, S | 1 |
| Uchida, M | 1 |
| Imanishi, N | 1 |
| Sugasawa, T | 1 |
| Morooka, S | 1 |
| Tarayre, JP | 1 |
| Aliaga, M | 1 |
| Barbara, M | 1 |
| Tisseyre, N | 1 |
| Vieu, S | 1 |
| Tisne-Versailles, J | 1 |
| Calonge, MC | 1 |
| Pastor, JC | 1 |
| Herreras, JM | 1 |
| González, JL | 1 |
| Heuer, H | 1 |
| Casals-Stenzel, J | 1 |
| Nath, C | 1 |
| Gulati, A | 1 |
| Dhawan, KN | 1 |
| Gupta, GP | 1 |
| Tanaka, K | 1 |
| Ueno, A | 1 |
| Katori, M | 1 |
| Yamamoto, Y | 1 |
| Tomoike, H | 1 |
| Egashira, K | 1 |
| Kawasaki, T | 1 |
| Nakamura, M | 1 |
| Serbus, DC | 1 |
| Stull, RE | 1 |
| Light, KE | 1 |
1 review available for pyrilamine and Disease Models, Animal
| Article | Year |
|---|---|
[Roles of histamine in the exacerbated allergic dermatitis].
Topics: Animals; Cyclosporine; Dermatitis, Atopic; Disease Models, Animal; Drug Therapy, Combination; Histam | 2011 |
58 other studies available for pyrilamine and Disease Models, Animal
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Combined treatment with H1 and H4 receptor antagonists reduces inflammation in a mouse model of atopic dermatitis.
Topics: Animals; Dermatitis, Atopic; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Com | 2017 |
Histaminergic Receptors Modulate Spinal Cord Injury-Induced Neuronal Nitric Oxide Synthase Upregulation and Cord Pathology: New Roles of Nanowired Drug Delivery for Neuroprotection.
Topics: Animals; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems | 2017 |
Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats.
Topics: Animals; Anticonvulsants; Benzothiazoles; Disease Models, Animal; Dose-Response Relationship, Drug; | 2018 |
Mast cell mediators cause early allergic bronchoconstriction in guinea-pigs in vivo: a model of relevance to asthma.
Topics: Acetates; Animals; Asthma; Bronchial Hyperreactivity; Constriction, Pathologic; Cyclopropanes; Disea | 2013 |
Histamine deficiency exacerbates myocardial injury in acute myocardial infarction through impaired macrophage infiltration and increased cardiomyocyte apoptosis.
Topics: Acute Disease; Animals; Apoptosis; Cell Line; Cimetidine; Creatine Kinase, MB Form; Disease Models, | 2015 |
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Benzothiazoles; Cholinesterase Inhibitors; Disease Models, Animal; Dizo | 2016 |
A critical time window for the analgesic effect of central histamine in the partial sciatic ligation model of neuropathic pain.
Topics: Analgesics; Animals; Central Nervous System; Cimetidine; Disease Models, Animal; Drug Administration | 2016 |
Myocardial ischemia-mediated excitatory reflexes: a new function for thromboxane A2?
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthetics, Local; Animals; Cat | 2008 |
Modification of the picryl chloride-induced allergic dermatitis model in mouse ear lobes by 12-O-tetradecanoylphorbol 13-acetate, and analysis of the role of histamine in the modified model.
Topics: Animals; Cell Count; Cimetidine; Cyclophosphamide; Cyclosporine; Cytokines; Dermatitis, Allergic Con | 2009 |
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions.
Topics: Allergens; Anaphylaxis; Animals; Arachis; Cholera Toxin; Cimetidine; Disease Models, Animal; Drug Th | 2009 |
Repeated histamine pretreatment decreased amnesia induced by post-training administration of the drug in a step-down inhibitory avoidance test in mice.
Topics: Amnesia; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Benzazepines; Disease | 2010 |
Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Hippocampus; Histami | 2011 |
Strain-dependent effects of the histamine H₄ receptor antagonist JNJ7777120 in a murine model of acute skin inflammation.
Topics: Animals; Anti-Inflammatory Agents; Croton Oil; Dermatitis; Dermatologic Agents; Dexamethasone; Disea | 2012 |
Anxiolytic-like effects of escitalopram, citalopram, and R-citalopram in maternally separated mouse pups.
Topics: Animals; Anti-Anxiety Agents; Anxiety, Separation; Body Temperature; Citalopram; Disease Models, Ani | 2004 |
Multiple cedar pollen challenge diminishes involvement of histamine in allergic conjunctivitis of Guinea pigs.
Topics: Administration, Oral; Administration, Topical; Albumins; Allergens; Animals; Conjunctivitis, Allergi | 2003 |
Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig.
Topics: Animals; Antigens; Chromones; Disease Models, Animal; Guinea Pigs; Histamine H1 Antagonists; Leukotr | 2003 |
ReN-1869 [(R)-1-(3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-propyl)-3-piperidine carboxylic acid], a novel histamine H1 receptor antagonist, produces potent and selective antinociceptive effects on dorsal horn neurons after inflammation and
Topics: Analgesics; Animals; Disease Models, Animal; Electrophysiology; Histamine H1 Antagonists; Inflammati | 2004 |
Prevention of brain infarction by postischemic administration of histidine in rats.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Functional Laterality; Histamine H1 Antagonists; Hi | 2005 |
Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
Topics: Airway Resistance; Animals; Anti-Allergic Agents; Area Under Curve; Carbazoles; Disease Models, Anim | 2005 |
Orally administered FPRL1 receptor agonist peptide MMK-1 inhibits etoposide-induced alopecia by a mechanism different from intraperitoneally administered MMK-1.
Topics: Administration, Oral; Alopecia; Animals; Cimetidine; Disease Models, Animal; Etoposide; Female; Indo | 2006 |
Contributions of histamine, prostanoids, and neurokinins to edema elicited by edema toxin from Bacillus anthracis.
Topics: Animals; Antigens, Bacterial; Aprepitant; Bacillus anthracis; Bacterial Toxins; Capillary Permeabili | 2007 |
Differential responses to various classes of drugs in a model of allergic rhinitis in guinea pigs.
Topics: Acetates; Acute Disease; Animals; Cetirizine; Cyclopropanes; Dexamethasone; Disease Models, Animal; | 2008 |
Pharmacological prevention of ocular inflammation induced by lens proteins.
Topics: Aminopyridines; Animals; Catechols; Cimetidine; Crystallins; Disease Models, Animal; Drug Therapy, C | 1984 |
Characterization of various antiallergic agents using a new method for inducing systemic anaphylaxis in the rat.
Topics: Anaphylaxis; Animals; Blood Pressure; Bronchodilator Agents; Chromones; Cromolyn Sodium; Disease Mod | 1984 |
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].
Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, D | 1994 |
Mast cell mediators and peritoneal adhesion formation in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Histamine Antagonists; Leukotriene D4; Male; Mast Cells; | 1995 |
The 5-lipoxygenase inhibitory activity of zileuton in in vitro and in vivo models of antigen-induced airway anaphylaxis.
Topics: Anaphylaxis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoconstriction; Disease Models, | 1994 |
Effect of a peptide leukotriene receptor antagonist, ONO-1078, on guinea-pig models of asthma.
Topics: Acetylcholine; Acute-Phase Reaction; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstrict | 1993 |
Pharmacologic characterization of wool dust extract in isolated guinea pig trachea.
Topics: Air Pollutants, Occupational; Animals; Atropine; Bronchoconstriction; Calcium Channel Blockers; Cycl | 1995 |
Characterization of a primate model of asthma using anti-allergy/anti-asthma agents.
Topics: Albuterol; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Antigens; Asthma; Bronchoconstri | 1996 |
Pharmacological characterisation of a new model of antigen-induced pulmonary late-phase reaction in the conscious guinea pig which uses additional polymyxin B inhalation.
Topics: Administration, Inhalation; Animals; Anti-Bacterial Agents; Antigens; Asthma; Azepines; Disease Mode | 1996 |
Antiedematous effects of combination therapies with the leukotriene synthesis inhibitor BAY X 1005 in the archidonic acid-induced mouse ear inflammation test.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Disease Models, Animal; Drug The | 1997 |
Effect of substance P on the short-circuit current of rat nasal mucosal epithelium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Disease Models, Animal; Electr | 1998 |
Roles of histamine receptor in a guinea pig asthma model.
Topics: Animals; Asthma; Cimetidine; Disease Models, Animal; Guinea Pigs; Histamine Antagonists; Lung; Male; | 1998 |
Nasal hyperresponsiveness to histamine induced by repetitive exposure to cedar pollen in guinea-pigs.
Topics: Administration, Inhalation; Airway Resistance; Allergens; Animals; Atropine; Disease Models, Animal; | 1999 |
Effects of drugs acting as histamine releasers or histamine receptor blockers on an experimental anxiety model in mice.
Topics: Animals; Anxiety; Cimetidine; Disease Models, Animal; Histamine Antagonists; Histamine Release; Inje | 2000 |
ReN 1869, a novel tricyclic antihistamine, is active against neurogenic pain and inflammation.
Topics: Animals; Benzoquinones; Binding Sites; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; C | 2002 |
Elevated nasal mucosal G protein levels and histamine receptor affinity in a guinea pig model of nasal hyperresponsiveness.
Topics: Animals; Area Under Curve; Binding, Competitive; Blotting, Western; Disease Models, Animal; GTP-Bind | 2002 |
The role of histamine receptors in the pathophysiology of gastric mucosal damage.
Topics: Animals; Disease Models, Animal; Dogs; Gastric Mucosa; Hydrogen-Ion Concentration; Metiamide; Pyrila | 1977 |
Pharmacology of Schultz-Dale reaction in canine lung strip in vitro: possible model for allergic asthma.
Topics: Anaphylaxis; Animals; Asthma; Autacoids; Disease Models, Animal; Dogs; Female; Histamine H1 Antagoni | 1979 |
Is histamine a mediator in bile-induced gastric mucosal injury?
Topics: Animals; Bile; Cimetidine; Disease Models, Animal; Dogs; Gastric Mucosa; Histamine; Histamine Releas | 1978 |
Model of allergic bronchoconstriction in the guinea pig. I. Characteristics of the system.
Topics: Administration, Intranasal; Aerosols; Animals; Antibodies; Antigens; Bronchi; Bronchography; Cattle; | 1978 |
Chasing the elusive animal model of late-phase bronchoconstriction: studies in dogs, guinea pigs and rats.
Topics: Animals; Ascaris; Bronchi; Bronchial Hyperreactivity; Disease Models, Animal; Dogs; Guinea Pigs; Met | 1992 |
Mechanisms contributing to ozone-induced bronchial hyperreactivity in guinea-pigs.
Topics: Adenine Nucleotides; Animals; Ascorbic Acid; Atropine; Bronchial Hyperreactivity; Bronchoconstrictio | 1992 |
Possible contributory role of the central histaminergic system in the forced swimming model.
Topics: Animals; Antidepressive Agents; Brain Chemistry; Central Nervous System; Depressive Disorder; Diseas | 1992 |
Inhibitory effect of NZ-107 on anaphylactic bronchoconstriction in guinea pigs and rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Anaphylaxis; Anim | 1992 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationshi | 1991 |
Pharmacological modulation of a model of bronchial inflammation after aerosol-induced active anaphylactic shock in conscious guinea pigs.
Topics: Albuterol; Anaphylaxis; Animals; Asthma; Bronchitis; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; | 1991 |
Pharmacologic modulation of vascular permeability in ocular allergy in the rat.
Topics: Animals; Capillary Permeability; Conjunctiva; Conjunctivitis, Allergic; Cromolyn Sodium; Dexamethaso | 1990 |
The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086.
Topics: Anaphylaxis; Animals; Antigens; Azepines; Disease Models, Animal; Endotoxins; Escherichia coli; Guin | 1989 |
Role of central histaminergic mechanism in behavioural depression (swimming despair) in mice.
Topics: Animals; Atropine; Central Nervous System; Cimetidine; Depression; Desipramine; Disease Models, Anim | 1988 |
Roles of leukotrienes in two rat allergic inflammatory models; IgE-mediated and IgG-antigen complex-induced pleurisies.
Topics: Animals; Antigen-Antibody Complex; Benzoquinones; Chemotaxis, Leukocyte; Chromatography, High Pressu | 1986 |
Pathogenesis of coronary artery spasm in miniature swine with regional intimal thickening after balloon denudation.
Topics: Animals; Atropine; Calcium; Coronary Vasospasm; Coronary Vessels; Disease Models, Animal; Endotheliu | 1987 |
Neonatal ethanol exposure to rat pups: resultant alterations of cortical muscarinic and cerebellar H1-histaminergic receptor binding dynamics.
Topics: Animals; Animals, Newborn; Cerebral Cortex; Disease Models, Animal; Ethanol; Female; Fetal Alcohol S | 1986 |